Abstract:
:Circulating tumor cells are rare in peripheral blood smears. We report the case of a patient with circulating breast carcinoma cells resembling circulating myeloid blasts and provide a brief review of the literature. Peripheral blood smears and a bone marrow aspirate were examined morphologically and by flow cytometry and fluorescence in situ hybridization (FISH). Bone marrow histology in conjunction with immunohistochemical stains was also evaluated. A population of atypical cells with blast-like morphology was present in the peripheral blood. Flow cytometry showed a 9% population of CD45 dim positive, CD13 partial positive, and CD15 variably positive cells. Peripheral blood FISH analysis revealed deletion 7q, gain of 8q, and deletions 16q and 17q in 32.5% to 36% of 200 interphase cells analyzed. The bone marrow biopsy showed cohesive groups of cytokeratin AE1/AE3 positive cells. Our report demonstrates that circulating carcinoma cells can mimic a high-grade myeloid neoplasm morphologically and by flow cytometry and FISH analysis.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Rowan DJ,Logunova V,van Tuinen P,Olteanu H,Peterson JFdoi
10.1177/1066896916664986subject
Has Abstractpub_date
2017-02-01 00:00:00pages
87-93issue
1eissn
1066-8969issn
1940-2465pii
1066896916664986journal_volume
25pub_type
杂志文章abstract::Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100102
更新日期:2003-01-01 00:00:00
abstract::Mesonephric adenocarcinoma is a rare tumor type that is usually found in areas where the Wolffian duct was present during the fetal period. We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-c...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896915611489
更新日期:2016-04-01 00:00:00
abstract::Mixed adenoneuroendocrine carcinomas (MANECs) of the biliary tract are rare tumors, and to date only a few cases arising in the gallbladder have been reported. Their histogenesis is a matter of debate, since the biliary tract normally lacks neuroendocrine cells. However, the immunohistochemical identification of nonne...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896915580433
更新日期:2015-08-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915603119
更新日期:2016-02-01 00:00:00
abstract::Spindle cell neoplasms arising in the testis are uncommon; most cases belong to the category of gonadal stromal tumors, and the presence of distinctive clinical and pathological features usually lead to a definitive diagnosis. In some instances, however, the diagnosis of these tumors can be challenging and special tec...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908323505
更新日期:2011-02-01 00:00:00
abstract::A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor wit...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920928584
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abstract::In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the th...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896908315754
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abstract::A 37-year-old woman was found to have multiple peritoneal nodules, including on the uterine serosa, at Cesarean section. Histology showed yellow crystalline material surrounded by histiocytes and occasional multinucleate giant cells. Further enquiry revealed that the patient underwent a cholecystectomy for a perforate...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896911409930
更新日期:2012-02-01 00:00:00
abstract::Dedifferentiated liposarcoma is typically a nonlipogenic high-grade sarcoma that arises from well-differentiated liposarcoma. It most commonly presents as a large mass in the retroperitoneum. Significant involvement of the gastrointestinal tract by dedifferentiated liposarcoma is uncommon. We present a unique case of ...
journal_title:International journal of surgical pathology
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abstract::Cells with a resemblance to Gaucher cells, sometimes called pseudo-Gaucher cells, are seen in the bone marrow of some patients with hematologic malignancy or anemia. These cells are derived from cells of the monocytic lineage but do not show the characteristic inclusions of true Gaucher cells when examined by electron...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896912456081
更新日期:2013-02-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896917746744
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:The phenomenon of vanishing carcinomas, first described in context of prostatic carcinomas, has been documented in endometrial carcinomas as well. METHODS:The archives of the department were searched for case files of endometrial carcinoma diagnosed on endometrial curetting/biopsy but which did not reveal a...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896918783581
更新日期:2019-02-01 00:00:00
abstract::Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) are round-cell sarcomas with varying degrees of neuroectodermal differentiation; they are considered members of the same family of tumors based on their common genetic profile. ES/PNET are very infrequent in the female genital tract, the vagina being the ra...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896911424898
更新日期:2012-06-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896913501385
更新日期:2014-08-01 00:00:00
abstract::Malignant melanoma (MM), the most common metastatic solid tumor to involve the breast, may present as a diagnostic problem, frequently requiring the use of ancillary studies for accurate diagnosis. The implication of hormonal interplay is strong since metastatic MM to the breast is seen nearly always in women. However...
journal_title:International journal of surgical pathology
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doi:10.1177/106689690501300102
更新日期:2005-01-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100112
更新日期:2003-01-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916654763
更新日期:2016-12-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100402
更新日期:2003-10-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896917723463
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896906299122
更新日期:2007-04-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/106689690000800307
更新日期:2000-07-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896909335509
更新日期:2009-08-01 00:00:00
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journal_title:International journal of surgical pathology
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更新日期:2012-08-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917696745
更新日期:2017-08-01 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896920986967
更新日期:2021-01-11 00:00:00
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journal_title:International journal of surgical pathology
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doi:10.1177/1066896916664990
更新日期:2017-04-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896909332728
更新日期:2009-06-01 00:00:00