Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length.

abstract：:Directed axonal growth depends on correct coordination of the actin and microtubule cytoskeleton in the growth cone. However, despite the relatively large number of proteins implicated in actin-microtubule crosstalk, the mechanisms whereby actin polymerization is coupled to microtubule stabilization and advancement in...

journal_title：Journal of cell science

authors： Szikora S,Földi I,Tóth K,Migh E,Vig A,Bugyi B,Maléth J,Hegyi P,Kaltenecker P,Sanchez-Soriano N,Mihály J

更新日期：2017-08-01 00:00:00

abstract：:We have investigated the effect of nitric oxide (NO) on apoptosis in Swiss 3T3 fibroblasts and compared it to the effect of the nitrosonium cation (NO+). Both species induced apoptosis, confirmed by electron microscopy, propidium iodide staining, DNA laddering and activation of caspases. The kinetics of triggering apo...

journal_title：Journal of cell science

authors： Khan S,Kayahara M,Joashi U,Mazarakis ND,Sarraf C,Edwards AD,Hughes MN,Mehmet H

更新日期：1997-09-01 00:00:00

abstract：:Nodal signaling induces the formation of the endoderm and mesoderm during gastrulation. Nodal expression persists until the definitive endoderm progenitor has completely formed, and disappears thereafter. A tightly regulated Nodal expression system is essential for the differentiation of embryonic stem (ES) cells into...

journal_title：Journal of cell science

authors： Takenaga M,Fukumoto M,Hori Y

更新日期：2007-06-15 00:00:00

abstract：:Sorting nexins are a large family of phox-homology-domain-containing proteins that have been implicated in the control of endosomal sorting. Sorting nexin-1 is a component of the mammalian retromer complex that regulates retrieval of the cation-independent mannose 6-phosphate receptor from endosomes to the trans-Golgi...

journal_title：Journal of cell science

authors： Carlton JG,Bujny MV,Peter BJ,Oorschot VM,Rutherford A,Arkell RS,Klumperman J,McMahon HT,Cullen PJ

更新日期：2005-10-01 00:00:00

abstract：:The tumor suppressor p53 is activated in response to many forms of cellular stress leading to cell cycle arrest, senescence or apoptosis. Appropriate sub-cellular localization is essential for modulating p53 function. We recently showed that p53 localizes to the nucleolus after proteasome inhibition with MG132 and thi...

journal_title：Journal of cell science

authors： Karni-Schmidt O,Zupnick A,Castillo M,Ahmed A,Matos T,Bouvet P,Cordon-Cardo C,Prives C

更新日期：2008-12-15 00:00:00

abstract：:The elliptical, anucleate erythrocytes of camels have been examined for the presence of marginal bands and their constituent microtubules. Lysis of erythrocytes under microtubule-stabilizing conditions readily revealed marginal bands in at least 3 % of the cells, as observed by phase-contrast and darkfield light micro...

journal_title：Journal of cell science

authors： Cohen WD,Terwilliger NB

更新日期：1979-04-01 00:00:00

abstract：:Nature Reviews Molecular Cell Biology Nature Publishing Group (2000). ISSN 1471-0072. Monthly First there was Annual Reviews, then came the monthly Elsevier Trends Journals, both of which try to identify hot topics in their chosen fields. The Current Opinion journals followed several years later, and Current Opinion i...

journal_title：Journal of cell science

authors： Hunt T

更新日期：2000-01-01 00:00:00

abstract：:Several lines of evidence indicate that increases in nuclear Ca(2+) have specific biological effects that differ from those of cytosolic Ca(2+), suggesting that they occur independently. The mechanisms involved in controlling nuclear Ca(2+) signaling are both controversial and still poorly understood. Using hypotonic ...

journal_title：Journal of cell science

authors： Cárdenas C,Liberona JL,Molgó J,Colasante C,Mignery GA,Jaimovich E

更新日期：2005-07-15 00:00:00

abstract：:Cell surface glycans are believed to play a role in tumour invasion and metastasis. Yet, we have previously shown that the inhibitors of N-linked glycan processing swainsonine (SW) and 1-deoxynojirimycin (dNM) did not prevent invasion of chick heart fragments by MO4 murine fibrosarcoma cells in organ culture. We now p...

journal_title：Journal of cell science

authors： Bruyneel EA,De Mets M,Dragonetti CH,Hooghe RJ,Di Virgilio S,Mareel MM

更新日期：1990-02-01 00:00:00

abstract：:Serotonin receptors 5-HT(1A) and 5-HT(7) are highly coexpressed in brain regions implicated in depression. However, their functional interaction has not been established. In the present study we show that 5-HT(1A) and 5-HT(7) receptors form heterodimers both in vitro and in vivo. Foerster resonance energy transfer-bas...

journal_title：Journal of cell science

authors： Renner U,Zeug A,Woehler A,Niebert M,Dityatev A,Dityateva G,Gorinski N,Guseva D,Abdel-Galil D,Fröhlich M,Döring F,Wischmeyer E,Richter DW,Neher E,Ponimaskin EG

更新日期：2012-05-15 00:00:00

abstract：:Vertebrate tropomyosins (TMs) are expressed from four genes, and at least 18 distinct isoforms are generated via a complex pattern of alternative RNA splicing and alternative promoters. The functional significance of this isoform diversity is largely unknown and it remains to be determined whether specific isoforms ar...

journal_title：Journal of cell science

authors： Helfman DM,Berthier C,Grossman J,Leu M,Ehler E,Perriard E,Perriard JC

更新日期：1999-02-01 00:00:00

abstract：:5'AMP nucleotidase activity was localized by electron microscopy in Dictyostelium discoideum during cell differentiation. In addition, the activity was assayed by micro enzymic methods in sections dissected from specific cellular regions of lyophilized individuals. The results of the 2 procedures were in agreement, de...

journal_title：Journal of cell science

authors： Armant DR,Stetler DA,Rutherford CL

更新日期：1980-10-01 00:00:00

abstract：:In sciarid flies (Diptera, Sciaridae), one or two paternally derived X chromosomes are discarded from the soma at early cleavages to determine the sex of the embryo (XX, females; X0, males). X chromosome(s) elimination is achieved by an abnormal anaphase segregation so that X sister chromatids do not reach the poles a...

journal_title：Journal of cell science

authors： Escribá MC,Goday C

更新日期：2013-07-15 00:00:00

abstract：:The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a sustained increase in lysosomal pH (pHly), and transient increases in cytosolic pH (pHcyt) and Ca...

journal_title：Journal of cell science

authors： Atakpa P,van Marrewijk LM,Apta-Smith M,Chakraborty S,Taylor CW

更新日期：2019-02-01 00:00:00

abstract：:The synaptonemal complex is an elaborate meiosis-specific supramolecular protein assembly that promotes chromosome synapsis and meiotic recombination. We inactivated the meiosis-specific gene Tex12 and found that TEX12 is essential for progression of meiosis in both male and female germ cells. Structural analysis of t...

journal_title：Journal of cell science

authors： Hamer G,Wang H,Bolcun-Filas E,Cooke HJ,Benavente R,Höög C

更新日期：2008-08-01 00:00:00

abstract：:MACF (microtubule actin cross-linking factor) is a large, 608-kDa protein that can associate with both actin microfilaments and microtubules (MTs). Structurally, MACF can be divided into 3 domains: an N-terminal domain that contains both a calponin type actin-binding domain and a plakin domain; a rod domain that is co...

journal_title：Journal of cell science

authors： Sun D,Leung CL,Liem RK

更新日期：2001-01-01 00:00:00

abstract：:In situ hybridization has become a powerful technique for dissecting nuclear structure. By localizing nucleic acids with high precision, it is possible to infer the native structure of chromosomes, replication factories and transcript processing complexes. To increase the value of this technique, we have established t...

journal_title：Journal of cell science

authors： Gunawardena S,Heddle E,Rykowski MC

更新日期：1995-05-01 00:00:00

abstract：:Bone morphogenetic protein (BMP)-6 is a member of the transforming growth factor (TGF)-(&bgr;) superfamily, and is most similar to BMP-5, osteogenic protein (OP)-1/BMP-7, and OP-2/BMP-8. In the present study, we characterized the endogenous BMP-6 signaling pathway during osteoblast differentiation. BMP-6 strongly indu...

journal_title：Journal of cell science

authors： Ebisawa T,Tada K,Kitajima I,Tojo K,Sampath TK,Kawabata M,Miyazono K,Imamura T

更新日期：1999-10-01 00:00:00

abstract：:Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As the major force-bearing adhesion-receptor protein, integrins have a central role in how cells sense and respond to the mechanics of their surroundings. Recent studies have shown that a key aspect of mechanotransduction is the...

journal_title：Journal of cell science

authors： Puklin-Faucher E,Sheetz MP

更新日期：2009-01-15 00:00:00

abstract：:To understand the molecular mechanisms underlying sorting of apical and basolateral membrane components in human intestinal epithelial cells, we have cloned the human homolog of rat syntaxin 3 and looked for its subcellular localization. Endogenous human syntaxin 3 was found to be localized at the apical membrane of c...

journal_title：Journal of cell science

authors： Delgrossi MH,Breuza L,Mirre C,Chavrier P,Le Bivic A

更新日期：1997-09-01 00:00:00

abstract：:Activation of the yeast cell wall integrity (CWI) pathway induces an adaptive transcriptional programme that is largely dependent on the transcription factor Rlm1 and the mitogen-activated protein kinase (MAPK) Slt2. Upon cell wall stress, the transcription factor Rlm1 is recruited to the promoters of RLM1 and SLT2, a...

journal_title：Journal of cell science

authors： García R,Sanz AB,Rodríguez-Peña JM,Nombela C,Arroyo J

更新日期：2016-04-15 00:00:00

abstract：:Previous reports have suggested that Cx26 exhibits unique intracellular transport pathways en route to the cell surface compared with other members of the connexin family. To directly examine and compare nascent and steady-state delivery of Cx43 and Cx26 to the plasma membrane and gap junction biogenesis we expressed ...

journal_title：Journal of cell science

authors： Thomas T,Jordan K,Simek J,Shao Q,Jedeszko C,Walton P,Laird DW

更新日期：2005-10-01 00:00:00

abstract：:Developing oral organelles of dividing Tetrahymena corlissi appear to be positioned by mechanisms which assess distances as a proportion of the organism's overall dimensions. In some respects, the cortex of this protozoan obeys the 'French flag' rule formulated by Wolpert for describing regulation of spatial proportio...

journal_title：Journal of cell science

authors： Lynn DH,Tucker JB

更新日期：1976-06-01 00:00:00

abstract：:To enhance our understanding of the function(s) of gamma-tubulin-complex proteins (GCPs), we identified and analyzed the functions of the Aspergillus nidulans homologs of GCP2-GCP6 (here designated GCPB-GCBF). The gamma-tubulin small complex (gamma-TuSC) components, gamma-tubulin, GCPB and GCPC, are essential for viab...

journal_title：Journal of cell science

authors： Xiong Y,Oakley BR

更新日期：2009-11-15 00:00:00

abstract：:Neutrophil extracellular traps (NETs) are one of the most intriguing discoveries in immunological research of the past few years. After their first description in 2004, the number of research articles on how NETs affect immunodefense, and also how they contribute to an ever-growing number of diseases, has skyrocketed....

journal_title：Journal of cell science

authors： Neubert E,Meyer D,Kruss S,Erpenbeck L

更新日期：2020-03-10 00:00:00

abstract：:Two variants (74AD and 74FL) established from rat ascites hepatoma AH7974 were examined for the production of glycosaminoglycans in culture. There was no difference between the adhesive (74AD) and the floating (74FL) variants in quantity of glycosaminoglycans produced by their cultivation in minimum essential medium s...

journal_title：Journal of cell science

authors： Kimura A,Kawaguchi T,Ono T,Sakuma A,Yokoya Y,Kochi H,Nakamura K

更新日期：1988-08-01 00:00:00

abstract：:Plastids in plants and algae evolved from the endosymbiotic integration of a cyanobacterium by a heterotrophic eukaryote. New plastids can only emerge through fission; thus, the synchronization of bacterial division with the cell cycle of the eukaryotic host was vital to the origin of phototrophic eukaryotes. Most of ...

journal_title：Journal of cell science

authors： de Vries J,Gould SB

更新日期：2018-01-29 00:00:00

abstract：:Schistosomula of Schistosoma mansoni bind human low density lipoproteins (LDL) in a concentration-dependent and saturable manner. The bound LDL could provide phospholipids and sterol to the worm, which cannot synthesize sterol de novo and lacks acyl chain-modifying capability. Here we have used three phospholipid anal...

journal_title：Journal of cell science

authors： Caulfield JP,Chiang CP,Yacono PW,Smith LA,Golan DE

更新日期：1991-05-01 00:00:00

abstract：:Increases in RNA, protein and cell size were determined cytophotometrically during the cell division cycle of Tetrahymena. For these parameters different patterns were found. RNA accumulates slowly during G1 period and faster during macronuclear S. This agrees with the changing uridine incorporation rate which is at l...

journal_title：Journal of cell science

authors： Cleffmann G,Reuter WO,Seyfert HM

更新日期：1979-06-01 00:00:00

abstract：:We have identified and characterized two proteins in rat brain that bind to the neuron-specific tropomyosin isoform, TMBr3. The two proteins were identified by blot overlay assay, in which the proteins immobilized on the membrane were probed by epitope-tagged TMBr3, followed by detection with anti-epitope antibody. We...

journal_title：Journal of cell science

authors： Watakabe A,Kobayashi R,Helfman DM

更新日期：1996-09-01 00:00:00