Abstract:
:Rhabdomyosarcoma is an aggressive malignant tumor often developing in the head and neck in children. In the sinonasal region, rhabdomyosarcoma constitutes a clinically important group because of the difficulty of surgical resection and its generally poor prognosis. We reviewed the archival pathology materials of 39 cases of rhabdomyosarcoma of the head and neck in children and young adults. The diagnosis was made through light microscopy, immunohistochemistry, electron microscopy, and/or reverse-transcriptase polymerase chain reaction (RT-PCR) molecular testing. We identified 14 tumors in the nose and paranasal sinuses. Patients' ages ranged from 9 to 40 years. Thirteen of the tumors were of the alveolar subtype. In 11 cases, the tumor cells were poorly differentiated, forming a solid alveolar pattern. In 2 cases, there was evidence of rhabdomyoblastic differentiation. Only one case was classified as embryonal rhabdomyosarcoma. A significant number of tumor cells in these cases had clear or vacuolated cytoplasm. Four alveolar rhabdomyosarcoma tumors were tested by RT-PCR; all showed PAX3/FKHR chromosomal translocation. We conclude that sinonasal rhabdomyosarcoma is predominantly of the alveolar subtype and frequently shows clear cells. A review of the literature shows that these tumors carry a poor prognosis, partly because of their parameningeal location and partly because of their "undifferentiated" alveolar histology.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Ahmed AA,Tsokos Mdoi
10.1177/1066896906299122subject
Has Abstractpub_date
2007-04-01 00:00:00pages
160-5issue
2eissn
1066-8969issn
1940-2465pii
15/2/160journal_volume
15pub_type
杂志文章abstract::Infiltrating ductal carcinoma (IDC) occurs frequently in patients with lobular carcinoma in-situ (LCIS). LCIS is not thought to be the direct precursor of the invasive component. The authors analyzed 15 cases of coexisting LCIS and IDC and found ductal carcinoma in situ (DCIS) in 12. The DCIS and IDC were of similar g...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690100900206
更新日期:2001-04-01 00:00:00
abstract::In this article, we report a very rare case of secondary angiosarcoma in a young woman with no prior history of breast cancer who had bilateral prophylactic mastectomies with autologous reconstruction due to a strong family history of breast cancer and BRCA1 gene variant of uncertain significance. The surgery was comp...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920930100
更新日期:2020-06-18 00:00:00
abstract::Colonic perineurioma has been depicted as characterized by a mucosal proliferation of monomorphic spindle perineurial cells leading to an evident separation, distortion, and entrapment of colonic crypts. The authors, however, believe that a sizable subset of the cases differ in that they display only a limited perineu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909350883
更新日期:2010-08-01 00:00:00
abstract::Unlike their cutaneous counterparts, head and neck mucosal malignant melanomas (HNMM) behave much more aggressively and their prognostic markers have not been fully elucidated. Therefore, the aim of this study was to review the clinicopathologic features of a contemporary series of primary HNMM, retrieved from archiva...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911417970
更新日期:2012-02-01 00:00:00
abstract::Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unclear pathogenesis. Collision lesions of CAPNONs with neoplasms are occasionally reported. In this article, we report the first case of collision lesions between CAPNON and rheumatoid nodules (RNs) in a patient with systemic lupus er...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920941939
更新日期:2020-07-15 00:00:00
abstract::We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200105
更新日期:2004-01-01 00:00:00
abstract::Juvenile xanthogranuloma (JXG) is a benign histiocytic disorder usually affecting the head and trunk region of a child. The isolated occurrence of JXG in the penile shaft of a young adult is hitherto unreported. This lesion is amenable to surgical resection although systemic and/or internal visceral involvement can oc...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920916242
更新日期:2020-09-01 00:00:00
abstract::Adenomyoma and adenomyomatous hyperplasia are benign tumor-like lesions that rarely involve the major or minor duodenal papilla. We report the case of a 73-year-old patient who underwent a cephalic duodenopancreatectomy due to clinical and radiological evidence of underlying malignant neoplasm. The histopathology resu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918767561
更新日期:2018-10-01 00:00:00
abstract::Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920964566
更新日期:2020-10-09 00:00:00
abstract::The role of histopathology for diagnosing celiac disease (CD) has been recently challenged. However, based in our experience with roughly 4,600 distal duodenal and jejunal biopsies in children it is apparent that appropriate biopsy site, handling, processing, and microscopic evaluation result in a consistent pattern o...
journal_title:International journal of surgical pathology
pub_type: 社论
doi:10.1177/106689690100900401
更新日期:2001-10-01 00:00:00
abstract::Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916680745
更新日期:2017-05-01 00:00:00
abstract::Diaphragm disease of small intestine usually presents with nonspecific clinical features. Radiological investigations often fail to differentiate it from small intestinal tumors and inflammatory bowel disease. It is therefore diagnosed on final histology after surgical resection. We hereby report an interesting case o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914563392
更新日期:2015-06-01 00:00:00
abstract::In this article, we report the case of a 40-year-old woman with a sessile polyp of the rectosigmoid junction that underwent endoscopic resection. The resected specimen showed spindle cell proliferation with eosinophilic cytoplasm between mucosal crypts, mimicking mucosal prolapse syndrome. However, these were immunohi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918818897
更新日期:2019-08-01 00:00:00
abstract::A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor wit...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920928584
更新日期:2021-02-01 00:00:00
abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896911424898
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Cysts of the jaws (JCs) are an important topic of oral pathology, but few epidemiological data are present in the literature, in particular about the potential of recurrence. The aim of this study was to describe a case series of JCs from a single institution, evaluating the frequency, the site, the age dist...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914541000
更新日期:2014-12-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896919880260
更新日期:2020-05-01 00:00:00
abstract::Verruciform xanthoma is a rare benign verrucopapillary lesion that develops in the oral mucosa and genital skin. Its development in the esophagus is extremely rare, with only 5 reported cases. We present 2 cases of verruciform xanthoma of the esophagus. Case 1 involved a 91-year-old woman, who had hypertension and chr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896919879495
更新日期:2020-05-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300207
更新日期:2005-04-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912454918
更新日期:2013-04-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896916630375
更新日期:2016-05-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896919846386
更新日期:2019-09-01 00:00:00
abstract::Carcinomas in the breast with a predominantly clear cytoplasm are rare. In this article, we review the differential diagnosis of clear cell breast neoplasms and report a case of invasive lobular carcinoma with extensive clear cell morphology that was diagnosed as invasive ductal carcinoma, not otherwise specified, on ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919881705
更新日期:2020-04-01 00:00:00
abstract::Microvillous inclusion disease (MVID) is a congenital condition presenting with intractable diarrhea. Biopsies demonstrate abnormal apical PAS and CD10 staining in surface enterocytes correlating with the presence of characteristic cytoplasmic inclusions. MVID has been linked to mutations in myosin Vb, important in ap...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911430959
更新日期:2012-06-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323505
更新日期:2011-02-01 00:00:00
abstract::To further study the characteristics of renal cell carcinoma (RCC) in young patients and better define their biological features, 46 RCCs of patients younger than 25 years were morphologically and immunohistochemically characterized with follow-up. Loss of heterozygosity (LOH) analysis of the von Hippel-Lindau (VHL) g...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909354337
更新日期:2011-04-01 00:00:00
abstract::Primary pulmonary mucin-rich lesions with abundant goblet cells growing within alveolar spaces are either classified as mucinous adenocarcinoma (previously called mucinous bronchioloalveolar carcinoma) or colloid carcinoma. Some of these lesions display a morphologic pattern characterized by paucicellular discontinuou...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896915568992
更新日期:2015-05-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/106689690100900114
更新日期:2001-01-01 00:00:00
abstract::Background. Solitary circumscribed neuroma (SCN), also known as palisaded encapsulated neuroma (PEN), is a benign neural tumor. It may be mistaken as either schwannoma or neurofibroma in pathology practice. In this study, we aimed to define clinicopathologic and immunohistochemical features and discuss its differentia...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919833172
更新日期:2019-08-01 00:00:00