Circulating Breast Carcinoma Cells Mimicking Therapy-Related Acute Myeloid Leukemia.

Abstract:

:Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry and fluorescence in situ hybridization (FISH). Bone marrow histology in conjunction with immunohistochemical stains was also evaluated. A population of atypical cells with blast-like morphology was present in the peripheral blood. Flow cytometry showed a 9% population of CD45 dim positive, CD13 partial positive, and CD15 variably positive cells. Peripheral blood FISH analysis revealed deletion 7q, gain of 8q, and deletions 16q and 17q in 32.5% to 36% of 200 interphase cells analyzed. The bone marrow biopsy showed cohesive groups of cytokeratin AE1/AE3 positive cells. Our report demonstrates that circulating carcinoma cells can mimic a high-grade myeloid neoplasm morphologically and by flow cytometry and FISH analysis.

journal_name

Int J Surg Pathol

authors

Rowan DJ,Logunova V,van Tuinen P,Olteanu H,Peterson JF

doi

10.1177/1066896916664986

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

87-93

issue

1

eissn

1066-8969

issn

1940-2465

pii

1066896916664986

journal_volume

25

pub_type

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