Differential regulation of CENP-A and histone H3 phosphorylation in G2/M.

abstract：:Microscopic green algae inhabiting desert microbiotic crusts are remarkably diverse phylogenetically, and many desert lineages have independently evolved from aquatic ancestors. Here we worked with five desert and aquatic species within the family Scenedesmaceae to examine mechanisms that underlie desiccation toleranc...

journal_title：Journal of cell science

authors： Cardon ZG,Peredo EL,Dohnalkova AC,Gershone HL,Bezanilla M

更新日期：2018-04-10 00:00:00

abstract：:BCL6 is a potent transcriptional repressor that plays important roles in germinal center formation, T helper cell differentiation and lymphomagenesis and regulates expression of several chemokine genes in macrophages. In a further investigation of its role in macrophages, we show that BCL6 inactivation in primary bone...

journal_title：Journal of cell science

authors： Pixley FJ,Xiong Y,Yu RY,Sahai EA,Stanley ER,Ye BH

更新日期：2005-05-01 00:00:00

abstract：:Expression of a dominant negative fragment of the spectrin family member Syne-1 causes an accumulation of binucleate cells, suggesting a role for this protein in cytokinesis. An association of this fragment with the C-terminal tail domain of the kinesin II subunit KIF3B was identified by yeast two-hybrid and co-precip...

journal_title：Journal of cell science

authors： Fan J,Beck KA

更新日期：2004-02-01 00:00:00

abstract：:Keratins 8 and 18 (collectively referred to as K8/K18) are the major components of intermediate filaments of simple epithelial cells. Recent studies have revealed the function of K8/K18 in apoptosis modulation. Here, we show that eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation...

journal_title：Journal of cell science

authors： Lin YM,Chen YR,Lin JR,Wang WJ,Inoko A,Inagaki M,Wu YC,Chen RH

更新日期：2008-07-15 00:00:00

abstract：:Isoamyl alcohol (IAA) induces a phenotype that resembles pseudohyphae in the budding yeast Saccharomyces cerevisiae. We show here that IAA causes the rapid formation of linear chains of anucleate buds, each of which is accompanied by the formation of a septin ring at its neck. This process requires the activity of Swe...

journal_title：Journal of cell science

authors： Martinez-Anaya C,Dickinson JR,Sudbery PE

更新日期：2003-08-15 00:00:00

abstract：:Understanding the interactions between distinct epithelial cells would help us to understand the development of tissues. Drosophila imaginal discs, which are made up of two types of epithelial cells, provide good model systems for such studies. The disc proper or the columnar epithelial cells are apposed to a layer of...

journal_title：Journal of cell science

authors： Pallavi SK,Shashidhara LS

更新日期：2005-08-01 00:00:00

abstract：:Exocytosis and membrane recycling at the cytoproct (cell anus) of Tetrahymena pyriformis were studied using thin-section electron microscopy. Single cells were fixed at specific times relative to the elimination of the vacuole's contents--before elimination, at elimination, 3--5 s and 10--15 s following elimination. T...

journal_title：Journal of cell science

authors： Allen RD,Wolf RW

更新日期：1979-02-01 00:00:00

abstract：:We report the first direct analysis of the endogenous β-catenin phosphorylation activity in colon cancer SW480 cells. By comparing parental SW480 cells that harbor a typical truncated adenomatous polyposis coli (APC) form, cells expressing full-length APC and APC-depleted cells, we provide the formal demonstration tha...

journal_title：Journal of cell science

authors： Wang L,Liu X,Gusev E,Wang C,Fagotto F

更新日期：2014-04-15 00:00:00

abstract：:Nematocysts are explosive organelles found in all Cnidaria. Explosion of nematocyst capsules is driven by the high pressure within the capsule formed by the high concentration of poly-gamma-glutamate in the capsule matrix. Poly-gamma-glutamate is a polyanion that binds cations tightly, including the fluorescent cation...

journal_title：Journal of cell science

authors： Szczepanek S,Cikala M,David CN

更新日期：2002-02-15 00:00:00

abstract：:HC11 is a normal mouse mammary epithelial cell line that requires certain growth factors, such as EGF or bFGF, to respond optimally to lactogenic hormones and produce the differentiation marker beta-casein. Growth in insulin (Ins) or PDGF does not produce cells competent to respond to lactogenic hormones. Here we show...

journal_title：Journal of cell science

authors： Chammas R,Taverna D,Cella N,Santos C,Hynes NE

更新日期：1994-04-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to edema and vascular leak, causing high morbidity and mortality. Previously, Abl kinase inhibition has been shown to protect against vascular leak. Using the distinct inhibitory profiles of clinically available Abl kinase inhibitors, we aimed to provide a mechanistic basis for no...

journal_title：Journal of cell science

authors： Botros L,Pronk MCA,Juschten J,Liddle J,Morsing SKH,van Buul JD,Bates RH,Tuinman PR,van Bezu JSM,Huveneers S,Bogaard HJ,van Hinsbergh VWM,Hordijk PL,Aman J

更新日期：2020-05-14 00:00:00

abstract：:The fractionation of human liver mitochondria into inner membrane, outer membrane and matrix material is reported. Compared with rat, human liver mitochondria are more fragile. Fractionation can be achieved in only 2 steps, a digitonin treatment for removal of the outer membrane and centrifugation of the inner membran...

journal_title：Journal of cell science

authors： Benga G,Hodarnau A,Tilinca R,Porutiu D,Dancea S,Pop V,Wrigglesworth J

更新日期：1979-02-01 00:00:00

abstract：:Successful cytokinesis requires proper assembly of the contractile actomyosin ring, its stable positioning on the cell surface and proper constriction. Over the years, many of the key molecular components and regulators of the assembly and positioning of the actomyosin ring have been elucidated. Here we show that cell...

journal_title：Journal of cell science

authors： Mishra M,Huang Y,Srivastava P,Srinivasan R,Sevugan M,Shlomovitz R,Gov N,Rao M,Balasubramanian M

更新日期：2012-08-15 00:00:00

abstract：:The main neuropathological features of Parkinson's disease are dopaminergic nigrostriatal neuron degeneration, and intraneuronal and intraneuritic proteinaceous inclusions named Lewy bodies and Lewy neurites, respectively, which mainly contain α-synuclein (α-syn, also known as SNCA). The neuronal phosphoprotein synaps...

journal_title：Journal of cell science

authors： Zaltieri M,Grigoletto J,Longhena F,Navarria L,Favero G,Castrezzati S,Colivicchi MA,Della Corte L,Rezzani R,Pizzi M,Benfenati F,Spillantini MG,Missale C,Spano P,Bellucci A

更新日期：2015-07-01 00:00:00

abstract：:alpha3beta1-integrin is abundantly expressed in the epidermis, and in mice, ablation of the alpha3 gene results in embryonic defects and perinatal lethality. To determine the role of alpha3-integrin in adult skin development, we grafted skin from newborn alpha3-integrin-deficient mice on to ICRF nu/nu recipients. We r...

journal_title：Journal of cell science

authors： Conti FJ,Rudling RJ,Robson A,Hodivala-Dilke KM

更新日期：2003-07-01 00:00:00

abstract：:Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As the major force-bearing adhesion-receptor protein, integrins have a central role in how cells sense and respond to the mechanics of their surroundings. Recent studies have shown that a key aspect of mechanotransduction is the...

journal_title：Journal of cell science

authors： Puklin-Faucher E,Sheetz MP

更新日期：2009-01-15 00:00:00

abstract：:The primary structures of three human forms of secretory carrier membrane proteins (SCAMPs) have been deduced from full-length clones isolated from a HeLa cell cDNA library and confirmed by a combination of comparison to expressed sequence tags, microsequencing of purified protein, and in vitro transcription and trans...

journal_title：Journal of cell science

authors： Singleton DR,Wu TT,Castle JD

更新日期：1997-09-01 00:00:00

abstract：:We previously showed that the cell-cell junction protein plakoglobin (PG) not only suppresses motility of keratinocytes in contact with each other, but also, unexpectedly, of single cells. Here we show that PG deficiency results in extracellular matrix (ECM)-dependent disruption of mature focal adhesions and cortical ...

journal_title：Journal of cell science

authors： Todorović V,Desai BV,Patterson MJ,Amargo EV,Dubash AD,Yin T,Jones JC,Green KJ

更新日期：2010-10-15 00:00:00

abstract：:The cellular microenvironment, characterized by an extracellular matrix (ECM), played an essential role in the transition from unicellularity to multicellularity in animals (metazoans), and in the subsequent evolution of diverse animal tissues and organs. A major ECM component are members of the collagen superfamily -...

journal_title：Journal of cell science

authors： Fidler AL,Boudko SP,Rokas A,Hudson BG

更新日期：2018-04-09 00:00:00

abstract：:By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin acts as the lynchpin between cell-cell contact and transcriptional regulation of proliferation, coordinating epithelial tissue homeostasis and regeneration. The integration of multiple growth-regulatory inputs with ...

journal_title：Journal of cell science

authors： Georgopoulos NT,Kirkwood LA,Southgate J

更新日期：2014-07-01 00:00:00

abstract：:The secreted Frizzled-related proteins (SFRPs) are a family of soluble proteins that are structurally related to Frizzled (Fz) proteins, the serpentine receptors that mediate the extensively used cell-cell communication pathway involving Wnt signalling. Because of their homology with the Wnt-binding domain on the Fz r...

journal_title：Journal of cell science

authors： Bovolenta P,Esteve P,Ruiz JM,Cisneros E,Lopez-Rios J

更新日期：2008-03-15 00:00:00

abstract：:Pregnancy-associated plasma protein A2 (PAPP-A2, also known as pappalysin-2) is a large metalloproteinase that is known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in the chordamesoderm, notochord and lower jaw of zebrafish (Danio reri...

journal_title：Journal of cell science

authors： Kjaer-Sorensen K,Engholm DH,Jepsen MR,Morch MG,Weyer K,Hefting LL,Skov LL,Laursen LS,Oxvig C

更新日期：2014-12-01 00:00:00

abstract：:Vascular endothelial (VE)-cadherin is the endothelium-specific member of the cadherin family of homotypic cell adhesion molecules. VE-cadherin, but not the cell adhesion molecule platelet/endothelial cell adhesion molecule (PECAM-1), markedly colocalizes with actin stress fibers at cell-cell junctions between human um...

journal_title：Journal of cell science

authors： Hordijk PL,Anthony E,Mul FP,Rientsma R,Oomen LC,Roos D

更新日期：1999-06-01 00:00:00

abstract：:We have used the H-7w subclone of a Chinese hamster ovary cell line (K1) to investigate the role of cell surface architecture (specifically microvilli, blebs, and sheets) in determining the relative agglutinability of a cell line with Con A. Our evidence clearly demonstrates that no specific, immediately recognizable ...

journal_title：Journal of cell science

authors： Noonan KD,Ukena T

更新日期：1978-12-01 00:00:00

abstract：:Collective cellular migration within the epithelial layer impacts upon development, wound healing and cancer invasion, but remains poorly understood. Prevailing conceptual frameworks tend to focus on the isolated role of each particular underlying factor - taken one at a time or at most a few at a time - and thus migh...

journal_title：Journal of cell science

authors： Park JA,Atia L,Mitchel JA,Fredberg JJ,Butler JP

更新日期：2016-09-15 00:00:00

abstract：:The sclerotome portion of the differentiating embryonic chick somite becomes infiltrated by neural crest cells prior to its dispersal towards the embryonic axis. This means that sclerotome cells explanted into culture for the purpose of examining their interactions in vitro are contaminated with a proportion of neural...

journal_title：Journal of cell science

authors： Sanders EJ,Cheung E

更新日期：1988-05-01 00:00:00

abstract：:The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in t...

journal_title：Journal of cell science

authors： Cai S,Bulus N,Fonseca-Siesser PM,Chen D,Hanks SK,Pozzi A,Zent R

更新日期：2005-03-01 00:00:00

abstract：:Talin binds to β-integrin tails to activate integrins, regulating cell migration, invasion and metastasis. There are two talin genes, TLN1 and TLN2, encoding talin1 and talin2, respectively. Talin1 regulates focal adhesion dynamics, cell migration and invasion, whereas the biological function of talin2 is not clear an...

journal_title：Journal of cell science

authors： Qi L,Jafari N,Li X,Chen Z,Li L,Hytönen VP,Goult BT,Zhan CG,Huang C

更新日期：2016-10-01 00:00:00

abstract：:PACSIN2, a membrane-sculpting BAR domain protein, localizes to caveolae. Here, we found that protein kinase C (PKC) phosphorylates PACSIN2 at serine 313, thereby decreasing its membrane binding and tubulation capacities. Concomitantly, phosphorylation decreased the time span for which caveolae could be tracked at the ...

journal_title：Journal of cell science

authors： Senju Y,Rosenbaum E,Shah C,Hamada-Nakahara S,Itoh Y,Yamamoto K,Hanawa-Suetsugu K,Daumke O,Suetsugu S

更新日期：2015-08-01 00:00:00

abstract：:Increases in reactive oxygen species (ROS) have been implicated in age-related diseases, including cancer. The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-kappaB signaling. We have previously shown th...

journal_title：Journal of cell science

authors： Cowell CF,Döppler H,Yan IK,Hausser A,Umezawa Y,Storz P

更新日期：2009-04-01 00:00:00