Abstract:
:Mixed adenoneuroendocrine carcinomas (MANECs) of the biliary tract are rare tumors, and to date only a few cases arising in the gallbladder have been reported. Their histogenesis is a matter of debate, since the biliary tract normally lacks neuroendocrine cells. However, the immunohistochemical identification of nonneoplastic neuroendocrine cells in both biliary adenocarcinomas and intestinal metaplasia has been documented. Here we report a case of a 55-year-old female patient presenting with right upper quadrant pain, cholelithiasis, and a gallbladder mass identified after cholecystectomy. The histopathologic examination showed a MANEC, composed of an intestinal-type adenocarcinoma and a large cell neuroendocrine carcinoma, arising in a background of enteric metaplasia with extensive high-grade dysplasia. Moreover, we report the presence of focal pancreatic intraepithelial neoplasia-like epithelial lesions, which has not been described for these tumors yet. The histopathologic features of this case provide further support for the theory that MANECs arise following a metaplasia-dysplasia-carcinoma pathway.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Acosta AM,Hamedani FS,Kajdacsy-Balla A,Wiley ELdoi
10.1177/1066896915580433subject
Has Abstractpub_date
2015-08-01 00:00:00pages
414-8issue
5eissn
1066-8969issn
1940-2465pii
1066896915580433journal_volume
23pub_type
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journal_title:International journal of surgical pathology
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