A quality assurance exercise to evaluate the accuracy and reproducibility of chromogenic in situ hybridisation for HER2 analysis in breast cancer.

abstract：:Three adults with alpha 1-antitrypsin deficiency are described. In two of the cases the deficiency was genetically determined (cases 1 and 2), and each demonstrated unusual features of the disease. The liver in case 1 (homozygous) showed cholangiolar hyperplasia which has been recorded only once before. Case 2 (hetero...

journal_title：Journal of clinical pathology

authors： Sweeney EC

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Clinical outcome in patients with diffuse large B cell lymphomas (DLBCL) is highly variable and poorly predictable. Microarray studies showed that patients with DLBCL with a germinal centre B cell-like (GCB) phenotype have a better prognosis than those with an activated B cell-like (ABC) phenotype. The BMI1 ...

journal_title：Journal of clinical pathology

authors： van Galen JC,Muris JJ,Oudejans JJ,Vos W,Giroth CP,Ossenkoppele GJ,Otte AP,Raaphorst FM,Meijer CJ

更新日期：2007-02-01 00:00:00

abstract：AIMS:To determine the potential efficiency of molecular markers specific for neoplastic change--mutations of the K-ras oncogene and the p53 tumour suppressor gene--in diagnosing pancreatic carcinoma. METHODS:Archival cytology samples obtained from 17 patients with established pancreatic carcinoma were assayed for alte...

journal_title：Journal of clinical pathology

authors： van Es JM,Polak MM,van den Berg FM,Ramsoekh TB,Craanen ME,Hruban RH,Offerhaus GJ

更新日期：1995-03-01 00:00:00

abstract：:A monoclonal antibody, produced by peptide immunisation was used to detect the distribution of p62c/myc by immunohistology in normal and coeliac small intestinal mucosa. The effect of gluten in four treated coeliac patients was investigated by taking serial jejunal biopsy specimens for six hours after a 10 g oral glut...

journal_title：Journal of clinical pathology

authors： Ciclitira PJ,Stewart J,Evan G,Wight DG,Sikora K

更新日期：1987-03-01 00:00:00

abstract：:As patients with multiple myeloma (MM) have a variable clinical course, predictive markers would help determine the appropriate treatment strategy. Clinical staging is commonly used to predict outcome, but tumour marker expression and the underlying genetic changes are increasingly used to assess the biological aggres...

journal_title：Journal of clinical pathology

authors： Yeung J,Chang H

更新日期：2008-07-01 00:00:00

abstract：:This review focuses on the pathological features of dysplasia in Barrett's oesophagus. Two categorisation schemes are used for grading dysplasia in the gastrointestinal tract, including Barrett's oesophagus. The inflammatory bowel disease dysplasia morphology study group system is the one most commonly used in the USA...

journal_title：Journal of clinical pathology

authors： Odze RD

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Subgroups of breast cancer that have an impaired response to endocrine treatment, despite hormone receptor positivity, are still poorly defined. Breast cancer can be subdivided according to standard pathological parameters including histological type, grade, and assessment of proliferation. These parameters ...

journal_title：Journal of clinical pathology

authors： Jirström K,Rydén L,Anagnostaki L,Nordenskjöld B,Stål O,Thorstenson S,Chebil G,Jönsson PE,Fernö M,Landberg G

更新日期：2005-11-01 00:00:00

abstract：AIM:An audit of serrated polyps diagnosed over a 4-year period: 2009 to 2012 was undertaken to ascertain the reporting trends of sessile serrated polyps (SSP). METHODS:All right sided hyperplastic polyps (HP) proximal to the splenic flexure and all polyps designated SSP were retrieved from the study period. Three path...

journal_title：Journal of clinical pathology

authors： Gill P,Wang LM,Bailey A,East JE,Leedham S,Chetty R

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Currently, no specific immunohistochemical markers are available to differentiate primary mucinous epithelial ovarian cancer (MOC) from adenocarcinomas originating at other sites that have metastasised to the ovary, which may have an impact on patient management and prognosis. AIM:To investigate the express...

journal_title：Journal of clinical pathology

authors： Heinzelmann-Schwarz VA,Scolyer RA,Scurry JP,Smith AN,Gardiner-Garden M,Biankin AV,Baron-Hay S,Scott C,Ward RL,Fink D,Hacker NF,Sutherland RL,O'Brien PM

更新日期：2007-06-01 00:00:00

abstract：AIMS:EGFR tyrosine kinase inhibitors (TKIs) are first-line molecularly targeted therapies in patients with advanced non-small cell lung cancer (NSCLC) who carry sensitising EGFR mutations, due to its superior survival outcomes compared with conventional chemotherapy regimens. In this study, we sought to identify clinic...

journal_title：Journal of clinical pathology

authors： Ng IK,Kumarakulasinghe NB,Syn NL,Soo RA

更新日期：2021-02-01 00:00:00

abstract：AIM:To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS:Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were gra...

journal_title：Journal of clinical pathology

authors： Phull PS,Price AB,Stephens J,Rathbone BJ,Jacyna MR

更新日期：1996-05-01 00:00:00

abstract：:Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese...

journal_title：Journal of clinical pathology

authors： So CC,Chan AY,Chow EY,Lin SY,Yip SF,Szeto SC,Chan LC

更新日期：2010-10-01 00:00:00

abstract：AIMS:To develop a specific radioimmunoassay for the routine determination of serum vitamin B12. METHODS:Antisera were raised in rabbits by immunisation with the monocarboxylic acid derivative of cyanocobalamin coupled to human serum albumin. Antibody titres and affinities were determined and the antiserum giving the h...

journal_title：Journal of clinical pathology

authors： O'Sullivan JJ,Leeming RJ,Lynch SS,Pollock A

更新日期：1992-04-01 00:00:00

abstract：AIM:To examine peripheral blood and skeletal muscle from patients with chronic fatigue syndrome for exogenous retrovirus. METHODS:Blood samples from 30 patients and muscle biopsy specimens of 15 patients were examined for retroviral sequences by DNA extraction, polymerase chain reaction (PCR), and Southern blotting hy...

journal_title：Journal of clinical pathology

authors： Gow JW,Simpson K,Schliephake A,Behan WM,Morrison LJ,Cavanagh H,Rethwilm A,Behan PO

更新日期：1992-12-01 00:00:00

abstract：:Three hundred and ninety eight serum samples from 270 human immunodeficiency virus (HIV) antibody positive asymptomatic homosexual men were tested in the Abbott and Dupont HIV antigen ELISA tests. In the Abbott test 62 (16%) of the sera were positive, according to the manufacturer's instructions, compared with 55 (14%...

journal_title：Journal of clinical pathology

authors： Shanson DC,Brown KE,Goonesekera S,Gazzard B,Coates AR

更新日期：1990-05-01 00:00:00

abstract：:In a retrospective series of 40 appendiceal tumours occurring over a 10-year period, 30 were carcinoid tumours of classical histological pattern, five were adenocarcinomas, and two were tumours intermediate in pattern between carcinoid and carcinoma. The remaining three tumours were secondaries from primary colonic tu...

journal_title：Journal of clinical pathology

authors： Jones RA,MacFarlane A

更新日期：1976-08-01 00:00:00

abstract：:Several studies have recently documented the presence of persistently abnormal liver function tests in asymptomatic haemophiliacs. While the aetiology is unknown it is possible that repeated exposure to agents transmitted in blood products may be important. This study has attempted to determine the prevalence of viral...

journal_title：Journal of clinical pathology

authors： McVerry BA,Ross MG,Knowles WA,Voke J

更新日期：1979-04-01 00:00:00

abstract：:The microwave tissue coagulator (MTC) is used in hepatectomy because it provides excellent haemostasis during the procedure. A 59 year old man underwent partial hepatic lobectomy with MTC, for metastasis from colon cancer. A tumorous necrotic nodule was discovered in the liver. The nodule measured 2.5 cm at its larges...

journal_title：Journal of clinical pathology

authors： Mikami Y,Shimizu M,Manabe T

更新日期：1997-08-01 00:00:00

abstract：:Specimens of muscle were obtained from non-suppurating lesions of nine patients with tropical myositis. When examined in an electron microscope, these revealed patchy myocytolysis with loss of band structure. Perimysial cells were also degenerate. Sections from two out of nine patients revealed intracellular vesicles,...

journal_title：Journal of clinical pathology

authors： Taylor JF,Fluck D,Fluck D

更新日期：1976-12-01 00:00:00

abstract：AIMS:To institute recommendations from a laboratory turnround time study; to evaluate audit methods; and to quantify improvements achieved. METHODS:Changes to result report distribution and specimen delivery were affected by posting results directly from the laboratory followed by the introduction of a twice daily cou...

journal_title：Journal of clinical pathology

authors： Smellie WS,Galloway PJ,Johnston JI

更新日期：1995-04-01 00:00:00

abstract：:Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed ...

journal_title：Journal of clinical pathology

authors： Franklin IM,Kernoff PB,Isherwood D,Leek J,Morgan DB

更新日期：1982-09-01 00:00:00

abstract：AIMS:To determine important factors influencing recurrence after local excision of duct carcinoma in situ (DCIS) of the breast. MATERIALS AND METHODS:The extent (size) in millimetres, classification (by cytonuclear grade (NHSBSP system), by extent of necrosis, and by the Van Nuys system), and excision margins of 115 c...

journal_title：Journal of clinical pathology

authors： Douglas-Jones AG,Logan J,Morgan JM,Johnson R,Williams R

更新日期：2002-08-01 00:00:00

abstract：:In order to classify the underlying disorder in four patients with biopsy-proven amyloidosis without overt monoclonal gammopathy, the cytoplasmic immunoglobulin (Ig) distribution of bone marrow plasma cells was evaluated using direct immunofluorescence microscopy. This procedure revealed the presence of a monoclonal p...

journal_title：Journal of clinical pathology

authors： Thielemans C,Aelbrecht W,Verbeelen D,Somers G,De Waele M,Van Camp B

更新日期：1982-03-01 00:00:00

abstract：:Using a short series of biochemical tests already in use in many routine laboratories, it is possible to identify strains of the genus Klebsiella and to differentiate K. aerogenes from other types. Marked production of slime is not peculiar to the group and colonial appearance alone is not a satisfactory basis for ide...

journal_title：Journal of clinical pathology

authors： DARRELL JH,HURDLE AD

更新日期：1964-11-01 00:00:00

abstract：:A pseudolymphomatous reaction involving subcutaneous tissue and underlying skeletal muscle is described in a woman who was receiving phenytoin sodium and phenobarbitone. The histological appearance was of nodular, densely cellular tissue composed of histiocytes, plasma cells, lymphocytes, fibroblasts, and occasional p...

journal_title：Journal of clinical pathology

authors： Wilden JN,Scott CA

更新日期：1978-08-01 00:00:00

abstract：:Pre-eclampsia complicated by deep jaundice occurred in a previously healthy primigravida. The main aetiological factor was disseminated intravascular coagulation; this caused both haemolysis and liver cell necrosis. Liver biopsy showed fibrin thrombi in the capillaries with microhaemorrhages and loss of periportal liv...

journal_title：Journal of clinical pathology

authors： Long RG,Scheuer PJ,Sherlock S

更新日期：1977-03-01 00:00:00

abstract：:In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than those of the corresponding group of male donors. In the whole series of female donors, there were significantly lower tota...

journal_title：Journal of clinical pathology

authors： Allan RN,Alexander MK

更新日期：1968-11-01 00:00:00

abstract：:When the posture was changed from horizontal to vertical, or the reverse, the alteration in plasma volume and in the levels of haematocrit, haemoglobin, and plasma protein was much greater in patients with oedema or low plasma protein or albumin concentrations ("the pathological group") than in patients without these ...

journal_title：Journal of clinical pathology

authors： FAWCETT JK,WYNN V

更新日期：1960-07-01 00:00:00

abstract：:A histochemical method is described of differentiating between normal and neoplastic cells in plasma using the activity of various enzymes characteristic of plasma cells. It was found that in both types of cell increased or diminished activity of cytoenzymes is a useful means of distinguishing between normal and abnor...

journal_title：Journal of clinical pathology

authors： SZMIGIELSKI S,LITWIN J,ZUPANSKA B

更新日期：1965-05-01 00:00:00

abstract：AIMS:To investigate the relation between sarcoidosis and lymphoma. METHODS:The hospital notes of five patients with sarcoidosis and a lymphoproliferative disorder were reviewed. Histological material on which the diagnoses of sarcoidosis and lymphoma were made was re-analysed. RESULTS:Four of the five patients had we...

journal_title：Journal of clinical pathology

authors： Karakantza M,Matutes E,MacLennan K,O'Connor NT,Srivastava PC,Catovsky D

更新日期：1996-03-01 00:00:00