Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.

abstract：:Natural killer (NK) cells eliminate abnormal cells through the release of cytolytic granule contents. In this process, NK cells must adhere to target cells through integrin-mediated adhesion, which is highly dependent on the generation of F-actin. Ena/VASP-like (EVL) is an actin regulatory protein previously shown to ...

journal_title：Journal of cell science

authors： Wilton KM,Overlee BL,Billadeau DD

更新日期：2019-07-18 00:00:00

abstract：:During spermatogenesis, the first morphological indication of spermatogonia differentiation is incomplete cytokinesis, followed by the assembly of stable intercellular cytoplasmic communications. This distinctive feature of differentiating male germ cells has been highly conserved during evolution, suggesting that reg...

journal_title：Journal of cell science

authors： Cunto FD,Imarisio S,Camera P,Boitani C,Altruda F,Silengo L

更新日期：2002-12-15 00:00:00

abstract：:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein that is restricted to certain cell types. In particular, this antigen shows a reduced level of expression during haemopoietic cell maturation. In this study, we have examined the relationship of this protein to known nuclear envelope proteins that ha...

journal_title：Journal of cell science

authors： Lord JM,Thick JA,Bunce CM,Taylor AM,Gallimore PH,Mills D,Brown G

更新日期：1988-06-01 00:00:00

abstract：:Cyclin E is a regulatory subunit of the cdc2-related protein kinase cdk2, which is activated shortly before S-phase entry, thus defining it as a G1 cyclin. We report here the existence of a 43 kDa splice variant of human cyclin E, termed cyclin Es, which lacks 49 amino acids within the cyclin box compared to the known...

journal_title：Journal of cell science

authors： Sewing A,Rönicke V,Bürger C,Funk M,Müller R

更新日期：1994-02-01 00:00:00

abstract：:We describe here the expression during development, tissue distribution and molecular properties of GP90: a major concanavalin A (ConA)-binding glycoprotein present in the neuronal membrane skeleton from chicken brain. GP90 is co-isolated with, and has a similar developmental profile to contactin (previously called GP...

journal_title：Journal of cell science

authors： Moss DJ,White CA

更新日期：1989-05-01 00:00:00

abstract：:The extracellular signal-regulated protein kinase ERK1/2 is a crucial effector linking extracellular stimuli to cellular responses: upon phosphorylation ERK [also known as mitogen-activated protein kinase P42/P44 (MAPK)] concentrates in the nucleus where it activates specific programs of gene expression. Notwithstandi...

journal_title：Journal of cell science

authors： Costa M,Marchi M,Cardarelli F,Roy A,Beltram F,Maffei L,Ratto GM

更新日期：2006-12-01 00:00:00

abstract：:Survivin, a human inhibitor of apoptosis protein (IAP), plays an important role in both cell cycle regulation and inhibition of apoptosis. Survivin is expressed in cells during the G(2)/M phase of the cell cycle, followed by rapid decline of both mRNA and protein levels at the G(1) phase. It has been suggested that ce...

journal_title：Journal of cell science

authors： Zhao J,Tenev T,Martins LM,Downward J,Lemoine NR

更新日期：2000-12-01 00:00:00

abstract：:Epithelial junctions depend on intercellular interactions between β(1) subunits of the Na(+)/K(+)-ATPase molecules of neighboring cells. The interaction between dog and rat subunits is less effective than the interaction between two dog β(1) subunits, indicating the importance of species-specific regions for β(1)-β(1)...

journal_title：Journal of cell science

authors： Tokhtaeva E,Sachs G,Sun H,Dada LA,Sznajder JI,Vagin O

更新日期：2012-03-15 00:00:00

abstract：:Yeast cells were cultivated at different growth rates in a chemostat by alterations in the flow of the limiting nutrient glucose and in batch cultures where variations in growth rate were achieved by alterations in the composition of nutrients. It was observed that the stage in the cycle at which S-phase was completed...

journal_title：Journal of cell science

authors： Jagadish MN,Carter BL

更新日期：1978-06-01 00:00:00

abstract：:Ca2+ is a second messenger in many physiological and phytopathological processes. Peroxisomes are subcellular compartments with an active oxidative and nitrosative metabolism. Previous studies have demonstrated that peroxisomal nitric oxide (NO) generation is dependent on Ca2+ and calmodulin (CaM). Here, we used Arabi...

journal_title：Journal of cell science

authors： Corpas FJ,Barroso JB

更新日期：2018-01-29 00:00:00

abstract：:We first identified Bves (blood vessel/epicardial substance) as a transmembrane protein that localized to the lateral compartment of the epithelial epicardium. Bves traffics to sites of cell-cell contact in cultured epicardial cells and promotes adhesion following transfection into non-adherent fibroblastic L-cells, r...

journal_title：Journal of cell science

authors： Osler ME,Chang MS,Bader DM

更新日期：2005-10-15 00:00:00

abstract：:Two of the best understood somatic cell mRNA cytoplasmic trafficking elements are those governing localization of beta-actin and myelin basic protein mRNAs. These cis-acting elements bind the trans-acting factors fibroblast ZBP-1 and hnRNP A2, respectively. It is not known whether these elements fulfil other roles in ...

journal_title：Journal of cell science

authors： Snee M,Kidd GJ,Munro TP,Smith R

更新日期：2002-12-01 00:00:00

abstract：:Successful implantation requires the synchronization of viable embryonic development with endometrial receptivity. The mechanisms allowing for the initiation of crosstalk between the embryo and the endometrium remain elusive; however, recent studies have revealed that there are alterations in endometrial microRNAs (mi...

journal_title：Journal of cell science

authors： Kang YJ,Lees M,Matthews LC,Kimber SJ,Forbes K,Aplin JD

更新日期：2015-02-15 00:00:00

abstract：:Atomic force microscopy (AFM) was used to probe topology, conformational changes and initial substrate-carrier interactions of Na+-glucose co-transporter (SGLT1) in living cells on a single-molecule level. By scanning SGLT1-transfected Chinese hamster ovary (CHO) cells with AFM tips carrying an epitope-specific antibo...

journal_title：Journal of cell science

authors： Puntheeranurak T,Wildling L,Gruber HJ,Kinne RK,Hinterdorfer P

更新日期：2006-07-15 00:00:00

abstract：:Distributions of ErbB receptors on membranes of SKBR3 breast cancer cells were mapped by immunoelectron microscopy. The most abundant receptor, ErbB2, is phosphorylated, clustered and active. Kinase inhibitors ablate ErbB2 phosphorylation without dispersing clusters. Modest co-clustering of ErbB2 and EGFR, even after ...

journal_title：Journal of cell science

authors： Yang S,Raymond-Stintz MA,Ying W,Zhang J,Lidke DS,Steinberg SL,Williams L,Oliver JM,Wilson BS

更新日期：2007-08-15 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease, but the precise physiological function of the protein remains ill-defined. Recently, our group proposed a model in which LRRK2 kinase activity is part of an EndoA phosphorylation cycle that facilitates efficient vesicle formatio...

journal_title：Journal of cell science

authors： Arranz AM,Delbroek L,Van Kolen K,Guimarães MR,Mandemakers W,Daneels G,Matta S,Calafate S,Shaban H,Baatsen P,De Bock PJ,Gevaert K,Vanden Berghe P,Verstreken P,De Strooper B,Moechars D

更新日期：2015-02-01 00:00:00

abstract：:The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hyd...

journal_title：Journal of cell science

authors： Kurokawa K,Suda Y,Nakano A

更新日期：2016-09-01 00:00:00

abstract：:Delayed wound healing caused by inefficient re-epithelialization underlines chronic skin lesions such as those found in diabetes. The dioxin receptor (AhR) modulates cell plasticity and migration and its activation by occupational polycyclic aromatic hydrocarbons (PAHs) results in severe skin lesions such as contact h...

journal_title：Journal of cell science

authors： Carvajal-Gonzalez JM,Roman AC,Cerezo-Guisado MI,Rico-Leo EM,Martin-Partido G,Fernandez-Salguero PM

更新日期：2009-06-01 00:00:00

abstract：:Cornichon proteins are structurally related transmembrane proteins that have been studied in and Drosophila and yeast. In Drosophila, Cornichon (Cni) is involved in embryo polarization by the TGFalpha-related Gurken. In yeast, the Cni-related Erv14 is required for axial budding. A cargo receptor function has been prop...

journal_title：Journal of cell science

authors： Castro CP,Piscopo D,Nakagawa T,Derynck R

更新日期：2007-07-15 00:00:00

abstract：:Programmed cell death comprises several subtypes, as revealed by electron microscopy. Apoptosis or type I programmed cell death is characterized by condensation of cytoplasm and preservation of organelles, essentially without autophagic degradation. Autophagic cell death or type II programmed cell death exhibits exten...

journal_title：Journal of cell science

authors： Bursch W,Hochegger K,Torok L,Marian B,Ellinger A,Hermann RS

更新日期：2000-04-01 00:00:00

abstract：:The elliptical, anucleate erythrocytes of camels have been examined for the presence of marginal bands and their constituent microtubules. Lysis of erythrocytes under microtubule-stabilizing conditions readily revealed marginal bands in at least 3 % of the cells, as observed by phase-contrast and darkfield light micro...

journal_title：Journal of cell science

authors： Cohen WD,Terwilliger NB

更新日期：1979-04-01 00:00:00

abstract：:In a wild population of the American newt Notophthalmus viridescens 15 females out of a total of 94 were found to be heterozygous for a paracentric inversion which includes almost the whole of the longer arm of the smallest chromosome (XI). The inversion was recognized in preparations of lampbrush chromosomes because ...

journal_title：Journal of cell science

authors： Hartley SE,Callan HG

更新日期：1977-04-01 00:00:00

abstract：:At the onset of development, the single cells of the eukaryotic micro-organism Dictyostelium discoideum secrete proteolytic activity which can be assayed using the insoluble substrate remazolbrilliant blue hide. The activity is not secreted by exponentially growing cells, but does appear extracellularly at the onset o...

journal_title：Journal of cell science

authors： Rossomando EF,Maldonado B,Crean EV,Kollar EJ

更新日期：1978-04-01 00:00:00

abstract：:Mitochondria play essential roles in cellular energy processes, including ATP production, control of reactive oxygen species (ROS) and apoptosis. While mitochondrial function is regulated by the dynamics of fusion and fission, mitochondrial homeostasis remains incompletely understood. Recent studies implicate dynamin-...

journal_title：Journal of cell science

authors： Farmer T,Reinecke JB,Xie S,Bahl K,Naslavsky N,Caplan S

更新日期：2017-07-15 00:00:00

abstract：:To evaluate the relative mobilities of cell surface glycoconjugates during myogenesis we have studied the redistribution of fluorescein-conjugated plant lectins on L6 rat myogenic cells. Previous experiments had demonstrated that the receptors for the lectins soybean agglutinin (SBA), wheat germ agglutinin, concanaval...

journal_title：Journal of cell science

authors： Sawyer JT,Akeson RA

更新日期：1986-07-01 00:00:00

abstract：:Epitectin, the mucin-like glycoprotein defined by the monoclonal antibodies CA1, CA2 and CA3, has been examined by electron microscopy to determine its shape and size. It appears to be a single extended strand with a mean length of about 270 nm. The antibodies CA1 and CA2 appear to bind preferentially to a terminal si...

journal_title：Journal of cell science

authors： Bramwell ME,Wiseman G,Shotton DM

更新日期：1986-12-01 00:00:00

abstract：:Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree of proteolytic release of the ligand. Although the spatial range of diffusion of released HB-EGF i...

journal_title：Journal of cell science

authors： Prince RN,Schreiter ER,Zou P,Wiley HS,Ting AY,Lee RT,Lauffenburger DA

更新日期：2010-07-01 00:00:00

abstract：:The development of DNA microarrays to study simultaneously the level of mRNA expressed from thousands of genes offers great promise to cell biologists. Microarrays can be used to gain detailed information about transcriptional changes involved in a specific pathway, potentially leading to the identification of novel c...

journal_title：Journal of cell science

authors： Schulze A,Downward J

更新日期：2000-12-01 00:00:00

abstract：:gamma-Tubulin exists in fission yeast as the product of an essential gene, encoding a 446 amino acid protein that is 77.3% identical to Aspergillus nidulans gamma-tubulin. The gene disruption caused cell lethality, displaying condensed, undivided chromosomes with aberrant spindle structures. Anti-gamma-tubulin stainin...

journal_title：Journal of cell science

authors： Horio T,Uzawa S,Jung MK,Oakley BR,Tanaka K,Yanagida M

更新日期：1991-08-01 00:00:00

abstract：:During mitosis, kinetochores need to attach to microtubules emanating from spindle poles. Several protein complexes have been shown to mediate the kinetochore-microtubule interaction. However, with the continually growing number of newly identified kinetochore proteins, it is unclear whether all major components of th...

journal_title：Journal of cell science

authors： Raaijmakers JA,Tanenbaum ME,Maia AF,Medema RH

更新日期：2009-07-15 00:00:00