Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI.

abstract：:The HB2 cell line, developed from luminal epithelial cells cultured from milk, forms ball-like structures in collagen gels which show a uniform branching response to hepatocyte growth factor. The alpha2beta1 integrin is the major integrin expressed by luminal epithelial cells, and the role of this integrin in mammary ...

journal_title：Journal of cell science

authors： Alford D,Baeckström D,Geyp M,Pitha P,Taylor-Papadimitriou J

更新日期：1998-02-01 00:00:00

abstract：:Mitotic spindle assembly in animal cells is orchestrated by a chromosome-dependent pathway that directs microtubule stabilization. RanGTP generated at chromosomes releases spindle assembly factors from inhibitory complexes with importins, the nuclear transport factors that facilitate protein import into the nucleus du...

journal_title：Journal of cell science

authors： Wu Z,Jiang Q,Clarke PR,Zhang C

更新日期：2013-08-01 00:00:00

abstract：:Expression of the vitronectin gene was detected in advanced human astrocytoma by in situ hybridization, whereas vitronectin mRNA was undetectable in low grade tumors or in normal adult brain, indicating that vitronectin is a marker of malignant astrocytoma. We established a model of human astrocytoma by transplanting ...

journal_title：Journal of cell science

authors： Gladson CL,Wilcox JN,Sanders L,Gillespie GY,Cheresh DA

更新日期：1995-03-01 00:00:00

abstract：:During growth, homeostasis and regeneration, stem cells are exposed to different energy demands. Here, we characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state. We show that quiescent satellite stem...

journal_title：Journal of cell science

authors： Pala F,Di Girolamo D,Mella S,Yennek S,Chatre L,Ricchetti M,Tajbakhsh S

更新日期：2018-07-27 00:00:00

abstract：:Double minutes (DMs) seen in a substantial fraction of human tumors are the cytogenetic manifestation of gene amplification which renders the tumor cells advantageous for growth and survival. DMs are acentric and atelomeric chromatin composed of circular DNA. In this study, we found they showed a remarkable relocation...

journal_title：Journal of cell science

authors： Itoh N,Shimizu N

更新日期：1998-11-01 00:00:00

abstract：:Although the kinase CHK1 is a key player in the DNA damage response (DDR), several studies have recently provided evidence of DDR-independent roles of CHK1, in particular following phosphorylation of its S280 residue. Here, we demonstrate that CHK1 S280 phosphorylation is cell cycle-dependent and peaks during mitosis....

journal_title：Journal of cell science

authors： Adam K,Cartel M,Lambert M,David L,Yuan L,Besson A,Mayeux P,Manenti S,Didier C

更新日期：2018-08-10 00:00:00

abstract：:Mammalian homologs of the Drosophila TRP protein have been shown to form cation-permeable channels in the plasma membrane but very little is known about the mechanisms that control their cell surface localization. Recently it has been demonstrated that the last three C-terminal amino acids (TRL) of TRPC4 comprise a PD...

journal_title：Journal of cell science

authors： Mery L,Strauss B,Dufour JF,Krause KH,Hoth M

更新日期：2002-09-01 00:00:00

abstract：:Coiled bodies are a special type of small round nuclear body, composed of coiled fibers and granules, especially prominent in the nucleoplasm of highly active cells (Brasch and Ochs (1992) Exp. Cell Res. 202, 211-223). Although no specific function has been assigned to coiled bodies, they contain spliceosome snRNAs an...

journal_title：Journal of cell science

authors： Ochs RL,Stein TW Jr,Tan EM

更新日期：1994-02-01 00:00:00

abstract：:Neural stem cells (NSCs) typically show efficient self-renewal and selective differentiation. Their invasion potential, however, is not well studied. In this study, Sox2-positive NSCs from the E14.5 rat cortex were found to be non-invasive and showed only limited migration in vitro. By contrast, FGF2-expanded NSCs sho...

journal_title：Journal of cell science

authors： Sailer MH,Gerber A,Tostado C,Hutter G,Cordier D,Mariani L,Ritz MF

更新日期：2013-08-15 00:00:00

abstract：:Fibrin deposits in tumor beds are an intriguing phenomenon. It has been suggested that fibrin plays a role as a provisional matrix in which the tumor grows and induces development of a vascular network. On the other hand fibrin possibly protects the tumor nodule from host defense mechanisms. We therefore investigate w...

journal_title：Journal of cell science

authors： Lichtenbeld HH,Muller AD,van Dam-Mieras MC,Blijham GH

更新日期：1993-10-01 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson’s disease, but the precise physiological function of the protein remains ill-defined. Recently, our group proposed a model in which LRRK2 kinase activity is part of an EndoA phosphorylation cycle that facilitates efficient vesicle formatio...

journal_title：Journal of cell science

authors： Arranz AM,Delbroek L,Van Kolen K,Guimarães MR,Mandemakers W,Daneels G,Matta S,Calafate S,Shaban H,Baatsen P,De Bock PJ,Gevaert K,Vanden Berghe P,Verstreken P,De Strooper B,Moechars D

更新日期：2015-02-01 00:00:00

abstract：:Intracellular pools of the heterotrimeric G-protein α-subunit Gαi3 (encoded by GNAI3) have been shown to promote growth factor signaling, while at the same time inhibiting the activation of JNK and autophagic signaling following nutrient starvation. The precise molecular mechanisms linking Gαi3 to both stress and grow...

journal_title：Journal of cell science

authors： Bastin G,Dissanayake K,Langburt D,Tam ALC,Lee SH,Lachhar K,Heximer SP

更新日期：2020-06-24 00:00:00

abstract：:Several lines of evidence indicate that increases in nuclear Ca(2+) have specific biological effects that differ from those of cytosolic Ca(2+), suggesting that they occur independently. The mechanisms involved in controlling nuclear Ca(2+) signaling are both controversial and still poorly understood. Using hypotonic ...

journal_title：Journal of cell science

authors： Cárdenas C,Liberona JL,Molgó J,Colasante C,Mignery GA,Jaimovich E

更新日期：2005-07-15 00:00:00

abstract：:Motile cilia generate directed hydrodynamic flow that is important for the motility of cells and extracellular fluids. To optimize directed hydrodynamic flow, motile cilia are organized and oriented into a polarized array. Basal bodies (BBs) nucleate and position motile cilia at the cell cortex. Cytoplasmic BB-associa...

journal_title：Journal of cell science

authors： Junker AD,Soh AWJ,O'Toole ET,Meehl JB,Guha M,Winey M,Honts JE,Gaertig J,Pearson CG

更新日期：2019-08-07 00:00:00

abstract：:Centriolar satellites are membrane-less structures that localize and move around the centrosome and cilium complex in a microtubule-dependent manner. They play important roles in centrosome- and cilium-related processes, including protein trafficking to the centrosome and cilium complex, and ciliogenesis, and they are...

journal_title：Journal of cell science

authors： Conkar D,Culfa E,Odabasi E,Rauniyar N,Yates JR 3rd,Firat-Karalar EN

更新日期：2017-04-15 00:00:00

abstract：:Endothelial cell-based angiogenesis requires activation of survival signals that generate resistance to external apoptotic stimuli, such as tumor necrosis factor-alpha (TNF-alpha), during pathobiologic settings. Mechanisms by which this is achieved are not fully defined. Here, we use a model in which the multifunction...

journal_title：Journal of cell science

authors： Kang-Decker N,Cao S,Chatterjee S,Yao J,Egan LJ,Semela D,Mukhopadhyay D,Shah V

更新日期：2007-02-01 00:00:00

abstract：:Actin filaments assemble into diverse protrusive and contractile structures to provide force for a number of vital cellular processes. Stress fibers are contractile actomyosin bundles found in many cultured non-muscle cells, where they have a central role in cell adhesion and morphogenesis. Focal-adhesion-anchored str...

journal_title：Journal of cell science

authors： Tojkander S,Gateva G,Lappalainen P

更新日期：2012-04-15 00:00:00

abstract：:The cell wall of 24-h zygotes of Fucus serratus is composed of 3 layers--an inner fibrillar layer (sulphated fucan), an outer fibrillar layer (alginic aicd/cellulose) and an exterior amorphous layer (sulphated fucan, alginic acid). The 2 layers containing sulphated fucan are preferentially thickened at the rhizoid pol...

journal_title：Journal of cell science

authors： Callow ME,Coughlan SJ,Evans LV

更新日期：1978-08-01 00:00:00

abstract：:The conformation and biological activities of fibronectin (FN) and vitronectin (VN) coated on different plastic surfaces were investigated using cell adhesion and a panel of domain-specific monoclonal antibodies (mAbs). The adhesion of BHK fibroblasts was markedly better on FN coated on hydrophilic tissue culture poly...

journal_title：Journal of cell science

authors： Underwood PA,Steele JG,Dalton BA

更新日期：1993-03-01 00:00:00

abstract：:Sperm fertilization reactions of Limulus polyphemus were examined by scanning electron and/or light microscopy. The following were considered: sperm motility, attachment of sperm to egg, acrosome reaction, and penetration of the acrosomal filament. The spermatozoa after semination are non-motile and become active only...

journal_title：Journal of cell science

authors： Brown GG

更新日期：1976-12-01 00:00:00

abstract：:BCL6 is a potent transcriptional repressor that plays important roles in germinal center formation, T helper cell differentiation and lymphomagenesis and regulates expression of several chemokine genes in macrophages. In a further investigation of its role in macrophages, we show that BCL6 inactivation in primary bone...

journal_title：Journal of cell science

authors： Pixley FJ,Xiong Y,Yu RY,Sahai EA,Stanley ER,Ye BH

更新日期：2005-05-01 00:00:00

abstract：:TGFβ binding to the TGFβ receptor (TβR) activates R-Smad-dependent pathways, such as Smad2/3, and R-Smad-independent pathways, such as ERK1/2. The mechanism of the TGFβ-TβRII-TβRI-Smad2/3 pathway is established; however, it is not known how TGFβ activates ERK1/2. We show here that although TGFβ equally activated Smad2...

journal_title：Journal of cell science

authors： Bandyopadhyay B,Han A,Dai J,Fan J,Li Y,Chen M,Woodley DT,Li W

更新日期：2011-01-01 00:00:00

abstract：:In sciarid flies (Diptera, Sciaridae), one or two paternally derived X chromosomes are discarded from the soma at early cleavages to determine the sex of the embryo (XX, females; X0, males). X chromosome(s) elimination is achieved by an abnormal anaphase segregation so that X sister chromatids do not reach the poles a...

journal_title：Journal of cell science

authors： Escribá MC,Goday C

更新日期：2013-07-15 00:00:00

abstract：:The process of regulated exocytosis is defined by the Ca2+-triggered fusion of two apposed membranes, enabling the release of vesicular contents. This fusion step involves a number of energetically complex steps and requires both protein and lipid membrane components. The role of cholesterol has been investigated usin...

journal_title：Journal of cell science

authors： Churchward MA,Rogasevskaia T,Höfgen J,Bau J,Coorssen JR

更新日期：2005-10-15 00:00:00

abstract：:Although loss of cell-cell adhesion and gain of invasive properties play a crucial role in the malignant progression of epithelial tumours, the molecular signals that trigger these processes have not been fully elucidated. In light of the well-established relationship between chronic inflammation and cancer, we hypoth...

journal_title：Journal of cell science

authors： Montesano R,Soulié P,Eble JA,Carrozzino F

更新日期：2005-08-01 00:00:00

abstract：:Studies of human cell hybrids have provided evidence that the tumorigenicity of a cervical carcinoma (HeLa) is under the control of a putative tumor suppressor on chromosome 11. Using these human cell hybrids, we found a tumor-associated glycosylation change in the glucose transporter GLUT1, which is an N-linked glyco...

journal_title：Journal of cell science

authors： Kitagawa T,Tsuruhara Y,Hayashi M,Endo T,Stanbridge EJ

更新日期：1995-12-01 00:00:00

abstract：:Although telomere formation occurs through a different mechanism in Drosophila compared with other organisms, telomere associations result from mutations in homologous genes, indicating the involvement of similar pathways in chromosome end protection. We report here that mutations of the Drosophila melanogaster gene C...

journal_title：Journal of cell science

authors： Komonyi O,Schauer T,Papai G,Deak P,Boros IM

更新日期：2009-03-15 00:00:00

abstract：:The spindle checkpoint detects errors in kinetochore attachment to microtubules and delays anaphase if attachment is improper. The checkpoint is activated by attachment-sensitive components including Mad2 and certain phosphorylated proteins detected by the 3F3/2 antibody. We have studied Mad2 and 3F3/2 immunofluoresce...

journal_title：Journal of cell science

authors： Nicklas RB,Waters JC,Salmon ED,Ward SC

更新日期：2001-12-01 00:00:00

abstract：:Hybrid cell lines between normal rat embryo fibroblasts and TA3B mouse tumour cells, or between TA3B and BI hamster sarcoma cells, have been examined for the expression of the cell surface large external-transformation-sensitive (LETS) protein and the organization of microfilament bundles. LETS protein was detected by...

journal_title：Journal of cell science

authors： Marshall CJ,Humphryes KC,Pollack RE

更新日期：1978-10-01 00:00:00

abstract：:The path that RNA takes through nuclear pores was mapped using two high-resolution techniques. Unexpectedly, no RNA in HL60 cells was detected by immunogold labelling in the central axis of the pore complex on its way to the transporter at the nuclear membrane; instead, it was distributed around the sides, apparently ...

journal_title：Journal of cell science

authors： Iborra FJ,Jackson DA,Cook PR

更新日期：2000-01-01 00:00:00