Urinary cyclic adenosine monophosphate in young adults and elderly subjects.

Abstract:

:The 24-hour urinary excretion of cyclic 3',5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between cAMP excretion and age demonstrated a progressive decrease from the age of 70 to the tenth decade. Many different factors could account for the reduced urinary cAMP excretion in elderly subjects: a decline in the reactivity of the adenyl cyclase-cAMP system related to physiological ageing; reduced physical activity; a reduction in the glomerular filtration rate or decreased production of cAMP by tubular cells in the senile kidney.

journal_name

J Clin Pathol

authors

Gennari C,Galli M,Montagnani M

doi

10.1136/jcp.29.1.69

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

69-72

issue

1

eissn

0021-9746

issn

1472-4146

journal_volume

29

pub_type

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