Abstract:
INTRODUCTION:Cellular blue naevi (CBN) measure 1-2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the maxillary and ethmoidal sinuses is reported. METHODS:Biopsies were taken from the skin, jugal mucosa and maxillary sinus. The following markers were used in the immunohistochemical evaluation: CD34, CD56, HMB-45, anti-S100, A-103, Melan A and MIB-1. RESULTS:The biopsy specimens showed a biphasic pattern affecting the lower dermis, subcutaneous fat, skeletal muscle, bone, jugal mucosa and maxillary sinus, but there was no histological evidence of malignancy. The tumour cells were CD34-, CD56-, HMB45+, anti-S100+ and A-103+. Melan A was focally expressed. No positive MIB-1 cells were identified. DISCUSSION:The present case shows that GCBN may infiltrate deeply, with no evidence of malignancy.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Bittencourt AL,Monteiro DA,De Pretto OJdoi
10.1136/jcp.2005.029488subject
Has Abstractpub_date
2007-01-01 00:00:00pages
82-4issue
1eissn
0021-9746issn
1472-4146pii
60/1/82journal_volume
60pub_type
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
abstract::A large body of evidence supports the idea that certain adult stem cells, particularly those of bone marrow origin, can engraft at alternative locations, particularly when the recipient organ is damaged. Under strong and positive selection pressure these cells will clonally expand/differentiate, making an important co...
journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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abstract::KRAS mutation status predicts response to anti-EGFR therapy in colorectal cancer patients. Here we report an interesting case of discordant KRAS mutation status in a patient with two separate tumour foci. Tumour A in sigmoid colon invaded through muscularis propria into the subserosal fat with metastatic disease in re...
journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:2010-08-01 00:00:00
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更新日期:2002-01-01 00:00:00
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journal_title:Journal of clinical pathology
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journal_title:Journal of clinical pathology
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更新日期:1985-04-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.7.719
更新日期:1981-07-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jclinpath-2017-204888
更新日期:2018-07-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.42.2.210
更新日期:1989-02-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.52.11.853
更新日期:1999-11-01 00:00:00
abstract::The proportion of fimbriate strains amongst Escherichia coli freshly isolated from infected urines did not differ significantly from the proportion amongst commensal Esch. coli isolated from the bowel and from non-infected urines. It is concluded that fimbriae play no major role in the pathogenesis of Esch. coli urina...
journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.20.1.84
更新日期:1967-01-01 00:00:00
abstract:AIMS:Positive direct antiglobulin tests (DATs) are valuable in identifying the aetiology of autoimmune haemolysis and in guiding therapeutic intervention. However, in HIV-positive individuals with background polyclonal gammopathy, a positive DAT in the absence of haemolysis is common. In this setting, IgG quantificatio...
journal_title:Journal of clinical pathology
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更新日期:2020-12-16 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.2003.010207
更新日期:2004-03-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.34.6.589
更新日期:1981-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:2016-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.15.6.503
更新日期:1962-11-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1973-07-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2003-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
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更新日期:1980-09-01 00:00:00
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journal_title:Journal of clinical pathology
pub_type: 杂志文章
doi:10.1136/jcp.22.6.731
更新日期:1969-11-01 00:00:00