Melphalan as a treatment for BRCA-related ovarian carcinoma: can you teach an old drug new tricks?

abstract：:Serum labelled with (59)Fe for ferrokinetic studies should contain only [(59)Fe] transferrin. [(59)Fe] ferric citrate was incubated at 37 degrees C for up to 24 hours with sera having an excess latent iron-binding capacity. The results showed that unbound [(59)Fe] ferric citrate may be present for several hours. An an...

journal_title：Journal of clinical pathology

authors： Cavill I

更新日期：1971-07-01 00:00:00

abstract：:An alternative method for detecting the production of slime by coagulase negative staphylococci was compared with the routinely used Christensen method on 124 isolates of coagulase negative staphylococci from carriage sites, blood cultures, and infected peritoneal dialysis fluids. The alternative method requires the u...

journal_title：Journal of clinical pathology

authors： Freeman DJ,Falkiner FR,Keane CT

更新日期：1989-08-01 00:00:00

abstract：:The results of a histological study of normal osteoid tissue in man, the monkey, the dog, and the rat, using thin microtome sections of plastic-embedded undecalcified bone, are described. Osteoid tissue covers the entire bone surface, except for areas of active resorption, although the thickness of the layer of osteoi...

journal_title：Journal of clinical pathology

authors： Raina V

更新日期：1972-03-01 00:00:00

abstract：AIMS:To assess the significance of flat epithelial atypia (FEA) on core biopsy by evaluating the proportion of cases upgraded to in-situ and invasive carcinoma on further sampling with vacuum-assisted biopsy (VAB) or diagnostic surgical biopsy. METHODS:A retrospective analysis was performed of all core biopsies contai...

journal_title：Journal of clinical pathology

authors： Rajan S,Sharma N,Dall BJ,Shaaban AM

更新日期：2011-11-01 00:00:00

abstract：AIM:Heart failure (HF) affects millions of older individuals in both developed and low/middle-income countries. Serum galectin-3 levels have been shown to have prognostic value. However, its use as a diagnostic biomarker has not been explored. The aim was to establish a saliva galectin-3 reference range and to demonstr...

journal_title：Journal of clinical pathology

authors： Zhang X,Wan Y,Chata R,Brazzale A,Atherton JJ,Kostner K,Dimeski G,Punyadeera C

更新日期：2016-12-01 00:00:00

abstract：:An enzyme linked immunosorbent assay (ELISA) based on the antibody class capture method for the detection of specific IgM against Toxoplasma gondii, using the microtitre plate format, was developed. Antigen binding was detected using a monoclonal antibody, CIE3, conjugated to horseradish peroxidase. Prior mixing of th...

journal_title：Journal of clinical pathology

authors： Payne RA,Joynson DH,Balfour AH,Harford JP,Fleck DG,Mythen M,Saunders RJ

更新日期：1987-03-01 00:00:00

abstract：:The simultaneous estimation of steroids in plasma was carried out by the assay of cortisol, corticosterone, and testosterone. The method entails separation by means of thin layer chromatography, followed by conversion to a fluorophore and fluorimetric measurement. Its major advantages are its high specificity, its abi...

journal_title：Journal of clinical pathology

authors： Mattingly D,Martin H,Tyler C

更新日期：1989-06-01 00:00:00

abstract：:Twenty five specimens of branchial cyst from the same number of patients have been examined. On staining with haematoxylin and eosin a consistent finding was that the mural lymphoid follicles were always aligned with their mantle zones towards the luminal epithelium. With conventional staining lymphatic sinuses were n...

journal_title：Journal of clinical pathology

authors： Crocker J,Jenkins R

更新日期：1985-07-01 00:00:00

abstract：AIMS:Optical microscopic (OM) evaluation of peripheral blood (PB) cells is still a crucial step of the laboratory haematological workflow. The morphological cell analysis is time-consuming and expensive and it requires skilled operator. To address these challenges, automated image-processing systems, as digital morphol...

journal_title：Journal of clinical pathology

authors： Da Rin G,Benegiamo A,Di Fabio AM,Dima F,Francione S,Fanelli A,Germagnoli L,Lorubbio M,Marzoni A,Pajola R,Pipitone S,Rolla R,Seghezzi M,Baigorria Vaca MDC,Bartolini A,Buoro S

更新日期：2020-09-14 00:00:00

abstract：:The costs of a clinical chemistry laboratory in a district general hospital were studied. The system used has certain advantages over the conventional Cooper Lybrand method. The time taken by technicians to perform tests was more variable than expected and the cost of sample collection was higher than process-cost for...

journal_title：Journal of clinical pathology

authors： Stilwell JA

更新日期：1981-06-01 00:00:00

abstract：AIMS:This cross-sectional study investigated the association between eight herpesviruses and the bacterial community profiles from the oral cavity of children with and without leukaemia. METHODS:Sixty participants (aged 3-13), divided into the leukaemia group (LG) and healthy group (HG), were evaluated. Collection of ...

journal_title：Journal of clinical pathology

authors： Bezerra TM,Ferreira DC,Carmo FL,Pinheiro R,Leite DC,Cavalcante FS,Belinho RA,Peixoto RS,Rosado AS,dos Santos KR,Castro GF

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not widely performed. AIMS:To examine retrospectively the value of hair examination by light microscopy, including polarisin...

journal_title：Journal of clinical pathology

authors： Smith VV,Anderson G,Malone M,Sebire NJ

更新日期：2005-12-01 00:00:00

abstract：:A commercial latex slide test (Oxoid DR 620) for the identification of Escherichia coli O157 was compared with a standard tube agglutination method using E coli O157 antiserum (Difco). Thirty isolates previously confirmed as E coli O157 were positive by both methods: 30 isolates of E coli of serogroups other than O157...

journal_title：Journal of clinical pathology

authors： Chapman PA

更新日期：1989-10-01 00:00:00

abstract：:Phosphate in both inorganic and organic form is essential for several functions in the body. Plasma phosphate level is maintained by a complex interaction between intestinal absorption, renal tubular reabsorption, and the transcellular movement of phosphate between intracellular fluid and bone storage pools. This home...

journal_title：Journal of clinical pathology

authors： Leung J,Crook M

更新日期：2019-11-01 00:00:00

abstract：AIMS:Venous invasion (VI) is a known independent prognostic indicator of recurrence and survival in colorectal cancer. The guidelines of the Royal College of Pathologists (RCPath) state that, in a series of resections, extramural VI should be detected in at least 25% of specimens. However, there is widespread variabili...

journal_title：Journal of clinical pathology

authors： Messenger DE,Driman DK,McLeod RS,Riddell RH,Kirsch R

更新日期：2011-11-01 00:00:00

abstract：:A case of chromoblastomycosis confined to the mucous membrane of one side of the nasal septum is reported. The organism was not cultivated, but its characteristics in histological preparations were typical of those of the organisms in sections of cutaneous lesions known to be caused by Phialophora pedrosoi and related...

journal_title：Journal of clinical pathology

authors： SYMMERS WS

更新日期：1960-07-01 00:00:00

abstract：AIMS:To evaluate two detailed step sectioning protocols for sentinel lymph nodes (SLNs). METHODS:After vital dye or combined dye and radiocolloid guided biopsy, SLNs were fixed in formalin and embedded in paraffin wax. In protocol A, SLNs from 123 patients were sectioned in steps of 50-100 micro m, whereas in protocol...

journal_title：Journal of clinical pathology

authors： Cserni G

更新日期：2002-12-01 00:00:00

abstract：:A latex enzyme immunoassay (LEIA) for detecting IgG class antibody to rubella virus was compared with the latex agglutination test (LA) and a haemagglutination inhibition assay (HI). Of 243 sera tested, four discrepant results were observed among all three techniques, corresponding to borderline values. Except for one...

journal_title：Journal of clinical pathology

authors： Duverlie G,Roussel C,Driencourt M,Orfila J

更新日期：1990-09-01 00:00:00

abstract：:The Scottish Meningococcus and Pneumococcus Reference Laboratory provides a national service for the laboratory confirmation of meningococcal and pneumococcal disease in Scotland. The main tests used for the laboratory confirmation of meningococcal disease are culture, the polymerase chain reaction (PCR), antibody tes...

journal_title：Journal of clinical pathology

authors： Clarke SC,Diggle MA,Reid JA,Thom L,Edwards GF

更新日期：2001-07-01 00:00:00

abstract：:Streptex was compared to routine laboratory identification methods available. The results from Streptex sometimes required several attempts before final identification could be achieved. In the main, group D streptococci other than Strep. faecalis failed to group with the Streptex antisera, and this method cannot ther...

journal_title：Journal of clinical pathology

authors： Waitkins SA,Ratcliffe JG,Anderson RD,Roberts C

更新日期：1979-12-01 00:00:00

abstract：:A case of bacterial endocarditis was caused by Cardiobacterium hominis in a 41-year-old man with mitral and aortic incompetence due to a previous episode of rheumatic fever. The main distinguishing characteristics of C. hominis are described, and the incidence of endocarditis is reviewed. After six weeks of treatment ...

journal_title：Journal of clinical pathology

authors： Jobanputra RS,Moysey J

更新日期：1977-11-01 00:00:00

abstract：:A case of Cryptococcus neoformans meningitis is described in an HIV negative patient with undiagnosed systemic sarcoidosis. The patient presented with signs of meningitis together with generalised lymphadenopathy and hepatosplenomegaly. Cryptococcal meningitis was diagnosed on lumbar puncture. She was treated with int...

journal_title：Journal of clinical pathology

authors： Botha RJ,Wessels E

更新日期：1999-12-01 00:00:00

abstract：AIM:Lymphocytic infiltration in the portal triads usually conceals the detection--in haematoxylin and eosin (H&E) stained sections--of bile ducts in two liver diseases: chronic hepatitis and primary biliary cirrhosis. The aim was to assess the number and the characteristics of the bile ducts in those diseases with the ...

journal_title：Journal of clinical pathology

authors： Rubio CA

更新日期：2000-10-01 00:00:00

abstract：:The analytical goals inferred desirable by a group of clinicians for the imprecisions of a wide range of analytes have been studied by survey. The goals required have not in general become more stringent in the past decade and are not as demanding as those promulgated by laboratory professionals. Clinical biochemistry...

journal_title：Journal of clinical pathology

authors： Barrett AE,Cameron SJ,Fraser CG,Penberthy LA,Shand KL

更新日期：1979-09-01 00:00:00

abstract：:Of the first 250 heart and 35 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 217 heart and 33 heart and lung patients were investigated serologically for evidence of Toxoplasma gondii infection. Six patients acquired primary T gondii in...

journal_title：Journal of clinical pathology

authors： Wreghitt TG,Hakim M,Gray JJ,Balfour AH,Stovin PG,Stewart S,Scott J,English TA,Wallwork J

更新日期：1989-02-01 00:00:00

abstract：:The histological appearances of the breast in a patient with mucoviscidosis are those of complete lobular agenesis. Ducts and ductules are well developed, and there is abundant fibrous tissue giving the breast a normal contour. The appearances are contrasted with those of gynaecomastia, and the aetiology is discussed....

journal_title：Journal of clinical pathology

authors： Ward AM

更新日期：1972-02-01 00:00:00

abstract：:Laboratory studies on clotrimazole showed that it had marked activity in vitro against all the Candida spp. and Cryptococcus spp. tested, against almost all strains of dermatophytes, and against Aspergillus spp and other fungal genera responsible for systemic mycoses; it had limited activity towards Gram-positive bact...

journal_title：Journal of clinical pathology

authors： Holt RJ,Newman RL

更新日期：1972-12-01 00:00:00

abstract：BACKGROUND:Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associ...

journal_title：Journal of clinical pathology

authors： Stewart CJ,Amanuel B,Grieu F,Carrello A,Iacopetta B

更新日期：2010-07-01 00:00:00

abstract：:Mixed lymphocyte reactions (MLRs) were measured in 25 HLA-A, B and DR compatible sibling bone marrow transplants. Only four of 25 MLRs were positive and in these the low reactivity was of doubtful clinical importance. There was no correlation between MLR and the subsequent development or severity of graft versus host ...

journal_title：Journal of clinical pathology

authors： Lim SH,Patton WN,Jobson S,Gentle TA,Baynham M,Franklin IM,Broughton BJ

更新日期：1988-11-01 00:00:00

abstract：:A study of 16 haematological and 24 biochemical parameters in healthy, adult, male, volunteer Saudi blood donors was made, and enabled a preliminary determination of the reference values for these parameters to be made for Saudi Arabia. Statistically significant low means were observed for all the haematological param...

journal_title：Journal of clinical pathology

authors： Scott TG

更新日期：1982-01-01 00:00:00