Non-invasive neural stem cells become invasive in vitro by combined FGF2 and BMP4 signaling.

abstract：:Ca(2+) signaling mediated by phospholipase C that produces inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] and diacylglycerol (DAG) controls lymphocyte activation. In contrast to store-operated Ca(2+) entry activated by Ins(1,4,5)P(3)-induced Ca(2+) release from endoplasmic reticulum, the importance of DAG-activated Ca(...

journal_title：Journal of cell science

authors： Numaga T,Nishida M,Kiyonaka S,Kato K,Katano M,Mori E,Kurosaki T,Inoue R,Hikida M,Putney JW Jr,Mori Y

更新日期：2010-03-15 00:00:00

abstract：:Inositol-(1,4,5)-triphosphate receptors (InsP(3)Rs) are ligand-gated Ca(2+) channels that control Ca(2+) release from intracellular stores and play a central role in a wide range of cellular responses. In most epithelial cells, InsP(3)Rs are not uniformly distributed within the endoplasmic reticulum (ER) membrane, wit...

journal_title：Journal of cell science

authors： Dingli F,Parys JB,Loew D,Saule S,Mery L

更新日期：2012-11-15 00:00:00

abstract：:After DNA replication, cells condense their chromosomes in order to segregate them during mitosis. The condensation process as well as subsequent segregation requires phosphorylation of histone H3 at serine 10. Histone H3 phosphorylation initiates during G2 in pericentric foci prior to H3 phosphorylation in the chromo...

journal_title：Journal of cell science

authors： Zeitlin SG,Barber CM,Allis CD,Sullivan KF

更新日期：2001-02-01 00:00:00

abstract：:The structure of a late endosomal compartment, which contains the bulk of the cation-independent mannose 6-phosphate receptor (MPR) in NRK cells, is documented using immunocytochemistry and cryo-sections, as well as conventional Epon sections. This compartment, which we refer to as the prelysosomal compartment (PLC), ...

journal_title：Journal of cell science

authors： Griffiths G,Matteoni R,Back R,Hoflack B

更新日期：1990-03-01 00:00:00

abstract：:Mammalian homologs of the Drosophila TRP protein have been shown to form cation-permeable channels in the plasma membrane but very little is known about the mechanisms that control their cell surface localization. Recently it has been demonstrated that the last three C-terminal amino acids (TRL) of TRPC4 comprise a PD...

journal_title：Journal of cell science

authors： Mery L,Strauss B,Dufour JF,Krause KH,Hoth M

更新日期：2002-09-01 00:00:00

abstract：:In trypanosomes, the flagellum is rooted in the flagellar pocket, a surface micro-domain that is the sole site for endocytosis and exocytosis. By analysis of anterograde or retrograde intraflagellar transport in IFT88RNAi or IFT140RNAi mutant cells, we show that elongation of the new flagellum is not required for flag...

journal_title：Journal of cell science

authors： Absalon S,Blisnick T,Bonhivers M,Kohl L,Cayet N,Toutirais G,Buisson J,Robinson D,Bastin P

更新日期：2008-11-15 00:00:00

abstract：:Sustained neurotransmission requires the tight coupling of synaptic vesicle (SV) exocytosis and endocytosis. The mechanisms underlying this coupling are poorly understood. We tested the hypothesis that a cGMP-dependent protein kinase (PKG), encoded by the foraging (for) gene in Drosophila melanogaster, is critical for...

journal_title：Journal of cell science

authors： Dason JS,Allen AM,Vasquez OE,Sokolowski MB

更新日期：2019-04-05 00:00:00

abstract：:Non-muscle myosin II (MyoII) contractility is central to the regulation of numerous cellular processes, including migration. Rho is a well-characterized modulator of actomyosin contractility, but the function of other GTPases, such as Rac, in regulating contractility is currently not well understood. Here, we show tha...

journal_title：Journal of cell science

authors： Jean L,Majumdar D,Shi M,Hinkle LE,Diggins NL,Ao M,Broussard JA,Evans JC,Choma DP,Webb DJ

更新日期：2013-12-15 00:00:00

abstract：:The key read-out of Wnt signalling is a change in the transcriptional profile of the cell, which is driven by β-catenin. β-catenin levels are normally kept low by a phosphorylation event that is mediated by glycogen synthase kinase 3 (GSK3, α- and β-isoforms), which targets β-catenin for ubiquitylation and proteasomal...

journal_title：Journal of cell science

authors： Metcalfe C,Bienz M

更新日期：2011-11-01 00:00:00

abstract：:Regulation of cell-cell contacts is essential for integrity of the vascular endothelium. Here, a critical role of the F-actin-binding protein drebrin in maintaining endothelial integrity is revealed under conditions mimicking vascular flow. Drebrin knockdown leads to weakening of cell-cell contacts, characterized by l...

journal_title：Journal of cell science

authors： Rehm K,Panzer L,van Vliet V,Genot E,Linder S

更新日期：2013-08-15 00:00:00

abstract：:Hepatocyte growth factor, also known as scatter factor, is a pleiotropic cytokine, which stimulates cell motility, invasion, proliferation, survival and morphogenesis, and induces the expression of specific genes by activating its receptor tyrosine kinase. In this work we have isolated, characterized and used as agoni...

journal_title：Journal of cell science

authors： Prat M,Crepaldi T,Pennacchietti S,Bussolino F,Comoglio PM

更新日期：1998-01-01 00:00:00

abstract：:BAG6 participates in protein quality control and, here, we address its role in endoplasmic-reticulum-associated degradation (ERAD) by using the polytopic membrane protein OpD, an opsin degron mutant. Both BAG6 knockdown and BAG6 overexpression delay OpD degradation; however, our data suggest that these two perturbatio...

journal_title：Journal of cell science

authors： Payapilly A,High S

更新日期：2014-07-01 00:00:00

abstract：:In a previous study we demonstrated that a homeobox peptide corresponding to the 60 amino acid long DNA-binding region of the Drosophila antennapedia homeo-protein was capable of crossing the plasma membrane of cells in culture. This finding has led us to investigate whether chimeric molecules encompassing the homeobo...

journal_title：Journal of cell science

authors： Perez F,Joliot A,Bloch-Gallego E,Zahraoui A,Triller A,Prochiantz A

更新日期：1992-08-01 00:00:00

abstract：:Hematopoietic and vascular endothelial cells constitute the circulatory system and are both generated from the ventral mesoderm. However, the molecules and signaling pathways involved in ventral mesoderm formation and specification remain unclear. We found that zebrafish etv5a was expressed in the ventral mesoderm dur...

journal_title：Journal of cell science

authors： Chen SY,Shih HY,Lin SJ,Hsiao CD,Li ZC,Cheng YC

更新日期：2013-12-15 00:00:00

abstract：:We have developed a procedure for sequential silver staining and in situ hybridization to analyze the relationship between the amount of rDNA present in nucleolar organizer regions, as estimated by in situ hybridization, and their level of expression, as estimated by the silver signal. For simplicity we used cells fro...

journal_title：Journal of cell science

authors： Zurita F,Jiménez R,Burgos M,de la Guardia RD

更新日期：1998-05-01 00:00:00

abstract：:CDC14 was originally identified by L. Hartwell in his famous screen for genes that regulate the budding yeast cell cycle. Subsequent work showed that Cdc14 belongs to a family of highly conserved dual-specificity phosphatases that are present in a wide range of organisms from yeast to human. Human CDC14B is even able ...

journal_title：Journal of cell science

authors： Mocciaro A,Schiebel E

更新日期：2010-09-01 00:00:00

abstract：:Tumour necrosis factor receptors (TNF-Rs) and their ligands, tumour necrosis factors, are highly conserved proteins described in all metazoan phyla. They function as inducers of extrinsic apoptotic signalling and facilitate inflammation, differentiation and cell survival. TNF-Rs use distinct adaptor molecules to activ...

journal_title：Journal of cell science

authors： Steichele M,Sauermann LS,König AC,Hauck S,Böttger A

更新日期：2021-01-25 00:00:00

abstract：:Injection of the circular plasmid FV1 (derived from type I bovine papilloma virus) into Xenopus eggs before the start of the first cell cycle dramatically increases the efficiency of plasmid replication once eggs are chemically activated. We call this the preloading effect and report kinetic and quantitative character...

journal_title：Journal of cell science

authors： Sanchez JA,Marek D,Wangh LJ

更新日期：1992-12-01 00:00:00

abstract：:Chloride intracellular channel 3 (CLIC3) drives invasiveness of pancreatic and ovarian cancer by acting in concert with Rab25 to regulate the recycling of α5β1 integrin from late endosomes to the plasma membrane. Here, we show that in two estrogen receptor (ER)-negative breast cancer cell lines, CLIC3 has little influ...

journal_title：Journal of cell science

authors： Macpherson IR,Rainero E,Mitchell LE,van den Berghe PV,Speirs C,Dozynkiewicz MA,Chaudhary S,Kalna G,Edwards J,Timpson P,Norman JC

更新日期：2014-09-15 00:00:00

abstract：:Connexin 30 (Cx30), a member of the large gap-junction protein family, plays a role in the homeostasis of the epidermis and inner ear through gap junctional intercellular communication (GJIC). Here, we investigate the underlying mechanisms of four autosomal dominant Cx30 gene mutations that are linked to hearing loss ...

journal_title：Journal of cell science

authors： Berger AC,Kelly JJ,Lajoie P,Shao Q,Laird DW

更新日期：2014-04-15 00:00:00

abstract：:We report the first direct analysis of the endogenous β-catenin phosphorylation activity in colon cancer SW480 cells. By comparing parental SW480 cells that harbor a typical truncated adenomatous polyposis coli (APC) form, cells expressing full-length APC and APC-depleted cells, we provide the formal demonstration tha...

journal_title：Journal of cell science

authors： Wang L,Liu X,Gusev E,Wang C,Fagotto F

更新日期：2014-04-15 00:00:00

abstract：:TGFβ binding to the TGFβ receptor (TβR) activates R-Smad-dependent pathways, such as Smad2/3, and R-Smad-independent pathways, such as ERK1/2. The mechanism of the TGFβ-TβRII-TβRI-Smad2/3 pathway is established; however, it is not known how TGFβ activates ERK1/2. We show here that although TGFβ equally activated Smad2...

journal_title：Journal of cell science

authors： Bandyopadhyay B,Han A,Dai J,Fan J,Li Y,Chen M,Woodley DT,Li W

更新日期：2011-01-01 00:00:00

abstract：:It is generally accepted that global translation varies during the cell cycle and is low during mitosis. However, addressing this issue is challenging because it involves cell synchronization, which evokes stress responses that, in turn, affect translation rates. Here, we have used two approaches to measure global tra...

journal_title：Journal of cell science

authors： Stonyte V,Boye E,Grallert B

更新日期：2018-09-03 00:00:00

abstract：:The redox status of human spermatozoa was found to have a profound influence on the fertilizing potential of these cells in association with qualitative and quantitative changes in the patterns of tyrosine phosphorylation. In general, oxidizing conditions enhanced tyrosine phosphorylation and stimulated sperm function...

journal_title：Journal of cell science

authors： Aitken RJ,Paterson M,Fisher H,Buckingham DW,van Duin M

更新日期：1995-05-01 00:00:00

abstract：:Mammalian cytochrome P-450s in the CYP1A gene family catalyse the oxidation of a wide range of drugs and foreign compounds resulting in their excretion. These enzymes are highly inducible by a range of compounds, including polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (3-MC) and dioxins. Analysis of th...

journal_title：Journal of cell science

authors： Campbell SJ,Carlotti F,Hall PA,Clark AJ,Wolf CR

更新日期：1996-11-01 00:00:00

abstract：:Candida albicans is a dimorphic fungus capable of growing as a budding yeast and as a filamentous hypha. We have used the technique of immunofluorescence to study the changes in the microtubule cytoskeleton during the cell cycle in both growth forms. This approach has revealed the presence of an extensive system of mi...

journal_title：Journal of cell science

authors： Barton R,Gull K

更新日期：1988-10-01 00:00:00

abstract：:BMP-dependent patterning in the Drosophila melanogaster wing imaginal disc serves as a paradigm to understand how morphogens specify cell fates. The observed profile of the transcriptional response to the graded signal of BMP relies upon two counter-active gradients of pMad and Brinker (Brk). This patterning model is ...

journal_title：Journal of cell science

authors： Ziv O,Finkelstein R,Suissa Y,Dinur T,Deshpande G,Gerlitz O

更新日期：2012-12-01 00:00:00

abstract：:gamma-Tubulin exists in fission yeast as the product of an essential gene, encoding a 446 amino acid protein that is 77.3% identical to Aspergillus nidulans gamma-tubulin. The gene disruption caused cell lethality, displaying condensed, undivided chromosomes with aberrant spindle structures. Anti-gamma-tubulin stainin...

journal_title：Journal of cell science

authors： Horio T,Uzawa S,Jung MK,Oakley BR,Tanaka K,Yanagida M

更新日期：1991-08-01 00:00:00

abstract：:The relative sensitivities of the motors for mitotic chromosome movements and saltatory motion were compared using a nonhydrolyzable analog of ATP, AMP-PNP. K+AMP-PNP was microinjected into PtKl cells at the time of nuclear envelope disassembly or at anaphase onset. To produce a dose-response curve for the effect of A...

journal_title：Journal of cell science

authors： Lee GM

更新日期：1989-11-01 00:00:00

abstract：:Cytokines, such as interferons, erythropoietin, leptin and most interleukins, signal through type 1 cytokine receptors and activate the canonical JAK-STAT pathway. Aberrant cytokine signalling underlies numerous pathologies and adequate, temporary receptor activation is therefore under tight control. Negative-feedback...

journal_title：Journal of cell science

authors： Wauman J,De Ceuninck L,Vanderroost N,Lievens S,Tavernier J

更新日期：2011-03-15 00:00:00