Abstract:
AIMS:To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH). METHODS:Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7) and smooth muscle actin in paraffin-embedded sections of proliferating and involuted IHs. RESULTS:The proteins hCG and hPL were expressed by the endothelium but not the pericyte layer of proliferating IH, but these proteins were not detected in involuted lesions. There was no expression of CK7 and HLA-G in IH. CONCLUSIONS:The expression of hCG and hPL, but not CK7 or HLA-G, by the endothelium of proliferating IH supports a placental chorionic villous mesenchymal core cellular origin for IH rather than a trophoblast origin.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Itinteang T,Tan ST,Guthrie S,Tan CE,McIntyre BC,Brasch HD,Day DJdoi
10.1136/jclinpath-2011-200191subject
Has Abstractpub_date
2011-10-01 00:00:00pages
870-4issue
10eissn
0021-9746issn
1472-4146pii
jclinpath-2011-200191journal_volume
64pub_type
杂志文章abstract::Neoplastic and non-neoplastic oxyphil cells in thyroid disorders were investigated for enzyme and synthetic activity, ultrastructural features, and immune complex deposition. A reduced but definite content of thyroglobuliin and similar enzyme profiles and ultrastructural features in all types of oxyphill change were f...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.45.4.299
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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更新日期:2003-12-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2003.010074
更新日期:2004-02-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1979-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.39.4.353
更新日期:1986-04-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.5.523
更新日期:1984-05-01 00:00:00
abstract::The interference of IgM-class rheumatoid factor (RF) in the solid-phase radioimmunoassay (RIA) of rubella virus IgM antibodies was studied. Acute rubella infections did not significantly activate RF. False-positive rubella antibody results were obtained, however, when patients with raised RF levels were tested. If a l...
journal_title:Journal of clinical pathology
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更新日期:1978-05-01 00:00:00
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更新日期:1994-05-01 00:00:00
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journal_title:Journal of clinical pathology
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doi:10.1136/jcp.2005.029934
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更新日期:2003-11-01 00:00:00
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journal_title:Journal of clinical pathology
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更新日期:2011-10-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1992-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
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更新日期:2007-10-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:2017-02-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1997-11-01 00:00:00