The anatomy of the normal placenta.

abstract：OBJECTIVE:Despite advances in therapy, lung cancer is still the leading cause of cancer-related mortality in the world. Further prognostic tools are warranted for risk-adapted therapeutic decisions. We analysed a cohort of primary surgically treated non-small cell lung cancers (NSCLCs) to determine the prognostic role ...

journal_title：Journal of clinical pathology

authors： Augustin F,Fiegl M,Schmid T,Pomme G,Sterlacci W,Tzankov A

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Nitric oxide synthase (NOS), particularly endothelial and inducible forms (e/i-NOS), are expressed in various cancers, including breast cancer. In mammary fibroepithelial lesions, NOS expression in stromal cells has been reported to be lower in fibroadenomas than in phyllodes tumours. AIMS:To investigate NO...

journal_title：Journal of clinical pathology

authors： Tse GM,Wong FC,Tsang AK,Lee CS,Lui PC,Lo AW,Law BK,Scolyer RA,Karim RZ,Putti TC

更新日期：2005-06-01 00:00:00

abstract：:A case is described in which marked hepatic fibrosis probably resulted from the prolonged treatment of acute leukaemia with methotrexate. ...

journal_title：Journal of clinical pathology

authors： Talerman A,Thompson RB

更新日期：1966-01-01 00:00:00

abstract：AIMS:Multiple myeloma (MM) is a heterogeneous disease characterised by genetically complex abnormalities. The classical mutational spectrum includes recurrent chromosomal aberrations and gene-level mutations. Recurrent translocations involving the IGH gene such as t(11;14), t(4;14) and t(14;16) are well known. However,...

journal_title：Journal of clinical pathology

authors： Lin M,Lee PL,Chiu L,Chua C,Ban KHK,Lin AHF,Chan ZL,Chung TH,Yan B,Chng WJ

更新日期：2018-08-01 00:00:00

abstract：:Three hundred and ninety eight serum samples from 270 human immunodeficiency virus (HIV) antibody positive asymptomatic homosexual men were tested in the Abbott and Dupont HIV antigen ELISA tests. In the Abbott test 62 (16%) of the sera were positive, according to the manufacturer's instructions, compared with 55 (14%...

journal_title：Journal of clinical pathology

authors： Shanson DC,Brown KE,Goonesekera S,Gazzard B,Coates AR

更新日期：1990-05-01 00:00:00

abstract：:In decalcified (5% nitric acid) and undecalcified (glycol-methacrylate or resin embedded) routinely processed bone specimens osteoclasts against resorbing surfaces were identified with monoclonal antibodies directed against leucocyte common antigen (LCA) (PD7/26, 2B11), CD68 (KP1), and gpIIIa (Y2/51) but not against H...

journal_title：Journal of clinical pathology

authors： Athanasou NA,Puddle B,Quinn J,Woods CG

更新日期：1991-08-01 00:00:00

abstract：AIM:To compare the attitudes of students towards the necropsy at different stages of their undergraduate career. METHOD:Students in the first, fourth and sixth academic years (n = 283) were asked to respond anonymously to a questionnaire comprised of 26 attitude statements. These statements dealt with the importance o...

journal_title：Journal of clinical pathology

authors： Botega NJ,Metze K,Marques E,Cruvinel A,Moraes ZV,Augusto L,Costa LA

更新日期：1997-01-01 00:00:00

abstract：:The excretion of 2,3-dinor-6-keto prostaglandin F1 alpha, a major urinary metabolite of prostacyclin, and the formation of thromboxane B2, a stable metabolite of thromboxane A2, by platelets stimulated by adenosine diphosphate, were studied in alcoholics, who had been admitted for detoxification. Once prolonged heavy ...

journal_title：Journal of clinical pathology

authors： Neiman J,Hillbom M,Benthin G,Anggård EE

更新日期：1987-05-01 00:00:00

abstract：:Carcinoma-associated fibroblast (CAF) as prominent cell type of the tumour microenvironment has complex interaction with both the cancer cells and other non-neoplastic surrounding cells. The CAF-derived regulators and extracellular matrix proteins can support cancer progression by providing a protective microenvironme...

journal_title：Journal of clinical pathology

authors： Valcz G,Sipos F,Tulassay Z,Molnar B,Yagi Y

更新日期：2014-12-01 00:00:00

abstract：:Cancer lineage/tissue-of-origin assignment in cancers of unknown primary remains a challenge even when aided by massively parallel sequencing. The stakes are high for patients as many contemporary therapeutic strategies are disease-specific, and the biological differences can influence the patients' responses. Herein,...

journal_title：Journal of clinical pathology

authors： Yoon JY,Rosenbaum JN,Vergara N,Cohen RB,Wilson RB

更新日期：2020-08-27 00:00:00

abstract：:Primary low grade marginal zone B cell lymphoma (MZL) of the breast and localised mammary amyloidosis are exceedingly rare entities. This report describes the case of a woman with long standing Sjögren's syndrome presenting with asymptomatic MZL of the breast showing plasmacytic differentiation, associated with local ...

journal_title：Journal of clinical pathology

authors： Kambouchner M,Godmer P,Guillevin L,Raphaël M,Droz D,Martin A

更新日期：2003-01-01 00:00:00

abstract：:Several diseases of the small intestine, including gluten-sensitivity, present with malabsorption and a "flat" mucosa. Determination of the mitotic index of epithelial lymphocytes provides a simple, objective method of assessing, and thus of predicting, whether a flat mucosa is due to gluten-sensitivity (index greater...

journal_title：Journal of clinical pathology

authors： Marsh MN,Haeney MR

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Prostate cancer diagnosis is routinely made by the histopathological examination of formalin fixed needle biopsy specimens. Frequently this is the only cancer tissue available from the patient for the analysis of diagnostic and prognostic biomarkers. There is, therefore, an urgent need for methods that allow...

journal_title：Journal of clinical pathology

authors： McCarthy F,Fletcher A,Dennis N,Cummings C,O'Donnell H,Clark J,Flohr P,Vergis R,Jhavar S,Parker C,Cooper CS

更新日期：2009-08-01 00:00:00

abstract：:A 45-year-old man is described in whom there is currently ERCP and histological evidence of primary sclerosing cholangitis (PSC). A liver biopsy obtained 29 years ago shows similar histological features confirming that he had PSC at that time. This case indicates that PSC may follow a relatively benign course. ...

journal_title：Journal of clinical pathology

authors： Goudie BM,Birnie GG,Watkinson G,MacSween RN

更新日期：1983-11-01 00:00:00

abstract：:Four assays for the detection of alphafetoprotein (AFP) in the diagnosis of primary hepatocellular carcinoma (HCC) were evaluated. The frequency of AFP detection was compared in 89 HCC patients and in 71 patients with chronic active hepatitis/cirrhosis. Of the four assays, immunodiffusion, counterimmunoelectrophoresis...

journal_title：Journal of clinical pathology

authors： Chan SH,Heng SH,Yo SL,Oon CJ

更新日期：1980-08-01 00:00:00

abstract：AIMS:To investigate a potential diagnostic use of alpha fetoprotein (alpha FP) isoform analysis by lectin affinity electrophoresis to distinguish between endodermal sinus tumours arising in the vagina in infants from those at other sites. METHODS:alpha FP in the serum of a patient with a vaginal endodermal sinus tumou...

journal_title：Journal of clinical pathology

authors： Yamamoto R,Taketa K,Ebina Y,Cho Y,Hareyama H,Sakuragi N,Makinoda S,Kobayashi K,Nishi S,Fujimoto S

更新日期：1997-10-01 00:00:00

abstract：UNLABELLED:Encapsulated papillary carcinoma (EPC) of the breast is a distinct histological subtype characterised by malignant epithelial proliferation supported by fibrovascular stalks. Although EPC typically lacks myoepithelial cells, it shows indolent clinical course. The classification of EPC as an in situ, or invas...

journal_title：Journal of clinical pathology

authors： Rakha EA,Tun M,Junainah E,Ellis IO,Green A

更新日期：2012-08-01 00:00:00

abstract：:A post-mortem examination, in the case of a 34-year-old man dying suddenly from head injuries sustained in a road accident, showed early cirrhosis of the liver and associated splenomegaly 17 years after an attack of infective hepatitis. The histology of the thymus showed abnormal changes in the medulla, consisting of ...

journal_title：Journal of clinical pathology

authors： CORRIDAN M

更新日期：1963-09-01 00:00:00

abstract：AIMS:Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. METHODS:Fifteen molecular laboratories from seven different European countries compa...

journal_title：Journal of clinical pathology

authors： Malapelle U,Pisapia P,Iaccarino A,Barberis M,Bellevicine C,Brunnström H,de Biase D,De Maglio G,Ericson Lindquist K,Fassan M,Fontanini G,Gruppioni E,Hofman P,Merkelbach-Bruse S,Molina Vila MA,Pujals A,Rapa I,Righi L,Ro

更新日期：2020-07-31 00:00:00

abstract：:A comprehensive neuropathological study was undertaken on 87 children aged between 2 and 15 years with fatal head injuries to identify those features which occurred at the time of head injury (fractured skull, contusions, intracranial haematoma and diffuse axonal injury) and those which were subsequently produced by c...

journal_title：Journal of clinical pathology

authors： Graham DI,Ford I,Adams JH,Doyle D,Lawrence AE,McLellan DR,Ng HK

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Serum prostate specific antigen (PSA) increases after radical prostatectomy are thought to indicate recurrent disease, although some suggest they result from benign prostatic epithelial tissue left at surgical margins. AIMS:To investigate whether presence, location, and extent of benign prostatic tissue at ...

journal_title：Journal of clinical pathology

authors： Kernek KM,Koch MO,Daggy JK,Juliar BE,Cheng L

更新日期：2005-07-01 00:00:00

abstract：:Renal endocrine tumours are extremely rare, and carcinoid tumoral elements in renal cell carcinoma have never been reported. This is the first report of a composite renal cell carcinoma containing a clear cell renal cell carcinoma associated with carcinoid tumoral elements, in a patient with synchronous metastatic dis...

journal_title：Journal of clinical pathology

authors： Bressenot A,Delaunay C,Gauchotte G,Oliver A,Boudrant G,Montagne K

更新日期：2010-02-01 00:00:00

abstract：:The rate of digestion of fibrin was measured in vitro by an isotopic technique in 140 blood samples of differing fibrinogen concentration; the assessment of fibrinolytic activity thus obtained was compared with a standard method of measurement, the dilute whole blood lysis time. The lysis time was related exponentiall...

journal_title：Journal of clinical pathology

authors： Hickman JA,Gordon-Smith IC,Whitfield PF,Godfrey SJ

更新日期：1973-03-01 00:00:00

abstract：:This report describes a patient with a gastric biopsy specimen showing histomorphological and immunohistochemical appearances indistinguishable from those usually present in lymphocytic gastritis, a rare condition of unknown aetiology with a distinctive phenotype. The patient had a history of a biopsy confirmed T cell...

journal_title：Journal of clinical pathology

authors： Nga ME,Tan SH,Teh M,Koay ES,Chong SM,Putti TC,Salto-Tellez M

更新日期：2004-11-01 00:00:00

abstract：AIM:To evaluate the clinical usefulness of three commercially available assays for Her-2/neu oncogene and protein measurements. The Her-2/neu protein is overexpressed, mostly as a result of gene amplification, in 20-30% of human breast cancers, and has been shown to have prognostic and predictive value for treatment wi...

journal_title：Journal of clinical pathology

authors： Wang S,Saboorian MH,Frenkel E,Hynan L,Gokaslan ST,Ashfaq R

更新日期：2000-05-01 00:00:00

abstract：:A miniaturised method for the identification of anaerobic bacteria is described which employs microtitre fermentation tests, a spot indole test and a nitrate reduction disc test. The results obtained are directly comparable with those produced by a standard conventional method in use at present. ...

journal_title：Journal of clinical pathology

authors： Levett PN

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:To determine whether antibiotics are prescribed appropriately for acute tonsillitis in an emergency department (ED). METHODS:Cross-sectional observational study in large district general hospital in London. Patients diagnosed and coded with 'acute tonsillitis' in the ED over a 3-month period in 2015. Medica...

journal_title：Journal of clinical pathology

authors： Kanji K,Saatci D,Rao GG,Khanna P,Bassett P,Williams B,Khan M

更新日期：2016-09-01 00:00:00

abstract：AIMS:To determine prognostic significance of immunohistochemical markers and investigate possible germinal centre (GC) derivation in primary lymphoma of bone (PLB). METHODS:Immunohistochemical expression of BCL-6, CD10, BCL-2, p53, CD30, CD44 and MUM-1 was studied in 36 patients with PLB. All cases were clinically sta...

journal_title：Journal of clinical pathology

authors： Heyning FH,Hogendoorn PC,Kramer MH,Holland CT,Dreef E,Jansen PM

更新日期：2009-09-01 00:00:00

abstract：:Strokes are one of the most common causes of mortality and long term severe disability. There is evidence that lipoprotein (a) (Lp(a)) is a predictor of many forms of vascular disease, including premature coronary artery disease. Several studies have also evaluated the association between Lp(a) and ischaemic (thrombot...

journal_title：Journal of clinical pathology

authors： Milionis HJ,Winder AF,Mikhailidis DP

更新日期：2000-07-01 00:00:00

abstract：:There is currently much speculation over the precise nature of lobular carcinoma in-situ of the breast and its significance. Histochemical study shows that it is rich in sialomucin. This has a characteristic intracellular distribution which distinghishes lobular carcinoma in-situ from cancerization of lobules. The sam...

journal_title：Journal of clinical pathology

authors： Gad A,Azzopardi JG

更新日期：1975-09-01 00:00:00