Detection of BRAF mutations in colorectal tumours and peritoneal washings using a mismatch ligation assay.

abstract：:The simultaneous estimation of steroids in plasma was carried out by the assay of cortisol, corticosterone, and testosterone. The method entails separation by means of thin layer chromatography, followed by conversion to a fluorophore and fluorimetric measurement. Its major advantages are its high specificity, its abi...

journal_title：Journal of clinical pathology

authors： Mattingly D,Martin H,Tyler C

更新日期：1989-06-01 00:00:00

abstract：:Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation. ...

journal_title：Journal of clinical pathology

authors： Bennett PN

更新日期：1967-09-01 00:00:00

abstract：AIMS:Positive direct antiglobulin tests (DATs) are valuable in identifying the aetiology of autoimmune haemolysis and in guiding therapeutic intervention. However, in HIV-positive individuals with background polyclonal gammopathy, a positive DAT in the absence of haemolysis is common. In this setting, IgG quantificatio...

journal_title：Journal of clinical pathology

authors： Chetty T,Bouwer N,Wan YO,Mahlangu J

更新日期：2020-12-16 00:00:00

abstract：AIMS:Evidence suggests that the presence of tumour necrosis is an adverse prognostic factor in renal cell carcinoma (RCC). However, it has also been shown that tumour regression, a microscopic feature associated with necrosis, may be a favourable short term prognostic factor in RCC. METHODS:Pathology reports of 253 RC...

journal_title：Journal of clinical pathology

authors： Foria V,Surendra T,Poller DN

更新日期：2005-01-01 00:00:00

abstract：AIMS:The macroH2A histone variants are epigenetic marks for inactivated chromatin. In this study, we examined the expression of macroH2A2 in anal neoplasm from anal intraepithelial neoplasia (AIN) to anal squamous cell carcinoma (SCC). METHODS:AIN and anal SCC samples were analysed for macroH2A2 expression, HIV and hu...

journal_title：Journal of clinical pathology

authors： Hu WH,Miyai K,Sporn JC,Luo L,Wang JY,Cosman B,Ramamoorthy S

更新日期：2016-07-01 00:00:00

abstract：:A biochemical typing method is described for Klebsiella pneumoniae (sensu lato) and Enterobacter aerogenes. The technique depends on differences in metabolism of five carbon substrates--glycerol, inositol, lactose, glucose, and xylose--at two concentrations. Reproducibility is satisfactory and is monitored by the inco...

journal_title：Journal of clinical pathology

authors： Barr JG,Hogg GM

更新日期：1979-09-01 00:00:00

abstract：:Veno-occlusive disease of the liver with clinical and pathological features similar to those of the condition occurring in the Caribbean is described in a young woman resident in Britain. The diagnosis was made from liver biopsies and hepatic venography and was confirmed at necropsy. Small amounts of pyrroliziding alk...

journal_title：Journal of clinical pathology

authors： McGee J,Patrick RS,Wood CB,Blumgart LH

更新日期：1976-09-01 00:00:00

abstract：:Starch gel electrophoresis has demonstrated that graded concentrations of sodium sulphate do not precipitate the serum globulins in any reasonable degree of purity. The use of this form of electrophoresis has shown that caeruloplasmin is associated with a globulin in the Fa(2) position.This technique can be employed a...

journal_title：Journal of clinical pathology

authors： CUMINGS JN,EARL CJ

更新日期：1960-01-01 00:00:00

abstract：:The relationship between the intensity of the delayed hypersensitivity reaction and the dose of antigen used for its elicitation change with time after sensitization. At three weeks the reactions to 100 mug of egg albumen were little different from those to 1 mug but at 14 weeks 100 mug gave much stronger reactions. T...

journal_title：Journal of clinical pathology

authors： Jokipii AM,Jokipii L

更新日期：1973-09-01 00:00:00

abstract：:During 1971 and 1972, 71 cultures of neisseriae that attacked lactose were received by this laboratory. All strains except one from an eye swab were from the nasopharynx of healthy subjects. Nineteen similar strains from the nasopharynx were isolated in this laboratory. The characteristics of these strains were compar...

journal_title：Journal of clinical pathology

authors： Pykett AH

更新日期：1973-06-01 00:00:00

abstract：AIMS:To assess the presence of carcinoma in situ (CIS) in patients with nasopharyngeal carcinoma (NPC) and to see if the number of biopsy sites facilitates detection of CIS. METHODS:Formalin fixed, paraffin wax embedded biopsy specimens (n = 285) from 187 patients with NPC in 1987 were studied for the presence of CIS ...

journal_title：Journal of clinical pathology

authors： Chan CW,Nicholls JM,Sham JS,Dickens P,Choy D

更新日期：1992-10-01 00:00:00

abstract：:In a post-mortem analysis of 1,500 patients, aged 70 years or more, heart disease and malignancy were the two major causes of death. Coronary disease was exceedingly prevalent, almost one in five being subject to this form of heart disease, and 13% dying from its effects. The levelling of the sex ratio in coronary dis...

journal_title：Journal of clinical pathology

authors： MCKEOWN F

更新日期：1963-11-01 00:00:00

abstract：:Xanthine oxidase (XO) activity was found to be negligible in sterile human urines (less than 480 units, as presently defined, per litre). Significant XO activity was found in all urines containing more than 10(5) bacteria/ml, except for urines infected with Staphylococcus aureus, in which XO activity ranged from 347 t...

journal_title：Journal of clinical pathology

authors： Giler S,Henig EF,Urca I,Sperling O,de Vries A

更新日期：1978-05-01 00:00:00

abstract：:In a twenty-year period 19 appendicectomy specimens were diagnosed as primary Crohn's disease. This represents 4.9% of the total number of both resection specimens and mucosal biopsies diagnosed as Crohn's disease during that time. This is a review of the main histopathological features found in these appendices and t...

journal_title：Journal of clinical pathology

authors： Allen DC,Biggart JD

更新日期：1983-06-01 00:00:00

abstract：:A 45-year-old man is described in whom there is currently ERCP and histological evidence of primary sclerosing cholangitis (PSC). A liver biopsy obtained 29 years ago shows similar histological features confirming that he had PSC at that time. This case indicates that PSC may follow a relatively benign course. ...

journal_title：Journal of clinical pathology

authors： Goudie BM,Birnie GG,Watkinson G,MacSween RN

更新日期：1983-11-01 00:00:00

abstract：:Fourteen formalin fixed and paraffin wax embedded biopsy specimens from 10 women (age range 34-68) presenting with pseudomembranous trigonitis were studied using a combination of anti-oestrogen receptor monoclonal antibodies in an avidin-biotin immunoperoxidase technique. All epithelial areas showing vaginal metaplasi...

journal_title：Journal of clinical pathology

authors： Stephenson TJ,Henry L,Harris SC,Giri DD,Fox M,Underwood JC

更新日期：1989-09-01 00:00:00

abstract：:A saccharogenic method is described for estimating amylase activity in human urine. Results accord with those reported elsewhere except that in this study the peak in the beta zone is a new finding. Comparison between normal and pathological urines suggests that the amylase activity of the beta peak is not of pancreat...

journal_title：Journal of clinical pathology

authors： Franzini C

更新日期：1965-09-01 00:00:00

abstract：:Activation of the complement system, the main humoral mediator of inflammation, is restrained by the action of enzyme inhibitors including alpha 1-antitrypsin. Deficiency leads to chronic liver disease in about one in five children with this genetic defect. Complement activation was investigated in 34 children with al...

journal_title：Journal of clinical pathology

authors： Littleton ET,Bevis L,Hansen LJ,Peakman M,Mowat AP,Mieli-Vergani G,Vergani D

更新日期：1991-10-01 00:00:00

abstract：:Serine esterases were detected in the granules of mucosal mast cells from rat, mouse, sheep, and man. Successful demonstration of enzyme activity required brief fixation (6 h) of tissues in 4% paraformaldehyde. Staining with naphthol AS-D chloroacetate produced an intense red reaction product in intraepithelial mucosa...

journal_title：Journal of clinical pathology

authors： Huntley JF,Newlands GF,Gibson S,Ferguson A,Miller HR

更新日期：1985-04-01 00:00:00

abstract：:The histological appearances of the breast in a patient with mucoviscidosis are those of complete lobular agenesis. Ducts and ductules are well developed, and there is abundant fibrous tissue giving the breast a normal contour. The appearances are contrasted with those of gynaecomastia, and the aetiology is discussed....

journal_title：Journal of clinical pathology

authors： Ward AM

更新日期：1972-02-01 00:00:00

abstract：:Three patients with aplastic anaemia had a history of substantial previous exposure to organochlorine pesticides. The temporal association between chemical exposure and the onset of first symptoms of anaemia was strongly supportive. Organochlorines have the property of lipid affinity and accumulation in adipose tissue...

journal_title：Journal of clinical pathology

authors： Rugman FP,Cosstick R

更新日期：1990-02-01 00:00:00

abstract：:The prognostic value of detection of human papillomavirus (HPV) type 16 DNA in histologically cancer free lymph nodes was assessed in left obturator lymph nodes from cervical cancer patients with HPV-16 positive primary tumours. HPV-16 DNA was detected by polymerase chain reaction in 12 of 35 patients with histologica...

journal_title：Journal of clinical pathology

authors： Baay MF,Koudstaal J,Hollema H,Duk JM,Burger MP,Quint WG,Stolz E,Herbrink P

更新日期：1997-11-01 00:00:00

abstract：:The fetal antigen i has been demonstrated by indirect immunofluorescence on cord erythrocytes and placental trophoblast. A patient with disseminated choriocarcinoma developed high-tire anti-i cold agglutinins, and minor elevation of anti-i titres was seen in four out of six further patients with treated choriocarcinom...

journal_title：Journal of clinical pathology

authors： Boughton BJ

更新日期：1979-06-01 00:00:00

abstract：AIMS:The localisation of the translocation breakpoint of the Ewing sarcoma family of tumours shows significant variability on relatively large regions of fusion partner genes. As a consequence, many alternative forms of EWSR1-ETS translocation exist which make the RNA-based molecular diagnostics of Ewing sarcoma family...

journal_title：Journal of clinical pathology

authors： Patócs B,Németh K,Garami M,Arató G,Kovalszky I,Szendroi M,Fekete G

更新日期：2012-12-01 00:00:00

abstract：:This study was undertaken to determine the interrelations between clinico-biochemical parameters and hepatic morphology in markedly obese patients. One hundred and sixty-six women and 52 men comprise this series. There was a statistically significant association of carbohydrate metabolism disturbance with increasing a...

journal_title：Journal of clinical pathology

authors： Manes JL,Taylor HB,Starkloff GB

更新日期：1973-10-01 00:00:00

abstract：:A prospective, randomized trial is described in which the usefulness of two tests in the control of anticoagulant therapy is compared. Fifty-two patients were controlled by the one-stage prothrombin time and 55 by the activated partial thromboplastin time. There was no significant difference in the incidence of bleedi...

journal_title：Journal of clinical pathology

authors： Pearce SJ,Sekar AS

更新日期：1973-01-01 00:00:00

abstract：AIMS:To isolate RNA and DNA simultaneously from formalin fixed paraffin wax embedded tissue to assess the clonality of enteropathy associated T cell lymphomas and to analyse it in detail by a non-radioactive method of T cell receptor complementarity determining region 3 (CDR3) spectratyping. METHODS:DNA and RNA were i...

journal_title：Journal of clinical pathology

authors： O'Shea U,Wyatt JI,Howdle PD

更新日期：1997-10-01 00:00:00

abstract：AIMS:To validate the Singapore nomogram for outcome prediction in breast phyllodes tumours in a large cohort of Singaporean patients, as previous validation studies were conducted on small numbers of patients. We also investigate the association of fibroadenomas and phyllodes tumours within a subset of our cohort. MET...

journal_title：Journal of clinical pathology

authors： Chng TW,Gudi M,Lim SH,Li H,Tan PH

更新日期：2018-02-01 00:00:00

abstract：:Cervical smears were reviewed from 62 women who developed squamous carcinoma of the cervix up to 18 years later. The findings indicate that the prevention of cervical cancer by screening depends very largely on the detection of severe dyskaryosis. In this series there was no evidence that mild dyskaryosis was a foreru...

journal_title：Journal of clinical pathology

authors： Robertson JH,Woodend B,Elliott H

更新日期：1994-03-01 00:00:00

abstract：:Cutaneous melanoma causes most of the skin cancer deaths in the USA. Melanoma is the fifth most common cancer among men and the sixth most common cancer among women. The incidence of melanoma has risen sharply over the past three decades. In this review, which is informed by our extensive experience at a large cancer ...

journal_title：Journal of clinical pathology

authors： Trinidad CM,Torres-Cabala CA,Curry JL,Prieto VG,Aung PP

更新日期：2019-04-01 00:00:00