Hemangioblastoma of the gastrointestinal tract: a first case.

Abstract:

:We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed an isoechoic lesion originating from the third layer of the intestinal wall; underlying layers were normal. Endoscopic ultrasound features were not suggestive of either cancer or malignant stromal tumor. Left hemicolectomy was subsequently performed due to repeated episodes of lower gastrointestinal bleeding. Grossly, a circumscribed submucosal yellowish nodule (13 mm) was observed, which was not attached to any peripheral nerve. Histologically, the lesion was composed of large, atypical cells traversed by a network of blood vessels. Immunohistochemically, the cells showed positivity for inhibin and NSE and weak positivity for S-100. A diagnosis of hemangioblastoma was made. This case highlights that hemangioblastoma of the gastrointestinal tract can also occur.

journal_name

Int J Surg Pathol

authors

Casadei Gardini A,Pieri F,Fusaroli P,Oboldi D,Passardi A,Monti M,Rosetti P,Calpona S,Valgiusti M,Ragazzini A,Amadori D,Frassineti GL

doi

10.1177/1066896912475082

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

192-6

issue

2

eissn

1066-8969

issn

1940-2465

pii

21/2/192

journal_volume

21

pub_type

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