Abstract:
:A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains showed the pigment to be acid fast and periodic acid-Schiff positive and negative for Masson-Fontana melanin stain. Additionally, the pigment displayed brilliant autofluorescence under ultraviolet light of a fluorescent microscope. Ultrastructure examination of the pigment revealed a non-membrane-bound biphasic structure with an electron-dense core and electron-lucent periphery. Only few similar case reports mention such pigmented ependymomas to contain a mixture of neuromelanin and lipofuscin while others mention it to be melanin itself. Our workup suggests the pigment to represent lipofuscin or its derivative. Generally known to be a pigment of wear and tear, the significance of finding it in a tumor with such abundance remains to be understood and explored.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Malhotra A,Rao S,Santhoshkumar R,Muralidharan N,Mitra S,Shetty Sdoi
10.1177/1066896920926700subject
Has Abstractpub_date
2021-02-01 00:00:00pages
80-84issue
1eissn
1066-8969issn
1940-2465journal_volume
29pub_type
杂志文章abstract::A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cy...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
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journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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abstract::Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma th...
journal_title:International journal of surgical pathology
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journal_title:International journal of surgical pathology
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