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White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort Study.

Abstract：

AIMS:To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population. METHODS:Three thousand and twenty men and 7,256 women aged 50-85 years were recruited and received a medical check-up including measurement of complete blood count, blood pressure, obesity indices, fasting total, LDL-, HDL-cholesterol, triglycerides, glucose and c-reactive protein (CRP). Information on socioeconomic and lifestyle factors was also collected. RESULTS:Vascular risk factors including waist circumference, body mass index, triglyceride, total-, LDL-cholesterol, CRP and systolic and diastolic blood pressures were all positively associated with WBC in both men and women (p from 0.0085 to <0.001). The risk of MS increased significantly with higher total WBC, with adjusted odds ratios (95% confident interval) for second and third tertiles of 1.86 (1.43, 2.42), 2.56 (1.98, 3.32) in men and 1.67 (1.46, 1.90), 2.66 (2.34, 3.03) in women, respectively. Neutrophil and lymphocyte were strongly correlated with total WBC and showed similar association with the MS. CONCLUSION:There is a strong relationship between total WBC, neutrophil and lymphocyte and the constellation of MS components and associated vascular risk in this older Chinese population.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Lao XQ,Neil Thomas G,Jiang C,Zhang W,Adab P,Lam TH,Cheng KK

doi

10.1016/j.atherosclerosis.2007.12.053

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

418-24

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00017-8

journal_volume

201

pub_type

杂志文章

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