Mesonephric Adenocarcinoma of the Uterine Corpus: A Case Report and Diagnostic Pitfall.


:Mesonephric adenocarcinoma is a rare tumor type that is usually found in areas where the Wolffian duct was present during the fetal period. We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-cm-sized irregular thickening and enhancement of the uterine body. The diagnosis following endometrial curettage biopsy was endometrioid adenocarcinoma, and the patient underwent a total hysterectomy with bilateral salpingo-oophorectomy. The tumor was composed of small tubular and ductal components, and a retiform appearance was also observed in the deeper areas. The tumor cells were immunopositive for cytokeratin, vimentin, CD10 with a luminal staining pattern, PAX2, and PAX8, and immunonegative for estrogen receptor and progesterone receptor, which was consistent with tumor of mesonephric origin. Mesonephric neoplasms reveal relatively low-grade nuclear feature, characteristic immunoprofiles (immunonegative for ER and PR, and immunopositive for CD10, PAX2, PAX8, and GATA3), and unique tumor location (myometrium), whereas Müllerian neoplasms such as endometrial adenocarcinoma show various morphology, immunopositivity for ER and PR, and primarily endometrial location. As described above, an integration of the clinical features, morphologic characteristics, and immunohistochemical profiles is needed to make a diagnosis.


Int J Surg Pathol


Kim SS,Nam JH,Kim GE,Choi YD,Choi C,Park CS




Has Abstract


2016-04-01 00:00:00














  • Primary CNS Nonamyloidogenic Light Chain Deposition Disease: Case Report and Brief Review.

    abstract::The true incidence of light chain deposition disease (LCDD) restricted to the central nervous system (CNS) is unknown. To our knowledge only 7 cases of LCDD restricted to the brain have been previously reported. We herein describe an unusual example. A 44-year-old man presented with a history of ischemic retinopathy i...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Mercado JJ,Markert JM,Meador W,Chapman P,Perry A,Hackney JR

    更新日期:2017-12-01 00:00:00

  • Adenocarcinoma-Papillary Cystic Pattern Arising in a Mixed Squamous and Glandular Papilloma of the Lung.

    abstract::Mixed squamous and glandular papilloma (mixed papilloma) of the lung has been reported in fewer than 25 cases in the English literature. Although it is known as a benign tumor, malignant transformation has been reported. Papillary cystic carcinoma is characterized by papillary and cystic growth patterns and has been r...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: An AR,Park SY,Kim JH,Chae KJ,Chung MJ

    更新日期:2020-09-01 00:00:00

  • Utility of Additional Tissue Sections in Surgical Pathology.

    abstract:BACKGROUND:To avoid diagnostic errors such as missed diagnosis and errors in staging tumors due to inadequate tissue sampling, pathologists submit additional sections (AS). OBJECTIVE:This study assessed frequency, diagnostic yield, distribution, and cost of AS. METHOD:Among 1542 AS cases, we calculated mean AS per ca...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Hamza A,Alrajjal A,Edens J,Khawar S,Khurram MS,Szpunar S,Bonnett M

    更新日期:2018-08-01 00:00:00

  • Metaplastic thymoma: report of an unusual thymic epithelial neoplasm arising in the wall of a thymic cyst.

    abstract::In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the th...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Poorabdollah M,Mehdizadeh E,Mohammadi F,Sabeti S

    更新日期:2009-02-01 00:00:00

  • Displaced epithelium after liposuction for gynecomastia.

    abstract::The authors describe the case of a 36-year-old man with gynecomastia who was previously treated with liposuction of the breast for cosmetic purposes. Histologic examination of a subsequent excisional biopsy revealed nests of displaced epithelial cells in adipose tissue. Epithelial cell displacement is a well-known ris...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: McLaughlin CS,Petrey C,Grant S,Ransdell JS,Reynolds C

    更新日期:2011-08-01 00:00:00

  • Lymphoplasmacyte-Rich Meningioma With Atypical Angiomatous Feature and an Increased Deposition of IgG4-Positive Plasma Cells: An Unusual Case Report.

    abstract::Lymphoplasmacyte-rich meningioma (LPRM) is an extremely rare variant of meningioma, and a small percentage of LPRM may be associated with IgG4-related disease. To date, the coexistence of 2 rare meningioma variants consisting of LPRM and angiomatous meningioma within one neoplasm has not been reported in the literatur...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Son HJ,Yu IK,Kim SM

    更新日期:2018-02-01 00:00:00

  • Fuzeon-induced collagenophagic granuloma: a peculiar granulomatous injection site reaction to Fuzeon--a case report and review of literature.

    abstract::Enfuvirtide (ENF, T-20, or Fuzeon [Hoffman-La Roche Inc, Nutley, NJ, and Trimeris, Inc, Durham, NC]) is an HIV-1 fusion inhibitor and is the only injectable antiretroviral drug available. Injection site reactions (ISRs) are the most frequently reported adverse events, occurring in about 98% of patients. A granuloma an...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Sidhu HK,Chaffee BH,Tvetenstrand CD,Sidhu JS

    更新日期:2010-10-01 00:00:00

  • Atypical adenomatous hyperplasia (adenosis) of the prostate: DNA ploidy analysis and immunophenotype.

    abstract::Atypical adenomatous hyperplasia (AAH) of the prostate is a microscopic proliferation of small acini that may be mistaken for adenocarcinoma. Although some data suggest that AAH is associated with adenocarcinoma arising in the transition zone, the clinical significance of this lesion is uncertain. Therefore we studied...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Lopez-Beltran A,Qian J,Montironi R,Luque RJ,Bostwick DG

    更新日期:2005-04-01 00:00:00

  • Testicular juvenile granulosa cell tumor in a newborn: case report and review of the literature.

    abstract::Juvenile granulosa cell tumor of the testis of neonates and infants is an uncommon lesion frequently associated with abnormal sex chromosome and ambiguous genitalia. This report describes a juvenile granulosa cell tumor arising in the testis of a neonate. Chromosome analysis of the tumor showed a normal male karyotype...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Alexiev BA,Alaish SM,Sun CC

    更新日期:2007-07-01 00:00:00

  • The histopathology of pediatric celiac disease: order must prevail out of chaos.

    abstract::The role of histopathology for diagnosing celiac disease (CD) has been recently challenged. However, based in our experience with roughly 4,600 distal duodenal and jejunal biopsies in children it is apparent that appropriate biopsy site, handling, processing, and microscopic evaluation result in a consistent pattern o...

    journal_title:International journal of surgical pathology

    pub_type: 社论


    authors: Drut R,Rúa EC

    更新日期:2001-10-01 00:00:00

  • Mid-Esophagus Columnar Metaplasia: What Is the Biopathogenic Pathway?

    abstract::We report a case of metaplastic columnar epithelium in the mid-esophagus in a patient with history of caustic ingestion. A cardiac-type gastric phenotype, with early signs of intestinalization, was confirmed by immunohistochemistry studies (MUC5AC, MUC6, SOX2, and CDX2). Nonmetaplastic mucosa had histologic evidence o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Rolim I,Rodrigues RV,Bettencourt A,Barros R,Camilo V,Dias Pereira A,Almeida R,Chaves P

    更新日期:2017-05-01 00:00:00

  • Immunohistochemical analysis of expressions of RB1, CDK4, HSP90, cPLA2G4A, and CHMP2B is helpful in distinction between myxofibrosarcoma and myxoid liposarcoma.

    abstract::The role and diagnostic efficacy of gene and protein products RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A, all previously shown to be involved in tumor genesis and cell proliferation, were examined by immunohistochemical techniques in 32 cases of myxofibrosarcomas and 29 myxoid liposarcomas (all diagnosis had been confirme...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Wang T,Goodman MA,McGough RL,Weiss KR,Rao UN

    更新日期:2014-10-01 00:00:00

  • Composite Hemangioendothelioma With Neuroendocrine Marker Expression: Report of a "Paraganglioma-Like" Paravertebral Case.

    abstract::Composite hemangioendothelioma is a rare vascular tumor morphologically comprising several distinct vascular components and exhibits a borderline malignant potential. We described the case of a 53-year-old female who presented with an infiltrative mass in the paravertebral soft tissue. The tumor showed discrete nests ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Cheuk W,Shum KS,Ng WK,Chan JKC

    更新日期:2020-10-01 00:00:00

  • Tissue microarrays in diffuse large B-cell lymphomas: are they really able to identify distinct prognostic groups in lymphomas of both nodal and extranodal origin?

    abstract:AIMS:Diffuse large B-cell lymphomas (DLBCL) can be divided into different subgroups (germinal center B-cell-like [GCB] and non-GCB) according to their gene expression profiles. Immunohistochemistry has been proposed as a surrogate for identifying these subgroups, but data about its efficacy in providing prognostic info...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Laszlo D,Pruneri G,Andreola G,Radice D,Calabrese L,Rafaniello PR,Nassi L,Sammassimo S,Alietti A,Agazzi A,Vanazzi A,Martinelli G

    更新日期:2011-08-01 00:00:00

  • Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid Leukemia.

    abstract::Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Rowan DJ,Logunova V,van Tuinen P,Olteanu H,Peterson JF

    更新日期:2017-02-01 00:00:00

  • IMP3 Is Strongly Expressed in Malignant Phyllodes Tumors of the Breast: An Immunohistochemical Study.

    abstract:BACKGROUND:Phyllodes tumors (PTs) of the breast are rare biphasic neoplasms and are classified as benign, borderline, or malignant. Many biological markers have been studied to discriminate between different grades of PTs. IMP3 is a member of the insulin-like growth factor II mRNA binding protein (IMP) family and is ex...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Bellezza G,Prosperi E,Del Sordo R,Colella R,Rulli A,Sidoni A

    更新日期:2016-02-01 00:00:00

  • Spermatocytic Tumor With Sarcoma: A Rare Testicular Neoplasm.

    abstract::Spermatocytic tumor, formerly known as spermatocytic seminoma, is an uncommon testicular neoplasm which is a distinct clinicopathologic entity from classic seminoma. These tumors are not associated with germ cell neoplasia in situ, other germ cell tumors, or isochromosome 12p. Although typically, these tumors have an ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Stueck AE,Grantmyre JE,Wood LA,Wang C,Merrimen J

    更新日期:2017-09-01 00:00:00

  • Warthin Tumor-Like Mucoepidermoid Carcinoma.

    abstract::Mucoepidermoid carcinoma (MEC) shows a wide morphologic spectrum, including epithelium with oncocytic or squamous metaplastic changes overlying a prominent cystic architecture, as well as tumor-associated lymphoid tissue. We illustrate a case of MEC of the parotid in a 17-year-old female, in which all these features o...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Heatley N,Harrington KJ,Thway K

    更新日期:2018-02-01 00:00:00

  • IgG4-positive sclerosing cholangitis following autoimmune pancreatitis with deranged CA19.9.

    abstract::Sclerosing cholangitis is an autoimmune condition characterized by lymphocytic infiltration within the biliary epithelium leading to multifocal stricturing of the biliary tree. Primary sclerosing cholangitis (PSC) is the most common type encountered clinically. However, a similar process may occur in conjunction with ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Ong SL,Garcea G,Puls F,Richards C,Mulcahy K,Grant A,Dennison AR,Berry DP

    更新日期:2011-02-01 00:00:00

  • Xp11.2 Translocation renal cell carcinomas have a poorer prognosis than non-Xp11.2 translocation carcinomas in children and young adults: a meta-analysis.

    abstract:OBJECTIVES:Renal cell carcinomas (RCCs) in children and adolescents are much rarer than in adults. In this age group, Xp11.2 translocation RCCs were the most common subtype of pediatric RCCs. Information regarding the clinical behavior of pediatric RCCs remains controversial because of their relatively rare incidence. ...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,meta分析


    authors: Qiu Rao,Bing Guan,Zhou XJ

    更新日期:2010-12-01 00:00:00

  • Mesothelial Cells Within Vascular Transformation of Mediastinal Lymph Node Sinuses: An Unusual Benign Collision Mimicking Colliding Malignancies.

    abstract::Vascular transformation of lymph node sinuses represents a rare benign entity mimicking malignant counterparts such as nodal Kaposi sarcoma. The presence of mildly atypical benign mesothelial cells within nodal sinuses raises the possibility of metastatic malignancy. Herein, a rare case of vascular transformation of l...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Jabbour MN,Tawil AN,Boulos FI

    更新日期:2016-04-01 00:00:00

  • Warty Carcinoma Arising in Condyloma Acuminatum of Urinary Bladder: A Case Report.

    abstract::We describe the case of a 62-year-old man with chronic irritation of the urinary bladder resulting in dysuria and hypogastric pain. Three neoplasms measuring 0.5, 1, and 1.5 cm, respectively, were observed by cystoscopy and removed by transurethral resection (TUR). Histologic examination showed a complex folding of sq...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Botella E,Burgués O,Navarro S,Ramos D,Ferrer J,Gimeno C,Llombart-Bosch A

    更新日期:2000-07-01 00:00:00

  • Microsatellite analysis of early stage (Ia-IIb) uterine cervical squamous carcinoma.

    abstract::Cervical cancer is the most common gynecologic malignancy of the developing world. The oncogenic role of human papilloma virus (HPV) is well known. Attention is now focusing on the complicit genetic changes, which allow progression of these tumors. Regarding these changes, deletion of tumor suppressor genes (loss of h...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Clarke B,Gordon M,Moodley M,Naidoo R,Chetty R

    更新日期:2003-10-01 00:00:00

  • Primary carcinoid tumor of the skin: a literature review.

    abstract::Primary carcinoid tumor of the skin (PCTS) is an uncommon indolent neoplasm, with 10 cases described in the literature. The tumors affect patients in the sixth to ninth decades of life (mean = 66.3 years) with an equal gender distribution and predilection for the head and trunk. They present as slowly enlarging nodule...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Jedrych J,Pulitzer M

    更新日期:2014-04-01 00:00:00

  • Jaw cysts diagnosed in an Italian population over a 20-year period.

    abstract:BACKGROUND:Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age dist...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Del Corso G,Righi A,Bombardi M,Rossi B,Dallera V,Pelliccioni GA,Marchetti C,Foschini MP

    更新日期:2014-12-01 00:00:00

  • The Perivascular Cuff of Large Lymphoid Cells: A Clue to Diagnosis of Anaplastic Large Cell Lymphoma.

    abstract::The small cell and lymphohistiocytic variants of anaplastic large cell lymphoma are commonly misdiagnosed as reactive lymphadenopathies. A helpful histologic clue is the presence of perivascular cuffs of large lymphoid cells, and the diagnosis can be readily confirmed by immunostaining for CD30 and ALK. Int J Surg Pat...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Chan JK

    更新日期:2000-04-01 00:00:00

  • Primary intratesticular spindle cell tumors: interdigitating dendritic cell tumor and inflammatory myofibroblastic tumor.

    abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Nistal M,Gonzalez-Peramato P,Serrano A,Reyes-Mugica M,Cajaiba MM

    更新日期:2011-02-01 00:00:00

  • Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review.

    abstract::Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulm...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章,评审


    authors: Nie L,Zhou C,Wu H,Zhou Q,Meng F

    更新日期:2019-09-01 00:00:00

  • Combination of Adenomyoma and Adenomyomatous Hyperplasia of the Ampullary System: A First Case Report.

    abstract::Adenomyoma and adenomyomatous hyperplasia are benign tumor-like lesions that rarely involve the major or minor duodenal papilla. We report the case of a 73-year-old patient who underwent a cephalic duodenopancreatectomy due to clinical and radiological evidence of underlying malignant neoplasm. The histopathology resu...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Gialamas E,Mormont M,Bagetakos I,Frossard JL,Morel P,Puppa G

    更新日期:2018-10-01 00:00:00

  • Topography of Protein Kinase C βII in Benign and Malignant Melanocytic Lesions.

    abstract:BACKGROUND:Protein kinase C βII promotes melanogenesis and affects proliferation of melanocytic cells but is frequently absent or decreased in melanoma cells in vitro. OBJECTIVE:To investigate PKC-βII expression and spatial distribution within a lesion in various benign and malignant melanocytic proliferations. METHO...

    journal_title:International journal of surgical pathology

    pub_type: 杂志文章


    authors: Krasagakis K,Tsentelierou E,Chlouverakis G,Stathopoulos EN

    更新日期:2017-09-01 00:00:00