Abstract:
:Reduction mammoplasty is a frequently performed procedure for the treatment of macromastia and for the achievement of symmetry in breast cancer patients following lumpectomy. Slides from 516 consecutive bilateral reduction mammoplasties performed for macromastia over 15 years were reviewed. Among these, 92 (18%) low-risk ductal intraepithelial neoplasia/intraductal hyperplasia, 28 (5%) ductal intraepithelial neoplasia 1 (1 low-grade ductal carcinoma in situ, 11 atypical intraductal hyperplasia, and 16 flat type), 17 (3%) lobular intraepithelial neoplasia, and 1 (0.2%) tubular carcinoma were identified. The patients were categorized into 3 age groups: <40 (n=352), 40 to 50 (n=107), and over 50 years (n=57); the frequency of the lesions increased with age. These data confirm the low frequency of clinically occult malignancies identified in reduction mammoplasty specimens and provide substantial information about the frequency of a variety of intraepithelial proliferations. Preoperative mammography, specimen orientation, and inking of margins with 1 color are advised when reduction mammoplasty is scheduled for women>or=40 years of age.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Dotto J,Kluk M,Geramizadeh B,Tavassoli FAdoi
10.1177/1066896907307176subject
Has Abstractpub_date
2008-01-01 00:00:00pages
25-30issue
1eissn
1066-8969issn
1940-2465pii
16/1/25journal_volume
16pub_type
杂志文章abstract::Transitional cell tumors of the ovary comprise about 1% to 2% of all ovarian neoplasms. Most of these tumors are benign Brenner tumors and account for about 5% of benign surface epithelial-stromal tumors. Spicules of calcifications are found in the stroma of about 50% of benign Brenner tumors. Although diagnostic chal...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896910387601
更新日期:2011-02-01 00:00:00
abstract::NET-1 is a member of the NET-x family. To explore the potential role of NET-1 in hepatocellular carcinoma (HCC), the expression of NET-1 and the relationship with HCC were examined for the first time. We found that NET-1 was frequently expressed in HCC and the peritumor tissue. The relative amounts of NET-1 mRNA in HC...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907306083
更新日期:2007-10-01 00:00:00
abstract::We describe a rare case of glomus tumor of the duodenum. The tumor was detected in a 46-year-old man being investigated for episodes of gastrointestinal bleeding. The excised specimen showed a 2.3 x 1.5 x 1.5 cm gray-tan tumor involving the mucosa and the submucosa. The overlying mucosa was focally ulcerated. Histolog...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200417
更新日期:2004-10-01 00:00:00
abstract::Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archiva...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911417970
更新日期:2012-02-01 00:00:00
abstract::Spontaneous regression of malignant tumour is a rare phenomenon. This report describes such an occurrence in a gastric large cell neuroendocrine carcinoma of a 77-year-old man. The patient presented with dyspepsia, and biopsy of the fungating mass in the cardia showed a high grade neuroendocrine carcinoma. The pre-ope...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911404412
更新日期:2011-06-01 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 yea...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896918771192
更新日期:2018-10-01 00:00:00
abstract::The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920986967
更新日期:2021-01-11 00:00:00
abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916646448
更新日期:2016-10-01 00:00:00
abstract::Colorectal liver metastases with intrabiliary growth are uncommon and difficult to characterize by radiology alone. We present the case of a 61-year-old woman previously operated on for a left colon cancer who developed a metacronous lesion at liver segment II-III. Radiologic workup was indicative for cholangiocarcino...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896913491317
更新日期:2014-05-01 00:00:00
abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912470165
更新日期:2013-08-01 00:00:00
abstract::Specimen misidentification is a common cause of errors in surgical pathology. We report a case where bone-marrow biopsies from patients of different genders were mislabeled and molecular methods were applied to resolve the identity. A short tandem repeat (STR)-polymerase chain reaction-based assay, commonly used in pa...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300304
更新日期:2005-07-01 00:00:00
abstract::A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cy...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914553666
更新日期:2015-02-01 00:00:00
abstract::Aims Epithelial mesenchymal transition (EMT) is a crucial process for acquisition of malignant phenotype, aggressiveness, and metastatic capacity in neoplasms. It is characterized by loss of epithelial markers and gain of mesenchymal markers. Studies on EMT and its potential association with the histological grading a...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916654763
更新日期:2016-12-01 00:00:00
abstract::Cystic squamous cell carcinomas (SCCs) of the jaws, including carcinoma cuniculatum, are rare, slow growing, and relentlessly invasive. The aim of this article is to present 12 cases, 4 of which were designated as carcinoma cuniculatum on the basis of deeply endophytic, anastomosing channels of cystic stratified squam...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920903388
更新日期:2020-09-01 00:00:00
abstract::Spitz tumors are a group of melanocytic neoplasms with distinct morphological features that tend to affect young individuals. Distinguishing benign from malignant Spitz tumors can be challenging, but cytogenetic and molecular tests have contributed to improvements in diagnostic accuracy. Spitz tumors harbor diverse ge...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916630375
更新日期:2016-05-01 00:00:00
abstract::The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896917717338
更新日期:2017-12-01 00:00:00
abstract::We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed an isoechoic lesion ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912475082
更新日期:2013-04-01 00:00:00
abstract::Lymphoplasmacyte-rich meningioma (LPRM) is an extremely rare variant of meningioma, and a small percentage of LPRM may be associated with IgG4-related disease. To date, the coexistence of 2 rare meningioma variants consisting of LPRM and angiomatous meningioma within one neoplasm has not been reported in the literatur...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917728103
更新日期:2018-02-01 00:00:00
abstract::We report our experience with Chromogenic in Situ Hybridization (CISH) for the evaluation of HER2 amplification on 55 cases of formalin-fixed, paraffin-embedded invasive breast carcinomas of different histology. All the results were corrected for chromosome 17 aneusomy and compared with immunohistochemistry (IHC); a s...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300406
更新日期:2005-10-01 00:00:00
abstract::Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100102
更新日期:2003-01-01 00:00:00
abstract::Mesonephric adenocarcinoma is a rare tumor type that is usually found in areas where the Wolffian duct was present during the fetal period. We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-c...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915611489
更新日期:2016-04-01 00:00:00
abstract::In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and BRCA1 gene variant of uncertain significance. The surgery was comp...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920930100
更新日期:2020-06-18 00:00:00
abstract:BACKGROUND:To avoid diagnostic errors such as missed diagnosis and errors in staging tumors due to inadequate tissue sampling, pathologists submit additional sections (AS). OBJECTIVE:This study assessed frequency, diagnostic yield, distribution, and cost of AS. METHOD:Among 1542 AS cases, we calculated mean AS per ca...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918755008
更新日期:2018-08-01 00:00:00
abstract::Tumor-to-tumor metastasis is a very rare phenomenon. The most common donor and recipient of tumor-to-tumor metastasis are carcinomas of lung and renal cell carcinoma, respectively. We report a case of primary lung adenocarcinoma that metastasized into a renal angiomyolipoma 9 years after the resection of primary lung ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915572224
更新日期:2015-05-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920964566
更新日期:2020-10-09 00:00:00
abstract::Cervical cancer is the most common gynecologic malignancy of the developing world. The oncogenic role of human papilloma virus (HPV) is well known. Attention is now focusing on the complicit genetic changes, which allow progression of these tumors. Regarding these changes, deletion of tumor suppressor genes (loss of h...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100402
更新日期:2003-10-01 00:00:00
abstract::Background. In this single-institution study, we applied the current (eighth edition) American Joint Committee on Cancer pathologic staging criteria to 64 low-grade mucinous neoplasms of the appendix (LAMNs), examined their histopathologic features, and studied the patients' clinical outcomes. Design. Sixty-four LAMNs...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919883679
更新日期:2020-05-01 00:00:00
abstract::We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200105
更新日期:2004-01-01 00:00:00
abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323505
更新日期:2011-02-01 00:00:00
abstract::A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907304519
更新日期:2008-04-01 00:00:00