Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis.

abstract：BACKGROUND:Laboratories traditionally culture toxoplasma tachyzoites in animals for testing and experimental use. This article considers why available cell culture methods are not used more often. AIM:To compare HeLa cell culture and animal culture for production of toxoplasma tachyzoites. METHODS:In 2000 HeLa cultur...

journal_title：Journal of clinical pathology

authors： Chatterton JM,McDonagh S,Ho-Yen DO

更新日期：2010-05-01 00:00:00

abstract：:Seven commercially available screening tests for rheumatoid factor and two quantitative tests have been compared with the standard Rose-Waaler test in a series of 477 sera from patients with various joint diseases. Markedly different results were obtained, and on the basis of our findings suggestions are made as to wh...

journal_title：Journal of clinical pathology

authors： MacSween RN,Hughes H,Breen C,Kitchen P,Cathcart B,Buchanan WW

更新日期：1974-05-01 00:00:00

abstract：BACKGROUND:Peutz-Jeghers syndrome (PJS) is an autosomal dominant hamartomatous polyposis syndrome of the gastrointestinal tract, caused by a germline STK11/LKB1 mutation. Nasal polyposis was described in the original report by Peutz. Recently, a molecular-genetic association between nasal polyposis and PJS has been rep...

journal_title：Journal of clinical pathology

authors： de Leng WW,Westerman AM,Weterman MA,Jansen M,van Dekken H,Giardiello FM,de Rooij FW,Paul Wilson JH,Offerhaus GJ,Keller JJ

更新日期：2007-04-01 00:00:00

abstract：:In 12 normal subjects plasma calcium and phosphorus concentrations were estimated during a normal working day. In the individual subjects fluctuations from the fasting values occurred during the period of study, but at no time during that period did the mean values differ significantly from the fasting plasma calcium ...

journal_title：Journal of clinical pathology

authors： Wills MR

更新日期：1970-12-01 00:00:00

abstract：AIM:To develop a polymerase chain reaction (PCR) for the specific detection of the C protein gene in strains of group B Streptococcus. METHODS:A single primer pair derived from the nucleotide sequence of the IgA binding beta antigen of the C protein complex permitted the specific amplification of a 592 base pair DNA f...

journal_title：Journal of clinical pathology

authors： Mawn JA,Simpson AJ,Heard SR

更新日期：1993-07-01 00:00:00

abstract：:Evaluation of histological diagnosis requires an index of agreement (to measure repeatability and validity) together with a method of assessing bias. Cohen's kappa statistic appears to be the most suitable tool for measuring levels of agreement, which if unsatisfactory may be caused by bias. Further study of bias is p...

journal_title：Journal of clinical pathology

authors： Silcocks PB

更新日期：1983-11-01 00:00:00

abstract：AIMS:To report the clinicopathological characteristics of patients with ocular adnexal marginal zone B cell lymphoma (MZBL) with IgG4-positive plasma cells. METHODS:114 biopsy samples of ocular adnexal MZBLs were analysed. MZBLs with IgG4-positive plasma cells were included when the IgG4:IgG ratio was >40% (IgG4-relat...

journal_title：Journal of clinical pathology

authors： Kubota T,Moritani S,Yoshino T,Nagai H,Terasaki H

更新日期：2010-12-01 00:00:00

abstract：:One hundred and twenty-one rectal biopsies from 99 patients with carcinoma of the rectum or lower sigmoid colon were investigated using a high iron-diamine-Alcian blue technique for sulphated and non-sulphated acid mucins. It was found that in normal rectal mucosa sulphomucins are the main carbohydrate component of th...

journal_title：Journal of clinical pathology

authors： Filipe MI

更新日期：1972-02-01 00:00:00

abstract：:Phosphate in both inorganic and organic form is essential for several functions in the body. Plasma phosphate level is maintained by a complex interaction between intestinal absorption, renal tubular reabsorption, and the transcellular movement of phosphate between intracellular fluid and bone storage pools. This home...

journal_title：Journal of clinical pathology

authors： Leung J,Crook M

更新日期：2019-11-01 00:00:00

abstract：:The performance of coagulometers in the National Quality Assessment Scheme (NEQAS) surveys of the prothrombin time conducted between 1986 and 1987 was reviewed. There were sufficient data for analysis for eight types of coagulometer used with a single type of thromboplastin reagent and one instrument with an alternati...

journal_title：Journal of clinical pathology

authors： Poller L,Thomson JM,Taberner DA

更新日期：1989-01-01 00:00:00

abstract：:This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFbeta signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). ...

journal_title：Journal of clinical pathology

authors： McKenna M,Arnold C,Catherwood MA,Humphreys MW,Cuthbert RJ,Bueso-Ramos C,McManus DT

更新日期：2009-08-01 00:00:00

abstract：:In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than those of the corresponding group of male donors. In the whole series of female donors, there were significantly lower tota...

journal_title：Journal of clinical pathology

authors： Allan RN,Alexander MK

更新日期：1968-11-01 00:00:00

abstract：:Four cases of human infection with Achromobacter anitratus, one of which was fatal, are described. They all occurred at one hospital within a period of two months. The bacteriology, antibiotic sensitivity, and pathogenicity of the organisms are discussed. One of the strains was found to differ from the other three. ...

journal_title：Journal of clinical pathology

authors： ASHLEY DJ,KWANTES W

更新日期：1961-11-01 00:00:00

abstract：:Of the first 166 heart and 15 heart and lung transplant recipients at Papworth Hospital, Cambridge, who survived for more than one month after transplantation, 162 were investigated for cytomegalovirus (CMV) infection by serological methods. Altogether, 73 (45%) developed CMV infection after transplantation: 30 (18.5%...

journal_title：Journal of clinical pathology

authors： Wreghitt TG,Hakim M,Gray JJ,Kucia S,Wallwork J,English TA

更新日期：1988-06-01 00:00:00

abstract：:Attempts to detect hepatitis B antigen in faeces and bile should take into account the degradation and disappearance of the surface antigens in an environment containing proteolytic enzymes in the presence of bile salts as in the intestinal lumen. The cores of the Dane particles are much more stable than the surface a...

journal_title：Journal of clinical pathology

authors： Moodie JW,Stannard LM,Kipps A

更新日期：1974-09-01 00:00:00

abstract：BACKGROUND:Ewing's sarcoma and peripheral primitive neuroectodermal tumour (pPNET) are now regarded as two morphological ends of a spectrum of neoplasms, characterised by a t(11;22) or other related chromosomal translocation involving the EWS gene on chromosome 22 and referred to as Ewing family of tumours (EFTs). EFTs...

journal_title：Journal of clinical pathology

authors： McCluggage WG,Sumathi VP,Nucci MR,Hirsch M,Dal Cin P,Wells M,Flanagan AM,Fisher C

更新日期：2007-06-01 00:00:00

abstract：:Results of serological investigations on patients with joint pain, arthralgia or polyarthritis were analysed and this information was used to develop a diagnostic algorithm to ensure optimal utilisation of laboratory resources. Accordingly, all cases are now examined for parvovirus IgM, mycoplasma IgM and streptococca...

journal_title：Journal of clinical pathology

authors： Jones JW,Pether JV,Frost RW

更新日期：1995-08-01 00:00:00

abstract：:The incidence of jaundice and of abnormal liver function tests has been assessed in 91 multitransfused patients with severe haemophilia A and B. Tests of hepatocyte function were within the normal range in the majority of patients. On the contrary, tests of biliary cell function, liver cell damage, and bromsulphthalei...

journal_title：Journal of clinical pathology

authors： Mannucci PM,Capitanio A,Del Ninno E,Colombo M,Pareti F,Ruggeri ZM

更新日期：1975-08-01 00:00:00

abstract：AIM:Primary biliary cirrhosis (PBC) is characterised by antimitochondrial antibody against the pyruvate dehydrogenase complex (PDC) and chronic non-suppurative destructive cholangitis (CNSDC). Pyruvate oxidation to acetyl-CoA by PDC is a key step in the glycolytic system. Oestrogen-related receptor-α (ERRα) is function...

journal_title：Journal of clinical pathology

authors： Harada K,Kakuda Y,Sato Y,Ikeda H,Shimoda S,Yamamoto Y,Inoue H,Ohta H,Kasashima S,Kawashima A,Nakanuma Y

更新日期：2014-05-01 00:00:00

abstract：:A new rapid automated method for the identification and classification of microorganisms is described. It is based on the incorporation of 35S-methionine into cellular proteins and subsequent separation of the radiolabelled proteins by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The protein ...

journal_title：Journal of clinical pathology

authors： Tabaqchali S,Silman R,Holland D

更新日期：1987-09-01 00:00:00

abstract：AIMS:To determine how epithelial and stromal thymidine phosphorylase expression affects angiogenesis, rapid tumour growth, and decreased apoptotic activity in cervical cancer at varying stages of progression. METHODS:Epithelial and stromal thymidine phosphorylase expression, the microvessel count (reflected by factor ...

journal_title：Journal of clinical pathology

authors： Fujiwaki R,Hata K,Iida K,Maede Y,Koike M,Miyazaki K

更新日期：1999-08-01 00:00:00

abstract：AIM:To analyse whether the mean nuclear area of the 10 largest nuclei (MNA-10), the mitotic activity index (MAI), and Ki-67 immunoquantitative features have additional value to discriminate different grades of T(A,1) transitional cell carcinoma (TCC) of the urinary bladder. MATERIALS/METHODS:One hundred and fifty of 2...

journal_title：Journal of clinical pathology

authors： Bol MG,Baak JP,de Bruin PC,Rep S,Marx W,Bos S,Kisman O

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND/AIMS:Mast cells, when activated, secrete a large number of fibrogenic factors and have been implicated in the development of fibrotic conditions of the liver, lung, and skin. There is evidence that renal fibrosis is closely linked with a chronic inflammatory cell infiltrate within the interstitium, but a pot...

journal_title：Journal of clinical pathology

authors： Roberts IS,Brenchley PE

更新日期：2000-11-01 00:00:00

abstract：:The discovery of cell-free circulating fetal nucleic acids in maternal plasma has opened up new possibilities in non-invasive prenatal diagnosis. The rapid advancement of this field in the past decade is catalysed by the discovery of new classes of fetal nucleic acid markers and technological developments in nucleic a...

journal_title：Journal of clinical pathology

authors： Hung EC,Chiu RW,Lo YM

更新日期：2009-04-01 00:00:00

abstract：:The necropsy findings in an elderly woman, who had been treated with methyldopa and who had died during treatment for accidental hypothermia, showed acute periductal inflammation of obviously similar duration in an entopic pancreas in the wall of the jejunum and in the ectopic pancreas. This supports the hypothesis th...

journal_title：Journal of clinical pathology

authors： Benbow EW

更新日期：1988-04-01 00:00:00

abstract：AIMS:To study whether differences in eradication rates of antibiotics may be explained by differences in secretion of antibiotics in gastric juice. METHODS:A single intravenous dose of either ampicillin 500 mg, erythromycin 500 mg, or metronidazole 500 mg was administered to four healthy Helicobacter pylori negative v...

journal_title：Journal of clinical pathology

authors： van Zanten SJ,Goldie J,Hollingsworth J,Silletti C,Richardson H,Hunt RH

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Receptor activator of nuclear factor kappabeta ligand (RANKL) has an important role in bone remodelling, and tumour necrosis factor related, apoptosis inducing ligand (TRAIL) can induce apoptosis in cancer cells. Their functions are linked by their interactions with osteoprotegerin (OPG). OBJECTIVE:To inves...

journal_title：Journal of clinical pathology

authors： Cross SS,Harrison RF,Balasubramanian SP,Lippitt JM,Evans CA,Reed MW,Holen I

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori related gastric intestinal metaplasia (IM) is considered to be a precancerous lesion. AIMS:To identify the effects of H pylori eradication on K-ras mutations, cell kinetics in IM and histological changes in patients with and without gastric cancers in a one-year prospective study. METHO...

journal_title：Journal of clinical pathology

authors： Watari J,Tanaka A,Tanabe H,Sato R,Moriichi K,Zaky A,Okamoto K,Maemoto A,Fujiya M,Ashida T,Das KM,Kohgo Y

更新日期：2007-08-01 00:00:00

abstract：:Concentration of factor VIII from fresh plasma by cryoprecipitation remains the basis for preparation of products used to treat haemophilia A. This paper describes the preparation of a factor VIII concentrate from small plasma pools in transfusion centres with drying facilities. The dried concentrate from one litre of...

journal_title：Journal of clinical pathology

authors： Millgan G,Graham R,Hanratty S,Muir W,Mitchell R

更新日期：1981-10-01 00:00:00

abstract：:A rapid and simple enzyme linked immunosorbent assay (ELISA) for the detection of specific IgG against Toxoplasma gondii was compared with the dye test on 533 serum samples. In general, results were comparable but not with sera that contained high concentrations of toxoplasma specific IgM or that had been heated at 56...

journal_title：Journal of clinical pathology

authors： Francis JM,Payne RA,Joynson DH

更新日期：1988-07-01 00:00:00