Abstract:
:This paper describes the value in diagnosis and the clinical implications of the detection of pneumococcal antigen in patients with lobar pneumonia. Ninety-eight patients with lobar pneumonia were investigated. Pneumococcal antigen was detected by counter-current immunoelectrophoresis in the sputum of 79% of patients with purulent sputum, in the serum of 29% of the patients, and in the urine of 54% of the patients. The diagnostic value of counter-current immunoelectrophoresis was not affected by prior antibiotic therapy. Patients with antigenaemia had a higher incidence of complications than those without as shown by an association between antigenaemia and jaundice, diarrhoea, and persistent pyrexia. Antigen persisted in the circulation for at least seven days in half the patients studied, possibly indicating the development of immunological tolerance to the polysaccharide antigen.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Tugwell P,Greenwood BMdoi
10.1136/jcp.28.2.118subject
Has Abstractpub_date
1975-02-01 00:00:00pages
118-23issue
2eissn
0021-9746issn
1472-4146journal_volume
28pub_type
杂志文章abstract::Distinctly increased levels of antibodies to measles virus envelope antigens haemolysin and haemagglutinin were found in the sera of patients with chronic active hepatitis compared with a normal control group, using immunofluorescence and functional tests. Similarly, a higher incidence of smooth muscle antibody of bot...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.11.1281
更新日期:1985-11-01 00:00:00
abstract:AIMS:To study the incidence, investigation, and management of severe hyponatraemia (serum sodium < 120 mmol/litre) over a period of six months in a district general hospital. METHODS:The laboratory computer was used to identify all inpatients who had a serum sodium concentration of less than 120 mmol/litre over a six ...
journal_title:Journal of clinical pathology
pub_type: 评论,杂志文章
doi:10.1136/jcp.55.12.893
更新日期:2002-12-01 00:00:00
abstract:AIMS:To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS:Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.51.3.204
更新日期:1998-03-01 00:00:00
abstract::A rare case of adult onset Langerhans' cell histiocytosis associated with dysgerminoma in a 35 year old Chinese woman is reported. The patient had a history of dysgerminoma of left ovary 15 years previously and had undergone surgery followed by radiotherapy and an uneventful recovery. She presented again in March 1994...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.10.963
更新日期:1995-10-01 00:00:00
abstract:AIMS:To determine the clinical performance of three cerebrospinal fluid (CSF) IgG synthesis formulae using data obtained from two quantitation methods. METHODS:Receiver operator characteristic (ROC) analysis and decision index plots were used to compare a rate nephelometric (RN) and a rocket immunoelectrophoretic (RIE...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.1.24
更新日期:1996-01-01 00:00:00
abstract:AIM:The rapid and fully automated Idylla EGFR Mutation Assay has been specifically designed to process formalin-fixed, paraffin-embedded sections without requiring preliminary DNA extraction. This study evaluates whether this approach can also process archival smears from patients with non-small cell lung cancer (NSCLC...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2019-205863
更新日期:2019-09-01 00:00:00
abstract::A method for the neutron activation analysis of copper in biological material is described and applied to the diagnosis and management of four cases of Wilson's disease. Results obtained for serum and urine are in agreement with values obtained by established colorimetric techniques. The method described can estimate ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.21.1.8
更新日期:1968-01-01 00:00:00
abstract:AIMS:Primary cilia play an important role in the regulation of cell signalling pathways and are thought to have a role in cancer but have seldom been studied in human cancer samples. METHODS:Primary cilia were visualised by dual immunofluorescence for anti-CROCC (ciliary rootlet coiled-coil) and anti-tubulin in a rang...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2016-204103
更新日期:2017-07-01 00:00:00
abstract::Melanocytes in melanocytic naevi and melanomas can display great variation. The presence of nuclear pseudoinclusions (NPI) is said to be useful in the histological and cytological differential diagnosis of malignant melanoma. The prevalence and characteristics of NPI in a series of 493 naevi and 50 melanomas are descr...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.7.676
更新日期:1995-07-01 00:00:00
abstract::A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.55.10.784
更新日期:2002-10-01 00:00:00
abstract::A clinical study of 401 cases of tumour of salivary tissue has been made and the results reported, together with a review of the literature. The histological variations of such tumours are classified and discussed. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.14.3.232
更新日期:1961-05-01 00:00:00
abstract::A case is reported of a patient with plasmacytoma which assumed different clinicopathological features over seven years. The tumour first presented as a subcutaneous mass which was misdiagnosed as anaplastic carcinoma. Complete response to radiotherapy ensued but recurrence took the form of an intracerebral tumour. Fu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.10.951
更新日期:1994-10-01 00:00:00
abstract::In a retrospective series of 40 appendiceal tumours occurring over a 10-year period, 30 were carcinoid tumours of classical histological pattern, five were adenocarcinomas, and two were tumours intermediate in pattern between carcinoid and carcinoma. The remaining three tumours were secondaries from primary colonic tu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.29.8.687
更新日期:1976-08-01 00:00:00
abstract::Zygomycosis is not often diagnosed in the United Kingdom, and so the possible importance of the findings in a patient with disseminated zygomycosis who had been treated with chemotherapy for erythroleukaemia was not appreciated until histological examination of specimens obtained at necropsy provided a presumptive dia...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.38.9.1039
更新日期:1985-09-01 00:00:00
abstract:AIMS:The perforin mediated pathway is the major pathway of cytotoxicity induced by activated T cells and natural killer cells, and may be involved in the development of pulmonary fibrosis. METHODS:Perforin and granzyme B expression were examined in idiopathic pulmonary fibrosis by means of immunohistochemistry, and pe...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2003.015495
更新日期:2004-12-01 00:00:00
abstract::Recent evidence shows that chronic liver disease induced by hepatitis delta virus is closely associated with production of autoantibodies. To verify this sera from patients with hepatitis delta virus and from those with hepatitis B virus mediated chronic liver disease were tested for a panel of autoantibodies. Althoug...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.8.897
更新日期:1986-08-01 00:00:00
abstract::In two out of three cases of idiopathic fibrosis of the mediastinum there was also retroperitoneal fibrosis, and in one of them extensive fibrosis of the lungs. One of these, a fit middle-aged man, died suddenly with severe coronary artery stenosis due to fibrosis. The third case was that of a young man with a solitar...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.1.78
更新日期:1978-01-01 00:00:00
abstract::Histological examination of the lower margin of the internal sphincter has demonstrated an increased amount of fibrous tissue in patients with haemorrhoids compared with controls. This finding may be of relevance to the treatment of haemorrhoids by maximal anal dilatation. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.31.3.268
更新日期:1978-03-01 00:00:00
abstract:AIMS:Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202626
更新日期:2015-06-01 00:00:00
abstract:AIMS:The IHC4+C score combines assessment of oestrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 with clinicopathological parameters to identify the risk of distant disease recurrence in patients with breast cancer, so, aiding treatment decision-making on adjuvant chemotherapy. Despite low cost and wide...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jclinpath-2015-203212
更新日期:2016-02-01 00:00:00
abstract::When the posture was changed from horizontal to vertical, or the reverse, the alteration in plasma volume and in the levels of haematocrit, haemoglobin, and plasma protein was much greater in patients with oedema or low plasma protein or albumin concentrations ("the pathological group") than in patients without these ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.13.4.304
更新日期:1960-07-01 00:00:00
abstract::Four cases of human infection with Achromobacter anitratus, one of which was fatal, are described. They all occurred at one hospital within a period of two months. The bacteriology, antibiotic sensitivity, and pathogenicity of the organisms are discussed. One of the strains was found to differ from the other three. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.14.6.670
更新日期:1961-11-01 00:00:00
abstract:AIMS:To study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. METHODS:A single intravenous dose of either ampicillin 500 mg, erythromycin 500 mg, or metronidazole 500 mg was administered to four healthy Helicobacter pylori negative v...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.3.225
更新日期:1992-03-01 00:00:00
abstract:AIMS:To compare prognostic information obtained by image analysis cytometry of paraffin wax embedded soft tissue sarcomas with conventional assessment. METHODS:A CAS 200 image analyser was used to determine DNA content of Feulgen stained cytology preparations and tissue sections and to quantify immunostaining by Ki67 ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.47.5.443
更新日期:1994-05-01 00:00:00
abstract::Platelet concentrates were prepared for in vitro storage in either Fenwal PL-732 or Cutter CLX platelet packs. The units were stored at 22 degrees C for seven days with either horizontal or tumbler agitation. Measurement of pH, hypotonic shock response and serotonin uptake indicated in vitro viability was well maintai...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.36.12.1382
更新日期:1983-12-01 00:00:00
abstract::Of the first 250 heart and 35 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 217 heart and 33 heart and lung patients were investigated serologically for evidence of Toxoplasma gondii infection. Six patients acquired primary T gondii in...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.2.194
更新日期:1989-02-01 00:00:00
abstract::Breast fibroepithelial lesions, including fibroadenomas and phyllodes tumours, are commonly encountered in clinical practice. As histological differences between these two related entities may be subtle, resulting in a challenging differential diagnosis, pathological techniques to assist the differential diagnosis of ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2015-203231
更新日期:2015-12-01 00:00:00
abstract::Immunoreactive trypsin (IRT) content in blood spots from 17 cystic fibrosis (CF) children born between 1975-80 were assayed with reagents from two commercial radioimmunoassay kits. The manufacturers' procedures were modified to allow assay of blood spot IRT. Half of the CF samples had a significantly raised IRT conten...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.8.906
更新日期:1981-08-01 00:00:00
abstract::The changes occurring at the periphery of invasive cervical carcinomas have been studied in detail, with particular reference to the incidence of preinvasive carcinoma. The various criteria used in the cytological diagnosis of malignancy have been evaluated, and the implications of large cytological screening programm...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.4.414
更新日期:1965-07-01 00:00:00
abstract::The cellularity of 104 primary breast carcinomata was determined by semiautomated image analysis to allow the relation between cellularity and oestrogen receptor content values to be assessed. The oestrogen receptor content of tumours detected by a steroid binding assay showed no correlation with cellularity, although...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.11.1166
更新日期:1989-11-01 00:00:00