Abstract:
:The monoclonal antibody AGF2.3 identifies a nuclear envelope protein that is restricted to certain cell types. In particular, this antigen shows a reduced level of expression during haemopoietic cell maturation. In this study, we have examined the relationship of this protein to known nuclear envelope proteins that have a similar molecular mass. Antigen extraction and immunoelectron microscope studies revealed that the AGF2.3 protein is an integral membrane protein present at both the inner and outer aspects of the nuclear envelope. The protein is not associated with nuclear pores and therefore is distinct from pore complex proteins. The AGF2.3 protein does not have ATPase activity. Therefore, this protein is also distinct from a myosin heavy chain-like ATPase that is associated with the nuclear envelope. The AGF2.3 antibody identifies a novel nuclear envelope protein. Further studies of the biochemical nature of the AGF2.3 protein should provide insight into novel cellular processes at the nuclear envelope relating to the lineage or maturation status of cells.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Lord JM,Thick JA,Bunce CM,Taylor AM,Gallimore PH,Mills D,Brown Gsubject
Has Abstractpub_date
1988-06-01 00:00:00pages
237-45eissn
0021-9533issn
1477-9137journal_volume
90 ( Pt 2)pub_type
杂志文章abstract::Protein kinase CK2, a vital, pleiotropic and highly conserved serine/threonine phosphotransferase is involved in transcription-directed signaling, gene control and cell cycle regulation and is suspected to play a role in global processes. Searching for these global roles, we analyzed the involvement of CK2 in gene exp...
journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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更新日期:2002-10-01 00:00:00
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journal_title:Journal of cell science
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更新日期:2009-07-15 00:00:00
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journal_title:Journal of cell science
pub_type: 杂志文章
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更新日期:1993-11-01 00:00:00
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journal_title:Journal of cell science
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doi:
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journal_title:Journal of cell science
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journal_title:Journal of cell science
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更新日期:2004-03-01 00:00:00
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