Abstract：
AIMS:The probabilistic approach is widely adopted for breast fine needle aspiration cytology. However, a definite cytological diagnosis is not always possible for C3 (atypia) cases, which poses a management dilemma as this represents a mixed category of benign and malignant cases. It would be beneficial to be able to predict malignancy based on specific cytological features in C3 aspirates. METHODS:A comprehensive panel of cytological features (including quantitative, cytomorphological and background features) in a large cohort of C3 breast aspirates with subsequent histological excisions was evaluated to identify relevant morphological criteria predicting the risk of subsequent malignancy. RESULTS:A total of 229 C3 specimens with histological follow-up were included. Malignant outcome was found in 30.1% of specimens and the majority were invasive cancers. Features that showed a significant association with malignant outcome included older age (p=0.001), lower percentage of epithelial cell clusters and high percentage of single cells (p=0.002), cribriform architecture in cell clusters (p=0.034), presence of intracellular mucin (p=0.027), increased cell clusters without myoepithelial cells (p=0.048), diminished fibromyxoid stromal fragments (p=0.001), reduced bipolar nuclei (p=0.021) and the presence of necrosis (p=0.023). Except for the percentages of single cells and cell clusters without myoepithelial cells, all other features were shown to be independent risk predictors in multivariate analysis. CONCLUSIONS:C3 aspirates were associated with a significant probability of histological malignancy. Certain quantitative, cytomorphological and background features were potentially helpful in predicting the risk of a malignant outcome. The prediction could be clinically useful in the management of C3 cases.
journal_name
J Clin Patholjournal_title
Journal of clinical pathologyauthors
Yu SN,Li J,Wong SI,Tsang JYS,Ni YB,Chen J,Tse GMdoi
10.1136/jclinpath-2016-204138subject
Has Abstractpub_date
2017-12-01 00:00:00pages
1024-1032issue
12eissn
0021-9746issn
1472-4146pii
jclinpath-2016-204138journal_volume
70pub_type
杂志文章,多中心研究abstract：:Rocket-line immunoelectrophoresis (R-LIE) with antigen containing intermediate gel, and co-agglutination utilising protein A-containing staphylococci coated with specific antibodies, were adapted for serotyping the prototypes of group B meningococci. Both were found to have the same specificity as agar gel double diff...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.2.136
更新日期：1979-02-01 00:00:00
abstract：:Pseudomonas cepacia (Ps. multivorans) can become adapted to a 1 in 30 dilution of Savlon hospital concentrate in distilled water, and can multiply in it. The organism so adapted did not survive in Savlon of the same strength made with hard tap water (pH 7.2). This effect was due to the difference of pH between the two...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.8.708
更新日期：1971-11-01 00:00:00
abstract：AIMS:To develop a strategy for neonatal screening of sickle cell disease (SCD) and effective enrollment of affected neonates in a comprehensive follow-up programme adapted to the socioeconomic conditions, health structures and cultural background of an African setting. METHODS:The strategy implemented at the two large...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,多中心研究
doi：10.1136/jcp.2008.059113
更新日期：2009-01-01 00:00:00
abstract：:A chemical method for the sterilization of pancreatin and trypsin is given. Evidence is presented to show that this treatment does not diminish the specific activity of the enzymes and has some advantages in microbiological techniques. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.7.658
更新日期：1971-10-01 00:00:00
abstract：:Serum labelled with (59)Fe for ferrokinetic studies should contain only [(59)Fe] transferrin. [(59)Fe] ferric citrate was incubated at 37 degrees C for up to 24 hours with sera having an excess latent iron-binding capacity. The results showed that unbound [(59)Fe] ferric citrate may be present for several hours. An an...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.5.472
更新日期：1971-07-01 00:00:00
abstract：:Three cases of fungal endocarditis are described, each following a homograft valve replacement for aortic stenosis. The causative organism was C. albicans. The characteristic findings included soft, easily detached vegetations consisting of fungal colonies, aneurysms, embolization of large vessels, and lack of respons...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.20.4.555
更新日期：1967-07-01 00:00:00
abstract：:This memorandum proposes a standardized system of reporting the histology of human lymph nodes based on commonly used simple staining techniques. The purpose is to provide a uniform, internationally acceptable system by which the histological structure of lymph nodes can be correlated with other parameters of immunolo...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.26.5.317
更新日期：1973-05-01 00:00:00
abstract：:A study of 260 patients with non-Hodgkin's lymphoma (NHL) who underwent bilateral bone marrow biopsy at initial diagnosis showed marrow disease in 99 (38%) cases. The highest incidence of disease (83%) was seen in small lymphocytic lymphoma (SLL) and the lowest (19%) in diffuse large cell lymphoma (DLCL). Among cases ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.43.8.630
更新日期：1990-08-01 00:00:00
abstract：:Rabbit antiserum, elicited by the intravenous injection of a strain of Campylobacter jejuni heated to 100 degrees C, cross reacted strongly with all other thermophilic campylobacters tested as well as with "C pyloridis" and could be detected by indirect fluorescence with labelled anti-rabbit serum. Antisera to formali...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.37.9.1007
更新日期：1984-09-01 00:00:00
abstract：:Three hundred and ninety eight serum samples from 270 human immunodeficiency virus (HIV) antibody positive asymptomatic homosexual men were tested in the Abbott and Dupont HIV antigen ELISA tests. In the Abbott test 62 (16%) of the sera were positive, according to the manufacturer's instructions, compared with 55 (14%...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.43.5.420
更新日期：1990-05-01 00:00:00
abstract：AIMS:To establish the number of histological levels necessary for the evaluation of breast needle core biopsy (NCB) specimens taken from areas of mammographic calcification in patients presenting via the UK National Health Service Breast Screening Programme. METHODS:Retrospective review of a series of breast NCB speci...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2006.038190
更新日期：2007-06-01 00:00:00
abstract：:One hundred and seventyone antenatal patients were examined for the presence of ;large colony' mycoplasmas in the vagina, and for complement-fixing antibody to Mycoplasma hominis. In 25 patients the findings before and after delivery were compared. In patients from whom M. hominis was grown, antibody was twice as comm...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.20.4.633
更新日期：1967-07-01 00:00:00
abstract：:An ultramicro electrophoretic technique for the separation of serum lipoproteins is described using agarose gel on microscope slides.The interaction between the agarose gel and lipoproteins has been reduced and the separation between beta- and pre-beta-lipoproteins has been improved over existing methods. A semiquanti...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.24.1.83
更新日期：1971-02-01 00:00:00
abstract：:A middle aged man developed very high fever, status epilepticus, and terminal acute renal failure with myoglobinuria after surgery. A post mortem examination showed widespread muscle necrosis with hypercontraction bands. Muscle enzyme studies and electron microscopic examination disclosed central core disease, a condi...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.45.4.361
更新日期：1992-04-01 00:00:00
abstract：:Using a short series of biochemical tests already in use in many routine laboratories, it is possible to identify strains of the genus Klebsiella and to differentiate K. aerogenes from other types. Marked production of slime is not peculiar to the group and colonial appearance alone is not a satisfactory basis for ide...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.17.6.617
更新日期：1964-11-01 00:00:00
abstract：AIMS:The assessment of lymphatic vessel density (LVD) has been suggested as a tool to determine the metastatic risk of neoplasias. On this premise, the authors aimed to verify whether progression risk of stage I colorectal cancer may be related to LVD. The authors also evaluated and correlated vascular endothelial grow...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2010.083550
更新日期：2011-01-01 00:00:00
abstract：:The 24-hour urinary excretion of cyclic 3',5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between c...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.29.1.69
更新日期：1976-01-01 00:00:00
abstract：BACKGROUND:Gastric mucosa associated lymphoid tissue (MALT) lymphoma is a low grade B cell lymphoma histologically characterised by neoplastic B cells surrounding follicles in a marginal zone pattern and selectively infiltrating epithelium to form characteristic lymphoepithelial lesions. AIMS:To identify solitary epit...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2004.023747
更新日期：2005-11-01 00:00:00
abstract：AIM:To investigate the tissue specificity of a novel monoclonal antibody raised to a tissue fraction of normal human liver and which identified certain cells of gastric and duodenal mucosa. METHODS:A total of 155 samples of various tissues obtained from 100 surgical specimens were fixed in cold ethanol-paraformaldehyd...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.47.1.53
更新日期：1994-01-01 00:00:00
abstract：:A rapidly fatal case of enteritis necroticans in a 24 year old man with diabetes was caused by Clostridium perfringens type C. The role of beta toxin in the disease is discussed. This type has not been previously described as a causative agent in necrotising bowel disease of man outside endemic areas. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.37.8.942
更新日期：1984-08-01 00:00:00
abstract：:A biochemical typing method is described for Klebsiella pneumoniae (sensu lato) and Enterobacter aerogenes. The technique depends on differences in metabolism of five carbon substrates--glycerol, inositol, lactose, glucose, and xylose--at two concentrations. Reproducibility is satisfactory and is monitored by the inco...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.32.9.935
更新日期：1979-09-01 00:00:00
abstract：:The excretion of 2,3-dinor-6-keto prostaglandin F1 alpha, a major urinary metabolite of prostacyclin, and the formation of thromboxane B2, a stable metabolite of thromboxane A2, by platelets stimulated by adenosine diphosphate, were studied in alcoholics, who had been admitted for detoxification. Once prolonged heavy ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.40.5.512
更新日期：1987-05-01 00:00:00
abstract：:A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.55.10.784
更新日期：2002-10-01 00:00:00
abstract：AIMS:To investigate whether the use of recombinant early antigens for detection of antibodies to human cytomegalovirus (HCMV) gene products CM(2) (UL44, UL57) and p52 (UL44) is specific in the diagnosis and differentiation of active HCMV infection in a subset of patients with chronic fatigue syndrome (CFS), a diagnosis...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2007.050633
更新日期：2008-05-01 00:00:00
abstract：:Platelet adhesiveness was measured in patients undergoing operation. With the rotating bulb technique adhesiveness increased steadily to the sixth and ninth days following surgery. The glass bead filter technique demonstrated a marked increase in platelet adhesiveness on the day following operation. ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.20.5.708
更新日期：1967-09-01 00:00:00
abstract：:In an attempt to confirm the presence or absence of central nervous tissue in commercially prepared beefburgers, four burgers were processed and stained using routine histological laboratory techniques. Constituent parts of the burgers could be identified readily. In this small sample no central nervous tissue was fou...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.44.2.164
更新日期：1991-02-01 00:00:00
abstract：:A comparison is made of tests for thyroglobulin antibody, using gel diffusion, electroprecipitin, bentonite flocculation, tanned red cell agglutination, and latex slide agglutination techniques on sera from cases of Hashimoto's disease and other thyroid disorders. Any increase in gamma globulin was also noted from the...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.15.2.153
更新日期：1962-03-01 00:00:00
abstract：:Foveolar dysplasia is an uncommon form of dysplasia that is encountered in the stomach and oesophagus in the context of Barrett’s oesophagus. Glands displaying foveolar dysplasia also show architectural abnormalities that are similar to those encountered in adenomatous dysplasia. However, from a cytological point of v...
journal_title：Journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1136/jclinpath-2014-202600
更新日期：2014-10-01 00:00:00
abstract：:During each of the four-year periods 1971-1975 and 1975-1979, the annual incidence of hepatitis B infection has been assessed in 56 patients with haemophilia A by measuring plasma HBsAg, anti-HBs and anti-HBc levels. Infection rates of 7% and 9.5% per annum respectively were observed for each four-year period despite ...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.36.5.577
更新日期：1983-05-01 00:00:00
abstract：BACKGROUND:Prognostic factors in predicting outcomes in patients with head and neck squamous-cell carcinoma (HNSCC) are limited to the clinical-pathological parameters, including lymph node metastasis, location, grade and stage of the disease. AIM:To determine whether the expression of these proteins has a value in pr...
journal_title：Journal of clinical pathology
pub_type： 杂志文章
doi：10.1136/jcp.2006.036624
更新日期：2007-02-01 00:00:00
