Evaluation of the clinical efficacy of minimally invasive procedures for breast cancer screening at a teaching hospital.

Abstract:

AIMS:To assess the clinical efficacy of diagnostic procedures for breast cancer at a teaching hospital using internal auditing tools and quality control measures. METHODS:A retrospective assessment of 500 patients who underwent core needle biopsy (wide-bore needle biopsy; WBN) of palpable or non-palpable breast nodes that were submitted for at least one cytological examination (fine needle aspiration (FNA) cytology and/or imprint of a WBN specimen). For statistical analysis the auditing tool and quality control proposed by the National Health Service breast screening programme was utilised. RESULTS:For FNA, full specificity, positive predictive value, inadequate rates and suspicious rates were satisfactory while absolute sensitivity, complete sensitivity, false negatives and false positives were unsatisfactory. For imprint, absolute sensitivity, complete sensitivity, inadequate rate from cancers and suspicious rates were satisfactory, and the remaining indicators were unsatisfactory. WBN displayed the best performance with absolute sensitivity, complete sensitivity, false negative, suspicious rates, full specificity and predictive value showing satisfactory results and only one unsatisfactory result (false positive). CONCLUSIONS:Based on an overall analysis, WBN displayed the highest clinical efficacy compared with FNA and imprint, and demonstrated adequate safety for confirming the appropriate diagnosis and management of patients, ensuring the efficacy of the service.

journal_name

J Clin Pathol

authors

Verenhitach BD,Elias S,Patrocínio AC,Nazário AC,Waizberg A

doi

10.1136/jclinpath-2011-200057

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

858-61

issue

10

eissn

0021-9746

issn

1472-4146

pii

jclinpath-2011-200057

journal_volume

64

pub_type

杂志文章
  • A rapid method for staining inclusions of Chlamydia psittaci and Chlamydia trachomatis.

    abstract::A new staining method was developed for the detection of inclusions of Chlamydia psittaci and Chlamydia trachomatis inclusions in cell cultures. Using a combination of methyl green and neutral red stains and washing at pH 5.0, inclusions were stained red while cell cytoplasm was pale pink and cell nuclei were pale gre...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.35.6.642

    authors: Woodland RM,Malam J,Darougar S

    更新日期:1982-06-01 00:00:00

  • The diagnosis of Hodgkin's disease in surgically excised spleens.

    abstract::A series of 44 spleens removed from patients with Hodgkin's disease before treatment has been reviewed. The difficulties encountered in detecting foci of Hodgkin's tissue and the histological features and characteristics of early invasion are described. ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.25.4.294

    authors: Farrer-Brown G,Bennett MH,Harrison CV,Millett Y,Jelliffe AM

    更新日期:1972-04-01 00:00:00

  • A comparison of formalin and GEWF in fixation of colorectal carcinoma specimens: rates of lymph node retrieval and effect on TNM staging.

    abstract:AIMS:The Royal College of Pathologists recommend that a median of at least 12 lymph nodes should be harvested during pathological staging of colorectal cancer. It is not always easy to harvest the required number, especially in patients with rectal cancer receiving neoadjuvant therapy. Lymph node revealing solutions, f...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2015-203281

    authors: Horne J,Carr NJ,Bateman AC,Kandala N 2nd,Adams J,Silva S,Ryder I

    更新日期:2016-06-01 00:00:00

  • Importance of carcinoma-associated fibroblast-derived proteins in clinical oncology.

    abstract::Carcinoma-associated fibroblast (CAF) as prominent cell type of the tumour microenvironment has complex interaction with both the cancer cells and other non-neoplastic surrounding cells. The CAF-derived regulators and extracellular matrix proteins can support cancer progression by providing a protective microenvironme...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1136/jclinpath-2014-202561

    authors: Valcz G,Sipos F,Tulassay Z,Molnar B,Yagi Y

    更新日期:2014-12-01 00:00:00

  • The chemokine receptor CXCR7 influences prognosis in human glioma in an IDH1-dependent manner.

    abstract:AIMS:The chemokine receptor CXCR7 is found on glioma cells and glioma-associated vessels and dependent upon its localisation on tumour or endothelial cells the CXCR7 receptor can mediate glioma cell invasion and tumour angiogenesis. Its expression predicts survival in several types of cancers. METHODS:We immunohistoch...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2015-202886

    authors: Birner P,Tchorbanov A,Natchev S,Tuettenberg J,Guentchev M

    更新日期:2015-10-01 00:00:00

  • Clinical evaluation of the polymerase chain reaction for the rapid diagnosis of tuberculosis.

    abstract:AIMS:Use of the polymerase chain reaction for the detection of Mycobacterium tuberculosis (TB PCR) as a basis for making clinical decisions on the initiation of antituberculosis treatment was studied. METHODS:A retrospective study involving a cohort of 155 patients being investigated for tuberculosis in an infectious ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2003.012658

    authors: Cheng VC,Yam WC,Hung IF,Woo PC,Lau SK,Tang BS,Yuen KY

    更新日期:2004-03-01 00:00:00

  • Longitudinal study of circulating gastric antibodies in pernicious anaemia.

    abstract::Temporal changes in gastric antibody response were investigated in 113 (51 men, 62 women) patients with confirmed pernicious anaemia. Their ages ranged from 31-92 years (mean (SD 13.2) 66). At diagnosis, parietal cell antibody and intrinsic factor antibody were detected in 90.9% and 39.1% of all patients, respectively...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.42.10.1092

    authors: Davidson RJ,Atrah HI,Sewell HF

    更新日期:1989-10-01 00:00:00

  • Effect of storage and postage on recovery and quantitation of bacteria in sputum samples.

    abstract:AIMS:The aims of the study were to compare bacterial recovery following storage of sputum samples at 20 degrees C room temperature and 4 degrees C (refrigerated) for 24 h, and to determine the effect of postage on viable bacterial numbers. METHODS:A total of 38 individual sputum samples from clinically stable patients...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2007.051490

    authors: Pye A,Hill SL,Bharadwa P,Stockley RA

    更新日期:2008-03-01 00:00:00

  • Evaluation of sensitivity of two serological tests for diagnosing pneumonia caused by Legionella pneumophila serogroup 1.

    abstract::The sensitivity of an indirect immunofluorescence antibody test (IFAT) and a rapid microagglutination test (RMAT) for the diagnosis of Legionnaires' disease caused by Legionella pneumophila serogroup 1 was evaluated using serum specimens from 119 patients with bacteriologically confirmed infections. The sensitivity of...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.40.1.77

    authors: Harrison TG,Dournon E,Taylor AG

    更新日期:1987-01-01 00:00:00

  • A histochemical comparison of the O-acylated sialic acids of the epithelial mucins in ulcerative colitis, Crohn's disease, and normal controls.

    abstract::Two histochemical techniques, the PAT/KOH/PAS and the PBT/KOH/PAS, were used to investigate the side chain O-acyl substitution patterns of the sialic acids of the colonic epithelial mucins in cases of ulcerative colitis and Crohn's disease. In both diseases there was, as compared to normal, a reduction in the proporti...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.12.1272

    authors: Culling CF,Reid PE,Dunn WL

    更新日期:1979-12-01 00:00:00

  • Evaluation of five commercial kits to detect dsDNA antibodies.

    abstract::Experiments were performed to evaluate five commercial kit assays used for the detection of antibodies to dsDNA. The kits were compared using a performance index score as recommended by the guidelines of the European Committee for Clinical Laboratory Standards. The highest performance score was obtained using the radi...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.41.11.1223

    authors: McMillan SA,Fay AC

    更新日期:1988-11-01 00:00:00

  • Audit of an emergency biochemistry service.

    abstract:AIM:To examine a model for the evaluation of appropriateness of testing in an emergency biochemistry laboratory. METHODS:A model was devised in which incoming emergency test requests were categorised as appropriate or inappropriate. Explicit criteria were used to define eight minor categories, which were chosen to ref...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.48.12.1126

    authors: Smellie WS,Murphy MJ,Galloway PJ,Hinnie J,McIlroy J,Dryburgh FJ

    更新日期:1995-12-01 00:00:00

  • Front-end genomics: using an alternative approach for the recovery of high-quality DNA from core needle biopsies.

    abstract:AIMS:Determine whether a simple prewash step will provide adequate amounts of high-quality DNA from core needle biopsies for molecular sequencing studies. METHODS:The quantitative and qualitative metrics of DNA recovered from core needle biopsies processed either by 1) formalin fixation and paraffin embedding (FFPE), ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2016-204061

    authors: Mojica WD,Hou T,Sykes D,Dey-Rao R

    更新日期:2017-06-01 00:00:00

  • Non-fusion mutations in endometrial stromal sarcomas: what is the potential impact on tumourigenesis through cell cycle dysregulation?

    abstract::Targeted next-generation sequencing using the 50-gene Ion AmpliSeq Cancer Hotspot Panel v2 identified two significant point mutations in endometrial stromal sarcomas (ESS). Case 1 is a uterine mass from a quadragenarian woman with a karyotype lacking any known ESS rearrangements but demonstrated to have a CTNNB1-activ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2020-206432

    authors: Patel SB,McCormack C,Hodge JC

    更新日期:2020-12-01 00:00:00

  • Gains of chromosomes 7 and 17 in tubulocystic carcinoma of kidney: two cases with fluorescence in situ hybridisation analysis.

    abstract::Tubulocystic carcinoma (TCC) is a very rare renal tumour with unique gross and microscopic features, alternatively considered as low-grade collecting duct carcinoma. Recent studies favoured distinction of TCC from collecting duct carcinoma, and some cases of TCC synchronously coexisting with other renal cell tumour su...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2014-202363

    authors: Chen N,Nie L,Gong J,Chen X,Xu M,Chen M,Zhou Q

    更新日期:2014-11-01 00:00:00

  • Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.

    abstract:AIMS:To determine the potential efficiency of molecular markers specific for neoplastic change--mutations of the K-ras oncogene and the p53 tumour suppressor gene--in diagnosing pancreatic carcinoma. METHODS:Archival cytology samples obtained from 17 patients with established pancreatic carcinoma were assayed for alte...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.48.3.218

    authors: van Es JM,Polak MM,van den Berg FM,Ramsoekh TB,Craanen ME,Hruban RH,Offerhaus GJ

    更新日期:1995-03-01 00:00:00

  • Connexin 43 expression predicts poor progression-free survival in patients with non-muscle invasive urothelial bladder cancer.

    abstract:OBJECTIVES:To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome. METHODS:A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladde...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2015-202898

    authors: Poyet C,Buser L,Roudnicky F,Detmar M,Hermanns T,Mannhard D,Höhn A,Rüschoff J,Zhong Q,Sulser T,Moch H,Wild PJ

    更新日期:2015-10-01 00:00:00

  • Telomerase expression shows differences across multiple regions of oligodendroglioma versus high grade astrocytomas but shows correlation with Mib-1 labelling.

    abstract:AIMS/BACKGROUND:Telomerase is an enzyme that is expressed in most human neoplasms and is associated with tumour immortality. Determination of the point in neoplastic transformation at which telomerase is expressed may aid the understanding of tumour pathogenesis and progression. Despite numerous reports on telomerase, ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.51.4.284

    authors: Kleinschmidt-DeMasters BK,Hashizumi TL,Sze CI,Lillehei KO,Shroyer AL,Shroyer KR

    更新日期:1998-04-01 00:00:00

  • p53 and hepatoma-derived growth factor expression and their clinicopathological association with Ewing family tumour.

    abstract:PURPOSE:To investigate p53 and hepatoma-derived growth factor (HDGF) expression and their association with clinicopathological features of Ewing family tumour (EFT). EXPERIMENTAL DESIGN:A total of 108 cases of EFT were retrospectively analysed. p53 and HDGF expression were detected using immunohistochemistry, and the ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jclinpath-2013-201705

    authors: Yang Y,Zhen T,Zhang F,Dai S,Kang L,Liang Y,Xue L,Han A

    更新日期:2014-03-01 00:00:00

  • Can the laboratory affect the investigation and diagnosis of primary biliary cirrhosis?

    abstract:BACKGROUND:Primary biliary cirrhosis (PBC) is an autoimmune liver disease characterised by the presence of various laboratory abnormalities but the precise role of laboratory staff in initiating clinical referral and subsequent biopsy is not clear. OBJECTIVE:To examine the impact of laboratory abnormalities in the inv...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2005.028936

    authors: Sinclair D,Spedding A,Young R

    更新日期:2006-04-01 00:00:00

  • Expression of P-glycoprotein in hepatocellular carcinoma: a potential marker of prognosis.

    abstract:AIMS:(1) To investigate the immunohistochemical expression of the multidrug resistance gene (MDR1) product P-glycoprotein in histological samples from 31 hepatocellular carcinomas (HCCs); and (2) to correlate the results with cell proliferation, p53 expression, the disease-free interval, and cumulative patient survival...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.49.6.470

    authors: Soini Y,Virkajärvi N,Raunio H,Pääkkö P

    更新日期:1996-06-01 00:00:00

  • Normal osteoid tissue.

    abstract::The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.25.3.229

    authors: Raina V

    更新日期:1972-03-01 00:00:00

  • Ovarian granulomas: a report of 32 cases.

    abstract:AIMS:To determine the causes of ovarian granulomatous inflammation and to discuss the differential diagnoses. METHODS:The pathological features of all ovarian granulomas identified by pathology SNOMED coding in Northern Ireland over a 13 year period were reviewed. Case notes of patients were also reviewed. RESULTS:Th...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.50.4.324

    authors: McCluggage WG,Allen DC

    更新日期:1997-04-01 00:00:00

  • Introduction of an automated service for the laboratory confirmation of meningococcal disease in Scotland.

    abstract::The Scottish Meningococcus and Pneumococcus Reference Laboratory provides a national service for the laboratory confirmation of meningococcal and pneumococcal disease in Scotland. The main tests used for the laboratory confirmation of meningococcal disease are culture, the polymerase chain reaction (PCR), antibody tes...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.54.7.556

    authors: Clarke SC,Diggle MA,Reid JA,Thom L,Edwards GF

    更新日期:2001-07-01 00:00:00

  • Microvessel density and clinicopathological characteristics in hepatitis C virus and hepatitis B virus related hepatocellular carcinoma.

    abstract:AIMS:To compare intratumorous microvessel density (MVD) and clinicopathological features in two different groups of hepatocellular carcinoma (HCC), namely: hepatitis B virus (HBV) related HCC (B-HCC) and HCV related HCC (C-HCC). METHODS:Fifty consecutive cases each of B-HCC and of C-HCC were studied. Microvessel numbe...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.2003.015784

    authors: Messerini L,Novelli L,Comin CE

    更新日期:2004-08-01 00:00:00

  • Serum specific IgA antibody to Chlamydia trachomatis in patients with chlamydial infections detected by ELISA and an immunofluorescence test.

    abstract::Sera obtained from 34 men with Chlamydia trachomatis positive non-gonococcal urethritis, 34 men with C trachomatis negative non-gonococcal urethritis, 42 women with acute salpingitis, 38 healthy women, and 34 healthy men were studied for the presence of specific serum C trachomatis IgA and IgG antibodies. Serological ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.37.6.686

    authors: Cevenini R,Sarov I,Rumpianesi F,Donati M,Melega C,Varotti C,La Placa M

    更新日期:1984-06-01 00:00:00

  • Grouping of streptococci by Streptex.

    abstract::Streptex was compared to routine laboratory identification methods available. The results from Streptex sometimes required several attempts before final identification could be achieved. In the main, group D streptococci other than Strep. faecalis failed to group with the Streptex antisera, and this method cannot ther...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.32.12.1234

    authors: Waitkins SA,Ratcliffe JG,Anderson RD,Roberts C

    更新日期:1979-12-01 00:00:00

  • C-erbB-2 immunostaining: problems with interpretation.

    abstract:AIMS:To assess the consistency and reproducibility of assessment of c-erbB-2 immunostaining, and to examine some of the problems relating to inter- and intraobserver variability in the documentation of positive staining; to profile the spectrum of cytoplasmic and membranous staining in a wide range of tumour types. ME...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.47.9.816

    authors: Kay EW,Walsh CJ,Cassidy M,Curran B,Leader M

    更新日期:1994-09-01 00:00:00

  • Effects of posture on plasma volume and some blood constituents.

    abstract::When the posture was changed from horizontal to vertical, or the reverse, the alteration in plasma volume and in the levels of haematocrit, haemoglobin, and plasma protein was much greater in patients with oedema or low plasma protein or albumin concentrations ("the pathological group") than in patients without these ...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.13.4.304

    authors: FAWCETT JK,WYNN V

    更新日期:1960-07-01 00:00:00

  • Cell volumes of normal and malignant mononuclear cells.

    abstract::The cell volumes of mononuclear cells, T lymphocytes, B lymphocytes, and monocytes from the peripheral blood of 20 normal individuals were compared to neoplastic lymphoid cells from 14 patients with chronic lymphocytic leukaemia (CLL), 20 individuals with acute lymphocytic leukaemia (ALL), and 18 cases of non-Hodgkin'...

    journal_title:Journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1136/jcp.34.10.1083

    authors: Chapman EH,Kurec AS,Davey FR

    更新日期:1981-10-01 00:00:00