Cystic Squamous Cell Carcinomas of the Jaws: Twelve Cases Highlighting Histopathological Pitfalls.


:Cystic squamous cell carcinomas (SCCs) of the jaws, including carcinoma cuniculatum, are rare, slow growing, and relentlessly invasive. The aim of this article is to present 12 cases, 4 of which were designated as carcinoma cuniculatum on the basis of deeply endophytic, anastomosing channels of cystic stratified squamous epithelium and keratin microabscesses. The other 8 were also cystic, but more heterogeneous morphologically and were diagnosed as well differentiated SCCs. Six patients were female, 6 were male (mean age = 74.0 years, range = 50-94 years). Six tumors affected the mandible, 6 the maxillary alveolus with or without extension into the hard palate. All patients underwent primary resection with neck dissection and were staged as T4a N0 M0. In 4 patients, diagnosis was delayed as a result of superficial biopsies and/or confusing histopathology. Cystic SCCs of the jaws can be difficult to diagnose and clinicoradiological correlation is essential. Long-term follow-up is mandatory.


Int J Surg Pathol


Barrett AW,Garg M,Armstrong D,Bisase BS,Newman L,Norris PM,Shelley M,Tighe JV,Hyde NC,Chaston NJ,Gulati A




Has Abstract


2020-09-01 00:00:00












  • Combined carcinoid tumor and squamous cell carcinoma of lung: expanding the spectrum of combined tumors of lung.

    abstract::Combined lung cancers containing both small cell and non-small cell carcinoma elements are uncommon but well recognized. Lung tumors with neuroendocrine differentiation form a group of histologically distinct tumors with differing clinical behavior ranging from low-grade tumors with good prognosis (typical carcinoid) ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Owens CL,Fraire AE

    更新日期:2011-04-01 00:00:00

  • Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrence.

    abstract::A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Vij K,Wang HL

    更新日期:2008-04-01 00:00:00

  • Xp11.2 Translocation renal cell carcinomas have a poorer prognosis than non-Xp11.2 translocation carcinomas in children and young adults: a meta-analysis.

    abstract:OBJECTIVES:Renal cell carcinomas (RCCs) in children and adolescents are much rarer than in adults. In this age group, Xp11.2 translocation RCCs were the most common subtype of pediatric RCCs. Information regarding the clinical behavior of pediatric RCCs remains controversial because of their relatively rare incidence. ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,meta分析


    authors: Qiu Rao,Bing Guan,Zhou XJ

    更新日期:2010-12-01 00:00:00

  • Hemangioblastoma of the gastrointestinal tract: a first case.

    abstract::We present the first documented case of hemangioblastoma located in the left colon. A 75-year-old woman undergoing adjuvant chemotherapy for breast cancer experienced rectal bleeding. Colonoscopy revealed a roundish mass covered with normal mucosa in the sigmoid colon. Endoscopic ultrasound showed an isoechoic lesion ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Casadei Gardini A,Pieri F,Fusaroli P,Oboldi D,Passardi A,Monti M,Rosetti P,Calpona S,Valgiusti M,Ragazzini A,Amadori D,Frassineti GL

    更新日期:2013-04-01 00:00:00

  • Spontaneous complete regression of gastric large-cell neuroendocrine carcinoma: mediated by cytomegalovirus-induced cross-autoimmunity?

    abstract::Spontaneous regression of malignant tumour is a rare phenomenon. This report describes such an occurrence in a gastric large cell neuroendocrine carcinoma of a 77-year-old man. The patient presented with dyspepsia, and biopsy of the fungating mass in the cardia showed a high grade neuroendocrine carcinoma. The pre-ope...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Ip YT,Pong WM,Kao SS,Chan JK

    更新日期:2011-06-01 00:00:00

  • Unsuspected Xp11 Translocation Renal Neoplasm Associated With Contralateral Clear Cell Carcinoma.

    abstract::In this report, we present for the first time the coexistence of a conventional renal cell carcinoma (RCC) and an undefined Xp11 translocation renal neoplasm in distinct kidneys, which was difficult to definitively classify as either carcinoma or PEComa (perivascular epithelioid cell tumor). While one of the tumors sh...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: D'Antonio A,Addesso M,Nappi O,Zeppa P

    更新日期:2016-05-01 00:00:00

  • Pigmented Ependymoma of the Fourth Ventricle-A Curious Entity: Report of a Rare Case With Review of Literature.

    abstract::A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Malhotra A,Rao S,Santhoshkumar R,Muralidharan N,Mitra S,Shetty S

    更新日期:2021-02-01 00:00:00

  • Primary intratesticular spindle cell tumors: interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor.

    abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Nistal M,Gonzalez-Peramato P,Serrano A,Reyes-Mugica M,Cajaiba MM

    更新日期:2011-02-01 00:00:00

  • Fuzeon-induced collagenophagic granuloma: a peculiar granulomatous injection site reaction to Fuzeon--a case report and review of literature.

    abstract::Enfuvirtide (ENF, T-20, or Fuzeon [Hoffman-La Roche Inc, Nutley, NJ, and Trimeris, Inc, Durham, NC]) is an HIV-1 fusion inhibitor and is the only injectable antiretroviral drug available. Injection site reactions (ISRs) are the most frequently reported adverse events, occurring in about 98% of patients. A granuloma an...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Sidhu HK,Chaffee BH,Tvetenstrand CD,Sidhu JS

    更新日期:2010-10-01 00:00:00

  • Mixed Intraepithelial Neoplasia-Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination.

    abstract::Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this lo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Kővári B,Turkevi-Nagy S,Lauwers GY,Jiang K

    更新日期:2021-01-09 00:00:00

  • Histopathologic Spectrum of Neuromuscular and Vascular Hamartoma With Special Reference to the Vasculopathic Phenomenon.

    abstract::Neuromuscular and vascular hamartoma (NMVH) is an unusual lesion presenting as intestinal obstruction by stricture formation. It is characterized by a hamartomatous mass comprising haphazardly arranged mesenchymal tissue native to the intestinal mucosa and submucosa. We aimed to characterize the clinicohistopathologic...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Ayyanar P,Purkait S,Mishra TS,Patra S,Mitra S

    更新日期:2020-06-01 00:00:00

  • Isolated Gallbladder Intramucosal Metastatic Melanoma With Features Mimicking Lymphoepithelial Carcinoma.

    abstract::Malignant melanoma has a variety of morphologic patterns and can metastasize and mimic any type of neoplastic process creating significant diagnostic difficulty. When metastasis to the gastrointestinal system is identified, it is most commonly associated with widely metastatic disease. We report a rare case of isolate...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Lo AA,Peevey J,Lo EC,Guitart J,Rao MS,Yang GY

    更新日期:2015-08-01 00:00:00

  • Early colonic perineurioma: a report of 11 cases.

    abstract::Colonic perineurioma has been depicted as characterized by a mucosal proliferation of monomorphic spindle perineurial cells leading to an evident separation, distortion, and entrapment of colonic crypts. The authors, however, believe that a sizable subset of the cases differ in that they display only a limited perineu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Groisman G,Amar M,Alona M

    更新日期:2010-08-01 00:00:00

  • Aberrant methylation of multiple genes in gastric carcinomas.

    abstract::In this study, we examined aberrant methylation of the E-cadherin, estrogen receptor, RB1 , p16, p15, p14, and MGMT genes by the methylation-specific polymerase chain reaction method in 101 gastric carcinomas. Hypermethylation was detected in E-cadherin, estrogen receptor, RB1, p16, p14, p15, and MGMT at the rates of ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Zhao YF,Zhang YG,Tian XX,Juan Du,Jie Zheng

    更新日期:2007-07-01 00:00:00

  • Incidental Prostate Adenocarcinoma in Cystoprostatectomy Specimens: Partial Versus Complete Prostate Sampling.

    abstract:BACKGROUND:The rate of incidental prostate adenocarcinoma (PCa) detection in radical cystoprostatectomy (RCP) varies widely, ranging from 15% to 54%. Such variability may be explained by institutional differences in prostate grossing protocols. Either partial or complete submission of the prostate gland in RCP may resu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Filter ER,Gabril MY,Gomez JA,Wang PZT,Chin JL,Izawa J,Moussa M

    更新日期:2017-08-01 00:00:00

  • Acute Appendicitis and Pneumatosis in a Duplicated Appendix With Schistosoma Remnants.

    abstract::Appendiceal pneumatosis is rare, reported either in the context of acute appendicitis or enterocolitis. Here, we report the case of an elderly adult in whom the acute appendicitis was associated with pneumatosis and occurred in the context of a malformed appendix with pathogenic organism remnants. A 72-year-old man pr...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Handra-Luca A,Bisseret D,Dragoescu E

    更新日期:2016-02-01 00:00:00

  • Lymphoplasmacyte-Rich Meningioma With Atypical Angiomatous Feature and an Increased Deposition of IgG4-Positive Plasma Cells: An Unusual Case Report.

    abstract::Lymphoplasmacyte-rich meningioma (LPRM) is an extremely rare variant of meningioma, and a small percentage of LPRM may be associated with IgG4-related disease. To date, the coexistence of 2 rare meningioma variants consisting of LPRM and angiomatous meningioma within one neoplasm has not been reported in the literatur...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Son HJ,Yu IK,Kim SM

    更新日期:2018-02-01 00:00:00

  • Secondary Angiosarcoma With C-MYC Amplification Following Prophylactic Bilateral Mastectomy and Autologous Breast Reconstruction: Report of a Case and Review of the Literature.

    abstract::In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and BRCA1 gene variant of uncertain significance. The surgery was comp...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Webb C,Partain N,Koduru P,Hwang H,Sarode VR

    更新日期:2020-06-18 00:00:00

  • Squamous metaplasia on the breast implant capsule.

    abstract::The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent pape...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Alikhan MB,Nassar A,Mansoor I

    更新日期:2010-12-01 00:00:00

  • Sinonasal SMARCB1 (INI1) Deficient Carcinoma With Yolk Sac Tumor Differentiation: Report of a Case and Comparison With INI1 Expression in Gonadal Germ Cell Tumors.

    abstract::SMARCB1 (INI1) deficient sinonasal carcinoma is a recently recognized entity with wide histomorphologic spectrum. We present a case of this carcinoma that contained, in addition to a "common" morphology, scattered foci of yolk sac tumor differentiation. The tumor occurred in paranasal sinuses in a 44-year-old woman. I...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Zamecnik M,Rychnovsky J,Syrovatka J

    更新日期:2018-05-01 00:00:00

  • Dysplasia in Chronic Ulcerative Colitis: A Molecular Approach to Its Differential Diagnosis.

    abstract::Ulcerative colitis-related epithelial dysplasia represents a premalignant lesion, which may lead to the development of ulcerative colitis-related adenocarcinoma. The proper management of this condition requires proctocolectomy before the acquisition of the invasive phenotype. Patients with chronic ulcerative colitis, ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Urbanski SJ,Fogt F

    更新日期:2000-01-01 00:00:00

  • Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules.

    abstract::A 72-year-old man had a unilateral pleural effusion and multiple bilateral pulmonary nodules. Thoracoscopic biopsy revealed multiple discrete nodules in the pleura and lung. The latter consisted of tall columnar malignant cells arranged on alveolar surfaces in a lepidic growth pattern. Mucin filled the alveolar lumina...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Felner KJ,Wieczorek R,Kline M,Smith RL,Sidhu GS

    更新日期:2006-07-01 00:00:00

  • Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review.

    abstract::Hodgkin lymphoma (HL) associated with Warthin tumor (WT) is extremely rare, accounting for only 3 cases of classical HLs. Here, we report for the first time the occurrence of a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) involving the lymphoid stroma of a WT of the parotid gland. Pathogenesis of WT is cont...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Di Napoli A,Mallel G,Bartolazzi A,Cavalieri E,Becelli R,Cippitelli C,Ruco L

    更新日期:2015-08-01 00:00:00

  • Abundant hepatic Gaucher-like cells following chemotherapy and bone marrow transplantation for hematologic malignancy: report of two cases.

    abstract::Cells with a resemblance to Gaucher cells, sometimes called pseudo-Gaucher cells, are seen in the bone marrow of some patients with hematologic malignancy or anemia. These cells are derived from cells of the monocytic lineage but do not show the characteristic inclusions of true Gaucher cells when examined by electron...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Stenzel P,Weeks DA

    更新日期:2013-02-01 00:00:00

  • Endobronchial Pagetoid Spread of a Breast Carcinoma Metastatic to the Lung.

    abstract::A case of endobronchial pagetoid spread of a breast carcinoma metastatic to the lung is described. A 73-year-old woman underwent wedge lung resection after the cytological diagnosis of lung metastasis from ductal invasive breast carcinoma. The breast carcinoma had been surgically removed 6 years previously; at the tim...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Monica MA,Baccarini P,Cucchi MC,Lacava N,Foschini MP

    更新日期:2017-02-01 00:00:00

  • Sinonasal rhabdomyosarcoma in children and young adults.

    abstract::Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 ca...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Ahmed AA,Tsokos M

    更新日期:2007-04-01 00:00:00

  • Jaw cysts diagnosed in an Italian population over a 20-year period.

    abstract:BACKGROUND:Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age dist...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Del Corso G,Righi A,Bombardi M,Rossi B,Dallera V,Pelliccioni GA,Marchetti C,Foschini MP

    更新日期:2014-12-01 00:00:00

  • Merkel cells in the oral mucosa.

    abstract::Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, ep...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Righi A,Betts CM,Marchetti C,Marucci G,Montebugnoli L,Prati C,Eusebi LH,Muzzi L,Ragazzini T,Foschini MP

    更新日期:2006-07-01 00:00:00

  • Low-Grade, Nonintestinal Nonsalivary Sinonasal Adenocarcinoma Associated With an Exophytic Schneiderian Papilloma: A Case Report.

    abstract::Sinonasal adenocarcinoma is a rare tumor of the head and neck accounting for 10% to 20% of all primary malignancies of the nose and paranasal sinuses. There tumors are classified as salivary, intestinal and nonintestinal, nonsalivary. Low-grade nonintestinal nonsalivary are rare tumors whose diagnosis is essentially t...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Blumberg JM,Escobar-Stein J,Vining EM,Prasad ML

    更新日期:2015-12-01 00:00:00

  • "Missed" diagnoses of phyllodes tumor on breast biopsy: pathologic clues to its recognition.

    abstract::Fibroadenoma and phyllodes tumors of the breast exhibit a continuum of pathologic features. We examined phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumor on the first biopsy specimen. The phyllodes tumors initially called fibroadenoma for features tha...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Yohe S,Yeh IT

    更新日期:2008-04-01 00:00:00