Abstract：
BACKGROUND:The terminology applied to vascular anomalies has been variable in previously published literature making interpretation suboptimal. The International Society for the Study of Vascular Anomalies (ISSVA) has proposed a revised classification based on clinical features and histopathological findings. This classification is increasingly being accepted as clinically useful and a platform for future studies. AIMS:To examine the extent to which the ISSVA classification can be practically applied to diagnostic histopathological specimens. METHODS:Cutaneous vascular lesions received in a single paediatric pathology unit during a 2-year period (2004-5) were reviewed, including glucose transporter protein 1 (GLUT1) immunostaining where required, and lesions were reclassified according to the ISSVA classification. RESULTS:144 specimens were identified. Appropriate full clinical information was provided in only 17% of cases at submission. Infantile haemangiomas comprised 46% of cases, 18% of which were regressive type, initially inaccurately identified as vascular malformations before GLUT1 immunostaining. 30% of lymphatic malformations and all lymphovenous malformations were previously classified as vascular malformations, not otherwise specified. CONCLUSIONS:The ISSVA classification of vascular anomalies provides a useful framework for histopathologists to classify vascular anomalies. However, meaningful and appropriate use of such a system is dependent on the adequacy of clinical information provided and routine use of immunohistochemical markers.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Al-Adnani M,Williams S,Rampling D,Ashworth M,Malone M,Sebire NJdoi
10.1136/jcp.2006.038240subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1278-82issue
12eissn
0021-9746issn
1472-4146pii
jcp.2006.038240journal_volume
59pub_type
杂志文章abstract：AIMS:To investigate treatment with glycerol/washing as a potential substitute for freeze-thawing in the production of leucocyte depleted red cell concentrates for patients with a history of non-haemolytic reactions following transfusion. METHODS:The standard procedure of treatment with glycerol/-80 degrees C freezing/...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.46.8.742
更新日期：1993-08-01 00:00:00
abstract：:Patients with bacterial infection may show altered membrane permeability of the primary azurophilic lysosomes of blood neutrophils. A new enzyme cytochemical technique, sensitive to increased membrane permeability caused by contact of neutrophils with acetone, saponin, low pH, Streptolysin O, bacteria, and nylon wool,...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.7.648
更新日期：1978-07-01 00:00:00
abstract：:A patient with rhabdomyosarcoma is described in whom the presenting clinical and laboratory features were those of disseminated intravascular coagulation. The patient's rapid downhill course was primarily expressed by haemorrhagic tendency. An alveolar rhabdomyosarcoma, affecting many organs, including vascular and ca...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.30.7.661
更新日期：1977-07-01 00:00:00
abstract：AIMS:Endotoxin detection assays are not validated for use in end-stage kidney disease (ESKD). We investigated the accuracy and precision of the kinetic turbidimetric Limulus amoebocyte lysate (LAL) assay to detect endotoxin in plasma from patients with ESKD. Optimisation of endotoxin recovery from plasma using the dete...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2014-202622
更新日期：2015-01-01 00:00:00
abstract：:Fluorigenic substrates prepared from 4-methylumbelliferone provide a simple, convenient method for detecting and assaying group-specific hydrolase activity in small quantities of whole mycobacteria. Physico-chemical properties of the enzymes such as pH dependence and heat stability may also be studied. A technique is ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.4.378
更新日期：1978-04-01 00:00:00
abstract：:Liver copper concentrations in percutaneous biopsy specimens were measured by neutron activation analysis and compared with histological staining for copper by rubeanic acid and rhodanine, and with copper-associated protein stained by orcein. Liver copper concentrations were elevated in 31 of 35 biopsies from patients...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.31.8.784
更新日期：1978-08-01 00:00:00
abstract：AIM:To develop an expert system model for the diagnosis of fine needle aspiration cytology (FNAC) of the breast. METHODS:Knowledge and uncertainty were represented in the form of a Bayesian belief network which permitted the combination of diagnostic evidence in a cumulative manner and provided a final probability for...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.4.329
更新日期：1994-04-01 00:00:00
abstract：:The performance of coagulometers in the National Quality Assessment Scheme (NEQAS) surveys of the prothrombin time conducted between 1986 and 1987 was reviewed. There were sufficient data for analysis for eight types of coagulometer used with a single type of thromboplastin reagent and one instrument with an alternati...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.42.1.97
更新日期：1989-01-01 00:00:00
abstract：AIMS:The probabilistic approach is widely adopted for breast fine needle aspiration cytology. However, a definite cytological diagnosis is not always possible for C3 (atypia) cases, which poses a management dilemma as this represents a mixed category of benign and malignant cases. It would be beneficial to be able to p...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1136/jclinpath-2016-204138
更新日期：2017-12-01 00:00:00
abstract：AIM:To investigate the natural history of patients with non-alcoholic steatohepatitis by means of a prospective histological study. METHODS:One thousand five hundred and seventy one patients underwent liver biopsy at the Western Infirmary in Glasgow during the 10 year period 1985 to 1994. All biopsies were reported by...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.9.689
更新日期：2002-09-01 00:00:00
abstract：:Two cases are described in which clostridial invasion of the liver and spleen was noted at post-mortem examination. In each there was a history of debilitating disease and it is suggested that the infection was consequent upon impaired immunological and cellular defence mechanisms. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.18.2.170
更新日期：1965-03-01 00:00:00
abstract：:During a two-year period of observation Bacteroides species were isolated from specimens of pus and vaginal swabs from 115 patients in this hospital. Thirty-five representative strains proved on examination to be Bacteroides fragilis. Minimal inhibitory and minimal bactericidal concentrations of six antibiotics for th...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.21.4.432
更新日期：1968-07-01 00:00:00
abstract：INTRODUCTION:Cellular blue naevi (CBN) measure 1-2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2005.029488
更新日期：2007-01-01 00:00:00
abstract：:Melanocytes in melanocytic naevi and melanomas can display great variation. The presence of nuclear pseudoinclusions (NPI) is said to be useful in the histological and cytological differential diagnosis of malignant melanoma. The prevalence and characteristics of NPI in a series of 493 naevi and 50 melanomas are descr...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.48.7.676
更新日期：1995-07-01 00:00:00
abstract：AIMS:To investigate proliferative activity in leukaemic and lymphomatous bone marrow infiltrates and to assess the feasibility of transport of specimens among institutions. METHODS:Proliferative activity in bone marrow trephine cryosections from 99 patients with non-Hodgkin's lymphoma (NHL), 23 patients with acute mye...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.3.209
更新日期：1994-03-01 00:00:00
abstract：:Serum and tissue hepatitis B virus (HBV) markers were compared in 35 alcoholic and 23 non-alcoholic subjects affected by chronic liver disease. Seventeen point one per cent of alcoholic and 21.7% of non-alcoholic subjects had HBV tissue markers, but not serum markers, for this virus. It is therefore concluded that sho...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.40.2.167
更新日期：1987-02-01 00:00:00
abstract：:A cytochemical study of the lysosomal enzyme beta-glucuronidase in 60 cases of acute leukaemia has shown a qualitative difference in the cytoplasmic distribution of the enzyme between blast cells of the lymphoid and myeloid cell series. This difference provides a useful additional method for cytochemical classificatio...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.9.831
更新日期：1971-12-01 00:00:00
abstract：:The aim of this article is to provide knowledge of the origin of catecholamines and metabolites so that there can be an informed approach to the methods for biochemical screening for a possible phaeochromocytoma; The article includes a review of catecholamine and metadrenaline metabolism, with methods used in biochemi...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jcp.2009.071647
更新日期：2010-08-01 00:00:00
abstract：:A patient with megaloblastic anaemia due to nutritional folate deficiency is described. Partial villous atrophy and malabsorption of xylose showed progressive improvement to normal with folic acid therapy. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.2.131
更新日期：1971-03-01 00:00:00
abstract：:Plasma diamine oxidase levels were assayed in 66 patients who presented with pregnancy complicated by threatened abortion. Levels within the normal range were associated with continuing pregnancies, whereas levels below the normal range were associated with subsequent abortion. Among those patients in whom gestation w...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.34.2.187
更新日期：1981-02-01 00:00:00
abstract：AIMS:Although the autopsy is still the gold standard for quality assessment of clinical diagnoses, autopsy rates have been declining over the last decades to <10%. The aim of this study was to investigate the value of autopsies in the high-tech medicine era by determining the frequency of discrepancies between clinical...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jclinpath-2013-202122
更新日期：2014-06-01 00:00:00
abstract：:A severe non-dose related skin eruption attributable to treatment with captopril was recently reported: this is distinct from the dose related rashes that have been widely described. Ultrastructural and immunohistochemical studies were carried out to determine in detail the histological features of this eruption: the ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.39.8.902
更新日期：1986-08-01 00:00:00
abstract：:Meningitis due to Gemella haemolysans developed in a 73 year old woman after thermolysis of the Gasserian ganglion for trigeminal neuralgia. The taxonomy of this organism is discussed, and previous cases of infection are reviewed. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.38.5.558
更新日期：1985-05-01 00:00:00
abstract：:Structural chromosomal aberrations, in the form of breaks, were found in a significantly higher proportion of bone marrow cells in patients with infective hepatitis than in controls. These anomalies were observed during the first and third weeks after the onset of jaundice but had subsided by the sixth week. Chromosom...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.23.7.553
更新日期：1970-10-01 00:00:00
abstract：AIMS:To compare the efficacy of and tolerance to oral fluconazole and intraconazole in preventing fungal infection in neutropenic patients with haematological malignancies. PATIENTS:213 consecutive, afebrile adult patients treated with or without autologous stem cell transplantation for haematological malignancies. M...
journal_title：Journal of clinical pathology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1136/jcp.52.5.376
更新日期：1999-05-01 00:00:00
abstract：:A 72 year old woman presented with a suspected myocardial infarction. An echocardiograph showed no acute changes but her plasma creatine kinase (CK) activity was increased at 343 U/l (< 175 normal range). The apparent creatine kinase-MB activity by a CK-M subunit immunoinhibition assay was 350 U/l. In view of the disc...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.6.552
更新日期：1994-06-01 00:00:00
abstract：:One hundred catalase-positive, coagulase-negative, Gram-positive cocci isolated in significant numbers from the urine of patients with urinary tract infections, provisionally subdivided by their sensitivity to nonoviocin, were classified according to a slightly model version of Baird-Parker's schemes (1965 and 1972). ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.28.4.270
更新日期：1975-04-01 00:00:00
abstract：:VARIOUS LABORATORIES HAVE REPORTED DIFFERING SUCCESS RATES IN THEIR ABILITY TO DETECT INTRATHECAL SYNTHESIS OF ANTIBODY WHEN COMPARING THE INDEX OF [FORMULA: see text] with electrophoretic analysis. We selected 44 patients in the borderline area of minimal and/or equivocal abnormality by IgG index. Electrophoretic ana...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.3.312
更新日期：1983-03-01 00:00:00
abstract：:A rapid and reproducible technique for in situ hybridisation, using biotin labelled probes for the Y chromosome, human DNA, hepatitis B virus DNA and cytomegalovirus DNA on formalin fixed, paraffin embedded liver tissue, was developed. The degree of proteolytic digestion of tissue specimens is critical to ensure adequ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.41.7.793
更新日期：1988-07-01 00:00:00
abstract：:The results of using a product of serum thyroxine and triiodothyronine binding coefficient, estimated by simple methods, to give a ;free thyroxine index' in normal women, in pregnant women, and in patients taking oral contraceptives is described. The method is believed to provide a reliable means of assessing thyroid ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.21.6.767
更新日期：1968-11-01 00:00:00
