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:Nature Reviews Molecular Cell Biology Nature Publishing Group (2000). ISSN 1471-0072. Monthly First there was Annual Reviews, then came the monthly Elsevier Trends Journals, both of which try to identify hot topics in their chosen fields. The Current Opinion journals followed several years later, and Current Opinion in Cell Biology is presently one of the highest 'impact factor' review journals, with a distinguished board of editors and advisors and a systematic approach to regular coverage of the major fields of cell biology. Important topics are visited once a year, whether or not something specially exciting happened in the last 12 months. Add to this list Seminars in Cell and Developmental Biology, the FASEB journal and the countless minireviews in 'real' journals, and you begin to wonder how anyone finds any time for doing experiments, or indeed reading the primary literature. So, into this already crowded field arrive three important newcomers: Nature Reviews in Molecular Cell Biology, Genetics, and Neurosciences, of which the first two will probably interest readers of Journal of Cell Science the most. Backed by the name and money of Nature and edited by experienced Nature staff, it is hard to see how these publications can possibly do other than succeed with writers and readers alike. What's inside the first issue? The cover of Nature Reviews in Molecular Cell Biology presents a 3-colour montage of a blue cell nucleus surrounded by splotches of green GPI-anchored GFP overlaid by orange actin stress fibres that seem to come from somewhere else. This image trails a comprehensive review from Kai Simons and Derek Toomre about Lipid Rafts. There are another five major review articles: calcium puffs and sparks, rings around DNA, HIV inhibitors, kinesin and the circadian clock provide a rich and varied mix of topics from authors who know what they're talking about. Surrounding this core is an entertaining mixture of 'highlights' at the front: news and views about a well-chosen selection of recent articles in the primary literature written by the three editors. These struck me as striking slightly too jokey a style. It is a terrible temptation and mistake in this kind of piece, I think, to equate lightheartedness with clarity. The sugar coating is more likely to irritate than enlighten. I would also question the wisdom, if it is indeed a policy, of only allowing editors to write in this section. I'm all for experienced writers writing, but I think I would prefer the variety of voice and authority evinced by the parental Nature News and Views. After the main reviews comes a section entitled 'perspectives', which include a 'Timeline' piece on Hayflick and his limit by Jerry Shay and Woodring Wright that I very much enjoyed, and a review (or Opinion) about cancer from Judah Folkman, Philip Hahnfeldt and Lynn Hlatky. In their own words, "the impetus for this Opinion article centres on the increasing awareness of the heterogeneity and instability of the cancer genome [. I]t is possible that suppressing this degenerative process may itself comprise an alternative constraint-based paradigm." The authors' fondness for portentous phrases of this kind rather spoiled their discussion for me. I also had trouble with an article on molecular computing. PCR reactions can solve the travelling salesman problem, it seems, but extremely slowly compared to a proper computer. The magazine has a nice heft to it, and is attractively designed and presented in glossy colour, although the main font is small enough to make reading difficult for your middle-aged reviewer in a particularly heavily overcast and rainy week in London. A first issue is supposed to be a kind of showcase, but if they can keep this up, the editors will surely have a success on their hands and you will probably be obliged to take out a personal subscription (£85), or persuade your library to part with £565. That's slightly cheaper than TiBS and a lot cheaper than Current Opinion in Cell Biology, both of which will have to run faster if they want to stay in the same place.

journal_name

J Cell Sci

journal_title

Journal of cell science

authors

Hunt T

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

4377-4378

issue

Pt 24

eissn

0021-9533

issn

1477-9137

journal_volume

113

pub_type

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    abstract::Chloroquine resistance in the human malaria parasite, Plasmodium falciparum, arises from decreased accumulation of the drug in the ;digestive vacuole' of the parasite, an acidic compartment in which chloroquine exerts its primary toxic effect. It has been proposed that changes in the pH of the digestive vacuole might ...

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  • Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines.

    abstract::Na+/H+ exchangers (NHEs) are transporters that exchange sodium and proton ions across the plasma membrane at the expense of their chemical gradient. In higher eukaryotes these transporters exist as multiple specialized isoforms. For example, NHE1, the ubiquitously expressed form is a major pH-regulating system whereas...

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  • Genome-wide expression screens indicate a global role for protein kinase CK2 in chromatin remodeling.

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  • Different GPI-attachment signals affect the oligomerisation of GPI-anchored proteins and their apical sorting.

    abstract::To understand the mechanism involved in the apical sorting of glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) we fused to the C-terminus of GFP the GPI-anchor-attachment signal of the folate receptor (FR) or of the prion protein (PrP), two native GPI-anchored proteins that are sorted apically or basolat...

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  • The Ski-Zeb2-Meox2 pathway provides a novel mechanism for regulation of the cardiac myofibroblast phenotype.

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  • Characterisation of transcriptionally active and inactive chromatin domains in neurons.

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    authors: Akhmanova A,Verkerk T,Langeveld A,Grosveld F,Galjart N

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  • Three-dimensional imaging of living neurons and glia with the atomic force microscope.

    abstract::The atomic force microscope (AFM) was used to directly image hippocampal neurons and glia. Using chemically fixed and living cells it was possible to reconstruct three-dimensional cell structure and detect sub-cellular features such as the nucleus, mitochondria and filaments. By repeatedly scanning a single living cel...

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    authors: Parpura V,Haydon PG,Henderson E

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  • Diacylglycerols and PMA induce actin polymerization and distinct shape changes in lymphocytes: relation to fluid pinocytosis and locomotion.

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    authors: Keller HU,Niggli V,Zimmermann A

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  • Canonical nucleators are dispensable for stress granule assembly in Drosophila intestinal progenitors.

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  • Phosphatase 2A and polo kinase, two antagonistic regulators of cdc25 activation and MPF auto-amplification.

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  • VE-cadherin antibody accelerates neutrophil recruitment in vivo.

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  • A 33 kDa protein with sequence homology to the 'laminin binding protein' is associated with the cytoskeleton in hydra and in mammalian cells.

    abstract::In hydra and in mammalian cells the monoclonal antibody V recognises an epitope which colocalises with cytoskeletal structures. Using this antibody for expression screening, a cDNA clone (955 bp) was isolated from hydra, which covers an open reading frame for a protein of 294 amino acids with a calculated molecular ma...

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  • Quantifying the range of a lipid phosphate signal in vivo.

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  • Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans.

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  • IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos.

    abstract::IGFBP3 is a multi-functional protein that has IGF-dependent and IGF-independent actions in cultured cells. Here we show that the IGF binding domain (IBD), nuclear localization signal (NLS) and transactivation domain (TA) are conserved and functional in zebrafish Igfbp3. The in vivo roles of these domains were investig...

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    abstract::The Arabidopsis thaliana ASY1 gene is essential for homologous chromosome synapsis. Antibodies specific to Asy1 protein and its homologue BoAsy1 from the related crop species Brassica oleracea have been used to investigate the temporal expression and localization of the protein in both species. Asy1 is initially detec...

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  • Microtubule remodelling is required for the front-rear polarity switch during contact inhibition of locomotion.

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  • Cell movements in a confluent monolayer are not caused by gaps: evidence for direct contact inhibition of overlapping.

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  • The dynein genes of Paramecium tetraurelia. Sequences adjacent to the catalytic P-loop identify cytoplasmic and axonemal heavy chain isoforms.

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  • Identification of MYO4, a second class V myosin gene in yeast.

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  • Disruption of Golgi structure and function in mammalian cells expressing a mutant dynamin.

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  • The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function.

    abstract::Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi intermediate compartment (ERGIC), the marker of which is the lectin ERGIC-53. The dynamic nature and functional role of the ERGIC have been debated for...

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  • gamma-Tubulin is present in acentriolar MTOCs during early mouse development.

    abstract::gamma-Tubulin, a recently discovered member of the tubulin superfamily, is a peri-centriolar component considered to be essential for microtubule nucleation. Mouse oocytes and early embryos lack centrioles until the blastocyst stage. Thus, early mouse embryos allowed us to study the location of gamma-tubulin in animal...

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    pub_type: 杂志文章

    doi:

    authors: Gueth-Hallonet C,Antony C,Aghion J,Santa-Maria A,Lajoie-Mazenc I,Wright M,Maro B

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  • Role of zinc in cell division of Euglena gracilis.

    abstract::Euglena gracilis is a suitable model system to investigate the role of zinc in the process of cell division. In zinc-deficient organisms there is a characteristic arrest of cellular proliferation, the DNA content of the cells doubles, whereas RNA and protein contents decrease. The present investigations include the gr...

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    pub_type: 杂志文章

    doi:

    authors: Falchuk KH,Fawcett DW,Vallee BL

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  • Cooperative interactions of LPPR family members in membrane localization and alteration of cellular morphology.

    abstract::The lipid phosphate phosphatase-related proteins (LPPRs), also known as plasticity-related genes (PRGs), are classified as a new brain-enriched subclass of the lipid phosphate phosphatase (LPP) superfamily. They induce membrane protrusions, neurite outgrowth or dendritic spine formation in cell lines and primary neuro...

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    doi:10.1242/jcs.169789

    authors: Yu P,Agbaegbu C,Malide DA,Wu X,Katagiri Y,Hammer JA,Geller HM

    更新日期:2015-09-01 00:00:00

  • Planar polarity from flies to vertebrates.

    abstract::Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. Tbe PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signall...

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    pub_type: 杂志文章,评审

    doi:10.1242/jcs.00973

    authors: Fanto M,McNeill H

    更新日期:2004-02-01 00:00:00