Cutaneous melanoma metastatic to uterine adenomyoma: report of a case.

Abstract:

:Rare cases of metastasis to uterine polyps have been reported in English literature but not, to the best of our knowledge, to uterine adenomyomas. All these cases are represented by breast cancer, most of them involving tamoxifen-associated polyps. We first report a case of cutaneous malignant melanoma metastatic to uterine adenomyoma. A computed tomography scan did not reveal any further evidence of disease, suggesting that this metastatic localization may represent something more than a fortuitous case. Based on these observations it is suggested that a subset of malignant melanoma and breast cancer cells share a sort of "homing'' phenomenon to polypoid lesions of uterus, due probably to the presence of some chemokines and their specific receptors. Pathologists should be aware of this possibility in order to look carefully for metastatic implants in similar lesions. It is proposed that chemokine profile of neoplastic cells can be a useful tool in predicting metastatic targets.

journal_name

Int J Surg Pathol

authors

Di Tommaso L,Rahal D,Bresciani G,Roncalli M

doi

10.1177/106689690501300217

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

223-5

issue

2

eissn

1066-8969

issn

1940-2465

journal_volume

13

pub_type

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