A case of clear cell meningioma with tyrosine-rich crystals.

Abstract:

:We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized magenta-colored extracellular deposits. On electron microscopy, these deposits were osmiophilic and "petaloid." The final diagnosis of clear cell meningioma rested on relatively inconspicuous intervening nests of glycogen-containing clear cells that were positive for epithelial membrane antigen. The unusual extracellular deposits seen in this case have previously been characterized as tyrosine-rich crystals of the type most commonly seen in salivary gland tumors. Recognition of this tumor as a clear cell meningioma, despite misleading clinical features and initially challenging histologic findings, is not only a matter of diagnostic accuracy but also imparts important prognostic information.

journal_name

Int J Surg Pathol

authors

Schollenberg E,Easton AS

doi

10.1177/1066896912470165

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

411-2

issue

4

eissn

1066-8969

issn

1940-2465

pii

1066896912470165

journal_volume

21

pub_type

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