Head and neck mucosal malignant melanoma: clinicopathologic correlation with contemporary review of prognostic indicators.

Abstract:

:Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archival material of 2 large medical centers, and to explore the association, if any, between these variables, the clinical features, and outcomes. The clinicopathologic, radiographic, and follow-up information as well as the dominant histologic pattern, mitotic rate, presence/absence of pigmentation, necrosis, ulceration, vascular invasion, and host-associated lymphocytic response were retrieved and recorded. Twenty cases were identified including 1 melanoma in situ. Eight-five percent of tumors arose in the sinonasal tract and 3 (15%) in the oral cavity. After a median follow-up of 25 months, all patients with invasive melanoma developed recurrence and/or metastasis. Local recurrences occurred in 82% of the patients after a median of 12 months, and distant metastasis occurred in 71% of the patients after a median of 13 months. Of those with adequate follow-up, 82% died with disease, and the remaining 3 had recurrent or metastatic disease. Fourth-seven percent of tumors were pigmented, 89% showed at least focal necrosis, and 93% demonstrated ulceration. Sixth-eight percent showed vascular invasion and 63% had a brisk host lymphocytic response. Mitotic rates ranged from 2 to 60/10 high-power fields. The absence of an invasive component might be associated with a better prognosis but other clinical and pathological features that predict outcome, and/or could influence therapy, remain to be determined in HNMM.

journal_name

Int J Surg Pathol

authors

Kerr EH,Hameed O,Lewis JS Jr,Bartolucci AA,Wang D,Said-Al-Naief N

doi

10.1177/1066896911417970

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

37-46

issue

1

eissn

1066-8969

issn

1940-2465

pii

1066896911417970

journal_volume

20

pub_type

杂志文章
  • Giardia Is Often Overlooked on Histopathologic Examination: A High-Volume, Single-Institution Experience.

    abstract:AIMS. GIARDIA:is sometimes missed by the pathologist, and we sought to determine how often this occurs at our institution-a large tertiary care center with a subspecialty gastrointestinal pathology service and what certain clinical and histologic clues can be used to flag cases with a higher likelihood of infection, ta...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920947795

    authors: Shen MJ,Voltaggio L,Robertson S

    更新日期:2020-08-10 00:00:00

  • Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall.

    abstract::Mesonephric adenocarcinoma is a rare tumor type that is usually found in areas where the Wolffian duct was present during the fetal period. We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-c...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915611489

    authors: Kim SS,Nam JH,Kim GE,Choi YD,Choi C,Park CS

    更新日期:2016-04-01 00:00:00

  • Evanescence of Endometrial Carcinomas in Hysterectomy Specimens: Observations on the "Vanishing Cancer" Phenomenon.

    abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896918783581

    authors: Bharani V,Rai B,Rajwanshi A,Gupta N,Dey P,Kalra J,Suri V,Srinivasan R

    更新日期:2019-02-01 00:00:00

  • Uterine glomeruloid hemangioma in a patient without POEMS syndrome.

    abstract::Cutaneous glomeruloid hemangioma is a hallmark of POEMS syndrome. These patients have elevated serum levels of vascular endothelial growth factor. The authors report an extracutaneous uterine glomeruloid hemangioma in an 82-year-old woman with a history of breast and endometrial carcinomas. Within the lumen of myometr...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896911429297

    authors: Giner F,Compañ A,Monteagudo C

    更新日期:2012-08-01 00:00:00

  • Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a "Paraganglioma-Like" Paravertebral Case.

    abstract::Composite hemangioendothelioma is a rare vascular tumor morphologically comprising several distinct vascular components and exhibits a borderline malignant potential. We described the case of a 53-year-old female who presented with an infiltrative mass in the paravertebral soft tissue. The tumor showed discrete nests ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920924120

    authors: Cheuk W,Shum KS,Ng WK,Chan JKC

    更新日期:2020-10-01 00:00:00

  • Reactive Nodular Fibrous Pseudotumor Mimicking Metastatic Gastrointestinal Stromal Tumor to Perigastric Lymph Node: A Case Report and Review of the Literature.

    abstract::Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 yea...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896918771192

    authors: Moodley J,Cutz JC,Schell M

    更新日期:2018-10-01 00:00:00

  • Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature.

    abstract::Acinar cell carcinoma of the pancreas is rare, accounting for less than 1% of carcinomas arising in the exocrine pancreas. Patients are typically between the fifth and seventh decade of life and show a 2:1 male predominance. Symptoms tend to be nonspecific, and approximately 50% of the patients have metastases at the ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896909339912

    authors: Toll AD,Mitchell D,Yeo CJ,Hruban RH,Witkiewicz AK

    更新日期:2011-12-01 00:00:00

  • Mesothelial Cells Within Vascular Transformation of Mediastinal Lymph Node Sinuses: An Unusual Benign Collision Mimicking Colliding Malignancies.

    abstract::Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of l...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915622277

    authors: Jabbour MN,Tawil AN,Boulos FI

    更新日期:2016-04-01 00:00:00

  • HIV-unrelated benign lymphoepithelial cyst of the parotid glands containing lymphoepithelial lesion--like structures: a report of 3 cases.

    abstract::Benign lymphoepithelial cyst (BLC) of the salivary gland is uncommon. Among report of these lesions, there were no previous cases of lymphoepithelial lesion (LeL) in human immunodeficiency virus type-1 (HIV-1) unrelated BLC. This study reports 3 cases of HIV-unrelated BLC containing LeL-like structures. Pathologically...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908328575

    authors: Kojima M,Nakamura N,Matsuda H,Kaba S,Itoh H,Masawa N

    更新日期:2009-12-01 00:00:00

  • Jaw cysts diagnosed in an Italian population over a 20-year period.

    abstract:BACKGROUND:Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age dist...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896914541000

    authors: Del Corso G,Righi A,Bombardi M,Rossi B,Dallera V,Pelliccioni GA,Marchetti C,Foschini MP

    更新日期:2014-12-01 00:00:00

  • Well-differentiated chondrosarcoma of the humerus with prominent granular cell component: a hitherto unreported occurrence.

    abstract::We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types,...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690601400211

    authors: Cremonini A,Kuhn E,De Biase P,Franchi A

    更新日期:2006-04-01 00:00:00

  • Loss of heterozygosity on chromosome 1 and 9 and hormone receptor analysis of metastatic malignant melanoma presenting in breast.

    abstract::Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300102

    authors: Beaty MW,Quezado M,Sobel ME,Duray P,Merino MJ

    更新日期:2005-01-01 00:00:00

  • Collagenous gastritis.

    abstract::A 25-year-old patient presented with epigastric pain, which on gastric biopsy revealed the characteristic appearance of collagenous gastritis. There was a thick prominent subepithelial band that was confirmed to be collagen with a Masson's trichrome stain. There was associated Helicobacter pylori gastritis but no evid...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908329588

    authors: Jain R,Chetty R

    更新日期:2010-12-01 00:00:00

  • Focal divergent chondrosarcomatous differentiation in a primary pleomorphic liposarcoma and expression of transforming growth factor beta.

    abstract::A rare case of primary pleomorphic liposarcoma of the thigh with a myxoid component, in which divergent differentiation to a well-differentiated chondrosarcoma was focally present, is described. Presence of heterologous elements has mainly been recognized in the context of dedifferentiated liposarcomas. Few cases of b...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690401200115

    authors: Panoussopoulos D,Theodoropoulos G,Lazaris AC,Papadimitriou K

    更新日期:2004-01-01 00:00:00

  • Autoimmune-Like Hepatitis: A "Hepatitic" Manifestation of Chronic Graft Versus Host Disease in Post-Stem Cell Transplant.

    abstract::A 59-year-old female received a matched related donor stem cell transplant for chronic myelogenous leukemia. After being successfully treated with prednisone for chronic graft versus host disease that initially started 50 days posttransplant, she developed hepatic dysfunction during the steroid taper on day 531, as ev...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915610817

    authors: Baniak NM,Kanthan R

    更新日期:2016-04-01 00:00:00

  • A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features.

    abstract::Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. In this article, we present a novel case of MFB arising in the left breas...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920947465

    authors: Strait AM,Linos K,Tafe LJ,Muller KE

    更新日期:2020-08-05 00:00:00

  • Displaced epithelium after liposuction for gynecomastia.

    abstract::The authors describe the case of a 36-year-old man with gynecomastia who was previously treated with liposuction of the breast for cosmetic purposes. Histologic examination of a subsequent excisional biopsy revealed nests of displaced epithelial cells in adipose tissue. Epithelial cell displacement is a well-known ris...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896910362990

    authors: McLaughlin CS,Petrey C,Grant S,Ransdell JS,Reynolds C

    更新日期:2011-08-01 00:00:00

  • Ameloblastic Fibrosarcoma of the mandible evolving from a prior Ameloblastic Fibroma after two years: an unusual finding.

    abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916646448

    authors: Bertoni F,Del Corso G,Bacchini P,Marchetti C,Tarsitano A

    更新日期:2016-10-01 00:00:00

  • Pediatric renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion.

    abstract::Renal cell carcinoma (RCC) in children and young adults is rare and pathologically problematic. RCC can be either hereditary or sporadic and has a guarded prognosis because appropriate management has not been established. A case of RCC in an 11-year-old is reported. The clinical presentation was a right abdominal mass...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907304994

    authors: Winarti NW,Argani P,De Marzo AM,Hicks J,Mulyadi K

    更新日期:2008-01-01 00:00:00

  • Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case, With Review of the Literature.

    abstract::Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English li...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896916644782

    authors: Mitra S,Kaur G,Nada R,Mohindra S

    更新日期:2016-09-01 00:00:00

  • Follicular Cholecystitis: Reappraisal of Incidence, Definition, and Clinicopathologic Associations in an Analysis of 2550 Cholecystectomies.

    abstract:CONTEXT.:Follicular cholecystitis (FC) is a poorly characterized entity. OBJECTIVE.:To determine its frequency/clinicopathologic associations. DESIGN.:A total of 2550 cholecystectomy specimens were examined. Two hundred three of these were consecutive routine cholecystectomies submitted entirely for microscopic exami...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920924079

    authors: Saka B,Memis B,Seven IE,Pehlivanoglu B,Balci S,Bagci P,Reid M,Dursun N,Escalano OT,Roa JC,Araya JC,Kong SY,Basturk O,Koshiol J,Adsay NV

    更新日期:2020-12-01 00:00:00

  • Testicular juvenile granulosa cell tumor in a newborn: case report and review of the literature.

    abstract::Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896907302423

    authors: Alexiev BA,Alaish SM,Sun CC

    更新日期:2007-07-01 00:00:00

  • Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma.

    abstract::The role and diagnostic efficacy of gene and protein products RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A, all previously shown to be involved in tumor genesis and cell proliferation, were examined by immunohistochemical techniques in 32 cases of myxofibrosarcomas and 29 myxoid liposarcomas (all diagnosis had been confirme...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896914532539

    authors: Wang T,Goodman MA,McGough RL,Weiss KR,Rao UN

    更新日期:2014-10-01 00:00:00

  • Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid Leukemia.

    abstract::Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916664986

    authors: Rowan DJ,Logunova V,van Tuinen P,Olteanu H,Peterson JF

    更新日期:2017-02-01 00:00:00

  • Topography of Protein Kinase C βII in Benign and Malignant Melanocytic Lesions.

    abstract:BACKGROUND:Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. OBJECTIVE:To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. METHO...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917706026

    authors: Krasagakis K,Tsentelierou E,Chlouverakis G,Stathopoulos EN

    更新日期:2017-09-01 00:00:00

  • α-Fetoprotein-Producing Hepatoid Gastric Adenocarcinoma With Osteoclast-Like Giant Cells and Neuroendocrine Differentiation: A Case Study With Molecular Profiling.

    abstract::Here we present the case of a 73-year-old woman with an ulcerated, advanced, hepatoid, and α-fetoprotein-producing poorly differentiated (G3) primary gastric adenocarcinoma pT3 N3a M1 with multinucleated cells and evident neuroendocrine component. This tumor was consistent with giant cell tumor type gastric carcinoma ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915586807

    authors: Wincewicz A,Kowalik A,Zięba S,Lewitowicz P,Góźdź S,Sulkowski S

    更新日期:2015-10-01 00:00:00

  • Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrence.

    abstract::A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907304519

    authors: Vij K,Wang HL

    更新日期:2008-04-01 00:00:00

  • IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study.

    abstract:BACKGROUND:Phyllodes tumors (PTs) of the breast are rare biphasic neoplasms and are classified as benign, borderline, or malignant. Many biological markers have been studied to discriminate between different grades of PTs. IMP3 is a member of the insulin-like growth factor II mRNA binding protein (IMP) family and is ex...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915603119

    authors: Bellezza G,Prosperi E,Del Sordo R,Colella R,Rulli A,Sidoni A

    更新日期:2016-02-01 00:00:00

  • Unusual presentation of benign cystic brenner tumor with exuberant psammomatous calcifications.

    abstract::Transitional cell tumors of the ovary comprise about 1% to 2% of all ovarian neoplasms. Most of these tumors are benign Brenner tumors and account for about 5% of benign surface epithelial-stromal tumors. Spicules of calcifications are found in the stroma of about 50% of benign Brenner tumors. Although diagnostic chal...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896910387601

    authors: Vemavarapu L,Alatassi H,Moghadamfalahi M

    更新日期:2011-02-01 00:00:00

  • The Giemsa stain: its history and applications.

    abstract::Gustav Giemsa was born in Germany in 1867, worked mainly as a chemist, and died in 1948. The staining method, which carries his name, was designed primarily for the demonstration of parasites in malaria, but it was also employed in histology because of the high-quality staining of the chromatin and the nuclear membran...

    journal_title:International journal of surgical pathology

    pub_type: 传,历史文章,杂志文章

    doi:10.1177/1066896907302239

    authors: Barcia JJ

    更新日期:2007-07-01 00:00:00