Monoclonal antibody to cytokeratin for use in routine histopathology.

abstract：:In an investigation of the in vitro phagocytic and microbicidal function of granulocytes collected by filtration leucapheresis (FL) from 18 donors and by discontinuous flow centrifugation leucapheresis (DFC) from six donors, comparison was made with the function of granulocytes obtained from the same donors by venepun...

journal_title：Journal of clinical pathology

authors： Martin S,Ghoneim AT,Robinson EA,Child JA

更新日期：1983-05-01 00:00:00

abstract：:Although the morphology of the pathognomonic Reed-Sternberg cells of Hodgkin lymphoma (HL) was described over a century ago, it was not until recently that their origin from B lymphocytes was recognised. The demonstration that a proportion of cases of HL harbour the Epstein-Barr virus (EBV) and that its genome is mono...

journal_title：Journal of clinical pathology

authors： Kapatai G,Murray P

更新日期：2007-12-01 00:00:00

abstract：AIMS:Soft tissue tumours are a heterogeneous group of neoplasms that can arise at almost every anatomical site. As they often show similar clinical and radiological findings, histology is the definitive diagnostic method and it is crucial that the surgical pathology report contains accurate, useful information for mana...

journal_title：Journal of clinical pathology

authors： Shah C,Wang J,Mubako T,Fisher C,Thway K

更新日期：2016-09-01 00:00:00

abstract：:Nasal biopsy findings in malignant histiocytosis presenting clinically as lethal midline granuloma are characterised by necrosis and infiltration of atypical histiocytic cells with a diffuse positive reaction for non-specific esterase. This cellular character was common to midline malignant reticulosis, and midline ma...

journal_title：Journal of clinical pathology

authors： Aozasa K

更新日期：1982-06-01 00:00:00

abstract：:An immunohistochemical study of the tissue CEA content of 82 epithelial neoplasms of the ovary has shown that mucinous tumours contain more of this substance than do their serous counterparts; otherwise a knowledge of tissue CEA content appears to be of little value in the differential histological diagnosis of this g...

journal_title：Journal of clinical pathology

authors： Heald J,Buckley CH,Fox H

更新日期：1979-09-01 00:00:00

abstract：:Renal involvement as the first manifestation of sarcoidosis is rare and has never been reported in India. This report describes a 35 year old man who was admitted to the emergency department with a clinical diagnosis of acute on chronic renal failure, secondary to obstructive uropathy. Postmortem examination unexpecte...

journal_title：Journal of clinical pathology

authors： Awasthi A,Nada R,Malhotra P,Goel R,Joshi K

更新日期：2004-10-01 00:00:00

abstract：:Monoclonal antibodies to factor VIII antigen (VIII:Ag) and von Willebrand factor (vWf:Ag) were immobilised on Sephacryl S-1000 and tested for their ability to deplete normal human citrated plasma of factor VIII. A combination of two antibodies to VIII:Ag and one antibody to vWf:Ag was required to produce plasma contai...

journal_title：Journal of clinical pathology

authors： Hornsey VS,Waterston YG,Prowse CV

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancers (TNBCs) are defined by their lack of oestrogen receptor, progesterone receptor and epidermal growth factor receptor 2. Although heterogeneous, the majority are aggressive and treatment options are limited. Caveolin acts as tumour suppressor or promoter depending on the cancer t...

journal_title：Journal of clinical pathology

authors： Yeong J,Thike AA,Ikeda M,Lim JCT,Lee B,Nakamura S,Iqbal J,Tan PH

更新日期：2018-02-01 00:00:00

abstract：:In-vivo studies of fibrinogen metabolism were carried out using an I-120 labelled preparation of fibrinogen supplied commercially by the Radiochemical Centre, Amerhsham for use in the diagnosis of deep venous thrombosis. These studies show that the material is suitable for obtaining the main metabolic parameters of c...

journal_title：Journal of clinical pathology

authors： Bradley J,Hickman JA

更新日期：1975-06-01 00:00:00

abstract：AIMS:Traditionally, advanced stage ovarian carcinoma is treated by debulking surgery followed by chemotherapy. However, in some circumstances preoperative chemotherapy may be given before optimal surgical debulking. This study aims to describe the morphological features found in ovarian carcinoma after chemotherapy bec...

journal_title：Journal of clinical pathology

authors： McCluggage WG,Lyness RW,Atkinson RJ,Dobbs SP,Harley I,McClelland HR,Price JH

更新日期：2002-01-01 00:00:00

abstract：AIM:To evaluate the clinical usefulness of three commercially available assays for Her-2/neu oncogene and protein measurements. The Her-2/neu protein is overexpressed, mostly as a result of gene amplification, in 20-30% of human breast cancers, and has been shown to have prognostic and predictive value for treatment wi...

journal_title：Journal of clinical pathology

authors： Wang S,Saboorian MH,Frenkel E,Hynan L,Gokaslan ST,Ashfaq R

更新日期：2000-05-01 00:00:00

abstract：:A series of 44 spleens removed from patients with Hodgkin's disease before treatment has been reviewed. The difficulties encountered in detecting foci of Hodgkin's tissue and the histological features and characteristics of early invasion are described. ...

journal_title：Journal of clinical pathology

authors： Farrer-Brown G,Bennett MH,Harrison CV,Millett Y,Jelliffe AM

更新日期：1972-04-01 00:00:00

abstract：:Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (k...

journal_title：Journal of clinical pathology

authors： BARON DN

更新日期：1960-05-01 00:00:00

abstract：:This is an unusual case of total granulomatous infarction of testis due to Schistosoma haematobium, the first such case to be reported. This report reinforces the theory of extraportal maturation of worms in spermatic veins and capillaries as postulated earlier (Joshi, 1962). ...

journal_title：Journal of clinical pathology

authors： Joshi RA

更新日期：1967-05-01 00:00:00

abstract：:Large cell neuroendocrine carcinoma (LCNEC) is a high grade type of neuroendocrine tumour with an aggressive clinical course. This report describes the first case of LCNEC combined with an adenocarcinoma component in the common bile duct. A 68 year old man presented with jaundice. Severe stenosis of the bile duct was ...

journal_title：Journal of clinical pathology

authors： Sato K,Waseda R,Tatsuzawa Y,Fujinaga H,Wakabayashi T,Ueda Y,Katsuda S

更新日期：2006-01-01 00:00:00

abstract：:The epithelium of the human fallopian tube (oviduct) and cervix were studied by histological, immunohistological, and ultrastructural methods with a view to establishing the nature of the so called "basal" and "reserve" cells. The results indicated that the "basal" cells of the oviductal epithelia were T lymphocytes, ...

journal_title：Journal of clinical pathology

authors： Peters WM

更新日期：1986-03-01 00:00:00

abstract：:An enzyme linked immunoadsorbent assay (ELISA) was used to detect IgG, IgM, and IgA antibody in urine to a crude antigenic mixture prepared from six arbitrarily chosen strains of common coliform urinary pathogens. In a group of patients with symptoms of urinary tract infection 24 of 80 (30%) urine samples were positiv...

journal_title：Journal of clinical pathology

authors： McKenzie H,Young DN

更新日期：1987-07-01 00:00:00

abstract：:A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls...

journal_title：Journal of clinical pathology

authors： Horne CH,Howie PW,Goudie RB

更新日期：1970-09-01 00:00:00

abstract：:TLE 1 is the human homologue belonging to a family of four genes and is located on chromosome 9q21. It consists of 19 exons. Although it does not bind directly to DNA, it acts as a repressor of several signalling pathways via transcription factors. TLE1 protein has several physiological roles in embryogenesis, haemato...

journal_title：Journal of clinical pathology

authors： Pinto K,Chetty R

更新日期：2021-01-13 00:00:00

abstract：AIMS:Most benign breast fibroepithelial lesions (FEL) in adults harbour recurrent somatic MED12 exon 2 mutations and rare TERT promoter hotspot mutations. We sought to determine the frequency of MED12 exon 2 and TERT promoter hotspot mutations in fibroadenomas (FA) and benign phyllodes tumours (BePT) in adolescents and...

journal_title：Journal of clinical pathology

authors： Pareja F,Da Cruz Paula A,Murray MP,Hoang T,Gularte-Mérida R,Brown D,da Silva EM,Sebastiao APM,Giri DD,Weigelt B,Reis-Filho JS,Brogi E

更新日期：2019-03-01 00:00:00

abstract：:Endocardial fibroelastosis, defined as an endocardium in excess of 30 microns thick, was found in 10 out of 34 cases of hydrops fetalis in a review of 1589 perinatal necropsies carried out between 1976 and 1989. The infants comprised 16 cases of rhesus haemolytic disease, of whom three had endocardial fibroelastosis, ...

journal_title：Journal of clinical pathology

authors： Newbould MJ,Armstrong GR,Barson AJ

更新日期：1991-07-01 00:00:00

abstract：:In all cases of primary endocardial fibroelastosis investigated diffuse degenerative changes in the ganglion cells were detected. Thickened endocardium was formed by the proliferation of mesenchymal cells located under the endothelial endocardium and of the mesenchyme surrounding the necrobiotic muscle cells. In some ...

journal_title：Journal of clinical pathology

authors： Zóltowska A

更新日期：1971-04-01 00:00:00

abstract：OBJECTIVE:We explore factors such as the blood sampling site (capillary vs venous), the equipment (HemoCue vs automated haematology analyser) and the model of the HemoCue device (201+ vs 301) that may impact haemoglobin measurements in capillary and venous blood. METHODS:Eleven studies were identified, and bias, conco...

journal_title：Journal of clinical pathology

authors： Rappaport AI,Karakochuk CD,Hess SY,Whitehead RD Jr,Namaste SML,Dary O,Parker ME,Neufeld LM,Larson LM,Newton S,Wegmuller R,Moorthy D

更新日期：2020-10-06 00:00:00

abstract：BACKGROUND:Autoreactive humoral and cellular immune responses may be involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC). Certain human leucocyte antigens (HLA) could also be linked to the development of IDC. AIM:To determine whether various markers of autoimmunity are present in the final phase of...

journal_title：Journal of clinical pathology

authors： de Leeuw N,Melchers WJ,Ruiter DJ,Caforio AL,Balk AH,de Jonge N,Galama JM

更新日期：1999-10-01 00:00:00

abstract：:Group-specific polysaccharides of Neisseria meningitidis groups A and C have been demonstrated by means of a rapid, sensitive slide agglutination test with latex particles coated with antibodies. In this manner, the diagnosis can be made from the cerebrospinal fluid of patients with meningococcal meningitis caused by ...

journal_title：Journal of clinical pathology

authors： Severin WP

更新日期：1972-12-01 00:00:00

abstract：AIMS:To investigate how the biopsy Gleason score (GS) and the clinical risk classification have been changed by the reporting rules. METHODS:565 prostate biopsy specimens were reassessed. Each Gleason pattern, 1 to 5, was interpreted according to the modified Gleason grading system proposed by the International Societ...

journal_title：Journal of clinical pathology

authors： Kuroiwa K,Uchino H,Yokomizo A,Naito S

更新日期：2009-03-01 00:00:00

abstract：:Several DNA extraction techniques were quantitatively and qualitatively compared using both fresh and paraffin wax embedded tissue and their suitability investigated for providing DNA and RNA for the polymerase chain reaction (PCR). A one hour incubation with proteinase K was the most efficient DNA extraction procedur...

journal_title：Journal of clinical pathology

authors： Jackson DP,Lewis FA,Taylor GR,Boylston AW,Quirke P

更新日期：1990-06-01 00:00:00

abstract：:One hundred and seventyone antenatal patients were examined for the presence of ;large colony' mycoplasmas in the vagina, and for complement-fixing antibody to Mycoplasma hominis. In 25 patients the findings before and after delivery were compared. In patients from whom M. hominis was grown, antibody was twice as comm...

journal_title：Journal of clinical pathology

authors： Jones DM

更新日期：1967-07-01 00:00:00

abstract：:Michaëlsson's (1961) method for the measurement of plasma bilirubin concentration was found to be complicated by conjugated bilirubin. Delaying the addition of the accelerator, diphylline, corrected this fault. The method was calibrated using serum or plasma, since reconstituted protein solutions introduced large erro...

journal_title：Journal of clinical pathology

authors： Thompson RP

更新日期：1969-07-01 00:00:00

abstract：:Review of published work and analysis of clinical data and pathology of four biopsy specimens from two patients with laryngeal contact granuloma showed that its peptic origin was derived from a gastro-oesophago-laryngeal reflux. It is proposed that the term "peptic granuloma" should be given to this phenomenon. This t...

journal_title：Journal of clinical pathology

authors： Miko TL

更新日期：1989-08-01 00:00:00