Abstract:
AIMS:To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS:Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In the cases associated with pseudoangiomatous hyperplasia of mammary stroma, immunoreactivity for cytokeratins (CAM 5.2), vimentin, CD34, factor VIII related antigen, and the oestrogen and progesterone receptors were studied. RESULTS:Pseudoangiomatous hyperplasia of mammary stroma was found in 21 of 88 cases of gynaecomastia (23.8%). In all cases, the cells lining the spaces were positive for vimentin, whereas CAM 5.2 and factor VIII related antigen were consistently negative. Nineteen of the 21 cases showed immunoreactivity for CD34. Ductal epithelial cells were positive for both the oestrogen receptor and the progesterone receptor, whereas stromal cells were negative. CONCLUSIONS:Pseudoangiomatous hyperplasia of mammary stroma was present in approximately one quarter of the cases of gynaecomastia. This immunohistochemical study confirms the mesenchymal origin of the stromal cells that line the pseudovascular spaces, as has been found in female cases of pseudoangiomatous hyperplasia of mammary stroma.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Milanezi MF,Saggioro FP,Zanati SG,Bazan R,Schmitt FCdoi
10.1136/jcp.51.3.204subject
Has Abstractpub_date
1998-03-01 00:00:00pages
204-6issue
3eissn
0021-9746issn
1472-4146journal_volume
51pub_type
杂志文章abstract::Mast cells were identified by electronmicroscopy in the alveolar wall of the lung in 20 subjects (10 normal, 10 abnormal). A quantitative and qualitative study was made of the mast cells. In the normal lung there was an average concentration of 350 mast cells/mm2 of alveolar wall and in the abnormal 523/mm2. Mast cell...
journal_title:Journal of clinical pathology
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doi:10.1136/jcp.34.12.1333
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更新日期:1986-03-01 00:00:00
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.55.8.623
更新日期:2002-08-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:2004-04-01 00:00:00
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doi:10.1136/jcp.46.6.551
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1979-12-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.28.2.118
更新日期:1975-02-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1980-07-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:1994-09-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.6.672
更新日期:1986-06-01 00:00:00
abstract:AIMS:To detect cells bearing BRAF mutations in colorectal tumour samples and peritoneal washings, using a mismatch ligation assay (MLA). METHODS:DNA from 46 colorectal tumours was studied. Part of exon 15 of the BRAF gene was amplified using the polymerase chain reaction, and T-->A mutations at codon 600 were detected...
journal_title:Journal of clinical pathology
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doi:10.1136/jcp.2004.018655
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.46.1.56
更新日期:1993-01-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.5.473
更新日期:1981-05-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.5.377
更新日期:1996-05-01 00:00:00
abstract::Sections from 100 cervical biopsy specimens were studied by 12 consultant histopathologists to determine the robustness of the existing pathology terminology and classification. Analysis by kappa statistics showed good agreement in the diagnosis of CIN 3 and squamous carcinoma but an inability to distinguish accuratel...
journal_title:Journal of clinical pathology
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doi:10.1136/jcp.42.3.231
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.2.199
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:The Royal College of Pathologists introduced the National Minimum Dataset (NMDS) for the histopathological reporting of cutaneous melanoma in February 2002. AIM:To determine if histological reporting of invasive primary cutaneous melanoma in the West Midlands region of the UK was compliant with the NMDS. M...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
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更新日期:2007-10-01 00:00:00