Basal cell carcinoma arising in a smallpox vaccination site.

abstract：BACKGROUND:Parafibromin is a novel protein product of HRPT2, a recently identified tumour suppressor gene. Mutations of the HRPT2 gene are common in parathyroid carcinomas, and these exhibit reduced protein expression. Parafibromin expression in breast cancer has not been previously studied. AIMS:To determine the dist...

journal_title：Journal of clinical pathology

authors： Selvarajan S,Sii LH,Lee A,Yip G,Bay BH,Tan MH,Teh BT,Tan PH

更新日期：2008-01-01 00:00:00

abstract：:Microsatellite instability (MSI) testing is tricky in gynaecological cancers (GC). Thus, we aimed to describe the instability patterns to improve MSI test interpretation in sporadic and hereditary GCs. Ninety-five cases, including uterine and ovarian cancers, with known genetic and immunohistochemical (IHC) features, ...

journal_title：Journal of clinical pathology

authors： Libera L,Sahnane N,Carnevali IW,Cimetti L,Cerutti R,Chiaravalli AM,Riva C,Tibiletti MG,Sessa F,Furlan D

更新日期：2017-09-01 00:00:00

abstract：AIMS:To assess the consistency and reproducibility of assessment of c-erbB-2 immunostaining, and to examine some of the problems relating to inter- and intraobserver variability in the documentation of positive staining; to profile the spectrum of cytoplasmic and membranous staining in a wide range of tumour types. ME...

journal_title：Journal of clinical pathology

authors： Kay EW,Walsh CJ,Cassidy M,Curran B,Leader M

更新日期：1994-09-01 00:00:00

abstract：AIMS:The aims of this study were (1) to determine the measurement accuracy of a widely used guaiac faecal occult blood test (gFOBT) compared with an immunochemical faecal occult blood test (iFOBT) during in vitro studies, including their analytical stability over time at ambient temperature and at 4°C; and (2) to compa...

journal_title：Journal of clinical pathology

authors： Lee CS,O'Gorman P,Walsh P,Qasim A,McNamara D,O'Morain CA,Boran GP

更新日期：2011-06-01 00:00:00

abstract：:An outbreak of rotavirus infection in elderly patients in a long-stay ward of a geriatric hospital is described. Virus was detected in 7/15 (47%) symptomatic individuals. Four members of staff were among those affected. The findings emphasise the need for electron microscopy to be used in the initial investigation of ...

journal_title：Journal of clinical pathology

authors： Cubitt WD,Holzel H

更新日期：1980-03-01 00:00:00

abstract：:In order to detect the heat labile toxin of Escherichia coli human embryo lung fibroblast cells were seeded with whole cell lysate preparations of the organism to be tested. Positive results consisted of growth inhibition and cytopathic change which were easily seen. Heat-labile toxin was produced by strains belonging...

journal_title：Journal of clinical pathology

authors： Holzel H

更新日期：1979-12-01 00:00:00

abstract：:The development of sensitive reagents and detection systems, together with the introduction of heat-induced antigen retrieval, has rapidly entrenched immunohistology as an indispensable adjunct to routine histological examination, contributing to diagnosis, prognosis and treatment. New antibodies continue to be produc...

journal_title：Journal of clinical pathology

authors： Leong AS,Leong TY

更新日期：2006-11-01 00:00:00

abstract：:The pathological findings of an intradural and extramedullary cyst in the mid cervical spinal canal are described in a 55 year old woman who presented with a short history of pain and paraesthesia of the right arm. Intradural well defined solitary cystic lesions in the spinal canal are uncommon, their pathogenesis is ...

journal_title：Journal of clinical pathology

authors： Wilkinson N,Reid H,Hughes D

更新日期：1992-11-01 00:00:00

abstract：:The case records and pathology of all children with kidney tumours treated in the West Midlands Health Authority Region (WMHAR) from 1957 to 1986 were reviewed. The histology was reviewed by a panel of three paediatric pathologists. Thirteen (6%) out of 211 cases were considered to have congenital mesoblastic nephroma...

journal_title：Journal of clinical pathology

authors： Barrantes JC,Toyn C,Muir KR,Parkes SE,Raafat F,Cameron AH,Marsden HB,Mann JR

更新日期：1991-04-01 00:00:00

abstract：AIMS:To evaluate two detailed step sectioning protocols for sentinel lymph nodes (SLNs). METHODS:After vital dye or combined dye and radiocolloid guided biopsy, SLNs were fixed in formalin and embedded in paraffin wax. In protocol A, SLNs from 123 patients were sectioned in steps of 50-100 micro m, whereas in protocol...

journal_title：Journal of clinical pathology

authors： Cserni G

更新日期：2002-12-01 00:00:00

abstract：AIMS:As part of the UK antimicrobial resistance strategy and action plan, the Public Health Laboratory Service (PHLS) is required to collect antibiotic susceptibility data so that resistance trends and patterns can be monitored. Most laboratories report urine Gram negative isolates, as "coliforms" according to morpholo...

journal_title：Journal of clinical pathology

authors： Fallon D,Andrews N,Frodsham D,Gee B,Howe S,Iliffe A,Nye KJ,Warren RE

更新日期：2002-07-01 00:00:00

abstract：:Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...

journal_title：Journal of clinical pathology

authors： Millgan G,Graham R,Hanratty S,Muir W,Mitchell R

更新日期：1981-10-01 00:00:00

abstract：:A rapid and simple enzyme linked immunosorbent assay (ELISA) for the detection of specific IgG against Toxoplasma gondii was compared with the dye test on 533 serum samples. In general, results were comparable but not with sera that contained high concentrations of toxoplasma specific IgM or that had been heated at 56...

journal_title：Journal of clinical pathology

authors： Francis JM,Payne RA,Joynson DH

更新日期：1988-07-01 00:00:00

abstract：AIMS:To determine the causes of ovarian granulomatous inflammation and to discuss the differential diagnoses. METHODS:The pathological features of all ovarian granulomas identified by pathology SNOMED coding in Northern Ireland over a 13 year period were reviewed. Case notes of patients were also reviewed. RESULTS:Th...

journal_title：Journal of clinical pathology

authors： McCluggage WG,Allen DC

更新日期：1997-04-01 00:00:00

abstract：:The test is an application of the method originally described by Boyden (1951) and adapted by Stavitsky and Arquilla (1958). Sera which contain anti-Panton-Valentine leucocidin agglutinate the prepared red cells, often to a very high dilution, and this has provided a useful serological test for the diagnosis of staphy...

journal_title：Journal of clinical pathology

authors： TOWERS AG

更新日期：1961-03-01 00:00:00

abstract：:Three selective chromogenic culture media (CHROMagars ESBL, CTX-M and KPC) were evaluated for their ability to support the growth of nine Klebsiella pneumoniae isolates producing OXA-48 carbapenemase in combination with other β-lactamases. CHROMagar ESBL and CHROMagar KPC were the most sensitive media, supporting grow...

journal_title：Journal of clinical pathology

authors： Hornsey M,Phee L,Woodford N,Turton J,Meunier D,Thomas C,Wareham DW

更新日期：2013-04-01 00:00:00

abstract：AIM:To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS:In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain react...

journal_title：Journal of clinical pathology

authors： Shimoyama T,Everett SM,Dixon MF,Axon AT,Crabtree JE

更新日期：1998-10-01 00:00:00

abstract：AIM:Definitive distinction between low-grade astrocytoma and astrogliosis is a long-standing difficulty due to their similar histopathological characteristics. To clarify differences in biological significance, this study focused on various components of the cell cycle machinery and proliferation as key parameters, com...

journal_title：Journal of clinical pathology

authors： Hara A,Saegusa M,Ichinoe M,Okayasu I

更新日期：2008-03-01 00:00:00

abstract：AIMS:To investigate staining patterns for mannan binding protein (MBP) by immunocytochemistry in liver biopsy specimens from patients with various hepatic disorders; to measure the serum MBP concentration in the patients at the time of biopsy; and to compare these to define further the role of MBP in disease. METHODS:...

journal_title：Journal of clinical pathology

authors： Ryley NG,Heryet AR,Lu J,Reid KB,Fleming KA

更新日期：1993-03-01 00:00:00

abstract：AIMS:Myospherulosis is a rare condition characterised by sac-like structures containing spheroid bodies in cysts or cystic spaces in the tissue. This condition has not previously been reported in the liver. The association with previous portal vein embolisation using a mixture of butyl 2-cyanoacrylate and ethiodised oi...

journal_title：Journal of clinical pathology

authors： Lui PC,Luk IS,Lee CK,Lui YH,Leung CY,Choi CH

更新日期：2004-02-01 00:00:00

abstract：AIM:The prognostic significance of perineural invasion (PNI) in oesophageal adenocarcinoma (EAC) is unclear. We examined the association of PNI with clinical outcomes in patients treated with neoadjuvant chemoradiotherapy (nCRT) and surgery. METHODS:We performed a single institutional retrospective study. We evaluated...

journal_title：Journal of clinical pathology

authors： Patel AK,Pan X,Vila DM,Frankel WL,Chen W,Perry KA,Merritt RE,D'Souza DM,Wuthrick EJ,Williams TM

更新日期：2020-04-21 00:00:00

abstract：AIMS:The Royal College of Pathologists recommend that a median of at least 12 lymph nodes should be harvested during pathological staging of colorectal cancer. It is not always easy to harvest the required number, especially in patients with rectal cancer receiving neoadjuvant therapy. Lymph node revealing solutions, f...

journal_title：Journal of clinical pathology

authors： Horne J,Carr NJ,Bateman AC,Kandala N 2nd,Adams J,Silva S,Ryder I

更新日期：2016-06-01 00:00:00

abstract：:In vitro morphological and functional studies were carried out on platelets which had been cryopreserved in the presence of 5% dimethyl sulphoxide (DMSO). Overall loss of platelets was around 50%. Those which survived freezing and reconstitution showed marked morphological deterioration, increase of procoagulant activ...

journal_title：Journal of clinical pathology

authors： Baythoon H,Tuddenham EG,Hutton RA

更新日期：1982-08-01 00:00:00

abstract：:Sera obtained from 34 men with Chlamydia trachomatis positive non-gonococcal urethritis, 34 men with C trachomatis negative non-gonococcal urethritis, 42 women with acute salpingitis, 38 healthy women, and 34 healthy men were studied for the presence of specific serum C trachomatis IgA and IgG antibodies. Serological ...

journal_title：Journal of clinical pathology

authors： Cevenini R,Sarov I,Rumpianesi F,Donati M,Melega C,Varotti C,La Placa M

更新日期：1984-06-01 00:00:00

abstract：:The association between asymptomatic primary sclerosing cholangitis and exocrine pancreatic disease was underlined by the findings in a patient with cystic fibrosis and in another with chronic pancreatitis. In each case hepatocytes showed extensive microvesicular steatosis and studies of drug metabolism suggested hepa...

journal_title：Journal of clinical pathology

authors： Benett I,Salh B,Haboubi NY,Braganza JM

更新日期：1989-05-01 00:00:00

abstract：:By means of enzyme immunoassays based on two monoclonal antibodies with specificities for distinct forms of placental type alkaline phosphatase (Pl-ALP), together with L-leucine inhibition studies, it has been possible to distinguish the Nagao type carcinoplacental enzyme from other placental type alkaline phosphatase...

journal_title：Journal of clinical pathology

authors： McLaughlin PJ,Twist AM,Evans CC,Johnson PM

更新日期：1984-07-01 00:00:00

abstract：:An investigation into the noise levels in a clinical chemistry laboratory has been carried out. It was shown that although the levels were insufficient to cause damage to hearing, they exceeded the criteria of acceptability for offices and workshops. ...

journal_title：Journal of clinical pathology

authors： Griffiths PD,Kell RL,Taylor W

更新日期：1970-07-01 00:00:00

abstract：AIMS:To evaluate an indirect immunofluorescence flow cytometry technique in a series of patients with large fetomaternal haemorrhage (FMH). METHODS:Patient samples identified by Kleihauer testing in local laboratories as having FMH > 4 ml were sent for flow cytometric analysis. In a proportion of cases the mothers rec...

journal_title：Journal of clinical pathology

authors： Johnson PR,Tait RC,Austin EB,Shwe KH,Lee D

更新日期：1995-11-01 00:00:00

abstract：AIMS:Neoadjuvant chemoradiation therapy (CRT) is an increasingly used therapeutic strategy for rectal cancer. Clinically, it remains a major challenge to predict therapeutic response and patient outcome after CRT. Rsf-1 (HBXAP), a novel nuclear protein with histone chaperon function, mediates ATPase-dependent chromatin...

journal_title：Journal of clinical pathology

authors： Lin CY,Tian YF,Wu LC,Chen LT,Lin LC,Hsing CH,Lee SW,Sheu MJ,Lee HH,Wang YH,Shiue YL,Wu WR,Huang HY,Hsu HP,Li CF,Chen SH

更新日期：2012-08-01 00:00:00

abstract：:Human papillomavirus antigen was found in 39 (16%) of 253 colposcopic biopsies from a group of women at high risk for cervical cancer who had been examined in the early 1970s. Immunohistochemical evidence of papillomavirus infection was found in 20 (30%) of 67 cervical intraepithelial neoplasia lesions infected with w...

journal_title：Journal of clinical pathology

authors： Singer A,Wilters J,Walker P,Jenkins D,Slavin G,Cowdell H,To A,Husain O

更新日期：1985-08-01 00:00:00