Angiosarcoma in Collision With a Merkel Cell Carcinoma: Case Report and Literature Review.

Abstract:

:Merkel cell carcinoma (MCC) is a rare entity that most commonly arises from the skin. Angiosarcoma (AS) is a rare malignancy with a predilection for elderly males, has endothelial differentiation and a notoriously poor prognosis despite aggressive therapy. Herein, we report an angiosarcoma colliding with a MCC, in a patient with a past medical history of squamous cell carcinoma, status-post radiation therapy. More specifically, our case represents a collision tumor, a rare entity composed of two histologically distinct neoplasms which coincide together at the same location. This case represents the first documented report of such a presentation. With that being said, its clinical course, prognosis, pathogenesis, and molecular profile, currently remains unclear. Importantly, neoplasms are increasingly being found to be associated with radiation therapy, of which our patient had received. Ultimately, however, with the lack of c-MYC immunohistochemical staining, and a short duration between radiation exposure and presentation, the AS in our case was likely coincidental.

journal_name

Int J Surg Pathol

authors

Hacking S,Chavaria H,Khan L,Das K

doi

10.1177/1066896919880260

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

325-329

issue

3

eissn

1066-8969

issn

1940-2465

journal_volume

28

pub_type

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