Assay of serum immunoreactive trypsin in dried blood spots and the early detection of cystic fibrosis.

abstract：AIMS:To determine the clinical performance of three cerebrospinal fluid (CSF) IgG synthesis formulae using data obtained from two quantitation methods. METHODS:Receiver operator characteristic (ROC) analysis and decision index plots were used to compare a rate nephelometric (RN) and a rocket immunoelectrophoretic (RIE...

journal_title：Journal of clinical pathology

authors： McMillan SA,Douglas JP,Droogan AG,Hawkins SA

更新日期：1996-01-01 00:00:00

abstract：AIMS:To demonstrate expression of immunoglobulin light chain mRNA in diagnostic fine needle aspiration (FNA) cytology specimens using an in situ hybridisation (ISH) technique; and to evaluate ISH in a series of reactive lymphoid proliferations and malignant lymphomas. METHODS:Forty diagnostic FNA specimens showing a l...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Farquharson MA,Kerr T,McCorriston J

更新日期：1996-09-01 00:00:00

abstract：AIMS:To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS:Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In th...

journal_title：Journal of clinical pathology

authors： Milanezi MF,Saggioro FP,Zanati SG,Bazan R,Schmitt FC

更新日期：1998-03-01 00:00:00

abstract：AIMS:To determine whether myelodysplastic syndromes (MDS) are associated with sea blue histiocytosis in the bone marrow. METHODS:A retrospective review of bone marrow aspirates from 35 patients presenting consecutively with MDS and from 20 patients with each of the following: normal marrow appearance (routine staging ...

journal_title：Journal of clinical pathology

authors： Howard MR,Kesteven PJ

更新日期：1993-11-01 00:00:00

abstract：:Forty six lymph nodes were examined with the indirect immunoperoxidase technique for the distribution of fibronectin and laminin. Fibronectin was present in the framework of the tissue and the basal lamina of blood vessels, giving a clear outline of nodal architecture. Intracellular fibronectin was observed in cases o...

journal_title：Journal of clinical pathology

authors： Reilly JT,Nash JR,Mackie MJ,McVerry BA

更新日期：1985-08-01 00:00:00

abstract：:Hereditary breast cancer accounts for up to 5-10% of all breast carcinomas. Recent studies have demonstrated that mutations in two high-penetrance genes, namely BRCA1 and BRCA2, are responsible for about 16% of the familial risk of breast cancer. Even though subsequent studies have failed to find another high-penetran...

journal_title：Journal of clinical pathology

authors： Tan DS,Marchiò C,Reis-Filho JS

更新日期：2008-10-01 00:00:00

abstract：:Members of a newly recognized group of hospital staphylococci, which are believed to have arisen from 83A staphylococci by lysogenization, differ from them in several cultural characters. Some but not all of these characters appear to be determined by the carriage of phage. ...

journal_title：Journal of clinical pathology

authors： Jevons MP,John M,Parker MT

更新日期：1966-07-01 00:00:00

abstract：:A modified nitroblue tetrazolium test (NBT) is described which is suitable for routine application in the haematology or bacteriology laboratory and which provides a rapid aid to the diagnosis of bacterial infection. Hitherto published methods have recommended the use of heparinized whole blood samples for the perform...

journal_title：Journal of clinical pathology

authors： Gordon AM,Rowan RM,Brown T,Carson HG

更新日期：1973-01-01 00:00:00

abstract：AIMS:To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival. METHODS:148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-t...

journal_title：Journal of clinical pathology

authors： Stankiewicz E,Ng M,Cuzick J,Mesher D,Watkin N,Lam W,Corbishley C,Berney DM

更新日期：2012-06-01 00:00:00

abstract：AIM:Ultraviolet light (UV) is known to cause DNA damage in the epidermis. The damaged DNA is repaired or deleted by apoptosis to prevent the generation of cancer. It has been suggested that a deficient apoptotic mechanism may predispose individuals to skin cancer. Therefore, the response of normal controls and patients...

journal_title：Journal of clinical pathology

authors： Murphy M,Mabruk MJ,Lenane P,Liew A,McCann P,Buckley A,O Flatharta C,Hevey D,Billet P,Robertson W,Javed S,Leader M,Kay E,Murphy GM

更新日期：2002-11-01 00:00:00

abstract：:During the last decade, a dramatic rise in the development and application of artificial intelligence (AI) tools for use in pathology services has occurred. This trend is often expected to continue and reshape the field of pathology in the coming years. The deployment of computational pathology and applications of AI ...

journal_title：Journal of clinical pathology

authors： Rakha EA,Toss M,Shiino S,Gamble P,Jaroensri R,Mermel CH,Chen PC

更新日期：2020-08-06 00:00:00

abstract：:Nasal biopsy findings in malignant histiocytosis presenting clinically as lethal midline granuloma are characterised by necrosis and infiltration of atypical histiocytic cells with a diffuse positive reaction for non-specific esterase. This cellular character was common to midline malignant reticulosis, and midline ma...

journal_title：Journal of clinical pathology

authors： Aozasa K

更新日期：1982-06-01 00:00:00

abstract：:During 1971 and 1972, 71 cultures of neisseriae that attacked lactose were received by this laboratory. All strains except one from an eye swab were from the nasopharynx of healthy subjects. Nineteen similar strains from the nasopharynx were isolated in this laboratory. The characteristics of these strains were compar...

journal_title：Journal of clinical pathology

authors： Pykett AH

更新日期：1973-06-01 00:00:00

abstract：:A polyclonal antiserum, produced in sheep and reactive against purified human leucocyte elastase, has been applied to paraffin sections from a range of human tissues by means of the indirect immunoperoxidase method. Striking and consistent results have been obtained. Normal or inflammatory granulocytes were intensely ...

journal_title：Journal of clinical pathology

authors： Crocker J,Jenkins R,Burnett D

更新日期：1984-10-01 00:00:00

abstract：AIMS:To establish a three dimensional reconstruction of an invasive breast carcinoma using basic laboratory equipment to evaluate and characterise the spatial arrangement of the parenchymal cells of the breast. METHODS:One hundred and twenty eight sequential 4 microm sections (20 microm apart) of the tumour were stain...

journal_title：Journal of clinical pathology

authors： Kurien T,Boyce RW,Paish EC,Ronan J,Maddison J,Rakha EA,Green AR,Ellis IO

更新日期：2005-09-01 00:00:00

abstract：:Electron microscopical and cytochemical studies of intestinal biopsies from a patient with typical features of the Cronkhite-Canada syndrome show that the primary process affects the crypts. This results in cystic dilatation associated with expansion and focal degeneration of the crypt compartment of the intestinal ep...

journal_title：Journal of clinical pathology

authors： Jenkins D,Stephenson PM,Scott BB

更新日期：1985-03-01 00:00:00

abstract：:Non-Hodgkin's lymphoma is not commonly a familial condition. This is believed to be the first two cases of primary pancreatic lymphoma within a single family. The two cases, a brother and sister, both presented in their 60s and were diagnosed histologically as having high grade B cell lymphoma affecting the pancreas, ...

journal_title：Journal of clinical pathology

authors： James JA,Milligan DW,Morgan GJ,Crocker J

更新日期：1998-01-01 00:00:00

abstract：:A manual system of microbiology reporting with a National Cash Register (NCR) form with printed names of bacteria and antiboitics required less time to compose reports than a previous manual system that involved rubber stamps and handwriting on plain report sheets. The NCR report cost 10-28 pence and, compared with a ...

journal_title：Journal of clinical pathology

authors： Goodwin CS

更新日期：1976-06-01 00:00:00

abstract：:Extracts of the seeds of Vicia cretica (NO Leguminosae) strongly agglutinate T- Th- but not Tk- or other polyagglutinable red cells. The V. cretica lectin is therefore a very useful laboratory reagent in the elucidation of erythrocyte polyagglutination due to T-like erythrocyte cryptantigens. ...

journal_title：Journal of clinical pathology

authors： Bird GW,Wingham J

更新日期：1981-01-01 00:00:00

abstract：:Three patients with aplastic anaemia had a history of substantial previous exposure to organochlorine pesticides. The temporal association between chemical exposure and the onset of first symptoms of anaemia was strongly supportive. Organochlorines have the property of lipid affinity and accumulation in adipose tissue...

journal_title：Journal of clinical pathology

authors： Rugman FP,Cosstick R

更新日期：1990-02-01 00:00:00

abstract：:Platelet transfusions have the highest incidence of post-transfusion sepsis compared with any other blood products. Recent reports suggest that platelet-related bacteraemia occurs at a frequency of approximately 50 times greater than that for red blood cells. The source is usually skin contaminants from the donor and ...

journal_title：Journal of clinical pathology

authors： Coutinho H,Galloway A,Ajdukiewicz K,Cleeve V

更新日期：2010-03-01 00:00:00

abstract：:A method is described for assessing thyroid status using Sephadex column chromatography of serum samples with added (125)I triiodothyronine. The method is simple and inexpensive. It gave a correct diagnostic result in 97% of 258 euthyroid, 90% of 80 hyperthyroid, 78% of 59 hypothyroid, and 67% of 50 euthyroid, ill pat...

journal_title：Journal of clinical pathology

authors： Gimlette TM

更新日期：1967-03-01 00:00:00

abstract：:An enzyme linked immunoadsorbent assay (ELISA) was used to detect IgG, IgM, and IgA antibody in urine to a crude antigenic mixture prepared from six arbitrarily chosen strains of common coliform urinary pathogens. In a group of patients with symptoms of urinary tract infection 24 of 80 (30%) urine samples were positiv...

journal_title：Journal of clinical pathology

authors： McKenzie H,Young DN

更新日期：1987-07-01 00:00:00

abstract：AIMS:Caucasian patients with disorders of sex development (DSD) are at a high risk of developing germ cell cancer (GCC). GCC is prominent in young adults in Western countries, while the incidence is significantly lower in Asia. So far, the risk of GCC in Asian DSD patients is unknown. METHODS AND RESULTS:A detailed st...

journal_title：Journal of clinical pathology

authors： Juniarto AZ,Setyawati BA,Miranti IP,Santosa A,Hersmus R,Stoop H,Cools M,Oosterhuis JW,Drop SL,Faradz SM,Looijenga LH

更新日期：2013-03-01 00:00:00

abstract：:Performance of CHROMagar Acinetobacter was assessed for the selective isolation and identification of Acinetobacter baumannii. The medium was effective in suppressing the growth of other Gram-positive and Gram-negative species while the addition of KPC supplement ensured growth of only carbapenem resistant A baumannii...

journal_title：Journal of clinical pathology

authors： Wareham DW,Gordon NC

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:During the last decade, whole slide images (WSI) have been used in many areas of pathology such as teaching, research, digital archiving, teleconsultation and quality assurance testing. However, WSI have not regularly been used for routine diagnosis, because of the lack of validation studies. AIM:To test th...

journal_title：Journal of clinical pathology

authors： Al-Janabi S,Huisman A,Vink A,Leguit RJ,Offerhaus GJ,Ten Kate FJ,van Dijk MR,van Diest PJ

更新日期：2012-02-01 00:00:00

abstract：AIMS:To compare prognostic information obtained by image analysis cytometry of paraffin wax embedded soft tissue sarcomas with conventional assessment. METHODS:A CAS 200 image analyser was used to determine DNA content of Feulgen stained cytology preparations and tissue sections and to quantify immunostaining by Ki67 ...

journal_title：Journal of clinical pathology

authors： Michie BA,Black C,Reid RP,Barrett A,Hamblen DL

更新日期：1994-05-01 00:00:00

abstract：:A rapid and reproducible electrophoretic method for the separation and quantitation of haemoglobins on cellulose acetate is described. The accuracy of the method and its possible sources of error are discussed. The normal range for haemoglobin A(2) by this method is 1% to 3% of the total haemoglobin concentration. Blo...

journal_title：Journal of clinical pathology

authors： Marengo-Rowe AJ

更新日期：1965-11-01 00:00:00

abstract：BACKGROUND:Chromogenic in situ hybridisation (CISH) is an alternative to immunohistochemistry or FISH for the assessment of HER2 oncogene status in breast cancer. Although CISH is being used increasingly in routine diagnostics, there are no established inter-laboratory quality assurance programmes for this test. METHO...

journal_title：Journal of clinical pathology

authors： Di Palma S,Collins N,Bilous M,Sapino A,Mottolese M,Kapranos N,Schmitt F,Isola J

更新日期：2008-06-01 00:00:00

abstract：AIMS:The incidence of RAS/RAF/PI3KA and TP53 gene mutations in colorectal cancer (CRC) is well established. Less information, however, is available on other components of the CRC genomic landscape, which are potential CRC prognostic/predictive markers. METHODS:Following a previous validation study, ion-semiconductor n...

journal_title：Journal of clinical pathology

authors： Malapelle U,Pisapia P,Sgariglia R,Vigliar E,Biglietto M,Carlomagno C,Giuffrè G,Bellevicine C,Troncone G

更新日期：2016-09-01 00:00:00