Abstract:
:It has been suggested that Coxsackie B virus infections may play a part in causing or triggering myocardial infarction. This study was designed to compare the incidence of such infections in Coronary Care Unit patients and normal controls. The choice of a suitable criterion for diagnosis of Coxsackie infection is discussed fully. Two hundred and fifty admissions to a Coronary Care Unit and 100 control subjects had a serum sample tested by microneutralisation for Coxsackie B antibodies. The incidence of infection among 130 patients diagnosed as acute myocardial infarction was 5% compared with 4% in the control group. In a subgroup classified as non-transmural myocardial infarction, the incidence of infection was 14%. The sex ratio of this group differed from the myocardial infarction group as a whole suggesting that the non-transmural group may not have been homogeneous. Normal coronary arteriograms were subsequently found in three patients who were diagnosed as non-transmural myocardial infarction but who had serological evidence of recent Coxsackie infection. This study does not demonstrate an association between Coxsackie infection and myocardial infarction as a whole and does not support the view that Coxsackie infection causes or provokes myocardial infarction. It does, however, suggest that myocarditis may simulate non-transmural infarction.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
O'Neill D,McArthur JD,Kennedy JA,Clements Gdoi
10.1136/jcp.36.6.658subject
Has Abstractpub_date
1983-06-01 00:00:00pages
658-61issue
6eissn
0021-9746issn
1472-4146journal_volume
36pub_type
杂志文章abstract::A rapid technique using a non-radioactive receptor molecule (digoxigenin) for intrahepatic hepatitis B virus (HBV) DNA detection using in situ hybridisation was developed. It can be adapted for use in combination with standard immunohistochemistry for simultaneous detection of both HBV DNA and HBV antigens. The total ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.11.905
更新日期:1991-11-01 00:00:00
abstract::Members of a newly recognized group of hospital staphylococci, which are believed to have arisen from 83A staphylococci by lysogenization, differ from them in several cultural characters. Some but not all of these characters appear to be determined by the carriage of phage. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.19.4.305
更新日期:1966-07-01 00:00:00
abstract::Colonising Campylobacter pyloridis were identified histologically in gastric biopsy specimens from 89% of 83 patients with non-ulcer dyspepsia and chronic gastritis, but not in 58 dyspeptic patients with normal mucosa. The presence and population density of organisms was associated with the presence of intraepithelial...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.8.863
更新日期:1986-08-01 00:00:00
abstract:AIMS:To establish the number of histological levels necessary for the evaluation of breast needle core biopsy (NCB) specimens taken from areas of mammographic calcification in patients presenting via the UK National Health Service Breast Screening Programme. METHODS:Retrospective review of a series of breast NCB speci...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2006.038190
更新日期:2007-06-01 00:00:00
abstract::A knowledge-based computer system, designed to assist pathologists in the histological diagnosis of breast disease, is described. This system represents knowledge in the form of "disease profiles" and uses a novel inference model based on the mathematical technique of hypergraphs. Its design overcomes many of the limi...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.44.6.502
更新日期:1991-06-01 00:00:00
abstract:AIMS:The miR-9 family microRNAs (miRNAs) are tumour suppressor miRNAs implicated in carcinogenesis. We postulated that miR-9-1, miR-9-2 and miR-9-3 may be inactivated by aberrant promoter methylation in multiple myeloma (MM). METHODS:Methylation of miR-9-1, miR-9-2 and miR-9-3 was studied by methylation-specific PCR (...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2014-202817
更新日期:2015-07-01 00:00:00
abstract::Human astrovirus infection often causes outbreaks of self limiting diarrhoea, but may also infect patients who are immunodeficient or immunocompromised. Although there are previous publications relating to various aspects of astroviruses, there is a minimal amount of literature on the histopathological features of gas...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2004.017178
更新日期:2004-09-01 00:00:00
abstract::During 1971 and 1972, 71 cultures of neisseriae that attacked lactose were received by this laboratory. All strains except one from an eye swab were from the nasopharynx of healthy subjects. Nineteen similar strains from the nasopharynx were isolated in this laboratory. The characteristics of these strains were compar...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.26.6.399
更新日期:1973-06-01 00:00:00
abstract::Hereditary breast cancer accounts for up to 5-10% of all breast carcinomas. Recent studies have demonstrated that mutations in two high-penetrance genes, namely BRCA1 and BRCA2, are responsible for about 16% of the familial risk of breast cancer. Even though subsequent studies have failed to find another high-penetran...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2008.057950
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Subgroups of breast cancer that have an impaired response to endocrine treatment, despite hormone receptor positivity, are still poorly defined. Breast cancer can be subdivided according to standard pathological parameters including histological type, grade, and assessment of proliferation. These parameters ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/jcp.2005.027185
更新日期:2005-11-01 00:00:00
abstract::A study of 16 haematological and 24 biochemical parameters in healthy, adult, male, volunteer Saudi blood donors was made, and enabled a preliminary determination of the reference values for these parameters to be made for Saudi Arabia. Statistically significant low means were observed for all the haematological param...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.35.1.69
更新日期:1982-01-01 00:00:00
abstract::An antibody was raised against a protein isolated from the cytoplasm of mesothelioma cells. It was subsequently used in an immunoperoxidase procedure on formalin fixed, paraffin embedded tissue sections. A representative sample of benign and malignant tumours from all the systems of the human body was examined. All th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.39.9.961
更新日期:1986-09-01 00:00:00
abstract::Painful lymphadenopathy developed in eight female patients after massive infusions of iron dextran for sideropaenic anaemia. Fever, arthralgias, and malaise were also features of the clinical picture. The histology of one lymph node is described and changes in it are discussed in relation to the pathogenesis of the sy...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.21.4.492
更新日期:1968-07-01 00:00:00
abstract::Recent publications have suggested that fixing neutrophils in formalin is a useful adjunct to the differentiation of antinuclear antibodies from perinuclear antineutrophil cytoplasmic antibodies. In this small comparative study of 30 sera the use of an additional slide of formalin fixed neutrophils did not add any use...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.1.89
更新日期:1995-01-01 00:00:00
abstract::A 60 year old woman with disseminated ductal carcinoma of the breast developed non-islet cell tumour induced hypoglycaemia (NICTH). The concentrations of the two insulin-like growth factors, IGF-I and IGF-II, were < 2 nmol/l and 94.1 nmol/l, respectively. The IGF-II to IGF-I ratio was > 47 (normal < 10). Insulin (< 3 ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.52.10.780
更新日期:1999-10-01 00:00:00
abstract:BACKGROUND:Hepatic fibrosis is one of the main consequences of liver disease. Both fibrosis and steatosis may be seen in some patients with chronic hepatitis C and alcoholic liver disease (ALD). AIMS:To quantitate fibrosis and steatosis by stereological and morphometric techniques in patients with chronic hepatitis C ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
doi:10.1136/jcp.54.6.461
更新日期:2001-06-01 00:00:00
abstract::This review focuses on the pathological features of dysplasia in Barrett's oesophagus. Two categorisation schemes are used for grading dysplasia in the gastrointestinal tract, including Barrett's oesophagus. The inflammatory bowel disease dysplasia morphology study group system is the one most commonly used in the USA...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.2005.035337
更新日期:2006-10-01 00:00:00
abstract::Normal haemoglobin is a tetramer molecule, consisting of two α and β haemoglobin chains. Haemoglobinopathies occur when abnormalities in these proteins are present. More than 1000 naturally occurring human haemoglobin variants with single amino acid substitution throughout the molecule have been identified and can be ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jclinpath-2018-205616
更新日期:2019-07-01 00:00:00
abstract::The routine estimation of large numbers of serum folic acid and vitamin B(12) levels using the Baird and Tatlock(1) Analmatic clinical system is described and the method evaluated.Precision, accuracy, and carryover are shown to be at acceptable levels, and the advantages and disadvantages of the use of the system are ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.24.1.18
更新日期:1971-02-01 00:00:00
abstract:AIMS:To clarify a clinical entity of juvenile polyposis of the stomach compared with generalised juvenile gastrointestinal polyposis. METHODS:The clinicopathological features of juvenile polyposis dominantly involving the stomach at initial presentation were reviewed in 12 patients (three new patients and nine from th...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1136/jcp.50.9.771
更新日期:1997-09-01 00:00:00
abstract::Gonococcal isolates resistant to ciprofloxacin collected from 2004 to 2005, in the Pretoria region, were characterised using Neisseria gonorrhoeae multi-antigen sequence typing (NG-MAST). The isolates were obtained from men presenting with urethritis to primary healthcare clinics and general practitioners. All isolate...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2007.052191
更新日期:2008-05-01 00:00:00
abstract::A case of a 20 year old Japanese woman who developed thyroid cancer exhibiting unusual cribriform structures while being followed up for familial adenomatous polyposis/Gardner's syndrome is reported. The patient presented with osteomas, pigmented retinal lesions, and adenomas of the duodenum and the papilla of Vater, ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.49.7.611
更新日期:1996-07-01 00:00:00
abstract:AIMS:To use the polymerase chain reaction to detect monoclonality at the immunoglobulin heavy chain gene locus in cells derived from lymph node aspirates. METHODS:A nested two-stage polymerase chain reaction (PCR) for the VDJ region of the immunoglobulin heavy chain gene was used to detect monoclonality. The total num...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.45.5.420
更新日期:1992-05-01 00:00:00
abstract::Metabolic balance studies for iron have been carried out on 24 apparently healthy elderly people (11 men and 13 women) aged 69.7 to 85.5 years living in their own homes and eating self selected diets. Several biochemical and haematological indices of iron state were also measured. The mean daily iron intake was 176 mu...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.37.12.1353
更新日期:1984-12-01 00:00:00
abstract::Melanocytes in melanocytic naevi and melanomas can display great variation. The presence of nuclear pseudoinclusions (NPI) is said to be useful in the histological and cytological differential diagnosis of malignant melanoma. The prevalence and characteristics of NPI in a series of 493 naevi and 50 melanomas are descr...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.7.676
更新日期:1995-07-01 00:00:00
abstract::A study has been made by clinical methods and by bio-assay of the effectiveness of a régime for prophylaxis against tetanus. The two principal objects of the method were to ensure that active immunization was offered to all patients who had received antitoxin and to measure the effect of the combined administration of...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.18.1.23
更新日期:1965-01-01 00:00:00
abstract:AIMS:Positive direct antiglobulin tests (DATs) are valuable in identifying the aetiology of autoimmune haemolysis and in guiding therapeutic intervention. However, in HIV-positive individuals with background polyclonal gammopathy, a positive DAT in the absence of haemolysis is common. In this setting, IgG quantificatio...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2020-207113
更新日期:2020-12-16 00:00:00
abstract:AIMS:To determine the potential efficiency of molecular markers specific for neoplastic change--mutations of the K-ras oncogene and the p53 tumour suppressor gene--in diagnosing pancreatic carcinoma. METHODS:Archival cytology samples obtained from 17 patients with established pancreatic carcinoma were assayed for alte...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.48.3.218
更新日期:1995-03-01 00:00:00
abstract::Four cases of human infection with Achromobacter anitratus, one of which was fatal, are described. They all occurred at one hospital within a period of two months. The bacteriology, antibiotic sensitivity, and pathogenicity of the organisms are discussed. One of the strains was found to differ from the other three. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.14.6.670
更新日期:1961-11-01 00:00:00
abstract::A case is described in which marked hepatic fibrosis probably resulted from the prolonged treatment of acute leukaemia with methotrexate. ...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.19.1.81
更新日期:1966-01-01 00:00:00