Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions.

abstract：:During development, general body plan information must be translated into distinct morphologies of individual cells. Shaping cells is thought to involve cortical cytoskeletal components and Bin-Amphiphysin-Rvs167 (BAR) superfamily proteins. We therefore conducted comprehensive side-by-side loss-of-function studies of ...

journal_title：Journal of cell science

authors： Schüler S,Hauptmann J,Perner B,Kessels MM,Englert C,Qualmann B

更新日期：2013-01-01 00:00:00

abstract：:Ena/VASP proteins are actin-binding proteins that localize to actin stress fibres, the tips of filopodia and the lamellipodial leading edge. In the past few years, a number of seemingly conflicting studies have confused the Ena/VASP field, pointing to roles for these proteins in both promotion and inhibition of actin-...

journal_title：Journal of cell science

authors： Krause M,Bear JE,Loureiro JJ,Gertler FB

更新日期：2002-12-15 00:00:00

abstract：:Rho GTPases and their downstream effectors regulate changes in the actin cytoskeleton that underlie cell motility and adhesion. They also participate, with RhoA, in the regulation of gene transcription by activating serum response factor (SRF)-mediated transcription from the serum response element (SRE). SRF-mediated ...

journal_title：Journal of cell science

authors： Xie Y,Tan EJ,Wee S,Manser E,Lim L,Koh CG

更新日期：2008-02-15 00:00:00

abstract：:Dynamic modulation of the physical contacts between neighboring cells is integral to epithelial processes such as tissue repair and cancer dissemination. Induction of matrix metalloproteinase (MMP) activity contributes to the disassembly of intercellular junctions and the degradation of the extracellular matrix, thus ...

journal_title：Journal of cell science

authors： Mauris J,Woodward AM,Cao Z,Panjwani N,Argüeso P

更新日期：2014-07-15 00:00:00

abstract：:Studies of human cell hybrids have provided evidence that the tumorigenicity of a cervical carcinoma (HeLa) is under the control of a putative tumor suppressor on chromosome 11. Using these human cell hybrids, we found a tumor-associated glycosylation change in the glucose transporter GLUT1, which is an N-linked glyco...

journal_title：Journal of cell science

authors： Kitagawa T,Tsuruhara Y,Hayashi M,Endo T,Stanbridge EJ

更新日期：1995-12-01 00:00:00

abstract：:Epithelial junctions depend on intercellular interactions between β(1) subunits of the Na(+)/K(+)-ATPase molecules of neighboring cells. The interaction between dog and rat subunits is less effective than the interaction between two dog β(1) subunits, indicating the importance of species-specific regions for β(1)-β(1)...

journal_title：Journal of cell science

authors： Tokhtaeva E,Sachs G,Sun H,Dada LA,Sznajder JI,Vagin O

更新日期：2012-03-15 00:00:00

abstract：:Cytokines are supposed to be mediators in diarrhoeal diseases. The aim of this study is to characterize the effect of tumor necrosis factor-alpha (TNFalpha) on epithelial barrier function in the colonic epithelial cell line HT-29/B6. Active ion transport and barrier function were measured as short-circuit current and ...

journal_title：Journal of cell science

authors： Schmitz H,Fromm M,Bentzel CJ,Scholz P,Detjen K,Mankertz J,Bode H,Epple HJ,Riecken EO,Schulzke JD

更新日期：1999-01-01 00:00:00

abstract：:Insect ovarian Sf9 cells extend processes with complex morphologies when infected with a recombinant baculovirus encoding the catalytic subunit of protein kinase A. Within the shafts of the processes are abundant microtubules, which, in contrast to those in Sf9 cells expressing the microtubule-associated protein tau, ...

journal_title：Journal of cell science

authors： Cheley S,Kosik KS,Paskevich P,Bakalis S,Bayley H

更新日期：1992-08-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) triggers apoptosis selectively in tumor cells through interaction with TRAIL-R1/DR4 or TRAIL-R2/DR5 and this process is considered a promising avenue for cancer treatment. TRAIL resistance, however, is frequently encountered and hampers anti-cancer ...

journal_title：Journal of cell science

authors： Azijli K,Yuvaraj S,Peppelenbosch MP,Würdinger T,Dekker H,Joore J,van Dijk E,Quax WJ,Peters GJ,de Jong S,Kruyt FA

更新日期：2012-10-01 00:00:00

abstract：:Insect flight muscle has a large component (Tn-H) in the tropomyosin-troponin complex that is not present in vertebrate striated muscle thin filaments. Tn-H is shown by gold/Fab labelling to be present at regular intervals in insect flight muscle thin filaments. The Fab fragment of a monoclonal antibody to Tn-H was co...

journal_title：Journal of cell science

authors： Newman R,Butcher GW,Bullard B,Leonard KR

更新日期：1992-03-01 00:00:00

abstract：:The identification and characterization of scaffold and targeting proteins of the ERK/MAP kinase pathway is important to understand the function and intracellular organization of this pathway. The F-actin binding protein leukocyte-specific protein 1 (LSP1) binds to PKCbetaI and expression of B-LSP1, an LSP1 truncate c...

journal_title：Journal of cell science

authors： Harrison RE,Sikorski BA,Jongstra J

更新日期：2004-04-15 00:00:00

abstract：:In fission yeast, Mid1p, a major determinant for division plane position, defines a medial cortical compartment where it recruits myosin II at the onset of mitosis to initiate contractile ring assembly. How Mid1p is restricted to the medial cortex is unknown. We report here that in a pom1 polarity mutant, which displa...

journal_title：Journal of cell science

authors： Celton-Morizur S,Racine V,Sibarita JB,Paoletti A

更新日期：2006-11-15 00:00:00

abstract：:Present in organisms ranging from yeast to man, homologues of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme CDC34 have been shown to play important roles in the regulation of cell cycle progression and checkpoint function. Here we analyze the expression and intracellular localization of endogenous CDC34 du...

journal_title：Journal of cell science

authors： Reymond F,Wirbelauer C,Krek W

更新日期：2000-05-01 00:00:00

abstract：:Ovarian follicles are the basic functional units of female reproduction in the mammalian ovary. We show here that the protein a disintegrin and metalloproteinase domain 10 (ADAM10), a cell surface sheddase, plays an indispensable role in controlling primordial follicle formation by regulating the recruitment of follic...

journal_title：Journal of cell science

authors： Feng L,Wang Y,Cai H,Sun G,Niu W,Xin Q,Tang X,Zhang J,Wang C,Zhang H,Xia G

更新日期：2016-06-01 00:00:00

abstract：:In the fission yeast Schizosaccharomyces pombe, the protein kinase Chk1 has an essential role in transducing a delay signal to the cell cycle machinery in the presence of DNA damage. Fission yeast cells lacking the chk1 gene do not delay progression of the cell cycle in response to damage and are thus sensitive to DNA...

journal_title：Journal of cell science

authors： Capasso H,Palermo C,Wan S,Rao H,John UP,O'Connell MJ,Walworth NC

更新日期：2002-12-01 00:00:00

abstract：:Postsynaptic density protein 95 (PSD-95/SAP-90) is a palmitoylated membrane-associated guanylate kinase that oligomerizes and clusters ion channels and associated signaling machinery at excitatory synapses in brain. However, the mechanism for PSD-95 oligomerization and its relationship to ion channel clustering remain...

journal_title：Journal of cell science

authors： Christopherson KS,Sweeney NT,Craven SE,Kang R,El-Husseini Ael-D,Bredt DS

更新日期：2003-08-01 00:00:00

abstract：:Although many pathogenic copy number variations (CNVs) are associated with neuropsychiatric diseases, few of them have been functionally characterised. Here we report multiple schizophrenia cases with CNV abnormalities specific to unc-51-like kinase 4 (ULK4), a serine/threonine kinase gene. Deletions spanning exons 21...

journal_title：Journal of cell science

authors： Lang B,Pu J,Hunter I,Liu M,Martin-Granados C,Reilly TJ,Gao GD,Guan ZL,Li WD,Shi YY,He G,He L,Stefánsson H,St Clair D,Blackwood DH,McCaig CD,Shen S

更新日期：2014-02-01 00:00:00

abstract：:The process of regulated exocytosis is defined by the Ca2+-triggered fusion of two apposed membranes, enabling the release of vesicular contents. This fusion step involves a number of energetically complex steps and requires both protein and lipid membrane components. The role of cholesterol has been investigated usin...

journal_title：Journal of cell science

authors： Churchward MA,Rogasevskaia T,Höfgen J,Bau J,Coorssen JR

更新日期：2005-10-15 00:00:00

abstract：:Currently >50 proteins have been reported to be associated with focal contacts and related ECM adhesions. Most of these contain multiple domains through which they can interact with different molecular partners, potentially forming a dense and heterogeneous protein network at the cytoplasmic faces of the adhesion site...

journal_title：Journal of cell science

authors： Zamir E,Geiger B

更新日期：2001-10-01 00:00:00

abstract：:Using a polyclonal antibody against purified zymogen granule membrane components from rat pancreas a cDNA coding for the 29 kDa protein (ZG29p) was identified by immunoscreening of a hormonally stimulated pancreas cDNA library. Western blot analysis suggests that ZG29p is a pancreas-specific protein and immunofluoresc...

journal_title：Journal of cell science

authors： Kleene R,Zdzieblo J,Wege K,Kern HF

更新日期：1999-08-01 00:00:00

abstract：:The notion that cell shape and spreading can regulate cell proliferation has evolved over several years, but only recently has this been linked to forces from within and upon the cell. This emerging area of mechanical signaling is proving to be wide-spread and important for all cell types. The microenvironment that su...

journal_title：Journal of cell science

authors： Provenzano PP,Keely PJ

更新日期：2011-04-15 00:00:00

abstract：:The cornified cell envelope (CE), a structure formed in the outermost layers of stratified squamous epithelia, provides a physical barrier against environmental insults. It is composed of several structural proteins, which are irreversibly crosslinked by calcium-activated transglutaminases. The small proline rich prot...

journal_title：Journal of cell science

authors： Cabral A,Sayin A,de Winter S,Fischer DF,Pavel S,Backendorf C

更新日期：2001-11-01 00:00:00

abstract：:The mechanisms by which volatile general anaesthetics (VAs) produce a depression of central nervous system are beginning to be better understood, but little is known about a number of side effects. Here, we show that the cold receptor transient receptor potential melastatin 8 (TRPM8) undergoes a complex modulation by ...

journal_title：Journal of cell science

authors： Vanden Abeele F,Kondratskyi A,Dubois C,Shapovalov G,Gkika D,Busserolles J,Shuba Y,Skryma R,Prevarskaya N

更新日期：2013-10-01 00:00:00

abstract：:Nopp44/46 is a phosphoprotein of the protozoan parasite Trypanosoma brucei that is localized to the nucleolus. Based on the primary sequence, Nopp44/46 appears to be a protein composed of distinct domains. This communication describes the relationship of these domains to the known functional interactions of the molecu...

journal_title：Journal of cell science

authors： Das A,Park JH,Hagen CB,Parsons M

更新日期：1998-09-01 00:00:00

abstract：:Cells govern tissue shape by exerting highly regulated forces at sites of matrix adhesion. As the major force-bearing adhesion-receptor protein, integrins have a central role in how cells sense and respond to the mechanics of their surroundings. Recent studies have shown that a key aspect of mechanotransduction is the...

journal_title：Journal of cell science

authors： Puklin-Faucher E,Sheetz MP

更新日期：2009-01-15 00:00:00

abstract：:The scaffold attachment factor SAFB1 and its recently discovered homologue SAFB2 might provide an important link between pre-mRNA splicing, intracellular signalling and transcription. Using novel mono-specific antisera, we found endogenous SAFB2 protein has a different spatial distribution from SAFB1 within the nucleu...

journal_title：Journal of cell science

authors： Sergeant KA,Bourgeois CF,Dalgliesh C,Venables JP,Stevenin J,Elliott DJ

更新日期：2007-01-15 00:00:00

abstract：:Ring canals connecting Drosophila germline, follicle and imaginal disc cells provide direct contact of cytoplasm between cells. To date, little is known about the formation, structure, or function of the somatic ring canals present in follicle and imaginal disc cells. Here, we show by confocal and electron microscopy ...

journal_title：Journal of cell science

authors： Airoldi SJ,McLean PF,Shimada Y,Cooley L

更新日期：2011-12-01 00:00:00

abstract：:Fusion of large and small karyoplasts produced from metaphase II mouse oocytes with interphase blastomeres from 2-cell and 8-cell embryos (volume ratio of partners, 1:1) results in premature chromosome condensation (PCC) of the interphase nucleus in the majority of the fusion products (hybrids). Fused under the same e...

journal_title：Journal of cell science

authors： Czołowska R,Waksmundzka M,Kubiak JZ,Tarkowski AK

更新日期：1986-08-01 00:00:00

abstract：:Host/symbiont specificity has been investigated in non-symbiotic and aposymbiotic brown and green hydra infected with various free-living and symbiotic species and strains of Chlorella and Chlorococcum. Morphology and ultrastructure of the symbioses obtained have been compared. Aposymbiotic Swiss Hydra viridis and Jap...

journal_title：Journal of cell science

authors： Rahat M,Reich V

更新日期：1986-12-01 00:00:00

abstract：:Diploid yeast, like most eukaryotes, can undergo meiotic differentiation to form haploid gametes. Meiotic differentiation and cell growth (proliferation) are mutually exclusive programs, and in yeast the switch between growth and meiosis is controlled by nutritional signals. The signaling pathways that mediate nutriti...

journal_title：Journal of cell science

authors： Honigberg SM,Purnapatre K

更新日期：2003-06-01 00:00:00