IDENTIFICATION AND CLINICAL SIGNIFICANCE OF KLEBSIELLA SPECIES IN CHEST INFECTIONS.

abstract：AIMS:The aims of this study were (1) to determine the measurement accuracy of a widely used guaiac faecal occult blood test (gFOBT) compared with an immunochemical faecal occult blood test (iFOBT) during in vitro studies, including their analytical stability over time at ambient temperature and at 4°C; and (2) to compa...

journal_title：Journal of clinical pathology

authors： Lee CS,O'Gorman P,Walsh P,Qasim A,McNamara D,O'Morain CA,Boran GP

更新日期：2011-06-01 00:00:00

abstract：:A young woman presented with bilateral ovarian tumours. Multiple sections of each tumour were shown to many pathologists for consultation; some considered the tumours to be borderline, whereas others thought that one or both of them was malignant. Morphometry showed that the numerical classification probabilities for ...

journal_title：Journal of clinical pathology

authors： Baak JP,Van der Ley G

更新日期：1984-10-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) testing is required for newly diagnosed breast cancer and advised for recurrent and metastatic breast cancer, to determine treatment planning using HER2-directed therapy in the neoadjuvant, adjuvant and advanced disease settings. Wide variation, nationally, in the turnar...

journal_title：Journal of clinical pathology

authors： Shaaban AM,Purdie CA,Bartlett JM,Stein RC,Lane S,Francis A,Thompson AM,Pinder SE,Translational Subgroup of the NCRI Breast Clinical Studies Group.

更新日期：2014-02-01 00:00:00

abstract：AIMS:To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells. METHODS:114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was >40% (IgG4-relat...

journal_title：Journal of clinical pathology

authors： Kubota T,Moritani S,Yoshino T,Nagai H,Terasaki H

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:To evaluate the protein expression of connexin 43 (Cx43) in primary urothelial bladder cancer and test its association with the histopathological characteristics and clinical outcome. METHODS:A tissue microarray containing 348 tissue samples from 174 patients with primary urothelial carcinomas of the bladde...

journal_title：Journal of clinical pathology

authors： Poyet C,Buser L,Roudnicky F,Detmar M,Hermanns T,Mannhard D,Höhn A,Rüschoff J,Zhong Q,Sulser T,Moch H,Wild PJ

更新日期：2015-10-01 00:00:00

abstract：AIM:To evaluate the clinical usefulness of three commercially available assays for Her-2/neu oncogene and protein measurements. The Her-2/neu protein is overexpressed, mostly as a result of gene amplification, in 20-30% of human breast cancers, and has been shown to have prognostic and predictive value for treatment wi...

journal_title：Journal of clinical pathology

authors： Wang S,Saboorian MH,Frenkel E,Hynan L,Gokaslan ST,Ashfaq R

更新日期：2000-05-01 00:00:00

abstract：AIMS:The aim of this study was to develop a computer-aided diagnosis (CADx) system for identifying breast pathology. METHODS:Two sets of 100 consecutive core needle biopsy (CNB) specimens were collected for test and validation studies. All 200 CNB specimens were stained with antibodies targeting oestrogen receptor (ER...

journal_title：Journal of clinical pathology

authors： Maeda I,Kubota M,Ohta J,Shinno K,Tajima S,Ariizumi Y,Doi M,Oana Y,Kanemaki Y,Tsugawa K,Ueno T,Takagi M

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To compare the whole genomes sequencing (WGS) results in the 100K Genomes project with the results of routine molecular diagnostics in precision medicine. MATERIALS AND METHODS:We analysed 374 cancers including a high tumour mutational burden (TMB-high) subgroup, defined as >10 non-synonymous single nucleoti...

journal_title：Journal of clinical pathology

authors： Echejoh G,Liu Y,Chung-Faye G,Charlton J,Moorhead J,Clark B,Davidson P,Sarker D,Ross P,Ooft ML

更新日期：2020-10-29 00:00:00

abstract：:Haemoglobin (Hb) Bonn is a newly described benign Hb variant that causes falsely depressed oxygen saturation as measured by pulse oximetry. It was found to be associated with mild haemolysis. Since its first report in a German family, no further cases have been documented in the literature. We report the first Chinese...

journal_title：Journal of clinical pathology

authors： So CC,Chan AY,Chow EY,Lin SY,Yip SF,Szeto SC,Chan LC

更新日期：2010-10-01 00:00:00

abstract：:The mechanism of DNA degradation and its clinical applications were examined. When purified lambda phage and extracted liver DNA were fixed in phosphate buffered formaldehyde, the DNA did not degrade, but there was incomplete digestion with endonuclease. Rat liver tissues were fixed under various conditions and DNA ex...

journal_title：Journal of clinical pathology

authors： Tokuda Y,Nakamura T,Satonaka K,Maeda S,Doi K,Baba S,Sugiyama T

更新日期：1990-09-01 00:00:00

abstract：:A case of IgD myeloma accompanied by diffuse osteosclerosis is reported. A trephine biopsy specimen showed only reticulin fibrosis, but histomorphometric analysis of a full thickness transiliac bone biopsy specimen showed increased trabecular bone mass, with no local deposit of tumour. An excess of bone surfaces were ...

journal_title：Journal of clinical pathology

authors： MacCallum PK,Freemont AJ,Geary CG,Liu Yin JA

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Transcription factors of the forkhead box P (FOXP1-4) family have been implicated in various human cancer types before. The relevance and role of neuronal transcription factor FOXP2 in prostate cancer is unknown. METHODS:A tissue microarray containing samples from more than 11 000 prostate cancers ...

journal_title：Journal of clinical pathology

authors： Stumm L,Burkhardt L,Steurer S,Simon R,Adam M,Becker A,Sauter G,Minner S,Schlomm T,Sirma H,Michl U

更新日期：2013-07-01 00:00:00

abstract：:CAM 5.2 is a murine monoclonal antibody, raised against the colon carcinoma cell line HT29, which recognises lower molecular weight intracellular cytokeratin proteins within secretory epithelia. Extensive indirect immunohistochemical studies have confirmed that this antibody stains formalin fixed (and freshly frozen) ...

journal_title：Journal of clinical pathology

authors： Makin CA,Bobrow LG,Bodmer WF

更新日期：1984-09-01 00:00:00

abstract：:The urinary excretion of the renal proximal tubular enzyme, gamma-glutamyltransferase (gamma-GT), has been studied in 41 patients receiving tobramycin, gentamicin or streptomycin for a variety of infections. All patients receiving tobramycin or gentamicin have shown increased excretion of gamma-GT in the urine. Only 4...

journal_title：Journal of clinical pathology

authors： Beck PR,Thomson RB,Chaudhuri AK

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:The Royal College of Pathologists introduced the National Minimum Dataset (NMDS) for the histopathological reporting of cutaneous melanoma in February 2002. AIM:To determine if histological reporting of invasive primary cutaneous melanoma in the West Midlands region of the UK was compliant with the NMDS. M...

journal_title：Journal of clinical pathology

authors： Kaur MR,Colloby PS,Martin-Clavijo A,Marsden JR

更新日期：2007-10-01 00:00:00

abstract：AIM:To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS:Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were gra...

journal_title：Journal of clinical pathology

authors： Phull PS,Price AB,Stephens J,Rathbone BJ,Jacyna MR

更新日期：1996-05-01 00:00:00

abstract：:Phyllodes tumours (PTs) of the breast are true biphasic neoplasms within which interactions between the epithelium and stroma are critical for tumour development and progression. Despite numerous studies reporting the results of ancillary marker investigations in PTs, the current histological grading systems remain un...

journal_title：Journal of clinical pathology

authors： Karim RZ,O'Toole SA,Scolyer RA,Cooper CL,Chan B,Selinger C,Yu B,Carmalt H,Mak C,Tse GM,Tan PH,Putti TC,Lee CS

更新日期：2013-06-01 00:00:00

abstract：AIMS:To compare the sensitivity and specificity of new rabbit monoclonal antibody SP3 with those of mouse monoclonal and rabbit polyclonal antibodies using HER2 amplification defined by chromogenic in situ hybridisation (CISH) as the gold standard. METHODS:Serial sections from tissue microarrays (TMAs) containing 84 b...

journal_title：Journal of clinical pathology

authors： Nunes CB,Rocha RM,Reis-Filho JS,Lambros MB,Rocha GF,Sanches FS,Oliveira FN,Gobbi H

更新日期：2008-08-01 00:00:00

abstract：:Foveolar dysplasia is an uncommon form of dysplasia that is encountered in the stomach and oesophagus in the context of Barrett’s oesophagus. Glands displaying foveolar dysplasia also show architectural abnormalities that are similar to those encountered in adenomatous dysplasia. However, from a cytological point of v...

journal_title：Journal of clinical pathology

authors： Serra S,Chetty R

更新日期：2014-10-01 00:00:00

abstract：:Guidance by bacteriologists and changes in theatre and ward disciplines have greatly improved the results of urological surgery in recent years. The most noteworthy successes have been in treatment of chronic retention with renal failure, and in prevention of the bacteraemia which may occur following removal of the po...

journal_title：Journal of clinical pathology

authors： MITCHELL JP,GILLESPIE WA

更新日期：1964-09-01 00:00:00

abstract：:The discovery of ETS gene fusions as common events in prostate cancer represents a paradigmatic shift in the significance attributed to chromosomal translocations as a key mechanistic player in carcinogenesis. However, these chromosomal fusion events are poorly understood, as their functional significance and therapeu...

journal_title：Journal of clinical pathology

authors： Attard G,Ang JE,Olmos D,de Bono JS

更新日期：2008-08-01 00:00:00

abstract：:The results of an investigation show that there is no statistically significant excess of blood group A in cases of carcinoma of the oesophagus or in cases of benign prostatic hyperplasia. ...

journal_title：Journal of clinical pathology

authors： BEASLEY WH

更新日期：1964-01-01 00:00:00

abstract：:Nearly two thousand clinical samples were examined by direct gas-liquid chromatography over a three year period. Absence of volatile fatty acids (VFAs) in the samples correlated well with negative culture results for anaerobic bacteria. In general the presence of acetic acid alone correlated well with the presence of ...

journal_title：Journal of clinical pathology

authors： Watt B,Geddes PA,Greenan OA,Napier SK,Mitchell A

更新日期：1982-07-01 00:00:00

abstract：:The concentrations of selenium, zinc, and copper were determined in whole blood, plasma, and leucocytes in 20 patients with relatively mild Crohn's disease, nine of whom were being treated with steroids, and compared with those of a control group. There was a significant decrease in the concentration of selenium in th...

journal_title：Journal of clinical pathology

authors： Hinks LJ,Inwards KD,Lloyd B,Clayton B

更新日期：1988-02-01 00:00:00

abstract：:A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastruc...

journal_title：Journal of clinical pathology

authors： Banerjee SS,Bishop PW,Nicholson CM,Eyden BP

更新日期：1996-11-01 00:00:00

abstract：AIMS:To elucidate potential mechanisms of drug resistance, levels of topoisomerase II alpha mRNA, a target for cytostatic drugs, were measured in cryopreserved tumour tissue from 36 patients with non-Hodgkin's lymphoma. To evaluate the potential association between topoisomerase II alpha and cell proliferation, Ki-67 i...

journal_title：Journal of clinical pathology

authors： Lohri A,Reuter J,Gudat F,Herrmann R

更新日期：1997-01-01 00:00:00

abstract：:Detection of Haemophilus influenzae type b (HIb) antigenuria by latex agglutination has been shown to be sensitive, specific, and rapid. In children, antigenuria persisted for a mean duration of 10 days and a maximum of 18 days. Antigenuria was demonstrated in 25 of 30 patients with HIb infection but not in 62 with ot...

journal_title：Journal of clinical pathology

authors： Kaldor J,Asznowicz R,Dwyer B

更新日期：1979-06-01 00:00:00

abstract：:A slight modification in tissue processing and staining technique enables a previously described method for staining aluminium to be used to demonstrate aluminium in osteomalacia associated with haemodialysis. The stain appears to be accurate in diagnosing this condition and may assist in establishing the diagnosis be...

journal_title：Journal of clinical pathology

authors： Buchanan MR,Ihle BU,Dunn CM

更新日期：1981-12-01 00:00:00

abstract：AIMS:To assess the relevance of genetic variants of hepatitis B virus (HBV) and to demonstrate the usefulness of the polymerase chain reaction (PCR) in cases of HBV diagnostic difficulty. METHODS:Five serum samples from patients that presented diagnostic difficulty in routine laboratories were sent to a research labor...

journal_title：Journal of clinical pathology

authors： van Deursen FJ,Hino K,Wyatt D,Molyneaux P,Yates P,Wallace LA,Dow BC,Carman WF

更新日期：1998-02-01 00:00:00

abstract：:The clinical and pathological findings in 23 patients with ischaemic lesions of the alimentary tract (ischaemic enterocolitis) are described. These are compared with findings in 13 patients with occlusive thrombosis of the superior mesenteric artery. The pathological features distinguishing the two conditions are disc...

journal_title：Journal of clinical pathology

authors： McDonald GS,Hourihane DO

更新日期：1972-02-01 00:00:00