Pathological findings in three cases of fungal endocarditis complicating open-heart surgery.

abstract：:Cancer lineage/tissue-of-origin assignment in cancers of unknown primary remains a challenge even when aided by massively parallel sequencing. The stakes are high for patients as many contemporary therapeutic strategies are disease-specific, and the biological differences can influence the patients' responses. Herein,...

journal_title：Journal of clinical pathology

authors： Yoon JY,Rosenbaum JN,Vergara N,Cohen RB,Wilson RB

更新日期：2020-08-27 00:00:00

abstract：:Fourteen formalin fixed and paraffin wax embedded biopsy specimens from 10 women (age range 34-68) presenting with pseudomembranous trigonitis were studied using a combination of anti-oestrogen receptor monoclonal antibodies in an avidin-biotin immunoperoxidase technique. All epithelial areas showing vaginal metaplasi...

journal_title：Journal of clinical pathology

authors： Stephenson TJ,Henry L,Harris SC,Giri DD,Fox M,Underwood JC

更新日期：1989-09-01 00:00:00

abstract：:Culture of peroral biopsy specimens from duodenal mucosa in vitro for 22 hours using a basic culture medium resulted in the formation of crypt cell nodules. The addition of collagen and serotonin to the culture medium increased the occurrence of the nodules and, invariably, their size. The nodules were situated on the...

journal_title：Journal of clinical pathology

authors： Challacombe DN,Wheeler EE

更新日期：1985-12-01 00:00:00

abstract：:Methods of speciating Candida isolates from clinical specimens are described and the necessity of speciation is emphasized. Differences in susceptibility of C. albicans and C. tropicalis to amphotericin B were observed and the implications of this in relation to treatment with amphotericin B and the development of res...

journal_title：Journal of clinical pathology

authors： Stieritz DD,Law EJ,Holder IA

更新日期：1973-06-01 00:00:00

abstract：:Components of the blood fibrinolytic system were measured in 43 patients with leukaemia. Increased fibrinolytic activity, indicated by a reduced plasma plasminogen level, was found in 14 patients. The combination of severe thrombocytopenia and increased fibrinolysis appeared to be a determinant in the production of a ...

journal_title：Journal of clinical pathology

authors： Ogston D,McAndrew GM,Ogston CM

更新日期：1968-03-01 00:00:00

abstract：:A monoclonal antibody, produced by peptide immunisation was used to detect the distribution of p62c/myc by immunohistology in normal and coeliac small intestinal mucosa. The effect of gluten in four treated coeliac patients was investigated by taking serial jejunal biopsy specimens for six hours after a 10 g oral glut...

journal_title：Journal of clinical pathology

authors： Ciclitira PJ,Stewart J,Evan G,Wight DG,Sikora K

更新日期：1987-03-01 00:00:00

abstract：:This paper illustrates a simple method of necropsy dissection of the abdominal organs after abdominal surgery. The organs are removed in one block as per the method described by Letulle. A retroperitoneal approach is then used. Structures are dissected away in a series of layers using the vasculature for guidance. Thi...

journal_title：Journal of clinical pathology

authors： Culora GA,Roche WR

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Somatic mutations are important determinants of cancer behaviour and response to therapy. However, molecular testing in this context has a relatively low profile within the clinical community, despite publicity surrounding targeted therapies such as Herceptin. AIMS:As the testing process affects many stakeh...

journal_title：Journal of clinical pathology

authors： Wordsworth S,Buchanan J,Papanicolas I,Taylor J,Frayling I,Tomlinson I

更新日期：2008-06-01 00:00:00

abstract：AIMS:To establish a mechanism to examine the components of turnaround time in a representative cross-section of laboratory users; and to identify potential areas for improvement. METHODS:Information was collected manually from result reports received by eight laboratory users: three wards in the main hospital, four GP...

journal_title：Journal of clinical pathology

authors： Smellie WS,Johnston J,Galloway PJ

更新日期：1994-07-01 00:00:00

abstract：AIMS:To assess the significance of flat epithelial atypia (FEA) on core biopsy by evaluating the proportion of cases upgraded to in-situ and invasive carcinoma on further sampling with vacuum-assisted biopsy (VAB) or diagnostic surgical biopsy. METHODS:A retrospective analysis was performed of all core biopsies contai...

journal_title：Journal of clinical pathology

authors： Rajan S,Sharma N,Dall BJ,Shaaban AM

更新日期：2011-11-01 00:00:00

abstract：AIMS:Most benign breast fibroepithelial lesions (FEL) in adults harbour recurrent somatic MED12 exon 2 mutations and rare TERT promoter hotspot mutations. We sought to determine the frequency of MED12 exon 2 and TERT promoter hotspot mutations in fibroadenomas (FA) and benign phyllodes tumours (BePT) in adolescents and...

journal_title：Journal of clinical pathology

authors： Pareja F,Da Cruz Paula A,Murray MP,Hoang T,Gularte-Mérida R,Brown D,da Silva EM,Sebastiao APM,Giri DD,Weigelt B,Reis-Filho JS,Brogi E

更新日期：2019-03-01 00:00:00

abstract：:Human epidermal growth factor receptor 2 (HER2) testing is required for newly diagnosed breast cancer and advised for recurrent and metastatic breast cancer, to determine treatment planning using HER2-directed therapy in the neoadjuvant, adjuvant and advanced disease settings. Wide variation, nationally, in the turnar...

journal_title：Journal of clinical pathology

authors： Shaaban AM,Purdie CA,Bartlett JM,Stein RC,Lane S,Francis A,Thompson AM,Pinder SE,Translational Subgroup of the NCRI Breast Clinical Studies Group.

更新日期：2014-02-01 00:00:00

abstract：:A microcomputer system for use in the sequential processing of specimens has been developed in a hospital microbiology department which receives 90 000 specimens a year. Data handling is performed directly through the computers without the use of cards or worksheets. The system facilitates the multistep processing of ...

journal_title：Journal of clinical pathology

authors： Ashley R,Downing B

更新日期：1985-02-01 00:00:00

abstract：:Laribacter hongkongensis is a Gram-negative, facultative anaerobic, motile, S-shaped, urease-positive bacillus associated with invasive infections in liver cirrhosis patients and community-acquired gastroenteritis. Most cases of L hongkongensis infections occur in eastern countries. Information is lacking on the usefu...

journal_title：Journal of clinical pathology

authors： Tang BS,Lau SK,Teng JL,Chan TM,Chan WS,Wong TY,Tong YT,Fan RY,Yuen KY,Woo PC

更新日期：2013-12-01 00:00:00

abstract：:This is an unusual case of total granulomatous infarction of testis due to Schistosoma haematobium, the first such case to be reported. This report reinforces the theory of extraportal maturation of worms in spermatic veins and capillaries as postulated earlier (Joshi, 1962). ...

journal_title：Journal of clinical pathology

authors： Joshi RA

更新日期：1967-05-01 00:00:00

abstract：:A rapid and reproducible electrophoretic method for the separation and quantitation of haemoglobins on cellulose acetate is described. The accuracy of the method and its possible sources of error are discussed. The normal range for haemoglobin A(2) by this method is 1% to 3% of the total haemoglobin concentration. Blo...

journal_title：Journal of clinical pathology

authors： Marengo-Rowe AJ

更新日期：1965-11-01 00:00:00

abstract：BACKGROUND:An increased level of serum C-reactive protein (CRP) is a known prognostic factor for acute coronary events and sudden cardiac death, and it is associated with coronary calcification. CRP is expressed in coronary arteries, but its role in the development of coronary plaques is unclear. AIM:To investigate CR...

journal_title：Journal of clinical pathology

authors： Norja S,Nuutila L,Karhunen PJ,Goebeler S

更新日期：2007-05-01 00:00:00

abstract：:The sensitivity of 12 commonly used anti-HIV-1/HIV-2 enzyme immunoassays was evaluated. The assays, each of which utilises at least one synthetic HIV antigen, were tested against a panel of 1092 specimens previously designated anti-HIV positive. In a total of 13 104 tests there were eight false negative results attrib...

journal_title：Journal of clinical pathology

authors： McAlpine L,Parry JV,Shanson D,Mortimer PP

更新日期：1995-05-01 00:00:00

abstract：:Cytological diagnosis in a series of 153 skin lesions is presented. The diagnosis in each case has been compared with the clinical assessment and, where available, the biopsy result (85 lesions). Of 131 basal cell carcinomas, a cytological diagnosis was possible in 124 while biopsyl failed to identify two of the 73 le...

journal_title：Journal of clinical pathology

authors： Brown CL,Klaber MR,Robertson MG

更新日期：1979-04-01 00:00:00

abstract：:A 72 year old woman presented with a suspected myocardial infarction. An echocardiograph showed no acute changes but her plasma creatine kinase (CK) activity was increased at 343 U/l (< 175 normal range). The apparent creatine kinase-MB activity by a CK-M subunit immunoinhibition assay was 350 U/l. In view of the disc...

journal_title：Journal of clinical pathology

authors： Crook M,Williams A,Sankaralingam A,Tutt P

更新日期：1994-06-01 00:00:00

abstract：:A "Centrifichem" centrifugal analyser was found using a double fluorescence/bacterial tracer method to be a source of airborne and surface contamination in the laboratory. The airborne contamination was controlled by a modification incorporating a filter. Ubiquitous surface contamination generally accompanied the proc...

journal_title：Journal of clinical pathology

authors： Kennedy DA,Stevens JF,Horn AN

更新日期：1988-11-01 00:00:00

abstract：AIMS:To develop a specific radioimmunoassay for the routine determination of serum vitamin B12. METHODS:Antisera were raised in rabbits by immunisation with the monocarboxylic acid derivative of cyanocobalamin coupled to human serum albumin. Antibody titres and affinities were determined and the antiserum giving the h...

journal_title：Journal of clinical pathology

authors： O'Sullivan JJ,Leeming RJ,Lynch SS,Pollock A

更新日期：1992-04-01 00:00:00

abstract：:The Royal College of Pathologists (RCPath) and College of American Pathologists recommend that at least 12 lymph nodes should be harvested for adequate staging of colorectal carcinoma. Just one nodal tumour deposit upstages the malignancy from pN0 to pN1. This is critically important as node-positive patients (pN1) ar...

journal_title：Journal of clinical pathology

authors： Horne J,Bateman AC,Carr NJ,Ryder I

更新日期：2014-05-01 00:00:00

abstract：:In a study of a group of 325 blood donors between the ages of 18 and 65 years, the total leucocyte and polymorph counts of the females aged 50 to 65 years were found to be significantly lower than those of the corresponding group of male donors. In the whole series of female donors, there were significantly lower tota...

journal_title：Journal of clinical pathology

authors： Allan RN,Alexander MK

更新日期：1968-11-01 00:00:00

abstract：BACKGROUND:Friend leukaemia integration-1 (FLI-1) antibody is a useful marker for Ewing's sarcoma/primitive neuroectodermal tumour (EWS/PNET) and vascular tumours. However, it is also expressed in subsets of lymphoblastic lymphoma, Merkel cell carcinoma (MCC) and desmoplastic small round cell tumour (DSRCT). AIM:To de...

journal_title：Journal of clinical pathology

authors： Mhawech-Fauceglia P,Herrmann FR,Bshara W,Odunsi K,Terracciano L,Sauter G,Cheney RT,Groth J,Penetrante R,Mhawech-Fauceglia P

更新日期：2007-06-01 00:00:00

abstract：:Of the 123 patients with acute mesenteric infarction treated over the past 12 years, 16 (13%) had mesenteric venous thrombosis. Eight of the patients with mesenteric venous thrombosis survived the initial episode; two have since died. The remaining six patients were studied for evidence of haemostatic deficiencies or ...

journal_title：Journal of clinical pathology

authors： Wilson C,Walker ID,Davidson JF,Imrie CW

更新日期：1987-08-01 00:00:00

abstract：AIMS:Myospherulosis is a rare condition characterised by sac-like structures containing spheroid bodies in cysts or cystic spaces in the tissue. This condition has not previously been reported in the liver. The association with previous portal vein embolisation using a mixture of butyl 2-cyanoacrylate and ethiodised oi...

journal_title：Journal of clinical pathology

authors： Lui PC,Luk IS,Lee CK,Lui YH,Leung CY,Choi CH

更新日期：2004-02-01 00:00:00

abstract：AIMS:To investigate staining patterns for mannan binding protein (MBP) by immunocytochemistry in liver biopsy specimens from patients with various hepatic disorders; to measure the serum MBP concentration in the patients at the time of biopsy; and to compare these to define further the role of MBP in disease. METHODS:...

journal_title：Journal of clinical pathology

authors： Ryley NG,Heryet AR,Lu J,Reid KB,Fleming KA

更新日期：1993-03-01 00:00:00

abstract：:Bone marrow infiltrates taken from 11 patients with peripheral T cell lymphoma were immunophenotyped as T cell lymphoma using monoclonal antibodies on frozen bone marrow trephine biopsy specimens. In nine these were taken at diagnosis and in two after failure of treatment to eradicate lymphoma in the marrow. Patterns ...

journal_title：Journal of clinical pathology

authors： White DM,Smith AG,Whitehouse JM,Smith JL

更新日期：1989-04-01 00:00:00

abstract：:It was postulated that the short chain fatty acids (SCFA) produced by anaerobic bacteria might serve as microbial markers in purulent material. Eighteen pus specimens from various sources were analysed by gas-liquid chromatography (GLC), and the SCFA detected were compared with the microorganisms isolated by conventio...

journal_title：Journal of clinical pathology

authors： Ladas S,Arapakis G,Malamou-Ladas H,Palikaris G,Arseni A

更新日期：1979-11-01 00:00:00