Effect of intravenous prostaglandin E 2 on platelet function, coagulation, and fibrinolysis.

Abstract:

:Prostaglandin E(2) (PGE(2)) was infused intravenously to eight women for the termination of pregnancy and tests of platelet function: coagulation and fibrinolysis were studied before and during the infusion.Platelet adhesiveness, as measured by a cellophane membrane test-cell system, was significantly diminished by PGE(2), a change which was not noted by the glass-bead column technique. The administration of PGE(2) caused more rapid platelet disaggregation following ADP-induced aggregation but had no effect on the platelet count, collagen-induced aggregation, or platelet factor 3 activity. An increase in plasma antithrombin concentration and euglobulin lysis activity was also noted. These results support the concept that prostaglandin E(2) might have a role in the prevention of thrombosis.

journal_name

J Clin Pathol

authors

Howie PW,Calder AA,Forbes CD,Prentice CR

doi

10.1136/jcp.26.5.354

subject

Has Abstract

pub_date

1973-05-01 00:00:00

pages

354-8

issue

5

eissn

0021-9746

issn

1472-4146

journal_volume

26

pub_type

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