Abstract:
:Peritoneal metastasis in colorectal carcinoma is associated with a dismal prognosis; however, features that correlate with patterns of metastatic spread are not well characterized. We analyzed the clinicopathologic and molecular features of 166 patients with colorectal carcinomas stratified by metastases to the peritoneum or liver. Mucinous and signet ring cell differentiation were more frequently observed in colorectal carcinoma with peritoneal dissemination compared to colorectal carcinoma with liver metastasis (mucinous differentiation: 62% vs 23%, P < .001; signet ring cell differentiation: 21% vs 0%, P < .0001). The significant association of mucinous differentiation with peritoneal dissemination compared with liver metastasis was identified in patients with both synchronous and metachronous development of metastasis ( P < .01). In contrast, colorectal carcinomas with liver metastasis were more frequently low-grade (90% vs 72%, P = .005) and associated with dirty necrosis (81% vs 56%, P = .001) compared with colorectal carcinomas with peritoneal dissemination. No significant differences were identified between colorectal carcinoma with peritoneal metastasis versus liver metastasis with respect to KRAS mutations, BRAF mutation, or high levels of microsatellite instability. Patients with tumors involving the peritoneum had a significantly worse overall survival in comparison to patients with liver metastasis lacking peritoneal involvement ( P = .02). When including only those patients with peritoneal metastasis, the presence of any mucinous or signet ring cell differentiation was associated with a significantly worse overall survival ( P = .006). Our findings indicate that mucinous and signet ring cell differentiation may be histologic features that are associated with an increased risk of peritoneal dissemination and poor overall survival in patients with peritoneal metastasis.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Kermanshahi TR,Magge D,Choudry H,Ramalingam L,Zhu B,Pingpank J,Ahrendt S,Holtzman M,Zeh H,Bartlett D,Zureikat A,Pai RKdoi
10.1177/1066896916664990subject
Has Abstractpub_date
2017-04-01 00:00:00pages
108-117issue
2eissn
1066-8969issn
1940-2465pii
1066896916664990journal_volume
25pub_type
杂志文章abstract::Palisaded mammary-type myofibroblastoma is a rare variant of benign stromal spindle cell tumor whose histological features are well known. Nevertheless, no cytological features have been reported to date. In this article, we describe the cytological features of a case of palisaded mammary-type myofibroblastoma in whic...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916665699
更新日期:2017-04-01 00:00:00
abstract:AIMS:Diffuse large B-cell lymphomas (DLBCL) can be divided into different subgroups (germinal center B-cell-like [GCB] and non-GCB) according to their gene expression profiles. Immunohistochemistry has been proposed as a surrogate for identifying these subgroups, but data about its efficacy in providing prognostic info...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909345596
更新日期:2011-08-01 00:00:00
abstract::In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 aden...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908319211
更新日期:2009-12-01 00:00:00
abstract::We review the clinical, pathologic, and molecular genetic features of 3 splenic T-cell-rich B-cell lymphomas and discuss their differential diagnosis. All patients presented with symptomatic splenomegaly and underwent diagnostic/therapeutic splenectomy. Microscopically, the spleen in all cases showed a micronodular pr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690401200105
更新日期:2004-01-01 00:00:00
abstract::Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916664986
更新日期:2017-02-01 00:00:00
abstract::To further study the characteristics of renal cell carcinoma (RCC) in young patients and better define their biological features, 46 RCCs of patients younger than 25 years were morphologically and immunohistochemically characterized with follow-up. Loss of heterozygosity (LOH) analysis of the von Hippel-Lindau (VHL) g...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909354337
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Epithelioid hemangioendothelioma (EHE) is an uncommon malignant endothelial neoplasm that most commonly arises in soft tissue, bone, lung, and liver. Crohn's disease (CD) is an inflammatory bowel disease of unknown etiology that is frequently associated with complications including strictures, fistulas/fissu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918801527
更新日期:2019-06-01 00:00:00
abstract::The aim of this study was to investigate protein expression of adenomatous polyposis coli (APC) in primary and metastatic serous ovarian carcinoma. The expression of beta-catenin and E-cadherin was additionally analyzed. One hundred and thirteen primary (n = 56) and metastatic (n = 57) lesions were immunohistochemical...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690201000302
更新日期:2002-07-01 00:00:00
abstract::Background. Solitary circumscribed neuroma (SCN), also known as palisaded encapsulated neuroma (PEN), is a benign neural tumor. It may be mistaken as either schwannoma or neurofibroma in pathology practice. In this study, we aimed to define clinicopathologic and immunohistochemical features and discuss its differentia...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896919833172
更新日期:2019-08-01 00:00:00
abstract::Ocular sebaceous carcinoma is an uncommon, aggressive tumor arising from the Meibomian gland, Zeis gland, or sebaceous glands in the caruncle or eyelashes. We described a rare case of sebaceous carcinoma in situ in a 51-year-old female that was characterized by intraepithelial growth of sebaceous carcinoma cells with ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920917445
更新日期:2020-12-01 00:00:00
abstract::Myositis ossificans (MO) and fibroosseous pseudotumor of digits (FP) are pseudotumoral mimics of malignancy. A review of 50 cases of MO and 14 cases of FP showed that a malignant diagnosis was suggested by referring pathologists in 23% of MO and 9% of FP. The most common misdiagnosis was osteosarcoma. Awareness of the...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100305
更新日期:2003-07-01 00:00:00
abstract::Fibroadenoma and phyllodes tumors of the breast exhibit a continuum of pathologic features. We examined phyllodes tumors initially called fibroadenoma for features that may accurately classify the tumor as phyllodes tumor on the first biopsy specimen. The phyllodes tumors initially called fibroadenoma for features tha...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907311378
更新日期:2008-04-01 00:00:00
abstract::Appendiceal pneumatosis is rare, reported either in the context of acute appendicitis or enterocolitis. Here, we report the case of an elderly adult in whom the acute appendicitis was associated with pneumatosis and occurred in the context of a malformed appendix with pathogenic organism remnants. A 72-year-old man pr...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915597750
更新日期:2016-02-01 00:00:00
abstract:BACKGROUND:The rate of incidental prostate adenocarcinoma (PCa) detection in radical cystoprostatectomy (RCP) varies widely, ranging from 15% to 54%. Such variability may be explained by institutional differences in prostate grossing protocols. Either partial or complete submission of the prostate gland in RCP may resu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917696745
更新日期:2017-08-01 00:00:00
abstract::We assessed the contribution of histopathological features to systemic recurrence (SR) in patients with colorectal cancer, using a case-control design: 71 cases and 184 controls were included, with a mean time until SR of 1.4 ± 0.1 years and a mean follow-up of controls of 1.6 ± 0.06 years. Cases had significantly gre...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914534464
更新日期:2014-09-01 00:00:00
abstract::Synchronous tumors of the stomach are uncommon. We present a unique case of gastric synchronous tumors composed of signet-ring cell adenocarcinoma and gastrointestinal stromal tumor (GIST). The two tumors arose at the same site and were sharply juxtaposed without intermingling of morphologically distinct elements. Coi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907302369
更新日期:2007-10-01 00:00:00
abstract:AIM:To describe a case of metastasis of malignant peritoneal epithelioid mesothelioma in gastric antral mucosa in a patient with a cryptogenic liver cirrhosis associated with esophageal varices, abdominal pain and distension, ascites, and weight loss. MATERIALS AND METHOD:The patient underwent esophageal gastric endos...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908324257
更新日期:2011-04-01 00:00:00
abstract::We report a fourth case of papilliferous keratoameloblastoma, with a 6-year follow-up. A 62-year-old man underwent resection of a right mandibular neoplasm infiltrating bone and soft tissues. Microscopically, there were cysts lined by papillary projections and containing necrotic debris. Cribriform, solid, and tubular...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/106689690201000210
更新日期:2002-04-01 00:00:00
abstract::We describe the case of a 62-year-old man with chronic irritation of the urinary bladder resulting in dysuria and hypogastric pain. Three neoplasms measuring 0.5, 1, and 1.5 cm, respectively, were observed by cystoscopy and removed by transurethral resection (TUR). Histologic examination showed a complex folding of sq...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800317
更新日期:2000-07-01 00:00:00
abstract::Mixed squamous and glandular papilloma (mixed papilloma) of the lung has been reported in fewer than 25 cases in the English literature. Although it is known as a benign tumor, malignant transformation has been reported. Papillary cystic carcinoma is characterized by papillary and cystic growth patterns and has been r...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920908330
更新日期:2020-09-01 00:00:00
abstract::Colonic perineurioma has been depicted as characterized by a mucosal proliferation of monomorphic spindle perineurial cells leading to an evident separation, distortion, and entrapment of colonic crypts. The authors, however, believe that a sizable subset of the cases differ in that they display only a limited perineu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909350883
更新日期:2010-08-01 00:00:00
abstract::A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor wit...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896920928584
更新日期:2021-02-01 00:00:00
abstract::Microvillous inclusion disease (MVID) is a congenital condition presenting with intractable diarrhea. Biopsies demonstrate abnormal apical PAS and CD10 staining in surface enterocytes correlating with the presence of characteristic cytoplasmic inclusions. MVID has been linked to mutations in myosin Vb, important in ap...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896911430959
更新日期:2012-06-01 00:00:00
abstract::Transformation of an ameloblastic fibroma to an ameloblastic fibrosarcoma has been reported rarely in the literature. The present case report describes such evolution in a patient under long-term follow-up. The patient was first treated in 2008, and he developed the malignant counterpart of the disease 2 years later. ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916646448
更新日期:2016-10-01 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 yea...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896918771192
更新日期:2018-10-01 00:00:00
abstract::Warthin tumor is the second most common salivary gland neoplasm. It occurs more commonly in males than in females. Malignant transformation in Warthin tumor is a rare but well-recognized phenomenon; however, the development or presentation of lymphoma in a Warthin tumor is rare. An 80-year-old man presented with painl...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896917734371
更新日期:2018-05-01 00:00:00
abstract::Synovial sarcoma is a high-grade sarcoma commonly affecting young adults. The sites of involvement include soft tissue near joints, lung, pleura, mediastinum, larynx, kidney, and buttocks. Histologic types include monophasic, biphasic, and undifferentiated. We report a unique case of synovial sarcoma with low-grade hi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917723463
更新日期:2018-02-01 00:00:00
abstract::Gustav Giemsa was born in Germany in 1867, worked mainly as a chemist, and died in 1948. The staining method, which carries his name, was designed primarily for the demonstration of parasites in malaria, but it was also employed in histology because of the high-quality staining of the chromatin and the nuclear membran...
journal_title:International journal of surgical pathology
pub_type: 传,历史文章,杂志文章
doi:10.1177/1066896907302239
更新日期:2007-07-01 00:00:00
abstract::Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916680745
更新日期:2017-05-01 00:00:00
abstract::The majority of alveolar RMSs have t(2;13)(q35;q14) or (1:13)(p36;q14),which generate PAX3/7 -FKHR fusion genes. Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR. PAX3 -FKHR and PAX7-FKHR transcripts were positive in 4/8...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323922
更新日期:2009-02-01 00:00:00