A leukemic presentation of alveolar rhabdomyosarcoma in a 52-year-old woman without an identifiable primary tumor.

Abstract:

:A 52-year-old woman presented with fatigue and thrombocytopenia. Imaging studies were unremarkable with the exception of a positron emission tomography scan, which demonstrated intense F-18 fluorodeoxyglucose uptake fusing to the marrow. A bone marrow aspirate was notable for large discohesive cells with basophilic cytoplasm, and flow cytometric analysis identified a population of phenotypically unusual cells that coexpressed CD56 and CD71. Immunohistochemical findings in the marrow biopsy demonstrated that the neoplasm was alveolar rhabdomyosarcoma, further supported by the presence of a t(2;13). This unusual case demonstrates that leukemic presentations of rhabdomyosarcoma can occur in older adults in the absence of an identifiable primary tumor.

journal_name

Int J Surg Pathol

authors

Kern JB,Hii A,Kruse MJ,Szabo Z,Argani P,Hibbard MK,Gladstone DE,Meyer C,Zheng R,Borowitz MJ,Duffield AS

doi

10.1177/1066896914553666

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

75-7

issue

1

eissn

1066-8969

issn

1940-2465

pii

1066896914553666

journal_volume

23

pub_type

杂志文章
  • Frequency of clinically occult intraepithelial and invasive neoplasia in reduction mammoplasty specimens: a study of 516 cases.

    abstract::Reduction mammoplasty is a frequently performed procedure for the treatment of macromastia and for the achievement of symmetry in breast cancer patients following lumpectomy. Slides from 516 consecutive bilateral reduction mammoplasties performed for macromastia over 15 years were reviewed. Among these, 92 (18%) low-r...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907307176

    authors: Dotto J,Kluk M,Geramizadeh B,Tavassoli FA

    更新日期:2008-01-01 00:00:00

  • Colorectal liver metastasis with intrabiliary growth: case report and review of the literature.

    abstract::Colorectal liver metastases with intrabiliary growth are uncommon and difficult to characterize by radiology alone. We present the case of a 61-year-old woman previously operated on for a left colon cancer who developed a metacronous lesion at liver segment II-III. Radiologic workup was indicative for cholangiocarcino...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896913491317

    authors: Coppola S,Zucchini N,Romano F,Bovo G,Gilardoni E,Nespoli L,Gianotti L

    更新日期:2014-05-01 00:00:00

  • Cystic Squamous Cell Carcinomas of the Jaws: Twelve Cases Highlighting Histopathological Pitfalls.

    abstract::Cystic squamous cell carcinomas (SCCs) of the jaws, including carcinoma cuniculatum, are rare, slow growing, and relentlessly invasive. The aim of this article is to present 12 cases, 4 of which were designated as carcinoma cuniculatum on the basis of deeply endophytic, anastomosing channels of cystic stratified squam...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920903388

    authors: Barrett AW,Garg M,Armstrong D,Bisase BS,Newman L,Norris PM,Shelley M,Tighe JV,Hyde NC,Chaston NJ,Gulati A

    更新日期:2020-09-01 00:00:00

  • Cutaneous melanoma metastatic to uterine adenomyoma: report of a case.

    abstract::Rare cases of metastasis to uterine polyps have been reported in English literature but not, to the best of our knowledge, to uterine adenomyomas. All these cases are represented by breast cancer, most of them involving tamoxifen-associated polyps. We first report a case of cutaneous malignant melanoma metastatic to u...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300217

    authors: Di Tommaso L,Rahal D,Bresciani G,Roncalli M

    更新日期:2005-04-01 00:00:00

  • Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report.

    abstract::Synchronous tumors of the stomach are uncommon. We present a unique case of gastric synchronous tumors composed of signet-ring cell adenocarcinoma and gastrointestinal stromal tumor (GIST). The two tumors arose at the same site and were sharply juxtaposed without intermingling of morphologically distinct elements. Coi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907302369

    authors: Lee FY,Jan YJ,Wang J,Yu CC,Wu CC

    更新日期:2007-10-01 00:00:00

  • Primary Leiomyosarcoma of the Ovarian Vein: Case Report and Literature Review.

    abstract::Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relati...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896916679888

    authors: López-Ruiz ME,Yébenes L,Berjón A,Hardisson D

    更新日期:2017-06-01 00:00:00

  • A Practical Approach to Investigating Cross-Contaminants in the Anatomical Pathology Laboratory.

    abstract::Tissue contaminants in anatomical pathology are not uncommon. While issues related to the presence of extraneous tissue on glass slides are often easily resolved, this is not always the case and several factors may contribute to diagnostic difficulty. Because of this, familiarity with the different steps involved in h...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920913110

    authors: Hodgson AJ,Shang YM,Boulianne P,Downes MR,Hwang D,Slodkowska E

    更新日期:2020-10-01 00:00:00

  • The Helpful Role of CD10 and Hormonal Receptors Co-Expression in the Histologic Diagnosis of Catamenial Pneumothorax.

    abstract::The histology in cases of primary spontaneous pneumothorax is generally nonspecific, but a careful examination, taking into account clinical data, may reveal subtle tissue alterations leading to a specific diagnosis in cases that might otherwise be taken as primary and spontaneous. In this article, we describe 3 cases...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919846386

    authors: Mataca E,Rossi G,Colby TV

    更新日期:2019-09-01 00:00:00

  • Angiosarcoma in Collision With a Merkel Cell Carcinoma: Case Report and Literature Review.

    abstract::Merkel cell carcinoma (MCC) is a rare entity that most commonly arises from the skin. Angiosarcoma (AS) is a rare malignancy with a predilection for elderly males, has endothelial differentiation and a notoriously poor prognosis despite aggressive therapy. Herein, we report an angiosarcoma colliding with a MCC, in a p...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896919880260

    authors: Hacking S,Chavaria H,Khan L,Das K

    更新日期:2020-05-01 00:00:00

  • Average Weight of Seminal Vesicles: An Adjustment Factor for Radical Prostatectomy Specimens Weighed With Seminal Vesicles.

    abstract::The International Society of Urological Pathology in 2010 recommended weighing prostates without seminal vesicles (SV) to include only prostate weight in prostate-specific antigen (PSA) density (PSAD) calculation, because SV do not produce PSA. Large retrospective cohorts exist with combined weight recorded that needs...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915600519

    authors: Tjionas GA,Epstein JI,Williamson SR,Diaz M,Menon M,Peabody JO,Gupta NS,Parekh DJ,Cote RJ,Jorda M,Kryvenko ON

    更新日期:2015-12-01 00:00:00

  • Mediastinal germ cell tumor associated with histiocytic sarcoma of spleen: case report of an unusual association.

    abstract::We present an unusual association of mediastinal germ cell tumor containing seminoma and angiosarcoma components and splenic histiocytic sarcoma. A 15-year-old boy presented with chest pain. Histopathologically, an anterior mediastinal mass contained typical seminoma, immature teratoma, embryonal carcinoma, angiosarco...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690501300314

    authors: Song SY,Ko YH,Ahn G

    更新日期:2005-07-01 00:00:00

  • Merkel cells in the oral mucosa.

    abstract::Ninety-eight consecutive surgical biopsies of oral mucosa from 96 patients were evaluated immunohistochemically with an anti-cytokeratin 20 (CK 20) anti-body to evidence Merkel cells (MC). Fifteen cases, showing the highest number of MC, were additionally studied with chromogranin A, S-100 protein, neuro filaments, ep...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896906290053

    authors: Righi A,Betts CM,Marchetti C,Marucci G,Montebugnoli L,Prati C,Eusebi LH,Muzzi L,Ragazzini T,Foschini MP

    更新日期:2006-07-01 00:00:00

  • CD138 Expression Is Observed in the Urothelial Epithelium and in Various Urothelial Carcinomas, and Cannot Be Evidence for Plasmacytoid Urothelial Carcinoma.

    abstract::CD138 (syndecan-1) immunoexpression has been reported to be specific for the plasmacytoid variant of urothelial carcinomas (UCs). The aim of this study was to examine the utility of CD138 immunohistochemistry for diagnosing the plasmacytoid variant of UCs. The extent and intensity of CD138 immunostaining were evaluate...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916653673

    authors: Goto K

    更新日期:2016-10-01 00:00:00

  • Papilliferous keratoameloblastoma of mandible: a papillary ameloblastic carcinoma: report of a case with a 6-year follow-up and review of the literature.

    abstract::We report a fourth case of papilliferous keratoameloblastoma, with a 6-year follow-up. A 62-year-old man underwent resection of a right mandibular neoplasm infiltrating bone and soft tissues. Microscopically, there were cysts lined by papillary projections and containing necrotic debris. Cribriform, solid, and tubular...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/106689690201000210

    authors: Collini P,Zucchini N,Vessecchia G,Guzzo M

    更新日期:2002-04-01 00:00:00

  • Metachronous Uterine Endometrioid Adenocarcinoma and Peritoneal Mesothelioma in Lynch Syndrome: A Case Report.

    abstract::Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma th...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916680745

    authors: Lu Y,Milchgrub S,Khatri G,Gopal P

    更新日期:2017-05-01 00:00:00

  • UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study.

    abstract::The aim of this study was to investigate the role of UbcH10 expression in the differential diagnosis of benign, hyperplastic, and malignant endometrial tissues and also the relationship of UbcH10 with the clinicopathologic parameters of malignant cases. A tissue microarray was performed for 81 endometrial curettage bi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896912437414

    authors: Kefeli M,Yildiz L,Celik H,Tosun M,Karagoz F

    更新日期:2012-08-01 00:00:00

  • Patterns of beta-catenin expression in gastric carcinoma: clinicopathological relevance and mutation analysis.

    abstract::Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690301100102

    authors: Nabais S,Machado JC,Lopes C,Seruca R,Carneiro F,Sobrinho-Simões M

    更新日期:2003-01-01 00:00:00

  • Mixed Intraepithelial Neoplasia-Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination.

    abstract::Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this lo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920986987

    authors: Kővári B,Turkevi-Nagy S,Lauwers GY,Jiang K

    更新日期:2021-01-09 00:00:00

  • Spontaneous complete regression of gastric large-cell neuroendocrine carcinoma: mediated by cytomegalovirus-induced cross-autoimmunity?

    abstract::Spontaneous regression of malignant tumour is a rare phenomenon. This report describes such an occurrence in a gastric large cell neuroendocrine carcinoma of a 77-year-old man. The patient presented with dyspepsia, and biopsy of the fungating mass in the cardia showed a high grade neuroendocrine carcinoma. The pre-ope...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896911404412

    authors: Ip YT,Pong WM,Kao SS,Chan JK

    更新日期:2011-06-01 00:00:00

  • Tumor-to-Tumor Metastasis: Prostate Carcinoma Metastatic to Soft Tissue Sarcoma, a Previously Unreported Event.

    abstract::Tumor-to-tumor metastasis is an unusual phenomenon wherein one distinct malignancy is present within the substance of another independent tumor. This event is rare, difficult to detect with imaging, and, due to conflicting terminology in the literature, can be challenging to classify. This article reports the first do...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919872805

    authors: Miller V,Hoellwarth JS,Hankins ML,McGough R,Schoedel K

    更新日期:2020-04-01 00:00:00

  • Clear cell change in colonic polyps.

    abstract::In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 aden...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908319211

    authors: Eloy C,Lopes JM,Faria G,Moreira H,Brandão A,Silva T,Carneiro F

    更新日期:2009-12-01 00:00:00

  • Clinicopathologic analysis of 4 perivascular epithelioid cell tumors (PEComas) of the gastrointestinal tract.

    abstract::This study describes the clinical, histologic, and immunohistochemical features of four cases of GI PEComa. The size of the tumors ranged from 3.5 to 6.0cm in diameter, and all were located in wall of the large bowel. Microscopically, the tumors were characterized by an epithelioid arrangement of tumor cells, which ha...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908330481

    authors: Shi HY,Wei LX,Sun L,Guo AT

    更新日期:2010-08-01 00:00:00

  • Goblet cell carcinoid of the appendix: a clinicopathological and immunohistochemical study of 26 cases from southwest china.

    abstract::Goblet cell carcinoid (GCC) of the appendix is characterized by a dual differentiation of both endocrine and gland. This study, therefore, explores its clinicopathological and immunohistochemical features. The authors reviewed clinicopathological and immunohistochemical features of 26 GCC cases in Southwest China betw...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896910379404

    authors: Yong Jiang,Huawei Liu,Hu Long,Yingying Yang,Dianying Liao,Xiuhui Zhang

    更新日期:2010-12-01 00:00:00

  • Spitz Tumors: Comparison of Histological Features in Relationship to Immunohistochemical Staining for ALK and NTRK1.

    abstract::Spitz tumors are a group of melanocytic neoplasms with distinct morphological features that tend to affect young individuals. Distinguishing benign from malignant Spitz tumors can be challenging, but cytogenetic and molecular tests have contributed to improvements in diagnostic accuracy. Spitz tumors harbor diverse ge...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916630375

    authors: Kiuru M,Jungbluth A,Kutzner H,Wiesner T,Busam KJ

    更新日期:2016-05-01 00:00:00

  • Crystalloid Granuloma of Parotid Gland: A Case Report With Review of the Literature.

    abstract::Crystalloid granuloma (CG) of salivary gland is an extremely rare inflammatory disease, and only 6 cases have been reported in the English literature. CG is histologically characterized by a granulomatous reaction to amylase crystalloid deposition. A 73-year-old woman presented with a painful left neck mass. Computed ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896918791031

    authors: Motoda N,Onda M,Nakamizo M,Ohashi R,Okubo K,Naito Z

    更新日期:2019-04-01 00:00:00

  • Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma.

    abstract::The aim of this study was to investigate protein expression of adenomatous polyposis coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of beta-catenin and E-cadherin was additionally analyzed. One hundred and thirteen primary (n = 56) and metastatic (n = 57) lesions were immunohistochemical...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690201000302

    authors: Karbova E,Davidson B,Metodiev K,Tropé CG,Nesland JM

    更新日期:2002-07-01 00:00:00

  • Well-differentiated chondrosarcoma of the humerus with prominent granular cell component: a hitherto unreported occurrence.

    abstract::We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types,...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690601400211

    authors: Cremonini A,Kuhn E,De Biase P,Franchi A

    更新日期:2006-04-01 00:00:00

  • Diagnostic Challenge of Sarcomatoid Variant of ALK-Positive Anaplastic Large Cell Lymphoma: Case Report and Updated Systematic Literature Review.

    abstract::The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920986967

    authors: Song F,Yu S,Jia M,Gao H,Sun PL

    更新日期:2021-01-11 00:00:00

  • Ameloblastic Fibrosarcoma of the mandible evolving from a prior Ameloblastic Fibroma after two years: an unusual finding.

    abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896916646448

    authors: Bertoni F,Del Corso G,Bacchini P,Marchetti C,Tarsitano A

    更新日期:2016-10-01 00:00:00

  • The histopathology of pediatric celiac disease: order must prevail out of chaos.

    abstract::The role of histopathology for diagnosing celiac disease (CD) has been recently challenged. However, based in our experience with roughly 4,600 distal duodenal and jejunal biopsies in children it is apparent that appropriate biopsy site, handling, processing, and microscopic evaluation result in a consistent pattern o...

    journal_title:International journal of surgical pathology

    pub_type: 社论

    doi:10.1177/106689690100900401

    authors: Drut R,Rúa EC

    更新日期:2001-10-01 00:00:00