Primary Mixed Adenoneuroendocrine Carcinoma of the Gallbladder in a 55-Year-Old Female Patient: A Case Report and Review of the Literature.

Abstract:

:Mixed adenoneuroendocrine carcinomas (MANECs) of the biliary tract are rare tumors, and to date only a few cases arising in the gallbladder have been reported. Their histogenesis is a matter of debate, since the biliary tract normally lacks neuroendocrine cells. However, the immunohistochemical identification of nonneoplastic neuroendocrine cells in both biliary adenocarcinomas and intestinal metaplasia has been documented. Here we report a case of a 55-year-old female patient presenting with right upper quadrant pain, cholelithiasis, and a gallbladder mass identified after cholecystectomy. The histopathologic examination showed a MANEC, composed of an intestinal-type adenocarcinoma and a large cell neuroendocrine carcinoma, arising in a background of enteric metaplasia with extensive high-grade dysplasia. Moreover, we report the presence of focal pancreatic intraepithelial neoplasia-like epithelial lesions, which has not been described for these tumors yet. The histopathologic features of this case provide further support for the theory that MANECs arise following a metaplasia-dysplasia-carcinoma pathway.

journal_name

Int J Surg Pathol

authors

Acosta AM,Hamedani FS,Kajdacsy-Balla A,Wiley EL

doi

10.1177/1066896915580433

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

414-8

issue

5

eissn

1066-8969

issn

1940-2465

pii

1066896915580433

journal_volume

23

pub_type

杂志文章,评审
  • Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge.

    abstract::A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor wit...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920928584

    authors: Govender D,Jackson C,Chetty D

    更新日期:2021-02-01 00:00:00

  • Adenomatous polyposis coli (APC) protein expression in primary and metastatic serous ovarian carcinoma.

    abstract::The aim of this study was to investigate protein expression of adenomatous polyposis coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of beta-catenin and E-cadherin was additionally analyzed. One hundred and thirteen primary (n = 56) and metastatic (n = 57) lesions were immunohistochemical...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/106689690201000302

    authors: Karbova E,Davidson B,Metodiev K,Tropé CG,Nesland JM

    更新日期:2002-07-01 00:00:00

  • Squamous metaplasia on the breast implant capsule.

    abstract::The development of squamous metaplasia or carcinoma is a rare occurrence in the setting of a ruptured or leaking silicone breast implant capsule. However, the oncogenic process in such a context is yet another intriguing example of how chronic inflammation plays an integral role in the tumorigenic process. Recent pape...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908329587

    authors: Alikhan MB,Nassar A,Mansoor I

    更新日期:2010-12-01 00:00:00

  • Diagnostic Challenge of Sarcomatoid Variant of ALK-Positive Anaplastic Large Cell Lymphoma: Case Report and Updated Systematic Literature Review.

    abstract::The sarcomatoid variant of anaplastic large cell lymphoma is an extremely rare histologic pattern of anaplastic large cell lymphoma that consists of spindle-shaped neoplastic cells and is easily misdiagnosed as a soft tissue sarcoma. We report a case of the sarcomatoid variant of anaplastic large cell lymphoma that wa...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920986967

    authors: Song F,Yu S,Jia M,Gao H,Sun PL

    更新日期:2021-01-11 00:00:00

  • Comparison of biochemical recurrence-free survival between periprostatic and pelvic lymph node metastases of prostate cancer.

    abstract:OBJECTIVE:To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis. M...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896913482729

    authors: González-Roibón N,Han JS,Lee S,Feng Z,Arslankoz S,Smith N,Pierorazio PM,Humphreys E,Deweese TL,Partin AW,Bivalacqua TJ,Han M,Trock B,Netto GJ

    更新日期:2013-08-01 00:00:00

  • Coexistence of Malakoplakia and Papillary Urothelial Carcinoma of the Urinary Bladder.

    abstract::Malakoplakia is a rare granulomatous disease that commonly involves the genitourinary tract, with the urinary bladder being the most frequently affected site. Grossly, malakoplakia can present as soft yellow plaques, nodules, bladder mass, or even without any visible lesion. In this article, we present a 74-year-old f...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915595464

    authors: Lee SL,Teo JK,Lim SK,Salkade HP,Mancer K

    更新日期:2015-10-01 00:00:00

  • Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrence.

    abstract::A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907304519

    authors: Vij K,Wang HL

    更新日期:2008-04-01 00:00:00

  • "Missed" diagnoses of phyllodes tumor on breast biopsy: pathologic clues to its recognition.

    abstract::Fibroadenoma and phyllodes tumors of the breast exhibit a continuum of pathologic features. We examined phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumor on the first biopsy specimen. The phyllodes tumors initially called fibroadenoma for features tha...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907311378

    authors: Yohe S,Yeh IT

    更新日期:2008-04-01 00:00:00

  • Acinar cell carcinoma with prominent intraductal growth pattern: case report and review of the literature.

    abstract::Acinar cell carcinoma of the pancreas is rare, accounting for less than 1% of carcinomas arising in the exocrine pancreas. Patients are typically between the fifth and seventh decade of life and show a 2:1 male predominance. Symptoms tend to be nonspecific, and approximately 50% of the patients have metastases at the ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896909339912

    authors: Toll AD,Mitchell D,Yeo CJ,Hruban RH,Witkiewicz AK

    更新日期:2011-12-01 00:00:00

  • Combined carcinoid tumor and squamous cell carcinoma of lung: expanding the spectrum of combined tumors of lung.

    abstract::Combined lung cancers containing both small cell and non-small cell carcinoma elements are uncommon but well recognized. Lung tumors with neuroendocrine differentiation form a group of histologically distinct tumors with differing clinical behavior ranging from low-grade tumors with good prognosis (typical carcinoid) ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896910397883

    authors: Owens CL,Fraire AE

    更新日期:2011-04-01 00:00:00

  • Mixed Intraepithelial Neoplasia-Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination.

    abstract::Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this lo...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920986987

    authors: Kővári B,Turkevi-Nagy S,Lauwers GY,Jiang K

    更新日期:2021-01-09 00:00:00

  • Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in a Warthin Tumor: Case Report and Literature Review.

    abstract::Warthin tumor is the second most common salivary gland neoplasm. It occurs more commonly in males than in females. Malignant transformation in Warthin tumor is a rare but well-recognized phenomenon; however, the development or presentation of lymphoma in a Warthin tumor is rare. An 80-year-old man presented with painl...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896917734371

    authors: Jawad H,McCarthy P,O'Leary G,Heffron CC

    更新日期:2018-05-01 00:00:00

  • Metaplastic thymoma: report of an unusual thymic epithelial neoplasm arising in the wall of a thymic cyst.

    abstract::In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the th...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896908315754

    authors: Poorabdollah M,Mehdizadeh E,Mohammadi F,Sabeti S

    更新日期:2009-02-01 00:00:00

  • Sinonasal rhabdomyosarcoma in children and young adults.

    abstract::Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 ca...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896906299122

    authors: Ahmed AA,Tsokos M

    更新日期:2007-04-01 00:00:00

  • Palisaded Encapsulated (Solitary Circumscribed) Neuroma: A Review of 30 Cases.

    abstract::Background. Solitary circumscribed neuroma (SCN), also known as palisaded encapsulated neuroma (PEN), is a benign neural tumor. It may be mistaken as either schwannoma or neurofibroma in pathology practice. In this study, we aimed to define clinicopathologic and immunohistochemical features and discuss its differentia...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919833172

    authors: Leblebici C,Savli TC,Yeni B,Cin M,Aksu AEK

    更新日期:2019-08-01 00:00:00

  • Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma.

    abstract::The role and diagnostic efficacy of gene and protein products RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A, all previously shown to be involved in tumor genesis and cell proliferation, were examined by immunohistochemical techniques in 32 cases of myxofibrosarcomas and 29 myxoid liposarcomas (all diagnosis had been confirme...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896914532539

    authors: Wang T,Goodman MA,McGough RL,Weiss KR,Rao UN

    更新日期:2014-10-01 00:00:00

  • Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case, With Review of the Literature.

    abstract::Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English li...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896916644782

    authors: Mitra S,Kaur G,Nada R,Mohindra S

    更新日期:2016-09-01 00:00:00

  • Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall.

    abstract::Mesonephric adenocarcinoma is a rare tumor type that is usually found in areas where the Wolffian duct was present during the fetal period. We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-c...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896915611489

    authors: Kim SS,Nam JH,Kim GE,Choi YD,Choi C,Park CS

    更新日期:2016-04-01 00:00:00

  • Synchronous gastric gastrointestinal stromal tumor and signet-ring cell adenocarcinoma: a case report.

    abstract::Synchronous tumors of the stomach are uncommon. We present a unique case of gastric synchronous tumors composed of signet-ring cell adenocarcinoma and gastrointestinal stromal tumor (GIST). The two tumors arose at the same site and were sharply juxtaposed without intermingling of morphologically distinct elements. Coi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907302369

    authors: Lee FY,Jan YJ,Wang J,Yu CC,Wu CC

    更新日期:2007-10-01 00:00:00

  • Pathologic and clinical features of Hodgkin lymphoma--like posttransplant lymphoproliferative disease.

    abstract::Because of its rarity, pathologic and clinical features of Hodgkin lymphoma-like posttransplant lymphoproliferative disorder (HL-like PTLD) are not well understood, and it is unclear whether its biological behavior is more closely related to classical Hodgkin disease or to monomorphic B-cell PTLD. The authors compared...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896909338597

    authors: Krishnamurthy S,Hassan A,Frater JL,Paessler ME,Kreisel FH

    更新日期:2010-08-01 00:00:00

  • A case of clear cell meningioma with tyrosine-rich crystals.

    abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896912470165

    authors: Schollenberg E,Easton AS

    更新日期:2013-08-01 00:00:00

  • Synovial Sarcoma Mimicking Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts: A Case Report.

    abstract::Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade hi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917723463

    authors: Gupta N,Kenan S,Kahn LB

    更新日期:2018-02-01 00:00:00

  • A Novel Case of Mammary-Type Myofibroblastoma With Sarcomatous Features.

    abstract::Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. In this article, we present a novel case of MFB arising in the left breas...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920947465

    authors: Strait AM,Linos K,Tafe LJ,Muller KE

    更新日期:2020-08-05 00:00:00

  • A Sclerosing Perineurioma With Collagen Rosette Formation: Benign Mimic of Low-Grade Fibromyxoid Sarcoma.

    abstract::We report the case of a sclerosing perineurioma with conspicious collagen rosette formation in a 20-year-old male presenting with a firm, painless nodule on the palmar side of his right ring finger. The main differential diagnosis is a low-grade fibromyxoid sarcoma. The distinction between these entities is important ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896917741551

    authors: Creytens D,Ferdinande L,Van Dorpe J

    更新日期:2018-04-01 00:00:00

  • A Practical Approach to Investigating Cross-Contaminants in the Anatomical Pathology Laboratory.

    abstract::Tissue contaminants in anatomical pathology are not uncommon. While issues related to the presence of extraneous tissue on glass slides are often easily resolved, this is not always the case and several factors may contribute to diagnostic difficulty. Because of this, familiarity with the different steps involved in h...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920913110

    authors: Hodgson AJ,Shang YM,Boulianne P,Downes MR,Hwang D,Slodkowska E

    更新日期:2020-10-01 00:00:00

  • Association of NET-1 gene expression with human hepatocellular carcinoma.

    abstract::NET-1 is a member of the NET-x family. To explore the potential role of NET-1 in hepatocellular carcinoma (HCC), the expression of NET-1 and the relationship with HCC were examined for the first time. We found that NET-1 was frequently expressed in HCC and the peritumor tissue. The relative amounts of NET-1 mRNA in HC...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896907306083

    authors: Chen L,Wang Z,Zhan X,Li DC,Zhu YY,Zhu J

    更新日期:2007-10-01 00:00:00

  • Pigmented Ependymoma of the Fourth Ventricle-A Curious Entity: Report of a Rare Case With Review of Literature.

    abstract::A 16-year-old boy presented with a tumor located in fourth ventricle, which showed histological features of an ependymoma replete with perivascular pseudorosettes and true ependymal rosettes. Interestingly, many of the tumor cells exhibited abundant cytoplasm stuffed with a grayish brown pigment. Histochemical stains ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896920926700

    authors: Malhotra A,Rao S,Santhoshkumar R,Muralidharan N,Mitra S,Shetty S

    更新日期:2021-02-01 00:00:00

  • Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.

    abstract:BACKGROUND:In this study, we retrospectively evaluated cases of patients who had undergone appendectomy in our hospital and aimed to present the efficiency of diagnostic tests and demographic data of cases. Pathological reports were analyzed for the following parameters: age, gender, and pathological diagnosis. In addi...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896918784650

    authors: Unver N,Coban G,Arıcı DS,Buyukpınarbasılı N,Gucin Z,Malya FÜ,Onaran OI,Topalan K

    更新日期:2019-04-01 00:00:00

  • Intra-Alveolar Intestinal Epithelium: A Reappraisal of the So-Called Mucinous Goblet-Cell Rich Carcinoma Apropos of Two Cases With Prolonged Follow-up and Literature Review.

    abstract::Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. Some of these lesions display a morphologic pattern characterized by paucicellular discontinuou...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审

    doi:10.1177/1066896915568992

    authors: Jessurun J

    更新日期:2015-05-01 00:00:00

  • The Helpful Role of CD10 and Hormonal Receptors Co-Expression in the Histologic Diagnosis of Catamenial Pneumothorax.

    abstract::The histology in cases of primary spontaneous pneumothorax is generally nonspecific, but a careful examination, taking into account clinical data, may reveal subtle tissue alterations leading to a specific diagnosis in cases that might otherwise be taken as primary and spontaneous. In this article, we describe 3 cases...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章

    doi:10.1177/1066896919846386

    authors: Mataca E,Rossi G,Colby TV

    更新日期:2019-09-01 00:00:00