Role of chromogenic in situ hybridization (CISH) in the evaluation of HER2 status in breast carcinoma: comparison with immunohistochemistry and FISH.

abstract：:A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cy...

journal_title：International journal of surgical pathology

authors： Kern JB,Hii A,Kruse MJ,Szabo Z,Argani P,Hibbard MK,Gladstone DE,Meyer C,Zheng R,Borowitz MJ,Duffield AS

更新日期：2015-02-01 00:00:00

abstract：:Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...

journal_title：International journal of surgical pathology

authors： Kojima M,Nakamura N,Matsuda H,Kaba S,Itoh H,Masawa N

更新日期：2009-12-01 00:00:00

abstract：:Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry...

journal_title：International journal of surgical pathology

authors： Rowan DJ,Logunova V,van Tuinen P,Olteanu H,Peterson JF

更新日期：2017-02-01 00:00:00

abstract：:In keeping with the stated goal of providing the surgical pathologist with tools to recognize abnormalities of the gastrointestinal (GI) tract due to drugs (AGIDS), in part II of this review we embark in a more organ-based description of AGIDS. Adequate space is given to the numerous adverse gastrointestinal effects o...

journal_title：International journal of surgical pathology

authors： De Petris G,Caldero SG,Chen L,Xiao SY,Dhungel BM,Spizcka AJ,Lam-Himlin D

更新日期：2014-05-01 00:00:00

abstract：:Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a newly recognized entity in adults. The authors report a new case of SSRMS in a 31-year-old woman who presented with a large right leg mass. Biopsy revealed a malignant spindle cell neoplasm with focal sclerotic areas. A diagnosis of monophasic synovial sarcoma was ...

journal_title：International journal of surgical pathology

authors： Gavino AC,Spears MD,Peng Y

更新日期：2010-10-01 00:00:00

abstract：:To further study the characteristics of renal cell carcinoma (RCC) in young patients and better define their biological features, 46 RCCs of patients younger than 25 years were morphologically and immunohistochemically characterized with follow-up. Loss of heterozygosity (LOH) analysis of the von Hippel-Lindau (VHL) g...

journal_title：International journal of surgical pathology

authors： Rao Q,Chen JY,Wang JD,Ma HH,Zhou HB,Lu ZF,Zhou XJ

更新日期：2011-04-01 00:00:00

abstract：AIMS. GIARDIA:is sometimes missed by the pathologist, and we sought to determine how often this occurs at our institution-a large tertiary care center with a subspecialty gastrointestinal pathology service and what certain clinical and histologic clues can be used to flag cases with a higher likelihood of infection, ta...

journal_title：International journal of surgical pathology

authors： Shen MJ,Voltaggio L,Robertson S

更新日期：2020-08-10 00:00:00

abstract：:The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...

journal_title：International journal of surgical pathology

authors： Mercado JJ,Markert JM,Meador W,Chapman P,Perry A,Hackney JR

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis. M...

journal_title：International journal of surgical pathology

authors： González-Roibón N,Han JS,Lee S,Feng Z,Arslankoz S,Smith N,Pierorazio PM,Humphreys E,Deweese TL,Partin AW,Bivalacqua TJ,Han M,Trock B,Netto GJ

更新日期：2013-08-01 00:00:00

abstract：:Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chr...

journal_title：International journal of surgical pathology

authors： Noguchi H,Kitazono I,Hamada K,Tanaka T,Tasaki T,Shirahama H,Yamamoto Y,Tanimoto A

更新日期：2020-05-01 00:00:00

abstract：:Epithelioid sarcoma is a rare malignant mesenchymal neoplasm (less than 1% of all sarcomas) with epithelioid morphology. Among the 2 subtypes, proximal represents only one-third of cases and commonly involves deep tissues of pelvic region, including the perineum, genital area, and groin, and occurs more frequently in ...

journal_title：International journal of surgical pathology

authors： Suárez-Zamora DA,Barrera-Herrera LE,Rodríguez-Urrego PA,Palau-Lázaro MA

更新日期：2017-08-01 00:00:00

abstract：:A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...

journal_title：International journal of surgical pathology

authors： Vij K,Wang HL

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissu...

journal_title：International journal of surgical pathology

authors： Spasic S,Brcic I,Freire R,Garcia-Buitrago MT,Rosenberg AE

更新日期：2019-06-01 00:00:00

abstract：:Intrasellar rhabdomyosarcoma is rare, and when arising in collusion with an unrelated entity, can present a diagnostic pitfall. We describe a case of a 56-year-old woman who presented with right eye ptosis and a pituitary mass, which was resected and diagnosed as atypical pituitary adenoma. Because of residual disease...

journal_title：International journal of surgical pathology

authors： Duncan VE,Nabors LB,Warren PP,Conry RM,Willey CD,Perry A,Riley KO,Hackney JR

更新日期：2016-12-01 00:00:00

abstract：:Polyoma virus nephritis is increasingly being recognized as a cause of allograft dysfunction in renal transplant patients. We describe and illustrate the findings in a renal biopsy and a concurrent urine sample from a patient with polyoma virus nephritis. The urine cytology findings were highly suggestive of a tumor d...

journal_title：International journal of surgical pathology

authors： Papadimitriou JC,Drachenberg CB,Bourquin PM

更新日期：2000-10-01 00:00:00

abstract：:We report a case of polymorphous hemangioendothelioma, a rare vascular neoplasm, arising in the liver of a 51-year-old woman. Microscopically, this neoplasm is characterized by a polymorphous blend of solid, primitive vascular and angiomatous areas in variable proportions. Polymorphous hemangioendothelioma is consider...

journal_title：International journal of surgical pathology

authors： El Hussein S,Omarzai Y

更新日期：2017-05-01 00:00:00

abstract：:Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 ca...

journal_title：International journal of surgical pathology

authors： Ahmed AA,Tsokos M

更新日期：2007-04-01 00:00:00

abstract：:Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-o...

journal_title：International journal of surgical pathology

authors： Matsuoka Y,Iemura Y,Fujimoto M,Shibuya S,Yamada A,Fujii S,Kusaka T,Shindo T,Minamiguchi S,Haga H

更新日期：2020-10-09 00:00:00

abstract：:We report the case of a sclerosing perineurioma with conspicious collagen rosette formation in a 20-year-old male presenting with a firm, painless nodule on the palmar side of his right ring finger. The main differential diagnosis is a low-grade fibromyxoid sarcoma. The distinction between these entities is important ...

journal_title：International journal of surgical pathology

authors： Creytens D,Ferdinande L,Van Dorpe J

更新日期：2018-04-01 00:00:00

abstract：:Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade hi...

journal_title：International journal of surgical pathology

authors： Gupta N,Kenan S,Kahn LB

更新日期：2018-02-01 00:00:00

abstract：:Primitive neuroepithelial differentiation in malignant peripheral nerve sheath tumors (MPNSTs) has been reported in children but is extremely rare in adults. The authors report the case of a 70-year-old woman who presented with swelling of the right leg of 1-month duration. Fine-needle aspiration cytology was suggesti...

journal_title：International journal of surgical pathology

authors： Anvikar AR,Kulkarni MP,Ramteerthakar NA,Gosavi AV,Sulhyan KR

更新日期：2012-10-01 00:00:00

abstract：:Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a hi...

journal_title：International journal of surgical pathology

authors： Horne G,Ming-Lum C,Kirkpatrick AW,Parker RL

更新日期：2007-04-01 00:00:00

abstract：:Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype...

journal_title：International journal of surgical pathology

authors： Alexiev BA,Alaish SM,Sun CC

更新日期：2007-07-01 00:00:00

abstract：:In this study based on the study of a centromeric DNA probe specific for chromosome 8 the authors standardized a method for the enzymatic detection of specific chromosome copy numbers on interphase nuclei from tumor tissue samples. Since the in situ hybridization (ISH) of chromosome 8 specific probe was revealed with ...

journal_title：International journal of surgical pathology

authors： Buonamici L,Serra M,Losi L,Eusebi V

更新日期：2000-07-01 00:00:00

abstract：:The histology in cases of primary spontaneous pneumothorax is generally nonspecific, but a careful examination, taking into account clinical data, may reveal subtle tissue alterations leading to a specific diagnosis in cases that might otherwise be taken as primary and spontaneous. In this article, we describe 3 cases...

journal_title：International journal of surgical pathology

authors： Mataca E,Rossi G,Colby TV

更新日期：2019-09-01 00:00:00

abstract：:Rare cases of metastasis to uterine polyps have been reported in English literature but not, to the best of our knowledge, to uterine adenomyomas. All these cases are represented by breast cancer, most of them involving tamoxifen-associated polyps. We first report a case of cutaneous malignant melanoma metastatic to u...

journal_title：International journal of surgical pathology

authors： Di Tommaso L,Rahal D,Bresciani G,Roncalli M

更新日期：2005-04-01 00:00:00

abstract：:A rare case of primary pleomorphic liposarcoma of the thigh with a myxoid component, in which divergent differentiation to a well-differentiated chondrosarcoma was focally present, is described. Presence of heterologous elements has mainly been recognized in the context of dedifferentiated liposarcomas. Few cases of b...

journal_title：International journal of surgical pathology

authors： Panoussopoulos D,Theodoropoulos G,Lazaris AC,Papadimitriou K

更新日期：2004-01-01 00:00:00

abstract：:Clear cell chondrosarcoma (CCCS) is a rare variant of conventional chondrosarcoma with low-grade malignant features that may be confused radiographically and histologically with chondroblastoma. We report a case of a 50-year-old female who presented with 6 months of left hip pain. Initial radiographs demonstrated an o...

journal_title：International journal of surgical pathology

authors： Kiefer RM,Wojcik J,Cooper K,Weber KL,Sebro R

更新日期：2018-12-01 00:00:00

abstract：:Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...

journal_title：International journal of surgical pathology

authors： Bertoni F,Del Corso G,Bacchini P,Marchetti C,Tarsitano A

更新日期：2016-10-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 yea...

journal_title：International journal of surgical pathology

authors： Moodley J,Cutz JC,Schell M

更新日期：2018-10-01 00:00:00