Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.

abstract：:We have reported earlier that the polyphosphoinositide messenger system may control mitosis in sea urchin eggs. Besides phospholipase C activation and its second messengers, phosphatidylinositol (PI) 3-kinase has been proposed to affect a wide variety of cellular processes in other cellular systems. Therefore, we have...

journal_title：Journal of cell science

authors： De Nadai C,Huitorel P,Chiri S,Ciapa B

更新日期：1998-09-01 00:00:00

abstract：:Proteins destined for the mitochondria travel an intricate pathway through two membranes, each with its own receptors and channels. These proteins interact with receptors via N-terminal presequences that form amphipathic helices. Generally, these helices contain abundant positive charges on one face and hydrophobic re...

journal_title：Journal of cell science

authors： Brydges SD,Carruthers VB

更新日期：2003-11-15 00:00:00

abstract：:Formation of crossovers between homologous chromosomes during meiosis is positively regulated by the ZMM proteins (also known as SIC proteins). DNA damage checkpoint proteins also promote efficient formation of interhomolog crossovers. Here, we examined, in budding yeast, the meiotic role of the heterotrimeric DNA dam...

journal_title：Journal of cell science

authors： Shinohara M,Hayashihara K,Grubb JT,Bishop DK,Shinohara A

更新日期：2015-04-15 00:00:00

abstract：:Accumulation of adipocytes and collagen type-I-producing cells (fibrosis) is observed in muscular dystrophies. The origin of these cells had been largely unknown, but recently we identified mesenchymal progenitors positive for platelet-derived growth factor receptor alpha (PDGFRα) as the origin of adipocytes in skelet...

journal_title：Journal of cell science

authors： Uezumi A,Ito T,Morikawa D,Shimizu N,Yoneda T,Segawa M,Yamaguchi M,Ogawa R,Matev MM,Miyagoe-Suzuki Y,Takeda S,Tsujikawa K,Tsuchida K,Yamamoto H,Fukada S

更新日期：2011-11-01 00:00:00

abstract：:Recent studies suggest that cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) elicit cell proliferation and promote angiogenesis. The aim of this study was to determine the role of CYP 2C8/9-derived EETs in the process of angiogenesis under hypoxic conditions. In human endothelial cells, hypox...

journal_title：Journal of cell science

authors： Michaelis UR,Fisslthaler B,Barbosa-Sicard E,Falck JR,Fleming I,Busse R

更新日期：2005-12-01 00:00:00

abstract：:Four developmental stages of Rana pipiens, R. pipiens female X R. catesbeiana female, and R. pipiens female X R. esculenta male embryos were fixed in standard electron microscopic fixatives with or without 1% lanthanum nitrate (LN) added. Embryos fixed without LN were embedded and sectioned at 0-5 micrometer and stain...

journal_title：Journal of cell science

authors： Johnson KE

更新日期：1977-06-01 00:00:00

abstract：:Nature Reviews Molecular Cell Biology Nature Publishing Group (2000). ISSN 1471-0072. Monthly First there was Annual Reviews, then came the monthly Elsevier Trends Journals, both of which try to identify hot topics in their chosen fields. The Current Opinion journals followed several years later, and Current Opinion i...

journal_title：Journal of cell science

authors： Hunt T

更新日期：2000-01-01 00:00:00

abstract：:Spindle pole bodies in the fission yeast Schizosaccharomyces pombe are required during meiosis, not only for spindle formation but also for the assembly of forespore membranes. The spo15 mutant is defective in the formation of forespore membranes, which develop into spore envelopes. The spo15(+)gene encodes a protein ...

journal_title：Journal of cell science

authors： Ikemoto S,Nakamura T,Kubo M,Shimoda C

更新日期：2000-02-01 00:00:00

abstract：:Hemidesmosomes are epithelial-specific attachment structures that maintain tissue integrity and resist tension. Despite their importance, how hemidesmosomes are regulated at the post-transcriptional level is poorly understood. Caenorhabditiselegans hemidesmosomes (CeHDs) have a similar structure and composition to the...

journal_title：Journal of cell science

authors： Fu R,Zhu Y,Jiang X,Li Y,Zhu M,Dong M,Huang Z,Wang C,Labouesse M,Zhang H

更新日期：2018-06-11 00:00:00

abstract：:Sox7, Sox17 and Sox18 constitute group F of the Sox family of HMG box transcription factor genes. Dominant-negative mutations in Sox18 underlie the cardiovascular defects observed in ragged mutant mice. By contrast, Sox18(-/-) mice are viable and fertile, and display no appreciable anomaly in their vasculature, sugges...

journal_title：Journal of cell science

authors： Matsui T,Kanai-Azuma M,Hara K,Matoba S,Hiramatsu R,Kawakami H,Kurohmaru M,Koopman P,Kanai Y

更新日期：2006-09-01 00:00:00

abstract：:The invasiveness of cells is correlated with the presence of dynamic actin-rich membrane structures called invadopodia, which are membrane protrusions that are associated with localized polymerization of sub-membrane actin filaments. Similar to focal adhesions and podosomes, invadopodia are cell-matrix adhesion sites....

journal_title：Journal of cell science

authors： Albiges-Rizo C,Destaing O,Fourcade B,Planus E,Block MR

更新日期：2009-09-01 00:00:00

abstract：:The adaptor protein Miranda plays a pivotal role in the asymmetric cell division of neuroblasts by asymmetrically segregating key differentiation factors. Miranda localization requires Myosin VI and Myosin II. The apical-then-basal localization pattern of Miranda detected in fixed tissue, and the localization defects ...

journal_title：Journal of cell science

authors： Erben V,Waldhuber M,Langer D,Fetka I,Jansen RP,Petritsch C

更新日期：2008-05-01 00:00:00

abstract：:The Sar1 GTPase controls coat assembly on coat protein complex II (COPII)-coated vesicles, which mediate protein transport from the endoplasmic reticulum (ER) to the Golgi. The GTP-bound form of Sar1, activated by the ER-localized guanine nucleotide exchange factor (GEF) Sec12, associates with the ER membrane. GTP hyd...

journal_title：Journal of cell science

authors： Kurokawa K,Suda Y,Nakano A

更新日期：2016-09-01 00:00:00

abstract：:The 43 kDa inositol polyphosphate 5-phosphatase (5-phosphatase) hydrolyses the signalling molecules inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4, 5)P(4)) in a signal-terminating reaction. We have utilised cell lines that stably underexpress the 43 kDa 5-phosphatase, a...

journal_title：Journal of cell science

authors： Speed CJ,Mitchell CA

更新日期：2000-07-01 00:00:00

abstract：:Pharmacological inhibitors of JNK (SP600125) and p38 (PD169316) sensitize tumor cells to Fas-mediated apoptosis. PD169316 is less potent than SP600125 and diminishes its effect when present together. Because the p38 isoforms that promote (p38alpha) or inhibit (p38beta) apoptosis are both suppressed by PD169316, we inv...

journal_title：Journal of cell science

authors： Tourian L Jr,Zhao H,Srikant CB

更新日期：2004-12-15 00:00:00

abstract：:Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport ...

journal_title：Journal of cell science

authors： Mackeh R,Perdiz D,Lorin S,Codogno P,Poüs C

更新日期：2013-03-01 00:00:00

abstract：:Pregnancy-associated plasma protein A2 (PAPP-A2, also known as pappalysin-2) is a large metalloproteinase that is known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in the chordamesoderm, notochord and lower jaw of zebrafish (Danio reri...

journal_title：Journal of cell science

authors： Kjaer-Sorensen K,Engholm DH,Jepsen MR,Morch MG,Weyer K,Hefting LL,Skov LL,Laursen LS,Oxvig C

更新日期：2014-12-01 00:00:00

abstract：:The tissue concentration of an endogenous beta-galactoside-specific lectin is developmentally regulated in rabbit tissues during foetal and neonatal development. Immunoassay data and localization studies both indicate that the lectin is particularly associated with late embryonic and early postnatal development. No le...

journal_title：Journal of cell science

authors： Catt JW,Harrison FL,Carleton JS

更新日期：1987-06-01 00:00:00

abstract：:To evaluate the relative mobilities of cell surface glycoconjugates during myogenesis we have studied the redistribution of fluorescein-conjugated plant lectins on L6 rat myogenic cells. Previous experiments had demonstrated that the receptors for the lectins soybean agglutinin (SBA), wheat germ agglutinin, concanaval...

journal_title：Journal of cell science

authors： Sawyer JT,Akeson RA

更新日期：1986-07-01 00:00:00

abstract：:A comparison of stained cytosolic proteins, in vivo 80 S ribosome translation products and in vitro translation products of poly(A)+ RNA from three species of Acetabularia was performed after characterization of their molecular weights and isoelectric points via two-dimensional electrophoresis. A total of 803 stained ...

journal_title：Journal of cell science

authors： Shoeman RL,Neuhaus G,Schweiger HG

更新日期：1983-03-01 00:00:00

abstract：:The Dlg tumour suppressor protein is intimately involved in the control of cell contact and polarity. Previous studies have shown that hDlg is a target for a number of viral transforming proteins. In particular, the high risk human papillomavirus (HPV) E6 proteins target hDlg for proteasome-mediated degradation, an ac...

journal_title：Journal of cell science

authors： Mantovani F,Massimi P,Banks L

更新日期：2001-12-01 00:00:00

abstract：:Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-kappaB signaling. We have previously shown th...

journal_title：Journal of cell science

authors： Cowell CF,Döppler H,Yan IK,Hausser A,Umezawa Y,Storz P

更新日期：2009-04-01 00:00:00

abstract：:We investigated the link between cell movement and plasma membrane recycling using a fast-acting, temperature-sensitive mutant of the Dictyostelium SecA exocytic protein. Strikingly, most mutant cells become almost paralysed within minutes at the restrictive temperature. However, they can still sense cyclic-AMP (cAMP)...

journal_title：Journal of cell science

authors： Zanchi R,Howard G,Bretscher MS,Kay RR

更新日期：2010-10-01 00:00:00

abstract：:The novel concept of a centrosomal anchoring complex, which is distinct from the gamma-tubulin nucleating complex, has previously been proposed following studies on cochlear epithelial cells. In this investigation we present evidence from two different cell systems which suggests that the centrosomal protein ninein is...

journal_title：Journal of cell science

authors： Mogensen MM,Malik A,Piel M,Bouckson-Castaing V,Bornens M

更新日期：2000-09-01 00:00:00

abstract：:Crumbs (Crb) is an evolutionarily conserved transmembrane protein localised to the apical membrane of epithelial cells. Loss or mislocalisation of Crb is often associated with disruption of apicobasal cell polarity. crb mRNA is also apically enriched in epithelial cells, and, as shown here, accumulates in the oocyte o...

journal_title：Journal of cell science

authors： Bhagavatula S,Knust E

更新日期：2021-01-25 00:00:00

abstract：:We report the first RNAi-induced phenotypes in mammalian cultured cells using RNA interference mediated by duplexes of 21-nt RNAs. The 21 gene products studied have different functions and subcellular localizations. Knockdown experiments monitored by immunofluorescence and immunoblotting show that even major cellular ...

journal_title：Journal of cell science

authors： Harborth J,Elbashir SM,Bechert K,Tuschl T,Weber K

更新日期：2001-12-01 00:00:00

abstract：:Errors during the first meiotic division are common in our species, but virtually all occur during female meiosis. The reason why oogenesis is more error prone than spermatogenesis remains unknown. Normal segregation of homologous chromosomes at the first meiotic division (MI) requires coordinated behavior of the sist...

journal_title：Journal of cell science

authors： Hodges CA,LeMaire-Adkins R,Hunt PA

更新日期：2001-07-01 00:00:00

abstract：:Onconase is an RNase with a very specific property because it is selectively toxic to transformed cells. This toxin is thought to recognize cell surface receptors, and the protection conferred by metabolic poisons against Onconase toxicity indicated that this RNase relies on endocytic uptake to kill cells. Nevertheles...

journal_title：Journal of cell science

authors： Rodríguez M,Torrent G,Bosch M,Rayne F,Dubremetz JF,Ribó M,Benito A,Vilanova M,Beaumelle B

更新日期：2007-04-15 00:00:00

abstract：:Friedreich's ataxia is a recessive neurodegenerative disease due to insufficient expression of the mitochondrial protein frataxin. Although it has been shown that frataxin is involved in the control of intracellular iron metabolism, by interfering with the mitochondrial biosynthesis of proteins with iron/sulphur (Fe/S...

journal_title：Journal of cell science

authors： Acquaviva F,De Biase I,Nezi L,Ruggiero G,Tatangelo F,Pisano C,Monticelli A,Garbi C,Acquaviva AM,Cocozza S

更新日期：2005-09-01 00:00:00

abstract：:Electron-microscope autoradiography has been used to obtain information on the localization of DNA labelled with [3H]thymidine in chloroplasts known to be replicating and concomitantly synthesizing and segregating DNA, in cultured leaf disks. The studies were made using both Microdol-X developer and a 'compact' develo...

journal_title：Journal of cell science

authors： Rose RJ,Possingham JV

更新日期：1976-03-01 00:00:00