Abstract：
:A large body of evidence supports the idea that certain adult stem cells, particularly those of bone marrow origin, can engraft at alternative locations, particularly when the recipient organ is damaged. Under strong and positive selection pressure these cells will clonally expand/differentiate, making an important contribution to tissue replacement. Similarly, bone marrow derived cells can be amplified in vitro and differentiated into many types of tissue. Despite seemingly irrefutable evidence for stem cell plasticity, a veritable chorus of detractors has emerged, some doubting its very existence, motivated perhaps by more than a little self interest. The issues that have led to this situation include the inability to reproduce certain quite startling observations, and extrapolation from the behaviour of embryonic stem cells to suggest that adult bone marrow cells simply fuse with other cells and adopt their phenotype. Although these issues need resolving and, accepting that cell fusion does appear to allow reprogramming of haemopoietic cells in special circumstances, criticising this whole new field because some areas remain unclear is not good science.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Alison MR,Poulsom R,Otto WR,Vig P,Brittan M,Direkze NC,Lovell M,Fang TC,Preston SL,Wright NAdoi
10.1136/jcp.2003.010074keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
113-20issue
2eissn
0021-9746issn
1472-4146journal_volume
57pub_type
杂志文章,评审abstract：:During each of the four-year periods 1971-1975 and 1975-1979, the annual incidence of hepatitis B infection has been assessed in 56 patients with haemophilia A by measuring plasma HBsAg, anti-HBs and anti-HBc levels. Infection rates of 7% and 9.5% per annum respectively were observed for each four-year period despite ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.5.577
更新日期：1983-05-01 00:00:00
abstract：:Experience gained in the last four years concerning the capabilities and limitations of an 8K Elliott 903 (18-bit word) computer with magnetic tape backing store in the routine operation of a clinical chemistry laboratory is described. Designed as a total system, routine operation has latterly had to be confined to da...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.26.7.480
更新日期：1973-07-01 00:00:00
abstract：:An ultramicro electrophoretic technique for the separation of serum lipoproteins is described using agarose gel on microscope slides.The interaction between the agarose gel and lipoproteins has been reduced and the separation between beta- and pre-beta-lipoproteins has been improved over existing methods. A semiquanti...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.1.83
更新日期：1971-02-01 00:00:00
abstract：:Several diseases of the small intestine, including gluten-sensitivity, present with malabsorption and a "flat" mucosa. Determination of the mitotic index of epithelial lymphocytes provides a simple, objective method of assessing, and thus of predicting, whether a flat mucosa is due to gluten-sensitivity (index greater...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.2.149
更新日期：1983-02-01 00:00:00
abstract：:The significance of seroconversion as detected by an ELISA screening test for hepatitis C virus (HCV) antibody with a negative supplemental/confirmatory recombinant immunoblot assay (RIBA) result was investigated. Of 118,220 established West Midlands blood donors with at least one negative HCV antibody screen, 43 had ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.49.3.254
更新日期：1996-03-01 00:00:00
abstract：:Of the first 166 heart and 15 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 162 were investigated for cytomegalovirus (CMV) infection by serological methods. Altogether, 73 (45%) developed CMV infection after transplantation: 30 (18.5%...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.41.6.660
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND/AIMS:To evaluate the need for routine histopathological analysis of enucleated/eviscerated eyes and changes in indications for eye removal. METHODS:Retrospective review of all enucleation/evisceration histopathology reports over 20 years. Clinical history was correlated with pathological findings. Two 10 ye...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2005.029744
更新日期：2006-02-01 00:00:00
abstract：:A method is described for assessing thyroid status using Sephadex column chromatography of serum samples with added (125)I triiodothyronine. The method is simple and inexpensive. It gave a correct diagnostic result in 97% of 258 euthyroid, 90% of 80 hyperthyroid, 78% of 59 hypothyroid, and 67% of 50 euthyroid, ill pat...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.20.2.170
更新日期：1967-03-01 00:00:00
abstract：:A case of florid rheumatoid heart disease with complete heart block is described, and the histopathology of the atrioventricular conducting tissue is described in detail. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.7.623
更新日期：1970-10-01 00:00:00
abstract：:Liver diseases are associated with complex haemostasis defects, in which platelets, coagulation, and fibrinolysis may all be affected. The low plasma concentrations of clotting factors often found can be the result of many changes such as impaired synthesis, increased catabolism due to intravascular coagulation, or al...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.37.5.523
更新日期：1984-05-01 00:00:00
abstract：:Fifteen cases of large-cell lymphoma, diagnosed as centroblastic (5), B-immunoblastic (5) or true histiocytic (5). lymphoma and one case of malignant histiocytosis were studied with monoclonal antibodies. Each diagnosis was based on morphological as well as marker studies. A panel of monoclonal and heterologous antibo...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.1.44
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:Few studies have modelled the economics of thyroid FNA. METHODS:A simple spreadsheet economic model for delivery of thyroid fine needle aspiration (FNA) cytology is described using the UK Royal College of Pathologists' Classification for thyroid FNA which is based on The Bethesda System for Reporting Thyroid...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2012-201339
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND/AIMS:The programmed cell death receptor 1 (PD-1) checkpoint inhibitor, nivolumab, has been approved for the treatment of metastatic renal cell carcinoma (RCC). However, the understanding of the expression and distribution of PD ligand 1 (PD-L1) in the tumour immune microenvironment and its prognostic role in...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2019-206092
更新日期：2020-08-01 00:00:00
abstract：AIMS:To evaluate the prevalence of pseudoangiomatous hyperplasia of mammary stroma in gynaecomastia and its immunohistochemical profile in this setting. METHODS:Eighty eight cases of gynaecomastia recovered from the files of the department of pathology, Botucatu School of Medicine from 1976 to 1996 were studied. In th...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.51.3.204
更新日期：1998-03-01 00:00:00
abstract：:Toxoplasmosis is an infection, congenital or acquired, caused by Toxoplasma gondii. A pilot study using toxoplasmin skin antigen was undertaken to establish the incidence of the infection in the London area as a preliminary to a larger study of the effects of the infection upon pregnancy, the foetus, and the newborn i...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.22.6.649
更新日期：1969-11-01 00:00:00
abstract：:In October 1859, 'The Queen of Hearts' was published by Wilkie Collins. This book is a collection of 10 short stories written by the protagonists (three retired brothers), in order to keep their niece (aka the queen of hearts) entertained, until the arrival of her fiancé-to-be. The second story of the book, titled 'Br...
journal_title：Journal of clinical pathology
pub_type： 历史文章,杂志文章
doi：10.1136/jcp.2010.085571
更新日期：2011-02-01 00:00:00
abstract：:Severe osteomalacia (confirmed by the examination of thin undecalcified bone biopsy sections) associated with hypophosphataemia developed in a 60 year old woman. A skeletal x-ray survey showed a lytic lesion in the right proximal femur, and this was curetted, showing a vascular tumour. The patient's symptoms improved ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.40.4.446
更新日期：1987-04-01 00:00:00
abstract：:The systematic screening of 253 children with transfusion-dependent homozygous beta-thalassaemia revealed a high incidence of hepatitis B virus markers. The highest frequencies of hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen (anti-HBc) were found in the group of patients with the smalle...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.33.10.949
更新日期：1980-10-01 00:00:00
abstract：:A 72 year old woman presented complaining of nasal obstruction, rhinorrea, and epistaxis. At examination, a polypoid mass on the right posterior choana was revealed and subsequently removed. Light microscopic findings consisted of a diffuse proliferation of spindle shaped, pleomorphic cells with eosinophilic cytoplasm...
journal_title：Journal of clinical pathology
pub_type： 信件
doi：10.1136/jcp.55.11.872
更新日期：2002-11-01 00:00:00
abstract：:Antibiotic discs from Oxoid, Mast, AB Biodisk, Difco, and Baltimore Biological Laboratories were compared, where discs of similar antibiotic content were available, in diffusion-sensitivity tests against organisms of known sensitivity. Discs from Oxoid and Mast gave zones 1-5 mm larger than discs from other manufactur...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.28.10.779
更新日期：1975-10-01 00:00:00
abstract：:The degree of inflammation in the trachea, bronchi, and lungs of 139 cot deaths has been analysed and each case allocated to one of four groups. In group I the changes were considered to be serious enough to have caused death, while group II cases showed similar abnormalities but of a less severe nature, and in this g...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.28.11.899
更新日期：1975-11-01 00:00:00
abstract：:A case is reported of a patient with plasmacytoma which assumed different clinicopathological features over seven years. The tumour first presented as a subcutaneous mass which was misdiagnosed as anaplastic carcinoma. Complete response to radiotherapy ensued but recurrence took the form of an intracerebral tumour. Fu...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.10.951
更新日期：1994-10-01 00:00:00
abstract：:A chemical method for the sterilization of pancreatin and trypsin is given. Evidence is presented to show that this treatment does not diminish the specific activity of the enzymes and has some advantages in microbiological techniques. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.7.658
更新日期：1971-10-01 00:00:00
abstract：AIMS:In the time of COVID-19, predictive molecular pathology laboratories must still timely select oncological patients for targeted treatments. However, the need to respect social distancing measures may delay results generated by laboratory-developed tests based on sequential steps a long hands-on time. Laboratory wo...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2020-206711
更新日期：2020-05-19 00:00:00
abstract：AIMS:To study the homozygous deletion and methylation status of the 5' CpG island of the p16 and p15 genes (9p21) in a set of primary advanced head and neck squamous cell carcinomas (SCC) and to test whether inactivation of these genes by these mechanisms contributes to head and neck SCC development. METHODS:DNA was e...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.50.6.509
更新日期：1997-06-01 00:00:00
abstract：:The peripheral lymphocytes of 50 cases of human immunodeficiency virus (HIV) infection (13 of acquired immune deficiency syndrome (AIDS), 17 of AIDS related complex (ARC), and 20 healthy carriers) were studied immunoultrastructurally. The prevalence of "tubuloreticular structures" and "tubular confronting cisternae" i...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.41.1.62
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:Thymidine phosphorylase (TP) is the key enzyme for capecitabine activation in tumour cells. AIMS:To examine whether TP expression in tumour cells and stroma is predictive of the tumour response to capecitabine plus docetaxel chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS...
journal_title：Journal of clinical pathology
pub_type： 临床试验,杂志文章
doi：10.1136/jcp.2004.022764
更新日期：2005-06-01 00:00:00
abstract：:A method for accurately counting platelets is described using the Coulter counter model B fitted with a standard 100mu aperture tube. This enables the counter to be used for red and white cell as well as platelet counts using the same aperture tube. The method uses standard equipment except for a small inexpensive ele...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.20.5.777
更新日期：1967-09-01 00:00:00
abstract：:A locally developed, computer-based clinical chemistry laboratory system has been in operation since 1970. This utilises a Digital Equipment Co Ltd PDP 12 and an interconnected PDP 8/F computer. Details are presented of the performance and quality control techniques incorporated into the system. Laboratory performance...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.2.100
更新日期：1979-02-01 00:00:00
abstract：:The pathological findings of an intradural and extramedullary cyst in the mid cervical spinal canal are described in a 55 year old woman who presented with a short history of pain and paraesthesia of the right arm. Intradural well defined solitary cystic lesions in the spinal canal are uncommon, their pathogenesis is ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.45.11.1032
更新日期：1992-11-01 00:00:00
