Abstract:
:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal lesions of the gastrointestinal tract. Many are treated surgically with or without the use of adjuvant tyrosine kinase inhibitors. Metastases to lymph nodes are infrequent. In this article, we present a case of a perigastric nodule presenting 3 years postsurgical treatment for biopsy-proven GIST, clinically suspicious for a recurrent/metastatic GIST. The patient had also received adjuvant tyrosine kinase inhibitor therapy. Microscopic sections from the perigastric lesion showed a spindle cell nodule felt initially to represent a GIST with posttherapeutic changes. Together with morphology, immunohistochemical workup supported the myofibroblastic origin of the spindle cells, consistent with a reactive nodular fibrous pseudotumor, and definitively excluded metastatic GIST. This case highlights an important diagnostic pitfall and is the first known case of a GIST preceding a reactive nodular fibrous pseudotumor.
journal_name
Int J Surg Patholjournal_title
International journal of surgical pathologyauthors
Moodley J,Cutz JC,Schell Mdoi
10.1177/1066896918771192subject
Has Abstractpub_date
2018-10-01 00:00:00pages
664-670issue
7eissn
1066-8969issn
1940-2465journal_volume
26pub_type
杂志文章,评审abstract::Calcifying epithelial odontogenic tumor, also known as Pindborg tumor, is a rare benign odontogenic tumor. This tumor predominantly involves the mandible, though the maxilla can also be involved in some cases. The involvement of maxillary sinuses, however, has been previously reported in only 8 case reports English li...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896916644782
更新日期:2016-09-01 00:00:00
abstract::Lynch syndrome is a hereditary disease with germline mutation in a DNA mismatch repair gene, most often presenting with colorectal and/or endometrial carcinomas; however, the spectrum of Lynch syndrome-associated tumors is expanding. In this article, we report a case of a primary peritoneal epithelioid mesothelioma th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916680745
更新日期:2017-05-01 00:00:00
abstract::Crystalloid granuloma (CG) of salivary gland is an extremely rare inflammatory disease, and only 6 cases have been reported in the English literature. CG is histologically characterized by a granulomatous reaction to amylase crystalloid deposition. A 73-year-old woman presented with a painful left neck mass. Computed ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896918791031
更新日期:2019-04-01 00:00:00
abstract::Simple melanosis of the bladder is an uncommon condition with fewer than 15 reported cases characterized by multifocal, diffuse melanin pigmentation of the urothelial mucosa. It is frequently associated with urinary incontinence or urgency. Histologically, melanin granules are present within urothelial cells or lamina...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896909352863
更新日期:2010-12-01 00:00:00
abstract::Male breast carcinomas (MBCs) are rare neoplasms that account for 0.1% of all male cancers. Still, there are 2000 new cases of MCB diagnosed annually in the United States. Because of its rarity, data regarding the etiology, risk factors, diagnosis, management, and prognosis of MBC are limited. MBC shares some similari...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/1066896916675953
更新日期:2017-05-01 00:00:00
abstract::In this report, a case of metaplastic thymoma arising in a thymic cyst wall is discussed. The patient was a 61-year-old male whose chief complaint was sweating and chest pain. Imaging study revealed a mediastinal mass with right hemithoracic extension. He underwent surgical resection of the mass and remnants of the th...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908315754
更新日期:2009-02-01 00:00:00
abstract::In this study, the pathogenesis of clear cell change in colorectal epithelial lesions was studied. A total of 4 cases of clear cell change (1 hyperplasic polyp and 3 adenomas) were characterized using histochemistry, immunohistochemistry, and electron microscopy. All lesions developed in the left colon. In all, 1 aden...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908319211
更新日期:2009-12-01 00:00:00
abstract::We report our experience with Chromogenic in Situ Hybridization (CISH) for the evaluation of HER2 amplification on 55 cases of formalin-fixed, paraffin-embedded invasive breast carcinomas of different histology. All the results were corrected for chromosome 17 aneusomy and compared with immunohistochemistry (IHC); a s...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690501300406
更新日期:2005-10-01 00:00:00
abstract::We report a fourth case of papilliferous keratoameloblastoma, with a 6-year follow-up. A 62-year-old man underwent resection of a right mandibular neoplasm infiltrating bone and soft tissues. Microscopically, there were cysts lined by papillary projections and containing necrotic debris. Cribriform, solid, and tubular...
journal_title:International journal of surgical pathology
pub_type: 杂志文章,评审
doi:10.1177/106689690201000210
更新日期:2002-04-01 00:00:00
abstract::Diaphragm disease of small intestine usually presents with nonspecific clinical features. Radiological investigations often fail to differentiate it from small intestinal tumors and inflammatory bowel disease. It is therefore diagnosed on final histology after surgical resection. We hereby report an interesting case o...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914563392
更新日期:2015-06-01 00:00:00
abstract::We present a case of clear cell meningioma with unusual clinical and pathologic features. The patient was a 54-year-old man who underwent laminectomy and durotomy for an intradural tumor in the lumbar spinal canal. Sections showed a predominance of dense collagenous tissue with irregularly shaped and irregularly sized...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896912470165
更新日期:2013-08-01 00:00:00
abstract::Gastric duplication cysts are rare congenital anomalies that are mostly discovered in children but can remain asymptomatic and undetected into adulthood. Malignant transformation in gastric duplications is extremely rare, with most reported cases being adenocarcinomas. Herein, the authors report the first case of a hi...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896906295777
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:Study of minimum adenocarcinoma has been done almost exclusively on conventional acinar adenocarcinoma. Pseudohyperplastic adenocarcinoma can be confused with benign lesions because of its well-differentiated appearance and has not been studied when the biopsy shows few malignant glands (limited carcinoma). ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896917715910
更新日期:2017-10-01 00:00:00
abstract::Gustav Giemsa was born in Germany in 1867, worked mainly as a chemist, and died in 1948. The staining method, which carries his name, was designed primarily for the demonstration of parasites in malaria, but it was also employed in histology because of the high-quality staining of the chromatin and the nuclear membran...
journal_title:International journal of surgical pathology
pub_type: 传,历史文章,杂志文章
doi:10.1177/1066896907302239
更新日期:2007-07-01 00:00:00
abstract::The role and diagnostic efficacy of gene and protein products RB1, CDK4, CHMP2B, HSP90, and cPLA2G4A, all previously shown to be involved in tumor genesis and cell proliferation, were examined by immunohistochemical techniques in 32 cases of myxofibrosarcomas and 29 myxoid liposarcomas (all diagnosis had been confirme...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896914532539
更新日期:2014-10-01 00:00:00
abstract::We report the case of a well-differentiated chondrosarcoma of the proximal humerus in a 60-year-old man that featured a prominent component of granular cells, the granules being shown by electron microscopy to be lysosomal. Although secondary granular cell changes have been described in a large variety of tumor types,...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690601400211
更新日期:2006-04-01 00:00:00
abstract::CD138 (syndecan-1) immunoexpression has been reported to be specific for the plasmacytoid variant of urothelial carcinomas (UCs). The aim of this study was to examine the utility of CD138 immunohistochemistry for diagnosing the plasmacytoid variant of UCs. The extent and intensity of CD138 immunostaining were evaluate...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896916653673
更新日期:2016-10-01 00:00:00
abstract::A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopatholo...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896907304519
更新日期:2008-04-01 00:00:00
abstract::We describe the case of a 62-year-old man with chronic irritation of the urinary bladder resulting in dysuria and hypogastric pain. Three neoplasms measuring 0.5, 1, and 1.5 cm, respectively, were observed by cystoscopy and removed by transurethral resection (TUR). Histologic examination showed a complex folding of sq...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690000800317
更新日期:2000-07-01 00:00:00
abstract::Mesonephric adenocarcinoma is a rare tumor type that is usually found in areas where the Wolffian duct was present during the fetal period. We report a case of mesonephric adenocarcinoma of the uterine corpus in a 66-year-old woman who presented with vaginal bleeding. Pelvic magnetic resonance imaging revealed a 2.7-c...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915611489
更新日期:2016-04-01 00:00:00
abstract::A 45-year-old woman presented with a short history of abdominal distension and features of intestinal obstruction. Computed tomography examination of the abdomen revealed a solid and cystic mass in the region of the left ovary, but spread within the abdomen was also noted. The ovarian tumor was removed, and an omentec...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690100900411
更新日期:2001-10-01 00:00:00
abstract::A 46-year-old man presented with nonproductive cough and lower limb swelling. Chest radiograph showed a left lower lobe lung mass and multiple subpleural nodules. Other investigations revealed that he had nephrotic syndrome. Core biopsies of the left lower lobe lung mass showed features of inflammatory pseudotumor wit...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920928584
更新日期:2021-02-01 00:00:00
abstract::Cystic neoplasms of the pancreas are rare and often mistaken for pseudocyst by imaging studies and macroscopic examination. We describe an unusual tumor of the pancreas composed of a mural nodule of anaplastic carcinoma arising from a huge ductal adenocarcinoma undergoing cystic degeneration. The cyst measured 27 x 13...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/106689690301100315
更新日期:2003-07-01 00:00:00
abstract::Tumor-to-tumor metastasis is a very rare phenomenon. The most common donor and recipient of tumor-to-tumor metastasis are carcinomas of lung and renal cell carcinoma, respectively. We report a case of primary lung adenocarcinoma that metastasized into a renal angiomyolipoma 9 years after the resection of primary lung ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915572224
更新日期:2015-05-01 00:00:00
abstract::Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described entity that, despite significant pleomorphism, carries a good prognosis. We briefly describe this tumor and its principal differential diagnoses. Recognition of SCPFTs, including the clinical context in which they arise, is important to avoid...
journal_title:International journal of surgical pathology
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doi:10.1177/1066896920938133
更新日期:2020-12-01 00:00:00
abstract::Rosai-Dorfman disease (RDD; sinus histiocytosis with massive lymphoadenopathy) is a rare, usually nodal self-limited disease. Sometimes nodal disease is coupled with extranodal localizations, in which case the disease can follow a protracted clinical course characterized by remissions and relapses and, exceptionally, ...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896908329590
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abstract::Alveolar soft part sarcoma (ASPS) is a rare neoplasm that most commonly presents in the lower extremities. Although ASPS has distinctive histologic features, it may cause diagnostic problems when it arises in unusual locations. To our knowledge, only 1 case of ASPS arising within the breast has previously been reporte...
journal_title:International journal of surgical pathology
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更新日期:2005-01-01 00:00:00
abstract::Studies on the expression of beta-catenin (beta-ct) in gastric carcinoma have provided conflicting results, and the role played by beta-ct mutations in gastric carcinogenesis remains unclear. In an attempt to clarify the aforementioned issues we undertook the retrospective study of 157 gastric carcinomas by using immu...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:International journal of surgical pathology
pub_type: 杂志文章
doi:10.1177/1066896915622277
更新日期:2016-04-01 00:00:00
abstract::The authors describe a case of multifocal perivascular epithelioid cell tumor (PEComa) arising in the pelvis of a 39-year-old woman affected by tuberous sclerosis. The tumor presented in the form of multiple fascicular, focally cystic nodules involving the uterine corpus, both ovaries, and the omentum. Microscopically...
journal_title:International journal of surgical pathology
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00