A placental chorionic villous mesenchymal core cellular origin for infantile haemangioma.

Abstract:

AIMS:To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH). METHODS:Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7) and smooth muscle actin in paraffin-embedded sections of proliferating and involuted IHs. RESULTS:The proteins hCG and hPL were expressed by the endothelium but not the pericyte layer of proliferating IH, but these proteins were not detected in involuted lesions. There was no expression of CK7 and HLA-G in IH. CONCLUSIONS:The expression of hCG and hPL, but not CK7 or HLA-G, by the endothelium of proliferating IH supports a placental chorionic villous mesenchymal core cellular origin for IH rather than a trophoblast origin.

journal_name

J Clin Pathol

authors

Itinteang T,Tan ST,Guthrie S,Tan CE,McIntyre BC,Brasch HD,Day DJ

doi

10.1136/jclinpath-2011-200191

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

870-4

issue

10

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2011-200191

journal_volume

64

pub_type

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