Association between sarcoidosis and lymphoma revisited.

Abstract:

AIMS:To investigate the relation between sarcoidosis and lymphoma. METHODS:The hospital notes of five patients with sarcoidosis and a lymphoproliferative disorder were reviewed. Histological material on which the diagnoses of sarcoidosis and lymphoma were made was re-analysed. RESULTS:Four of the five patients had well documented sarcoidosis preceding the development of lymphoma by 18 months to 28 years; the fifth patient had lymphoplasmacytic lymphoma with a reactive granuloma reaction. Two patients had chronic sarcoidosis and three were treated with prednisolone. The types of lymphoma were: Hodgkin's disease (n = 1), B cell lymphoma (n = 2) (mantle cell and lymphoplasmacytic/local plasmacytoma) and large granular lymphocyte leukaemia (T cell) (n = 1). CONCLUSIONS:The association between sarcoidosis and lymphoma is confirmed, suggesting that sarcoidosis may be a predisposing factor for the development of a lymphoid malignancy due to disturbance of the immune system. All types of lymphoma may develop. The first case of T cell granular lymphocytic leukaemia in a patient with sarcoidosis has been documented.

journal_name

J Clin Pathol

authors

Karakantza M,Matutes E,MacLennan K,O'Connor NT,Srivastava PC,Catovsky D

doi

10.1136/jcp.49.3.208

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

208-12

issue

3

eissn

0021-9746

issn

1472-4146

journal_volume

49

pub_type

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