Angiogenesis in melanoma: an update with a focus on current targeted therapies.

abstract：:A patient with multiple myeloma had antigenically related monoclonal Fc-gamma fragments and complete IgG-kappa molecules in the serum. The urine contained only Fc-gamma fragments in the absence of Bence-Jones protein. The two distinct M-components in the serum showed electrophoretic identity but could be separated by ...

journal_title：Journal of clinical pathology

authors： Bartoloni C,Flamini G,Gentiloni N,Russo MA,Barone C,Gambassi G,Terranova T

更新日期：1980-10-01 00:00:00

abstract：:Immunoreactive plasminogen activators were studied in tissue sections using a peroxidase method and monospecific antibodies to tissue plasminogen activator produced by a melanoma. Tissue plasminogen activator reactivity was found in skin melanomas and in endothelial and smooth muscle cells of arteries and veins. Vesse...

journal_title：Journal of clinical pathology

authors： Larsson A,Astedt B

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Clinical outcome in patients with diffuse large B cell lymphomas (DLBCL) is highly variable and poorly predictable. Microarray studies showed that patients with DLBCL with a germinal centre B cell-like (GCB) phenotype have a better prognosis than those with an activated B cell-like (ABC) phenotype. The BMI1 ...

journal_title：Journal of clinical pathology

authors： van Galen JC,Muris JJ,Oudejans JJ,Vos W,Giroth CP,Ossenkoppele GJ,Otte AP,Raaphorst FM,Meijer CJ

更新日期：2007-02-01 00:00:00

abstract：AIM:To determine the reliability of international normalised ratio (INR) measurement in primary care by practice nurses using near patient testing (NPT), in comparison with results obtained within hospital laboratories by varied methods. METHODS:As part of an MRC funded study into primary care oral anticoagulation man...

journal_title：Journal of clinical pathology

authors： Hobbs FD,Fitzmaurice DA,Murray ET,Holder R,Rose PE,Roper JL

更新日期：1999-07-01 00:00:00

abstract：:A technique is described whereby inclusion-bearing cells identified by light microscopy in stained smears of urinary sediment were reprocessed for examination in the electron microscope. The nuclei of the abnormal cells were found to contain numerous virus particles, 35 nm in diameter, which morphologically resembled ...

journal_title：Journal of clinical pathology

authors： Coleman DV,Russell WJ,Hodgson J,Pe T,Mowbray JF

更新日期：1977-11-01 00:00:00

abstract：:Experiments are described with glass fibre filter paper and complete glass filters as fitted to high pre-vacuum autoclaves to determine whether organisms can grow or penetrate through the filters. A filter consisting of four layers of glass fibre paper fitted inside a sterilizer chamber for a year and used for 96 ster...

journal_title：Journal of clinical pathology

authors： Fallon RJ

更新日期：1963-05-01 00:00:00

abstract：:Specimens from 95 patients attending a venereal diseases clinic were examined for gonococci by three methods--a conventional culture technique using modified Thayer-Martin medium, microscopy of a Gram-stained direct smear, and the Microcult system. For 56% of the specimens the results by all three methods agreed. Assu...

journal_title：Journal of clinical pathology

authors： Williams RJ,Ratnatunga CS,Hamilton-Miller JM,Brumfitt W

更新日期：1978-03-01 00:00:00

abstract：AIMS:To establish the current sensitivity of two commercial kits for culture confirmation of Neisseria gonorrhoeae strains circulating in the UK. METHODS:A total of 544 strains were studied (199 gonococci from male patients attending hospitals in the county of Avon, 204 unselected N gonorrhoeae isolates from male pati...

journal_title：Journal of clinical pathology

authors： Turner A,Gough KR,Jephcott AE

更新日期：1995-10-01 00:00:00

abstract：:Late-stage ovarian carcinoma is almost universally fatal. BRCA mutations are associated with an improved outcome and enhanced sensitivity to platinum chemotherapy, yet recurrence and platinum resistance remain a major problem and highly effective regimens following platinum failure do not yet exist. Here we report a r...

journal_title：Journal of clinical pathology

authors： Osher DJ,Kushner YB,Arseneau J,Foulkes WD

更新日期：2011-10-01 00:00:00

abstract：AIM:Definitive distinction between low-grade astrocytoma and astrogliosis is a long-standing difficulty due to their similar histopathological characteristics. To clarify differences in biological significance, this study focused on various components of the cell cycle machinery and proliferation as key parameters, com...

journal_title：Journal of clinical pathology

authors： Hara A,Saegusa M,Ichinoe M,Okayasu I

更新日期：2008-03-01 00:00:00

abstract：:A method utilizing a general dehydrogenase reaction has been used to demonstrate early gross myocardial infarctions. The procedure takes advantage of substrate and enzyme loss from the damaged myocardium. In the viable muscle, where endogenous substrates, coenzymes, and dehydrogenases are present, reduction of Nitro-B...

journal_title：Journal of clinical pathology

authors： Ramkissoon RA

更新日期：1966-09-01 00:00:00

abstract：AIMS:To compare prognostic information obtained by image analysis cytometry of paraffin wax embedded soft tissue sarcomas with conventional assessment. METHODS:A CAS 200 image analyser was used to determine DNA content of Feulgen stained cytology preparations and tissue sections and to quantify immunostaining by Ki67 ...

journal_title：Journal of clinical pathology

authors： Michie BA,Black C,Reid RP,Barrett A,Hamblen DL

更新日期：1994-05-01 00:00:00

abstract：AIM:To evaluate the sources of fetal haemoglobin (HbF) as an indicator in cancer. An immunohistochemical study was carried out on some of the most common kinds of cancer. All of these cancers had serologically high levels of HbF as evaluated previously. METHODS:Immunoaffinity-purified anti-HbF was immunohistochemicall...

journal_title：Journal of clinical pathology

authors： Wolk M,Martin JE,Reinus C

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Chromogenic in situ hybridisation (CISH) is an alternative to immunohistochemistry or FISH for the assessment of HER2 oncogene status in breast cancer. Although CISH is being used increasingly in routine diagnostics, there are no established inter-laboratory quality assurance programmes for this test. METHO...

journal_title：Journal of clinical pathology

authors： Di Palma S,Collins N,Bilous M,Sapino A,Mottolese M,Kapranos N,Schmitt F,Isola J

更新日期：2008-06-01 00:00:00

abstract：:Bilateral adrenalectomy produces a reduction in the alkaline phosphatase concentration in rat intestine, which is not prevented by the administration of saline, but is prevented by the administration of cortisone. The administration of A.C.T.H. to normal rats leads to a rise in intestinal alkaline phosphatase levels a...

journal_title：Journal of clinical pathology

authors： Watson WC,Murray ES,Gardner MD

更新日期：1967-03-01 00:00:00

abstract：:Early epidemiological studies of cervical neoplasia suggested a causal relation with sexual activity and human papillomaviruses (HPVs) have emerged as prime suspects as venerally transmitted carcinogens. HPVs fall into two broad camps: low risk types, associated with cervical condylomas and CIN 1; and high risk types ...

journal_title：Journal of clinical pathology

authors： Arends MJ,Buckley CH,Wells M

更新日期：1998-02-01 00:00:00

abstract：AIMS:Marked thrombocytosis is uncommon in chronic myelogenous leukaemia (CML) but may be associated with mutation of JAK2 V617F, calreticulin (CALR) and/or phospho-STAT5 (p-STAT5) activation in other myeloproliferative neoplasms (MPNs), particularly essential thrombocythaemia (ET). We investigated the JAK2 V617F, CALR ...

journal_title：Journal of clinical pathology

authors： Turakhia SK,Murugesan G,Cotta CV,Theil KS

更新日期：2016-08-01 00:00:00

abstract：:Adenocarcinoma of the anal glands is very rare but it is an important lesion to recognise as with early diagnosis, it has an excellent prognosis. Because it involves the submucosa widely and penetrates the mucosa late, it can be mistaken for metastatic gastrointestinal carcinoma, or tumour arising in sinuses and fistu...

journal_title：Journal of clinical pathology

authors： Behan WM,Burnett RA

更新日期：1996-12-01 00:00:00

abstract：AIMS:To assess the occurrence of diagnostic delay in primary antibody deficiency in the period 1989-2002, since a similar study in 1989, and to assess the impact of UK national guidelines communicated in 1995. METHODS:A retrospective case note review was performed of 89 consecutive patients with antibody deficiency re...

journal_title：Journal of clinical pathology

authors： Seymour B,Miles J,Haeney M

更新日期：2005-05-01 00:00:00

abstract：:A severe non-dose related skin eruption attributable to treatment with captopril was recently reported: this is distinct from the dose related rashes that have been widely described. Ultrastructural and immunohistochemical studies were carried out to determine in detail the histological features of this eruption: the ...

journal_title：Journal of clinical pathology

authors： Furness PN,Goodfield MJ,MacLennan KA,Stevens A,Millard LG

更新日期：1986-08-01 00:00:00

abstract：:The T(4)-free thyroxine index was used as the thyroid function test of first choice in a district general hospital for one year. Ninety-two patients were assessed both initially and at follow up by a single physician. The index agreed with clinical assessment in 69 out of 74 patients in whom diagnosis was unequivocal....

journal_title：Journal of clinical pathology

authors： Howorth PJ,Ward RL

更新日期：1972-03-01 00:00:00

abstract：:The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...

journal_title：Journal of clinical pathology

authors： Raina V

更新日期：1972-03-01 00:00:00

abstract：:An enzyme immunoassay technique based on the direct detection of Chlamydia trachomatis antigen in urethral or cervical swabs was used for the rapid diagnosis of chlamydial genital infection. Urethral and cervical samples from 140 patients were tested in parallel by enzyme immunoassay and cell culture using iodine stai...

journal_title：Journal of clinical pathology

authors： Mumtaz G,Mellars BJ,Ridgway GL,Oriel JD

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Serum prostate specific antigen (PSA) increases after radical prostatectomy are thought to indicate recurrent disease, although some suggest they result from benign prostatic epithelial tissue left at surgical margins. AIMS:To investigate whether presence, location, and extent of benign prostatic tissue at ...

journal_title：Journal of clinical pathology

authors： Kernek KM,Koch MO,Daggy JK,Juliar BE,Cheng L

更新日期：2005-07-01 00:00:00

abstract：:In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than those of the corresponding group of male donors. In the whole series of female donors, there were significantly lower tota...

journal_title：Journal of clinical pathology

authors： Allan RN,Alexander MK

更新日期：1968-11-01 00:00:00

abstract：AIM:The rapid and fully automated Idylla EGFR Mutation Assay has been specifically designed to process formalin-fixed, paraffin-embedded sections without requiring preliminary DNA extraction. This study evaluates whether this approach can also process archival smears from patients with non-small cell lung cancer (NSCLC...

journal_title：Journal of clinical pathology

authors： De Luca C,Conticelli F,Leone A,Gragnano G,Salatiello M,Galasso P,Pisapia P,Grillo LR,Iaccarino A,Vigliar E,Bellevicine C,Malapelle U,Troncone G

更新日期：2019-09-01 00:00:00

abstract：:Three patients with aplastic anaemia had a history of substantial previous exposure to organochlorine pesticides. The temporal association between chemical exposure and the onset of first symptoms of anaemia was strongly supportive. Organochlorines have the property of lipid affinity and accumulation in adipose tissue...

journal_title：Journal of clinical pathology

authors： Rugman FP,Cosstick R

更新日期：1990-02-01 00:00:00

abstract：:In two families with severe sex-linked muscular dystrophy, high levels of alpha-hydroxybutyrate dehydrogenase (HBD), lactate dehydrogenase (LD), aspartate transaminase (AspT), aldolase, and creatine phosphokinase (CPK) were found in the sera of three young affected males. In both families the mother had a raised level...

journal_title：Journal of clinical pathology

authors： Johnston HA,Wilkinson JH,Withycombe WA,Raymond S

更新日期：1966-05-01 00:00:00

abstract：:Serum and tissue hepatitis B virus (HBV) markers were compared in 35 alcoholic and 23 non-alcoholic subjects affected by chronic liver disease. Seventeen point one per cent of alcoholic and 21.7% of non-alcoholic subjects had HBV tissue markers, but not serum markers, for this virus. It is therefore concluded that sho...

journal_title：Journal of clinical pathology

authors： Cuccurullo L,Rambaldi M,Iaquinto G,Ferraraccio F,Ambrosone L,Giardullo N,De Vita A

更新日期：1987-02-01 00:00:00

abstract：:A study has been made of 523 strains of staphylococci on the basis of biological properties, phage typing, and serology. The value of serology in the identification of pathogenic staphylococci has been assessed. ...

journal_title：Journal of clinical pathology

authors： Choudhuri KK,Chakrabarty AN

更新日期：1970-05-01 00:00:00