Implications on laboratory workload of breast cancer screening.

abstract：AIMS:The signalling system of phosphoinositides (PIs) is involved in a number of cell and tissue functions including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation and cell and tissue polarity. Recently, a role in cell migration was hypothesised for PI and related molecules including...

journal_title：Journal of clinical pathology

authors： Lo Vasco VR,Pacini L,Di Raimo T,D'arcangelo D,Businaro R

更新日期：2011-10-01 00:00:00

abstract：:The incidence of jaundice and of abnormal liver function tests has been assessed in 91 multitransfused patients with severe haemophilia A and B. Tests of hepatocyte function were within the normal range in the majority of patients. On the contrary, tests of biliary cell function, liver cell damage, and bromsulphthalei...

journal_title：Journal of clinical pathology

authors： Mannucci PM,Capitanio A,Del Ninno E,Colombo M,Pareti F,Ruggeri ZM

更新日期：1975-08-01 00:00:00

abstract：:The calcium, vitamin D, and osteocalcin concentrations were investigated in 17 patients with anorexia nervosa. Serum 25-hydroxyvitamin D (25 OHD) concentrations below normal were observed in 15 (88%); only two patients has serum 1,25 dihydroxycholecalciferol (1,25(OH)2D) concentrations below normal. Serum parathyroid ...

journal_title：Journal of clinical pathology

authors： Fonseca VA,D'Souza V,Houlder S,Thomas M,Wakeling A,Dandona P

更新日期：1988-02-01 00:00:00

abstract：:It has been suggested that Coxsackie B virus infections may play a part in causing or triggering myocardial infarction. This study was designed to compare the incidence of such infections in Coronary Care Unit patients and normal controls. The choice of a suitable criterion for diagnosis of Coxsackie infection is disc...

journal_title：Journal of clinical pathology

authors： O'Neill D,McArthur JD,Kennedy JA,Clements G

更新日期：1983-06-01 00:00:00

abstract：:A manual system of microbiology reporting with a National Cash Register (NCR) form with printed names of bacteria and antiboitics required less time to compose reports than a previous manual system that involved rubber stamps and handwriting on plain report sheets. The NCR report cost 10-28 pence and, compared with a ...

journal_title：Journal of clinical pathology

authors： Goodwin CS

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Many patients with advanced cancer are malnourished. Anorexia is common, as is the use of chemotherapy, which may cause nausea and poor appetite. Ten per cent of these patients experience haemorrhagic events. AIM:Since vitamin K deficiency (VKD) causes bleeding, to establish the prevalence of VKD in patient...

journal_title：Journal of clinical pathology

authors： Harrington DJ,Western H,Seton-Jones C,Rangarajan S,Beynon T,Shearer MJ

更新日期：2008-04-01 00:00:00

abstract：:The changes occurring at the periphery of invasive cervical carcinomas have been studied in detail, with particular reference to the incidence of preinvasive carcinoma. The various criteria used in the cytological diagnosis of malignancy have been evaluated, and the implications of large cytological screening programm...

journal_title：Journal of clinical pathology

authors： MEYER PC

更新日期：1965-07-01 00:00:00

abstract：:During the last decade, a dramatic rise in the development and application of artificial intelligence (AI) tools for use in pathology services has occurred. This trend is often expected to continue and reshape the field of pathology in the coming years. The deployment of computational pathology and applications of AI ...

journal_title：Journal of clinical pathology

authors： Rakha EA,Toss M,Shiino S,Gamble P,Jaroensri R,Mermel CH,Chen PC

更新日期：2020-08-06 00:00:00

abstract：:Attempts to detect hepatitis B antigen in faeces and bile should take into account the degradation and disappearance of the surface antigens in an environment containing proteolytic enzymes in the presence of bile salts as in the intestinal lumen. The cores of the Dane particles are much more stable than the surface a...

journal_title：Journal of clinical pathology

authors： Moodie JW,Stannard LM,Kipps A

更新日期：1974-09-01 00:00:00

abstract：:Eighty-four children with acute lymphoblastic leukaemia (ALL) who had relapsed in bone marrow were studied to assess whether treatment would be more successful if relapse was detected before the disease became clinically evident. Patients whose relapse was detected by routine bone marrow examination before the disease...

journal_title：Journal of clinical pathology

authors： Haworth C,Heppleston AD,Morris Jones PH,Campbell RH,Evans DI,Palmer MK

更新日期：1981-05-01 00:00:00

abstract：:Electron microscopical and cytochemical studies of intestinal biopsies from a patient with typical features of the Cronkhite-Canada syndrome show that the primary process affects the crypts. This results in cystic dilatation associated with expansion and focal degeneration of the crypt compartment of the intestinal ep...

journal_title：Journal of clinical pathology

authors： Jenkins D,Stephenson PM,Scott BB

更新日期：1985-03-01 00:00:00

abstract：:In an investigation of the in vitro phagocytic and microbicidal function of granulocytes collected by filtration leucapheresis (FL) from 18 donors and by discontinuous flow centrifugation leucapheresis (DFC) from six donors, comparison was made with the function of granulocytes obtained from the same donors by venepun...

journal_title：Journal of clinical pathology

authors： Martin S,Ghoneim AT,Robinson EA,Child JA

更新日期：1983-05-01 00:00:00

abstract：:Mallory bodies were isolated from necropsy livers from patients with alcoholic hepatitis with and without cirrhosis with a Ficoll viscosity barrier. The purity of Mallory bodies in the isolate varied between 70 and 90%, estimated by counting Mallory bodies and non-Mallory body structures in haematoxylin-eosin stained ...

journal_title：Journal of clinical pathology

authors： Gluud C,Hardt F,Aldershvile J,Christoffersen P,Lyon H,Nielsen J

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND/AIMS:A twofold increased risk for breast cancer has been reported recently for women with late onset diabetes. Most studies showed that there were differences in serum concentrations of insulin-like growth factors and related proteins between women with and without diabetes who have breast cancer. This study...

journal_title：Journal of clinical pathology

authors： Nardon E,Buda I,Stanta G,Buratti E,Fonda M,Cattin L

更新日期：2003-08-01 00:00:00

abstract：:The relation between the choline containing surfactant phospholipids lecithin and sphingomyelin in amniotic fluid and fetal lung maturity is well established. An enzymatic method that had been automated and optimised for use on a centrifugal analyser was used to measure the total choline containing phospholipids in am...

journal_title：Journal of clinical pathology

authors： Teng SH,Andrews AG,Horacek I

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Acute B lymphoblastic leukaemia (B-ALL) is the most common type of childhood malignancy worldwide but little is known of its origin. Recently, many studies showed both a high incidence of Epstein-Barr virus (EBV) infection and high levels of CD4+CD25+Foxp3+(Treg cells) in children with B-ALL. In our study, we...

journal_title：Journal of clinical pathology

authors： Ateyah ME,Hashem ME,Abdelsalam M

更新日期：2017-02-01 00:00:00

abstract：:This 14th best practice review is the second of a pair that examines tumour marker requesting primary care situations. This review considers carbohydrate antigen 125, α-fetoprotein and human chorionic gonadotropin. It is presented in question-answer format, referenced for each question. The recommendations represent a...

journal_title：Journal of clinical pathology

authors： Cabrera-Abreu JC,Smellie WS,Bowley R,Shaw N

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The Wnt pathway is important in cell signalling transduction and is involved in the pathogenesis of multiple tumour types. A comprehensive analysis of the expression of Wnt signalling pathway proteins in mammary phyllodes tumours (PTs) has not been previously performed. AIMS:To evaluate the immunohistochemi...

journal_title：Journal of clinical pathology

authors： Karim RZ,Gerega SK,Yang YH,Horvath L,Spillane A,Carmalt H,Scolyer RA,Lee CS

更新日期：2009-11-01 00:00:00

abstract：:The association between asymptomatic primary sclerosing cholangitis and exocrine pancreatic disease was underlined by the findings in a patient with cystic fibrosis and in another with chronic pancreatitis. In each case hepatocytes showed extensive microvesicular steatosis and studies of drug metabolism suggested hepa...

journal_title：Journal of clinical pathology

authors： Benett I,Salh B,Haboubi NY,Braganza JM

更新日期：1989-05-01 00:00:00

abstract：AIMS:Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive non-Hodgkin's lymphoma that represents a heterogeneous group of disease that is differentially characterised by clinical, molecular and cytogenetic features. MYC, BCL2 and BCL6 gene rearrangements have been identified as prognostic factors...

journal_title：Journal of clinical pathology

authors： Tourneret A,Alame M,Rigau V,Bauchet L,Fabbro M,De Oliveira L,Cacheux V,Costes V,Lacheretz-Szablewski V

更新日期：2020-09-10 00:00:00

abstract：:A case of squamous cell carcinoma of the terminal ileum with no underlying duplication or inflammatory disorder is described. The neoplasm seemed to have originated from the surface epithelium, invading the wall and metastasising to the regional lymph nodes. The 65 year old patient was free of disease three years afte...

journal_title：Journal of clinical pathology

authors： Platt CC,Haboubi NY,Schofield PF

更新日期：1991-03-01 00:00:00

abstract：:A patient with multiple injuries developed a severe coagulation defect due to a deficiency of vitamin K. None of the usual predisposing factors was present and the patient's diet was very poor. Dietary deficiency of vitamin K and the importance of antibiotic therapy in its production are discussed. ...

journal_title：Journal of clinical pathology

authors： Colvin BT,Lloyd MJ

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Chromogenic in situ hybridisation (CISH) is an alternative to immunohistochemistry or FISH for the assessment of HER2 oncogene status in breast cancer. Although CISH is being used increasingly in routine diagnostics, there are no established inter-laboratory quality assurance programmes for this test. METHO...

journal_title：Journal of clinical pathology

authors： Di Palma S,Collins N,Bilous M,Sapino A,Mottolese M,Kapranos N,Schmitt F,Isola J

更新日期：2008-06-01 00:00:00

abstract：AIMS:The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett's oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review in the Netherlands, a web-based digital review panel has been set up, which currently consists of ei...

journal_title：Journal of clinical pathology

authors： Klaver E,van der Wel M,Duits L,Pouw R,Seldenrijk K,Offerhaus J,Visser M,Ten Kate F,Biermann K,Brosens L,Doukas M,Huysentruyt C,Karrenbeld A,Kats-Ugurlu G,van der Laan J,van Lijnschoten I,Moll F,Ooms A,Tijssen J,Meij

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Cytokeratin immunohistochemistry (IHC) reveals a higher rate of occult lymph node metastases among lobular carcinomas than among ductal breast cancers. IHC is widely used but is seldom recommended for the evaluation of sentinel lymph nodes in breast cancer patients. OBJECTIVE:To assess the value of cytokera...

journal_title：Journal of clinical pathology

authors： Cserni G,Bianchi S,Vezzosi V,Peterse H,Sapino A,Arisio R,Reiner-Concin A,Regitnig P,Bellocq JP,Marin C,Bori R,Penuela JM,Iturriagagoitia AC

更新日期：2006-05-01 00:00:00

abstract：:The presence of serum agglutinins and precipitins to Candida albicans in men and women who had impaired bladder function following spinal injury is compared with that in other patients in hospital and in apparently fit men and women. Antibody levels which have commonly been regarded as significant were found in 35 of ...

journal_title：Journal of clinical pathology

authors： Everall PH,Morris CA,Morris DF

更新日期：1974-09-01 00:00:00

abstract：:Large cell neuroendocrine carcinoma (LCNEC) is a high grade type of neuroendocrine tumour with an aggressive clinical course. This report describes the first case of LCNEC combined with an adenocarcinoma component in the common bile duct. A 68 year old man presented with jaundice. Severe stenosis of the bile duct was ...

journal_title：Journal of clinical pathology

authors： Sato K,Waseda R,Tatsuzawa Y,Fujinaga H,Wakabayashi T,Ueda Y,Katsuda S

更新日期：2006-01-01 00:00:00

abstract：:In a retrospective series of 40 appendiceal tumours occurring over a 10-year period, 30 were carcinoid tumours of classical histological pattern, five were adenocarcinomas, and two were tumours intermediate in pattern between carcinoid and carcinoma. The remaining three tumours were secondaries from primary colonic tu...

journal_title：Journal of clinical pathology

authors： Jones RA,MacFarlane A

更新日期：1976-08-01 00:00:00

abstract：:Two cases of peritoneal granulomatous reactions to food starch are described. They followed bowel perforation and clinically mimicked tuberculous and glove-powder starch peritonitis. Their histological differences from corn-starch peritonitis warrant attention in the absence of previous documentation of starch as a co...

journal_title：Journal of clinical pathology

authors： Davies JD,Ansell ID

更新日期：1983-04-01 00:00:00

abstract：:Synovium was collected from 15 patients who were undergoing joint surgery. Two groups were defined by clinical diagnosis: patients with primary osteoarthritis (n = 4); and those with rheumatoid arthritis (n = 11). The synovium was studied using histological and morphometric techniques. In agreement with previous studi...

journal_title：Journal of clinical pathology

authors： Kennedy TD,Plater-Zyberk C,Partridge TA,Woodrow DF,Maini RN

更新日期：1988-08-01 00:00:00