Abstract:
:Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-old man; histiocytosis was detected when endoscopy was performed for an examination of epigastric pain. Case 2 involved the stomach of a 56-year-old woman wherein the lesion was detected during a follow-up endoscopy after Helicobacter pylori infection. Both biopsy specimens exhibited diffuse proliferation of mononuclear cells with nuclear convolution and a background of eosinophilic infiltrate. The cells were immunohistochemically positive for CD1a and langerin, and BRAF V600E mutation was detected in Case 2. Follow-up endoscopy for both cases revealed that the lesions disappeared without any treatment. It is important to avoid misdiagnosing LCH of the upper-GI tract as a malignant neoplasm.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Matsuoka Y,Iemura Y,Fujimoto M,Shibuya S,Yamada A,Fujii S,Kusaka T,Shindo T,Minamiguchi S,Haga Hdoi
10.1177/1066896920964566subject
Has Abstractpub_date
2020-10-09 00:00:00pages
1066896920964566eissn
1066-8969issn
1940-2465pub_type
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